Estimating risk for developing epilepsy: A population-based study in Rochester, Minnesota
Open accessAbstract
OBJECTIVES: Previous studies that have assessed the risk of developing epilepsy have failed to account for the competing risk of death, significant in the elderly where epilepsy incidence is highest. We report the lifetime risk for epilepsy, accounting for the competing risk of mortality. METHODS: Lifetime risk and cumulative incidence of epilepsy were examined among Rochester, MN, residents between 1960 and 1979. Age-, gender-, and calendar year-specific deaths were obtained for Rochester, MN. Lifetime risk was calculated as the conditional probability of developing epilepsy by a specific age for a person reaching that age who had not yet developed epilepsy. Lifetime risk and cumulative incidence were compared for age and time period. RESULTS: We identified 412 individuals with incident epilepsy diagnosed between January 1, 1960, and December 31, 1979. Lifetime risk was 1.6% to age 50 and 3.0% to age 80; cumulative incidence was 1.7% to age 50 and 3.4% to age 80. Similar differences were seen across epilepsy etiologies. Lifetime risk through 87 years of age increased over time from 3.5% in 1960-1969 to 4.2% in 1970-1979. CONCLUSIONS: One in 26 people will develop epilepsy during their lifetime. Lifetime risk provides an estimate of an individual's risk for epilepsy over his or her remaining lifetime, translates into the number of people who are expected to develop epilepsy, and assists health care planners as they estimate service needs for epilepsy.
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PTE is a common comorbidity after TBI, and TBI is known as a leading cause of adulthood epilepsy.
“It is a common comorbidity after TBI, and TBI is known as a leading cause of adulthood epilepsy [6,7].”
From Impact of a Prison-Based Religious Program on Mental Health State and Aggression Level Among Female Inmates (2019) · cites this paper as [6]
The Abstract and Results report population-wide epilepsy risk, but neither addresses epilepsy after traumatic brain injury or whether TBI is a leading cause of adult epilepsy. Searches of our copy for post-traumatic epilepsy, TBI, and head trauma found no passage establishing either point. (LLM, conf=0.74)
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Department of Health, Education, and Welfare
Cooper, T. (1976) · Military Medicine · doi:10.1093/milmed/141.8.521 · Cited by 3,994 · see citing works
Survival Analysis Techniques for Censored and Truncated Data
Rao, M. B., Klein, J. P., & Moeschberger, M. L. (1998) · Technometrics · doi:10.2307/1270658 · Cited by 3,617 · see citing works
Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984
Hauser, W. A., Annegers, J. F., & Kurland, L. T. (1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb02586.x · Cited by 2,084 · see citing works
Self-citationKlein, J. P., & Moeschberger, M. L. (2003) · Statistics for biology and health · doi:10.1007/b97377 · Cited by 1,832 · see citing works
Guidelines for Epidemiologic Studies on Epilepsy
(1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb00433.x · Cited by 1,360 · see citing works
Guidelines for epidemiologic studies on epilepsy
Prognosis (1993) · Epilepsia · Cited by 1,183 · see citing works
Kung, H.-C., Hoyert, D. L., Xu, J., & Murphy, S. L. (2008) · PubMed · Cited by 931 · see citing works
Lifetime risk of developing coronary heart disease
Lloyd‐Jones, D. M., Larson, M. G., Beiser, A., & Levy, D. A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10279-9 · Cited by 927 · see citing works
Gaynor, J. J., Feuer, E. J., Tan, C. C., Wu, D. H. Y., Little, C., Straus, D. J., Clarkson, B. D., & Brennan, M. F. (1993) · Journal of the American Statistical Association · doi:10.1080/01621459.1993.10476289 · Cited by 483 · see citing works
Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study
Seshadri, S. S., & Wolf, P. A. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70291-0 · Cited by 367 · see citing works
Incidence and remaining lifetime risk of Parkinson disease in advanced age
Driver, J. A., Logroscino, G., Gaziano, J. M., & Kurth, T. (2009) · Neurology · doi:10.1212/01.wnl.0000341769.50075.bb · Cited by 298 · see citing works
Self-citationCancer incidence: life table risk versus cumulative risk.
Schouten, L. J., Straatman, H., Kiemeney, L. A. L. M., & Verbeek, A. L. M. (1994) · Journal of Epidemiology & Community Health · doi:10.1136/jech.48.6.596 · Cited by 63 · see citing works
(1970) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1970.tb63407.x · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 14 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Analysis of shared heritability in common disorders of the brain
The Brainstorm Consortium, Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., Escott-Price, V., Falcone, G. J., Gormley, P., et al. (2018) · Science · doi:10.1126/science.aap8757 · Cited by 1,924 · see citing works
Astrocytes: a central element in neurological diseases
Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J., Parpura, V., Hol, E. M., Sofroniew, M. V., & Verkhratsky, A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1513-1 · Cited by 755 · see citing works
Epilepsy across the spectrum: Promoting health and understanding.
England, M. J., Liverman, C. T., Schultz, A. M., & Strawbridge, L. M. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.06.016 · Cited by 733 · see citing works
Epilepsy in poor regions of the world
Newton, C. R., & Garcia, H. H. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61381-6 · Cited by 493 · see citing works
The pharmacological treatment of epilepsy in adults
Perucca, E., & Tomson, T. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70047-3 · Cited by 334 · see citing works
Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies
(2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70171-1 · Cited by 293 · see citing works
Perucca, P., Bahlo, M., & Berkovic, S. F. (2020) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-120219-074937 · Cited by 235 · see citing works
Marson, A. G., Burnside, G., Appleton, R. E., Smith, D., Leach, J. P., Sills, G. J., Smith, C. T., Plumpton, C., Hughes, D. A., Williamson, P. R., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00246-4 · Cited by 222 · see citing works
Wirrell, E. C., Grossardt, B. R., Wong‐Kisiel, L. C., & Nickels, K. C. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.03.009 · Cited by 220 · see citing works
Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., Tudur-Smith, C., Plumpton, C., Hughes, D. A., Williamson, P., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00247-6 · Cited by 208 · see citing works
Binder, D. K., Nagelhus, E. A., & Ottersen, O. P. (2012) · Glia · doi:10.1002/glia.22317 · Cited by 171 · see citing works
Genetic testing for the epilepsies: A systematic review
Sheidley, B. R., Malinowski, J. R., Bergner, A. L., Bier, L., Gloss, D. S., Mu, W., Mulhern, M., Partack, E., & Poduri, A. (2021) · Epilepsia · doi:10.1111/epi.17141 · Cited by 156 · see citing works
Polygenic burden in focal and generalized epilepsies
Leu, C., Stevelink, R., Smith, A. C. W., Goleva, S. B., Kanai, M., Ferguson, L., Campbell, C., Kamatani, Y., Okada, Y., Sisodiya, S. M., et al. (2019) · Brain · doi:10.1093/brain/awz292 · Cited by 148 · see citing works
Astrocytes as Guardians of Neuronal Excitability: Mechanisms Underlying Epileptogenesis
Verhoog, Q. P., Holtman, L., Aronica, E., & van Vliet, E. A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.591690 · Cited by 144 · see citing works
The causes of new-onset epilepsy and seizures in the elderly
Lü, Y., Liu, S., & Yu, W. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s107905 · Cited by 146 · see citing works
Hubbard, J. A., Szu, J. I., Yonan, J. M., & Binder, D. K. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.003 · Cited by 140 · see citing works
Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy
Winawer, M. R., Griffin, N. G., Samanamud, J. L., Baugh, E. H., Rathakrishnan, D., Ramalingam, S., Zagzag, D., Schevon, C. A., Dugan, P. C., Hegde, M., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25243 · Cited by 134 · see citing works
Smith, L. A., Malinowski, J. R., Ceulemans, S., Peck, K., Walton, N., Sheidley, B. R., & Lippa, N. C. (2022) · Journal of Genetic Counseling · doi:10.1002/jgc4.1646 · Cited by 133 · see citing works
Approaches to refractory epilepsy
Engel, J. (2014) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.128644 · Cited by 125 · see citing works
Crucial role of astrocytes in temporal lobe epilepsy
Steinhäuser, C., Grunnet, M., & Carmignoto, G. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.047 · Cited by 116 · see citing works
Epilepsy genetics: Current knowledge, applications, and future directions
Myers, K. A., Johnstone, D. L., & Dyment, D. A. (2018) · Clinical Genetics · doi:10.1111/cge.13414 · Cited by 118 · see citing works
Reddy, D. S., Thompson, W. J., & Calderara, G. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135753 · Cited by 114 · see citing works
Christian, C. A., Reddy, D. S., Maguire, J., & Forcelli, P. A. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.017392 · Cited by 105 · see citing works
Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders
Liu, B., Teschemacher, A. G., & Kasparov, S. (2017) · Glia · doi:10.1002/glia.23136 · Cited by 107 · see citing works
Mitochondrial calcium cycling in neuronal function and neurodegeneration
Walters, G. C., & Usachev, Y. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1094356 · Cited by 105 · see citing works
Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy
Li, P., Fu, X., Smith, N., Ziobro, J. M., Curiel, J., Tenga, M. J., Martin, B. S., Freedman, S., Rio, C. A. C.-D., Oboti, L., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.044 · Cited by 98 · see citing works
Aquaporins in Brain Edema and Neuropathological Conditions
Filippidis, A., Carozza, R. B., & Rekate, H. L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010055 · Cited by 96 · see citing works
Psychosocial and sociodemographic associates of felt stigma in epilepsy
Leaffer, E. B., Hesdorffer, D. C., & Begley, C. E. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.06.006 · Cited by 96 · see citing works
Self-citationCognitive impairment in older adults with epilepsy: Characterization and risk factor analysis
Miller, L. A., Galioto, R., Tremont, G. N., Davis, J. D., Bryant, K., Roth, J. L., LaFrance, W. C., Jr., & Blum, A. S. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.01.011 · Cited by 96 · see citing works
The contribution of next generation sequencing to epilepsy genetics
Møller, R. S., Dahl, H. A., & Helbig, I. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1113132 · Cited by 88 · see citing works
Deshpande, T., Li, T., Herde, M. K., Becker, A., Vatter, H., Schwarz, M. K., Henneberger, C., Steinhäuser, C., & Bedner, P. (2017) · Glia · doi:10.1002/glia.23196 · Cited by 87 · see citing works
Descriptive epidemiology of epilepsy in the U . S . population: A different approach
Helmers, S. L., Thurman, D. J., Durgin, T. L., Pai, A. K., & Faught, E. (2015) · Epilepsia · doi:10.1111/epi.13001 · Cited by 85 · see citing works
Characterizing the role of the structural connectome in seizure dynamics.
Shah, P., Ashourvan, A., Mikhail, F., Pines, A., Kini, L. G., Oechsel, K. F., Das, S. R., Stein, J., Shinohara, R., Bassett, D., et al. (2019) · Brain : a journal of neurology · doi:10.1093/brain/awz125 · Cited by 80 · see citing works
Khoshkhoo, S., Wang, Y., Chahine, Y., Erson-Omay, Z., Robert, S. M., Kiziltug, E., Damisah, E. C., Nelson-Williams, C. J., Zhu, G., Kong, W., et al. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.0473 · Cited by 83 · see citing works
Orexin Receptor Antagonism Improves Sleep and Reduces Seizures inKcna1-null Mice
Roundtree, H. M., Simeone, T. A., Johnson, C., Matthews, S. A., Samson, K. K., & Simeone, K. A. (2016) · SLEEP · doi:10.5665/sleep.5444 · Cited by 83 · see citing works
The neuroendocrine basis of sex differences in epilepsy
Reddy, D. S. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.07.002 · Cited by 79 · see citing works
The COX-2/prostanoid signaling cascades in seizure disorders
Rojas, A., Chen, D., Ganesh, T., Varvel, N. H., & Dingledine, R. J. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1554056 · Cited by 76 · see citing works
Villanueva, V., Serratosa, J. M., Guillamón, E., Garcés, M., Giráldez, B. G., Toledo, M., Salas‐Puig, J., González, F. J. L., Flores, J., Rodríguez-Uranga, J., et al. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.04.014 · Cited by 70 · see citing works
Baker, E. M., Thompson, C. H., Hawkins, N. A., Wagnon, J. L., Wengert, E. R., Patel, M. K., George, A. L., Meisler, M. H., & Kearney, J. A. (2018) · Epilepsia · doi:10.1111/epi.14196 · Cited by 69 · see citing works
Eimon, P. M., Ghannad‐Rezaie, M., Rienzo, G. D., Allalou, A., Wu, Y., Gao, M., Roy, A., Skolnick, J., & Yanik, M. F. (2018) · Nature Communications · doi:10.1038/s41467-017-02404-4 · Cited by 65 · see citing works
Resolving the Micro-Macro Disconnect to Address Core Features of Seizure Networks
Farrell, J. S., Nguyen, Q.-A., & Soltész, I. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.043 · Cited by 54 · see citing works
Motelow, J. E., Povysil, G., Dhindsa, R. S., Stanley, K. E., Allen, A. S., Feng, Y. A., Howrigan, D. P., Abbott, L. E., Tashman, K. C., Cerrato, F. E., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.04.009 · Cited by 53 · see citing works
Cooper, Y. A., Pianka, S., Alotaibi, N. M., Babayan, D., Salavati, B., Weil, A., Ibrahim, G. M., Wang, A. C., & Fallah, A. (2017) · Epilepsia Open · doi:10.1002/epi4.12092 · Cited by 49 · see citing works
Simeone, K. A., Hallgren, J., Bockman, C. S., Aggarwal, A., Kansal, V., Netzel, L., Iyer, S. H., Matthews, S. A., Deodhar, M., Oldenburg, P. J., et al. (2018) · Epilepsia · doi:10.1111/epi.13971 · Cited by 56 · see citing works
Purinergic signaling in epilepsy
Rassendren, F., & Audinat, É. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23770 · Cited by 54 · see citing works
The Epilepsy Phenome/Genome Project
Collaborative, T. E., McGovern, K., Stillman, N., McKenna, K., Mays, V. M., Williams, M. J. A., Carpenter, A., Miller, K., Agarwal, P., Ayala, J., et al. (2013) · Clinical Trials · doi:10.1177/1740774513484392 · Cited by 51 · see citing works
Cause-specific mortality and life years lost in people with epilepsy: a Danish cohort study
Dreier, J. W., Laursen, T. M., Tomson, T., Plana‐Ripoll, O., & Christensen, J. (2022) · Brain · doi:10.1093/brain/awac042 · Cited by 48 · see citing works
Shostak, S., Zarhin, D., & Ottman, R. (2011) · Social Science & Medicine · doi:10.1016/j.socscimed.2011.06.043 · Cited by 48 · see citing works
Sex differences in the anticonvulsant activity of neurosteroids
Reddy, D. S. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23853 · Cited by 47 · see citing works
Glial source of nitric oxide in epileptogenesis: A target for disease modification in epilepsy
Sharma, S., Puttachary, S., & Thippeswamy, T. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24205 · Cited by 47 · see citing works
Role of astrocyte purinergic signaling in epilepsy
Nikolic, L. M., Nobili, P., Shen, W., & Audinat, É. (2019) · Glia · doi:10.1002/glia.23747 · Cited by 49 · see citing works
Chemically-induced TLE models: Topical application
Jefferys, J. G. R., Steinhäuser, C., & Bedner, P. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.04.011 · Cited by 47 · see citing works
Hajek, M. A., & Buchanan, G. F. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00011.2016 · Cited by 47 · see citing works
Kim, H., Thurman, D. J., Durgin, T., Faught, E., & Helmers, S. (2016) · Journal of Child Neurology · doi:10.1177/0883073815620676 · Cited by 45 · see citing works
Depression and Anxiety in the Epilepsies: from Bench to Bedside
Krishnan, V. (2020) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-020-01065-z · Cited by 47 · see citing works
Astrocytic GABA Accumulation in Experimental Temporal Lobe Epilepsy
Müller, J., Timmermann, A., Henning, L., Müller, H., Steinhäuser, C., & Bedner, P. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.614923 · Cited by 42 · see citing works
Epilepsy Imaging in Adults: Getting It Right
Friedman, E. R. (2014) · American Journal of Roentgenology · doi:10.2214/ajr.13.12035 · Cited by 41 · see citing works
An update on the prevalence and incidence of epilepsy among older adults
Ip, Q., Malone, D. C., Chong, J., Harris, R. B., & Labiner, D. M. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.11.022 · Cited by 41 · see citing works
Model systems for studying cellular mechanisms of SCN1A -related epilepsy
Schutte, S. S., Schutte, R. J., Barragan, E. V., & O’Dowd, D. K. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00824.2015 · Cited by 39 · see citing works
New anti-seizure medication for elderly epilepsy patients - a critical narrative review
Rohracher, A., Kalss, G., Kuchukhidze, G., Neuray, C., Leitinger, M., Höfler, J., Kreidenhuber, R., Rossini, F., Volna, K., Mauritz, M., et al. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1843636 · Cited by 36 · see citing works
Role of neuroimaging in first seizure diagnosis
Crocker, C. E., Pohlmann-Eden, B., & Schmidt, M. H. (2016) · Seizure · doi:10.1016/j.seizure.2016.05.015 · Cited by 35 · see citing works
England, M. J., AUSTIN, J. K., Beck, V., Escoffery, C., & Hesdorffer, D. C. (2014) · Health Promotion Practice · doi:10.1177/1524839914523779 · Cited by 34 · see citing works
Self-citationKruse, S. W., Dayton, K. G., Purnell, B. S., Rosner, J., & Buchanan, G. F. (2019) · Epilepsia · doi:10.1111/epi.14652 · Cited by 34 · see citing works
Narayanan, J., Dobrin, S., Choi, J. S., Rubin, S., Pham, A. T., Patel, V. A., Frigerio, R., Maurer, D., Gupta, P., Link, L., et al. (2016) · Epilepsia · doi:10.1111/epi.13607 · Cited by 34 · see citing works
Intravenous immunoglobulin as treatment for myasthenia gravis: current evidence and outcomes
Alabdali, M. M., Barnett, C., Katzberg, H. D., Breiner, A., & Bril, V. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.971757 · Cited by 33 · see citing works
Lewis, A. K., Taylor, N. F., Carney, P. W., & Harding, K. E. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2021.108192 · Cited by 32 · see citing works
Iyer, S. H., Matthews, S. A., Simeone, T. A., Maganti, R. K., & Simeone, K. A. (2017) · Epilepsia · doi:10.1111/epi.13953 · Cited by 32 · see citing works
Glial cell changes in epilepsy: Overview of the clinical problem and therapeutic opportunities
Hubbard, J. A., Hsu, M. S., Fiacco, T. A., & Binder, D. K. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.01.017 · Cited by 31 · see citing works
Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology
Becchetti, A., Grandi, L. C., Colombo, G., Meneghini, S., & Amadeo, A. (2020) · Brain Sciences · doi:10.3390/brainsci10120907 · Cited by 31 · see citing works
Cell death of hippocampal CA1 astrocytes during early epileptogenesis
Wu, Z., Deshpande, T., Henning, L., Bedner, P., Seifert, G., & Steinhäuser, C. (2021) · Epilepsia · doi:10.1111/epi.16910 · Cited by 34 · see citing works
Galán, F., Beier, A. D., & Sheth, R. D. (2021) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2021.06.004 · Cited by 31 · see citing works
Astrocytic Ca2+ Signaling in Epilepsy
Heuser, K., & Enger, R. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.695380 · Cited by 31 · see citing works
Zhu, X., Dubey, D., Bermudez, C. L., & Porter, B. E. (2015) · Epilepsia · doi:10.1111/epi.13211 · Cited by 30 · see citing works
West, P. J., Saunders, G. W., Billingsley, P., Smith, M. D., White, H. S., Metcalf, C. S., & Wilcox, K. S. (2018) · Epilepsia · doi:10.1111/epi.14563 · Cited by 30 · see citing works
Bai, Y., He, X., Bai, Y., Sun, Y., Zhao, Z., Chen, X., Li, B., Xie, J., Li, Y., Jia, P., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111650 · Cited by 30 · see citing works
Kim, Y., & Han, K. R. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16040589 · Cited by 29 · see citing works
“It is a common comorbidity after TBI, and TBI is known as a leading cause of adulthood epilepsy [6,7].”
BackgroundPatient-centered outcomes in older adults with epilepsy
Miller, W. R. (2014) · Seizure · doi:10.1016/j.seizure.2014.04.010 · Cited by 28 · see citing works
Wong, M. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s14208 · Cited by 27 · see citing works
Ali, R., & Siddiqui, N. (2015) · Archiv der Pharmazie · doi:10.1002/ardp.201400466 · Cited by 26 · see citing works
Ma, J., Huang, S., & You, C. (2015) · Epilepsy Research · doi:10.1016/j.eplepsyres.2015.04.017 · Cited by 25 · see citing works
Miller, W. R., Bakas, T., & Buelow, J. M. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.11.011 · Cited by 25 · see citing works
Mohandas, N., Loke, Y. J., Hopkins, S., Mackenzie, L., Bennett, C., Berkovic, S. F., Vadlamudi, L., & Craig, J. M. (2019) · Epigenomics · doi:10.2217/epi-2018-0136 · Cited by 24 · see citing works
Mortality in Patients With Late-Onset Epilepsy
Johnson, E. L., Krauss, G. L., Kucharska‐Newton, A., Lam, A. D., Sarkis, R. A., & Gottesman, R. F. (2021) · Neurology · doi:10.1212/wnl.0000000000012483 · Cited by 24 · see citing works
Berteotti, C., Calvello, C., & Liguori, C. (2023) · Epilepsia · doi:10.1111/epi.17661 · Cited by 24 · see citing works
Driving regulations for epilepsy in Europe
Möller, L., Krämer, G., Habermehl, L., Menzler, K., & Knake, S. (2023) · Seizure · doi:10.1016/j.seizure.2023.05.016 · Cited by 24 · see citing works
Erster epileptischer Anfall und Epilepsien im Erwachsenenalter
Bast, T., Bauer, J. M., Berkenfeld, R., Elger, C. E., Hamer, H. M., Malter, M. P., Mayer, T., von Podewils, F., Runge, U., Schmidt, D., et al. (2017) · Aktuelle Neurologie · doi:10.1055/s-0043-124999 · Cited by 24 · see citing works
Kee, N. N., Foster, E., Marquina, C., Tan, A., Pang, S. S. T., O'Brien, T. J., Kwan, P., Jackson, G. D., Chen, Z. Z., & Ademi, Z. (2023) · Neurology · doi:10.1212/wnl.0000000000207137 · Cited by 24 · see citing works
Astroglial Networks and Implications for Therapeutic Neuromodulation of Epilepsy
Witcher, M. R., & Ellis, T. L. (2012) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2012.00061 · Cited by 23 · see citing works
Using EHRs to advance epilepsy care
Mbwana, J., Grinspan, Z. M., Bailey, R. C., Berl, M. M., Buchhalter, J., Bumbut, A., Danner, Z., Glauser, T. A., Glotstein, A., Goodkin, H. P., et al. (2019) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000000575 · Cited by 22 · see citing works
Remigio, G. J., Loewen, J. L., Heuston, S., Helgeson, C., White, H. S., Wilcox, K. S., & West, P. J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.06.006 · Cited by 22 · see citing works
Silva, A. B., Khambhati, A. N., Speidel, B. A., Chang, E. F., & Rao, V. R. (2021) · Epilepsy & Behavior Reports · doi:10.1016/j.ebr.2021.100467 · Cited by 21 · see citing works
Brain structural and neuroendocrine basis of sex differences in epilepsy
Reddy, D. S. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00016-3 · Cited by 21 · see citing works
ForeSeiz: An IoMT based headband for Real-time epileptic seizure forecasting
Prathaban, B. P., Баласубраманиан, Р., & Kalpana, R. (2021) · Expert Systems with Applications · doi:10.1016/j.eswa.2021.116083 · Cited by 21 · see citing works
Sulfasalazine decreases mouse cortical hyperexcitability
Alcoreza, O. B., Tewari, B. P., Bouslog, A., Savoia, A., Sontheimer, H. W., & Campbell, S. L. (2019) · Epilepsia · doi:10.1111/epi.16073 · Cited by 21 · see citing works
Zheng, F. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1088-4_11 · Cited by 20 · see citing works
Epilepsy: Old Syndromes, New Genes
Weckhuysen, S., & Korff, C. M. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0447-7 · Cited by 20 · see citing works
Akyüz, E., Tiber, P. M., Beker, M., & Akbaş, F. (2018) · Cellular and Molecular Biology · doi:10.14715/cmb/2017.64.15.8 · Cited by 20 · see citing works
Definitions and Risk Factors for Drug-Resistant Epilepsy in an Adult Cohort
Denton, A., Thorpe, L. U., Carter, A., Fonseca, A. A., Waterhouse, K., & Hernández‐Ronquillo, L. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.777888 · Cited by 20 · see citing works
Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability
LaCoursiere, C. M., Ullmann, J. F. P., Koh, H. Y., Turner, L. H., Baker, C. M., Robens, B. K., Shao, W., Rotenberg, A., McGraw, C. M., & Poduri, A. (2024) · iScience · doi:10.1016/j.isci.2024.110172 · Cited by 20 · see citing works
Eberle, M. M., Reynolds, C. L., Szu, J. I., Wang, Y., Hansen, A. M., Hsu, M. S., Islam, M. S., Binder, D. K., & Park, B. H. (2012) · Biomedical Optics Express · doi:10.1364/boe.3.002700 · Cited by 20 · see citing works
- Authors
- Hesdorffer, D. C., Logroscino, G., Benn, E. K. T., Katri, N., Cascino, G., & Hauser, W. A.
- Affiliations
- Mayo Clinic (US)
- Venue
- Neurology
- Published
- 2011-01-04
- Volume
- 76
- Issue
- 1
- Pages
- 23-27
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3032191
- OpenAlex
- W2064064788
- Cited by
- 324
- References
- 14
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 20 · 2023: 25 · 2022: 22 · 2021: 34 · 2020: 24 · 2019: 20 · 2018: 22 · 2017: 23 · 2016: 26 · 2015: 19 · 2014: 17 · 2013: 9 · 2012: 17
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Association of American Medical Colleges
- University of Minnesota
- NeuroPace
- Ministero della Salute
- H. Lundbeck A/S
- National Institutes of Health (NS043209)
- Centers for Disease Control and Prevention (DP002209)
- National Institute of Neurological Disorders and Stroke (NS043209, T32NS007153, NS07153, P50NS016308)
- National Center for Research Resources (MO1 RR00645, M01RR000645)
- Maternal and Child Health Bureau
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- epilepsy, lifetime risk, cumulative incidence, competing risk of death, older adults, Rochester, Minnesota, epilepsy etiology, health planning
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Epilepsy, Female, Humans, Male, Middle Aged, Minnesota, Predictive Value of Tests, Probability, Retrospective Studies, Risk Factors, Sex Factors, Incidence, Community Health Planning
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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