The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Dark microglia: A new phenotype predominantly associated with pathological states
Open accessAbstract
The past decade has witnessed a revolution in our understanding of microglia. These immune cells were shown to actively remodel neuronal circuits, leading to propose new pathogenic mechanisms. To study microglial implication in the loss of synapses, the best pathological correlate of cognitive decline across chronic stress, aging, and diseases, we recently conducted ultrastructural analyses. Our work uncovered the existence of a new microglial phenotype that is rarely present under steady state conditions, in hippocampus, cerebral cortex, amygdala, and hypothalamus, but becomes abundant during chronic stress, aging, fractalkine signaling deficiency (CX 3 CR1 knockout mice), and Alzheimer's disease pathology (APP‐PS1 mice). Even though these cells display ultrastructural features of microglia, they are strikingly distinct from the other phenotypes described so far at the ultrastructural level. They exhibit several signs of oxidative stress, including a condensed, electron‐dense cytoplasm and nucleoplasm making them as “dark” as mitochondria, accompanied by a pronounced remodeling of their nuclear chromatin. Dark microglia appear to be much more active than the normal microglia, reaching for synaptic clefts, while extensively encircling axon terminals and dendritic spines with their highly ramified and thin processes. They stain for the myeloid cell markers IBA1 and GFP (in CX 3 CR1‐GFP mice), and strongly express CD11b and microglia‐specific 4D4 in their processes encircling synaptic elements, and TREM2 when they associate with amyloid plaques. Overall, these findings suggest that dark microglia, a new phenotype that we identified based on their unique properties, could play a significant role in the pathological remodeling of neuronal circuits, especially at synapses. GLIA 2016;64:826–839
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Dysregulation of microglial functions is associated with several health concerns that often show sex prevalences, not only affecting Alzheimer’s disease, which shows more prevalence among females, and Parkinson’s disease, more male-prevalent, but also including various other neurodevelopmental, neuropsychiatric and neurodegenerative disorders [38–43].”
From Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus (2025) · cites this paper as [38]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Bialas, A. R., & Stevens, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3560 · Cited by 519
RetractedThe mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244
Self-citationMicroglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599
Immune attack: the role of inflammation in Alzheimer disease
Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134
From circuits to behaviour in the amygdala
Janak, P. H., & Tye, K. M. (2015) · Nature · doi:10.1038/nature14188 · Cited by 2,011 · cited 1×
“3H).”
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 423
St‐Pierre, M., Carrier, M., Ibáñez, F. G., Khakpour, M., Wallman, M., Parent, M., & Tremblay, M. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02752-7 · Cited by 28
Self-citationVascular Metabolism as Driver of Atherosclerosis: Linking Endothelial Metabolism to Inflammation
Dzobo, K. E., Hanford, K., & Kroon, J. (2021) · Immunometabolism · doi:10.20900/immunometab20210020 · Cited by 27
Lipid Droplets as Regulators of Metabolism and Immunity
Boucher, D. M., Vijithakumar, V., & Ouimet, M. I. (2021) · Immunometabolism · doi:10.20900/immunometab20210021 · Cited by 26
Microglial Endocannabinoid Signalling in AD
Scipioni, L., Ciaramellano, F., Carnicelli, V., Leuti, A., Lizzi, A. R., Dominicis, N. D., Oddi, S., & Maccarrone, M. (2022) · Cells · doi:10.3390/cells11071237 · Cited by 26
VanderZwaag, J., Halvorson, T., Dolhan, K., Šimončičová, E., Ben‐Azu, B., & Tremblay, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03772-0 · Cited by 28
Self-citationMicroglia Reactivity: Heterogeneous Pathological Phenotypes
Hirbec, H., Rassendren, F., & Audinat, É. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9658-2_4 · Cited by 24
Muth, C., Schröck, K., Madore, C., Hartmann, K., Fanek, Z., Butovsky, O., Glatzel, M., & Krasemann, S. (2017) · Brain Pathology · doi:10.1111/bpa.12441 · Cited by 23
Self-citationBöing, C., Fabrizio, M. D., Burger, D., Bol, J. G. J. M., Huisman, E., Rozemüller, A. J. M., van de Berg, W. D. J., Stahlberg, H., & Lewis, A. J. (2024) · Brain · doi:10.1093/brain/awae137 · Cited by 26
Glial cells as drug targets: What does it take?
Möller, T., & Boddeke, H. W. G. M. (2016) · Glia · doi:10.1002/glia.22993 · Cited by 24
Morales‐Ropero, J. M., Arroyo‐Urea, S., Neubrand, V. E., Martín‐Oliva, D., Marín‐Teva, J. L., Cuadros, M. Á., Vangheluwe, P., Navascués, J., Mata, A. M., & Sepúlveda, M. R. (2020) · Glia · doi:10.1002/glia.23931 · Cited by 23
Carrier, M., Guilbert, J., Lévesque, J.-P., Tremblay, M., & Desjardins, M. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.595002 · Cited by 23
Self-citationHui, C. W., Bhardwaj, S. K., Sharma, K. P., Joseph, A. T., Bisht, K., Picard, K., Tremblay, M., & Srivastava, L. K. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.007 · Cited by 23
Self-citationBrain resident microglia in Alzheimer’s disease: foe or friends
Kaur, S., Malleshwari, K., Sharma, A., Giridharan, V. V., & Dandekar, M. P. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01550-8 · Cited by 23
Microglia in Alzheimer’s Disease
Süß, P., & Schlachetzki, J. C. M. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200212155234 · Cited by 26
Assessing Microglial Dynamics by Live Imaging
Andoh, M., & Koyama, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.617564 · Cited by 23
Caruso, G., Pietro, L. D., & Caraci, F. (2023) · Biomolecules · doi:10.3390/biom13030505 · Cited by 24
St‐Pierre, M., Ibáñez, F. G., Kroner, A., & Tremblay, M. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02953-0 · Cited by 22
Self-citationThe Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma
Elder, G. A., Sosa, M. A. G., Gasperi, R. D., Garcia, G. S. P., Perez, G. M., Abutarboush, R., Kawoos, U., Zhu, C. W., Janssen, W. G. M., Stone, J. R., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021150 · Cited by 25
Microglia contact cerebral vasculature through gaps between astrocyte endfeet
Morris, G. P., Foster, C. G., Sutherland, B. A., & Grubb, S. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241280775 · Cited by 23
Nakamura, Y., Kimura, S., Takada, N., Takemura, M., Iwamoto, M., Hisaoka-Nakashima, K., Nakata, Y., & Morioka, N. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104751 · Cited by 18
Microglia as a Hub for Suicide Neuropathology: Future Investigation and Prevention Targets
de Andrade, E. G., Ibáñez, F. G., & Tremblay, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.839396 · Cited by 22
Self-citationMicroglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer’s Disease
Xie, J., Wang, H., Lin, T., & Bi, B. (2017) · BioMed Research International · doi:10.1155/2017/2986460 · Cited by 22
Illouz, T., Madar, R., Biragyn, A., & Okun, E. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.10.004 · Cited by 22
Augusto‐Oliveira, M., Arrifano, G. D. P., Leal-Nazaré, C. G., Chaves-Filho, A. J. M., Santos-Sacramento, L., Lopes-Araújo, A., Tremblay, M., & Lopez, M. E. C. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106091 · Cited by 28
Self-citationLill, J. K., Thiebes, S., Pohl, J., Bottek, J., Subramaniam, N., Christ, R., Soun, C., Gueler, F., Zwanziger, D., Hoffmann, F. S., et al. (2021) · Kidney International · doi:10.1016/j.kint.2021.03.039 · Cited by 21
Key roles of glial cells in the encephalopathy of prematurity
Steenwinckel, J. V., Bokobza, C., Laforge, M., Shearer, I. K., Miron, V. E., Rua, R., Matta, S. M., Hill‐Yardin, E. L., Fleiss, B., & Gressèns, P. (2023) · Glia · doi:10.1002/glia.24474 · Cited by 26
Hull, C. E., Dekeryte, R., Koss, D. J., Crouch, B., Buchanan, H. M., Delibegović, M., & Platt, B. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01722-6 · Cited by 20
Tremblay, M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.628347 · Cited by 21
Self-citationEmerging contributions of formyl peptide receptors to neurodegenerative diseases
Busch, L., Vieten, S., Brödel, S., Endres, K., & Bufe, B. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0258 · Cited by 21
Zhou, K., Han, J., Lund, H., Boggavarapu, N. R., Lauschke, V. M., Goto, S., Cheng, H., Wang, Y., Tachi, A., Xie, C., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02381-6 · Cited by 20
van Rees, G. F., Lago, S. G., Cox, D., Tomasik, J., Rustogi, N., Weigelt, K., Özcan, S., Cooper, J. D., Drexhage, H. A., Leweke, F. M., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.003 · Cited by 22
Spiteri, A. G., Wishart, C. L., & King, N. J. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.600822 · Cited by 31
Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement
Morini, R., Bizzotto, M., Perrucci, F., Filipello, F., & Matteoli, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.640937 · Cited by 22
Behl, T., Kaur, G., Sehgal, A., Zengin, G., Singh, S., Ahmadi, A., & BUNGAU, S. G. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210524152817 · Cited by 22
Fundamental Neurochemistry Review: Lipids across microglial states
Traetta, M. E., Vecchiarelli, H. A., & Tremblay, M. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16259 · Cited by 21
Self-citationCell-lineage specificity of primary cilia during postnatal epididymal development
Bernet, A., Bastien, A., Soulet, D., Jerczynski, O., Roy, C., Alves, M. B. R., Lecours, C., Tremblay, M., Bailey, J. L., Robert, C., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey276 · Cited by 20
Self-citationThe Dual Nature of Microglia in Alzheimer’s Disease: A Microglia-Neuron Crosstalk Perspective
Xie, Z., Meng, J., Wu, Z., Nakanishi, H., Hayashi, Y., Kong, W., Lan, F., Narengaowa, Yang, Q., Qing, H., et al. (2023) · The Neuroscientist · doi:10.1177/10738584211070273 · Cited by 19
Chen, R., Routh, B. N., Gaudet, A. D., & Fonken, L. K. (2023) · Journal of Biological Rhythms · doi:10.1177/07487304231178950 · Cited by 21
Bobotis, B. C., Halvorson, T., Carrier, M., & Tremblay, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1317125 · Cited by 22
Self-citationAlterations in Chromatin Structure and Function in the Microglia
Fujita, Y., & Yamashita, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.626541 · Cited by 22
Neuro-immune crosstalk in depressive symptoms of multiple sclerosis
Wang, C., Zhou, Y., & Feinstein, A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106005 · Cited by 20
Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases
Lana, D., Magni, G., Landucci, E., Wenk, G. L., Pellegrini-Giampietro, D. E., & Giovannini, M. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813668 · Cited by 20
Evaluating the Role of Microglial Cells in Clearance of Aβ from Alzheimer’s Brain
Manchikalapudi, A. L., Chilakala, R. R., Kalia, K., & Sunkaria, A. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00627 · Cited by 18
Bobotis, B. C., Khakpour, M., Braniff, O., de Andrade, E. G., Gargus, M., Allen, M., Carrier, M., Baillargeon, J., Rangachari, M., & Tremblay, M.-È. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03341-6 · Cited by 17
“However, microglia display a broad spectrum of morphologies, ranging from hyper-ramified forms in response to stress [88], to senescent, dark and dystrophic phenotypes in stress, aging and disease [28, 77, 89, 90].”
Self-citationDecoeur, F., Picard, K., St‐Pierre, M., Greenhalgh, A. D., Delpech, J.-C., Séré, A., Layé, S., Tremblay, M., & Nadjar, A. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.802411 · Cited by 16
Self-citationMaheshwari, U., Mateos, J. M., Weber‐Stadlbauer, U., Ni, R., Tamatey, V., Sridhar, S., Restrepo, A., de Jong, P. A., Huang, S., Schaffenrath, J., et al. (2023) · Brain Pathology · doi:10.1111/bpa.13189 · Cited by 17
Toomey, C. E., Heywood, W., Benson, B. C., Packham, G., Mills, K. A., & Lashley, T. (2020) · Brain Pathology · doi:10.1111/bpa.12842 · Cited by 17
TREM2 in neurodegeneration and diseases
Abdulkhaliq, A. A., Alasiri, G., Kim, B., Khan, J., Ajoolabady, A., Yousof, S. M., Ren, J., Tuomilehto, J., Borai, A., Alrfaei, B. M., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03505-7 · Cited by 16
Stress, Affective Status and Neurodegenerative Onslaughts
Archer, T., & Rapp‐Ricciardi, M. (2019) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-90065-0_3 · Cited by 17
Monoclonal antibody therapy for Alzheimer's disease focusing on intracerebral targets
Gu, X., Long, Q., Qi, Q., Zhou, J., Chen, S., & Wang, L. (2024) · BioScience Trends · doi:10.5582/bst.2023.01288 · Cited by 17
Badina, A. M., Ceyzériat, K., Amossé, Q., Tresh, A., Abjean, L., Guénat, L., Vauthey, E., Tsartsalis, S., Millet, P., & Tournier, B. B. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106950 · Cited by 17
Parsi, S., Zhu, C., Motlagh, N. J., Kim, D., Kuellenberg, E. G., Kim, H.-H., Gillani, R. L., & Chen, J. W. (2024) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2024.01.003 · Cited by 15
Refining the interactions between microglia and astrocytes in Alzheimer’s disease pathology
Chen, J., Xu, S., Wang, L., Liu, X., Liu, G., Tan, Q., Li, W., Zhang, S., & Du, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.033 · Cited by 17
Checkpoints to the Brain: Directing Myeloid Cell Migration to the Central Nervous System
Harrison‐Brown, M., Liu, G. J., & Banati, R. B. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122030 · Cited by 14
Multitasking Microglia and Alzheimer’s Disease: Diversity, Tools and Therapeutic Targets
Grubman, A., Kanninen, K. M., & Malm, T. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0825-5 · Cited by 14
Kinase-Based Taming of Brain Microglia Toward Disease-Modifying Therapy
Lee, S. H., & Suk, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00474 · Cited by 15
Cao, L., Zhao, Y., Bai, M., Geliebter, D., Geliebter, J., Tiwari, R. K., He, H.-J., Wang, Z., Jia, X.-Y., Li, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.838261 · Cited by 16
Miller‐Rhodes, P., Li, H., Velagapudi, R., Chiang, W., Terrando, N., & Gelbard, H. A. (2022) · The FASEB Journal · doi:10.1096/fj.202200184rr · Cited by 12
The implication of a diversity of non-neuronal cells in disorders affecting brain networks
Carrier, M., Dolhan, K., Bobotis, B. C., Desjardins, M., & Tremblay, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1015556 · Cited by 16
Self-citationThe intricate interplay between microglia and adult neurogenesis in Alzheimer’s disease
Früholz, I., & Meyer‐Luehmann, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1456253 · Cited by 16
Peña‐Ortega, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160928151546 · Cited by 14
Behavioral and cellular responses to circadian disruption and prenatal immune activation in mice
Delorme, T. C., Ozell-Landry, W., Cermakian, N., & Srivastava, L. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-34363-w · Cited by 13
Lipid-Laden Microglia: Characterization and Roles in Diseases
Xing, J., McKenzie, T., & Hu, J. (2025) · Cells · doi:10.3390/cells14161281 · Cited by 13
Shaik, S. M., Cao, Y., Gogola, J. V., Dodiya, H. B., Zhang, X., Boutej, H., Han, W., Križ, J., & Sisodia, S. S. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00668-7 · Cited by 12
Pumo, A., & Legeay, S. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148817 · Cited by 14
Shen, Z., Yang, X., Lan, Y., & Chen, G. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231159 · Cited by 13
Llorca-Bofí, V., Madero, S., Amoretti, S., Cuesta, M. J., Moreno, C., González-Pinto, A., Bergé, D., Rodríguez–Jiménez, R., Roldán, A., García‐León, M. Á., et al. (2024) · Schizophrenia Research · doi:10.1016/j.schres.2024.03.011 · Cited by 13
General Pathophysiology of Microglia
Tremblay, M., & Verkhratsky, A. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_1 · Cited by 13
Self-citationUranova, N. A., Vikhreva, O. V., & Рахманова, В. И. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01621-x · Cited by 12
Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition
Benedetto, S. D., & Müller, L. (2019) · Springer eBooks · doi:10.1007/978-3-030-16073-9_14 · Cited by 12
Stephenson, C. P., & Baguley, I. J. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.12.010 · Cited by 13
Role of TREM2 in neuroinflammation
Abdulkhaliq, A. A., Alasiri, G. A., Almoghrabi, Y. M., Kim, B., Khan, J., Ajoolabady, A., Ren, J. T., Tuomilehto, J. O., Borai, A., & Praticò, D. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115547 · Cited by 10
Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease
McKinney, J. E., Bennett, M. L., & Bennett, F. C. (2026) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-042624-114332 · Cited by 13
Anwar, M. M., Pérez‐Martínez, L., & Pedraza‐Alva, G. (2024) · Immunological Investigations · doi:10.1080/08820139.2024.2358446 · Cited by 11
Geroyska, S., Mejia, I., Chan, A. A., Navarrete, M. S., Pandey, V., Kharpatin, S., Noguti, J., Wang, F., Srole, D. N., Chou, T., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0428 · Cited by 10
Vecchiarelli, H. A., Lopes, L. T., Paolicelli, R. C., Stevens, B., Wake, H., & Tremblay, M. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_11 · Cited by 10
Self-citationNovel insights into the role of TREM2 in cerebrovascular diseases
Awuah, W. A., Ben-Jaafar, A., Kong, J. S. H., Sanker, V., Shah, M. H., Poornaselvan, J., Frimpong, M., Imran, S., Alocious, T., Abdul-Rahman, T., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149245 · Cited by 10
Neuroinflammation als Motor der Alzheimer-Erkrankung
Castro‐Gomez, S., Binder, J., & Heneka, M. T. (2019) · Der Nervenarzt · doi:10.1007/s00115-019-0778-3 · Cited by 11
Headmasters: Microglial regulation of learning and memory in health and disease
Weinhard, L., d’Errico, P., & Tay, T. L. (2018) · AIMS molecular science · doi:10.3934/molsci.2018.1.63 · Cited by 11
Sui, Y., Zhang, Y., Dong, C., Xu, B., & Sun, X. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.022 · Cited by 11
Vecchiarelli, H. A., Bisht, K., Sharma, K. P., Novak, S. W., Traetta, M. E., Garcia‐Segura, M. E., St‐Pierre, M., Savage, J. C., Willis, C. M., Picard, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.15.618087 · Cited by 10
Self-citationUltrastructural features of psychological stress resilience in the brain: a microglial perspective
Ibáñez, F. G., VanderZwaag, J., Deslauriers, J., & Tremblay, M. (2024) · Open Biology · doi:10.1098/rsob.240079 · Cited by 11
Self-citationBarthelemy, A., Demais, V., Stancu, I., Vasile, E., Houben, T., Reber, M., Pallottini, V., Perraut, M., Reibel, S., & Pfrieger, F. W. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105469 · Cited by 8
Vidal, P. M., Ulndreaj, A., Tetreault, L. A., Hong, J., & Fehlings, M. G. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.577024 · Cited by 9
Microglia heterogeneity during neuroinflammation and neurodegeneration in the mouse retina
Rao, B., Liu, X., Xiao, J., Wu, X., He, F., Yang, Q., Zhao, W., Lin, X., & Zhang, J. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02875-4 · Cited by 12
Senescent microglia: The hidden culprits accelerating Alzheimer’s disease
Li, W., Xie, Y., Jia-Xin, M., Shu-Chao, G., & Li-Ping, H. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149480 · Cited by 11
Sanadgol, N., Feriz, A. M., Lisboa, S. F. D. S., & Joca, S. R. L. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122025 · Cited by 10
Melnik, M., Miyoshi, E., Ma, R., Corrada, M. M., Kawas, C. H., Bohannan, R. C., Caraway, C. A., Miller, C. A., Hinman, J. D., John, V., et al. (2024) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2024.110137 · Cited by 8
Spalloni, A., Stefano, S. D., Gimenez, J., Greco, V., Mercuri, N. B., Chiurchiù, V., & Longone, P. (2023) · Cells · doi:10.3390/cells12131691 · Cited by 8
Multiple sclerosis: what have we learned and can we still learn from electron microscopy
Oost, W., Meilof, J. F., & Baron, W. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05690-0 · Cited by 7
Wang, S., Wang, J., Hu, Z., Wu, L., & Huang, L. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115663 · Cited by 7
Liu, J., Hou, L., Ma, Y., Tian, L., Hong, J.-S., Zhao, J., & Wang, Q. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104062 · Cited by 10
Perochon, T., Krsnik, Ž., Massimo, M., Ruchiy, Y., Romero, A. L., Mohammadi, E., Li, X., Long, K. R., Parkkinen, L., Blomgren, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56560-z · Cited by 7
Shulyatnikova, T. V., Tumanskiy, V. A., & Hayden, M. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214455 · Cited by 8
Shafit‐Zagardo, B., Sidoli, S., Goldman, J. E., DuBois, J. C., Corboy, J. R., Strittmatter, S. M., Guzik, H. M., Edema, U., Arackal, A. G., Botbol, Y. M., et al. (2023) · Cells · doi:10.3390/cells12131734 · Cited by 9
Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease
Iovino, L., VanderZwaag, J., Kaur, G., Khakpour, M., Giusti, V., Donadon, M., Chiavegato, A., Lopes, L. T., Greggio, E., Tremblay, M., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106481 · Cited by 7
Self-citationThe Activation of Hippocampal Microglial Cells and Their Role in the Regulation of Pain
Chen, L., Zeng, L., Li, W., & Li, J. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin27730 · Cited by 7
Jeong, J., Kim, J. H., & Kim, M. S. (2025) · Genes · doi:10.3390/genes16080957 · Cited by 6
Bridlance, C., Viguier, S., Olivié, N., Dupont, E., Thobois, D., Mathieu, B., Jiang, J. X., López‐Bendito, G., Greter, M., Becher, B., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00625-8 · Cited by 6
Glial cells in neuropathic pain
Berta, T., Khoutorsky, A., Xu, J., & Ji, R. (2026) · Physiological Reviews · doi:10.1152/physrev.00034.2025 · Cited by 7
Metadata
- Authors
- Bisht, K., Sharma, K. P., Lecours, C., Gabriela Sánchez, M., El Hajj, H., Milior, G., Olmos‐Alonso, A., Gómez‐Nicola, D., Luheshi, G., Vallières, L., Branchi, I., Maggi, L., Limatola, C., Butovsky, O., & Tremblay, M.
- Affiliations
- Centre de recherche du CHU de Québec-Université Laval (CA)
- Axe Neurosciences Centre De Recherche Du CHU De Québec Québec Québec Canada
- Istituto Pasteur (IT)
- University of Southampton (GB)
- Douglas Mental Health University Institute (CA)
- Istituto Superiore di Sanità (IT)
- Brigham and Women's Hospital (US)
- Corresponding author
- Tremblay, Marie‐Ève
- ORCID
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2016-02-05
- Volume
- 64
- Issue
- 5
- Pages
- 826-839
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- PMC
- PMC4949554
- OpenAlex
- W2256955303
- Cited by
- 421
- References
- 68
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 52 · 2023: 48 · 2022: 44 · 2021: 64 · 2020: 42 · 2019: 42 · 2018: 30 · 2017: 26 · 2016: 12
- FWCI
- 20.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Glia (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Natural Sciences and Engineering Research Council of Canada (NSERC) (RGPIN-2014-05308)
- Medical Research Council (MR/K022687/1)
- The Banting Research Foundation
- The Scottish Rite Charitable Foundation of Canada
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglial phenotype, oxidative stress, chronic stress, aging, CX3CR1, Alzheimer's disease, APP/PS1 mice, amyloid plaques, TREM2, synaptic loss, dendritic spines, axon terminals, hippocampus, cerebral cortex, amygdala, hypothalamus
- MeSH terms
- CX3C Chemokine Receptor 1, Formyltetrahydrofolate Dehydrogenase, Aging, Aldehyde Dehydrogenase, Alzheimer Disease, Oxidoreductases Acting on CH-NH Group Donors, Animals, Cerebral Cortex, Disease Models, Animal, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Phenotype, Stress, Psychological, Antigens, CD, Amyloid beta-Protein Precursor, Microglia, Receptors, Chemokine, Green Fluorescent Proteins, Mice, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
