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Cited by 368

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Altered antigen expression of microglia in the aged rodent CNS

Perry, V. H., Matyszak, M. K., Fearn, S.·1993·Glia
DOI 10.1002/glia.440070111
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Abstract

Microglia, the resident macrophages of the central nervous system, are characterised by a highly specialized morphology and unusual antigenic phenotype. Microglia appear to be downregulated by their microenvironment when compared to other tissue macrophages. We have studied the microglia in brains of healthy, aged rats with a panel of monoclonal antibodies. We have found that microglia in the brains of these aged rats express antigens that are downregulated or absent from microglia of juvenile rats. The stimuli which give rise to this upregulated phenotype are not known. Age related changes in the phenotype of microglia should be taken into account when considering the possible role of microglia in neuropathological conditions.

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Citations

Cites

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Metadata

Authors
Perry, V. H., Matyszak, M. K., & Fearn, S.
Venue
Glia
Publisher
Wiley
Published
1993-01
Volume
7
Issue
1
Pages
60-67
ISSN
  • 0894-1491 (ISSN-L)
  • 1098-1136
DOI
10.1002/glia.440070111
OpenAlex
W2065470571
Cited by
368
References
4
FWCI
5.39
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4302 d)

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