The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury
Open accessAbstract
The expression of immune-associated (MHC class II) antigen was studied immunohistochemically over several months in the rat facial nucleus after nerve transection and after intraneural injection of toxic ricin. Cells expressing Ia antigen were of a perivascular type and parenchymal ramified microglia. In the first few weeks after nerve lesions we observed a gradual increase in the number of Ia-immunoreactive cells starting with an initial appearance of Ia-positive perivascular cells which were succeeded by increasing numbers of Ia-positive ramified microglia. In long-term animals Ia expression was almost exclusively found in microglia. We propose (a) the existence of a population of immunocompetent perivascular cells normally present in adult rat brain that can be stimulated to express Ia antigen, and (b) the existence of a subpopulation of ramified microglia that arises through transformation of Ia-positive perivascular cells in the adult under pathological conditions.
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Citations
Cites
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466
Cited by
Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096
Self-citationMicroglial Activation and Chronic Neurodegeneration
Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047
“A possible mechanism for this could be replenishment from perivascular cells, which are bone marrow-derived and have been shown to enter the CNS and differentiate into microglia.(12,13) The mechanisms through which circulating cells are recruited to the CNS, and whether they enter the CNS under normal, resting conditi…”
BackgroundDystrophic microglia in the aging human brain
Streit, W. J., Sammons, N. W., Kuhns, A. J., & Sparks, D. L. (2004) · Glia · doi:10.1002/glia.10319 · Cited by 705
Self-citationMicroglia in degenerative neurological disease
McGeer, P. L., Kawamata, T., Walker, D. G., Akiyama, H., Tooyama, I., & McGeer, E. G. (1993) · Glia · doi:10.1002/glia.440070114 · Cited by 596
Microglia during development and aging
Harry, G. J. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.04.013 · Cited by 524
Metadata
- Authors
- Streit, W. J., Graeber, M. B., & Kreutzberg, G. W.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 1989-08
- Volume
- 105
- Issue
- 2
- Pages
- 115-126
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2036931179
- Cited by
- 287
- References
- 2
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury. https://app.cochat.ai/papers/10.1016/0014-4886(89)90111-8
- The paper
- Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1989). Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury. Experimental Neurology. https://doi.org/10.1016/0014-4886(89)90111-8
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