The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identity of ED2‐positive perivascular cells in rat brain
Abstract
A controversial, though fundamental, issue in neurobiology concerns the nature, origin, and function of brain macrophages. By immunocytochemical analysis using monoclonal antibodies directed against rat macrophage antigens, i.e., ED1 −3, Ox‐41, Ox‐42, and KiM2R, we show that a group of perivascular cells located within the basal membrane of CNS blood vessels are immunoreactive. These cells, which resemble pericytes in terms of their anatomical distribution, are distinct from resting parenchymal microglia immunologically as well as morphologically. Our results demonstrate considerable heterogeneity in the immunophenotype of resident brain macrophages, which may be part of the immune—nervous system interface.
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Citations
Cites
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466
Cited by
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Self-citationMicroglia-specific localisation of a novel calcium binding protein, Iba1
Ito, D., Imai, Y., Ohsawa, K., Nakajima, K., Fukuuchi, Y., & Kohsaka, S. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00040-0 · Cited by 1,476
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578
van Dam, A.-M., Brouns, M., Louisse, S., & Berkenbosch, F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91588-6 · Cited by 333
Schilling, M., Besselmann, M., Müller, M., Strecker, J. K., Ringelstein, E. B., & Kiefer, R. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.004 · Cited by 288
Metadata
- Authors
- Graeber, M. B., Streit, W. J., & Kreutzberg, G. W.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 1989-01
- Volume
- 22
- Issue
- 1
- Pages
- 103-106
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2018766926
- Cited by
- 280
- References
- 1
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Graeber, M. B., Streit, W. J., & Kreutzberg, G. W. (1989). Identity of ED2‐positive perivascular cells in rat brain. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.490220114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
