A pilot randomized controlled trial of sleep therapy in Parkinson's disease: effect on patients and caregivers
Abstract
Objective: By means of a controlled trial, to investigate the efficacy, tolerability and feasibility of a multi‐component sleep therapy intervention versus basic sleep hygiene education in PD patients with sleep disturbances and their live‐in carers. Methods: Patient‐carer dyads were randomised to either of the two interventions. Quantitative measures of sleep, psychiatric and overall functioning were administered at baseline and two weeks after the intervention to patients and carers. Results: Sleep disturbances in the PD patients improved significantly in both the groups. Between group comparisons in both carers and patients revealed no significant differences on any outcome measures. The intervention was found to be well tolerated, feasible and could easily be translated into the clinical setting. Conclusions: This pilot study makes the case for further, more rigorous study of pragmatic, non‐pharmacological interventions for sleep disturbances in PD. Copyright © 2010 John Wiley & Sons, Ltd.
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Four RCTs showed significant improvements in insomnia and sleep quality when comparing face-to-face or computerised CBT with education on basic sleep hygiene, sham light therapy, or TAU.
“In particular, four RCTs showed significant improvements in participants' levels of insomnia and sleep quality when comparing face-to-face or computerised CBT with education on basic sleep hygiene (Leroi, Baker, Kehoe, Daniel, & Byrne, 2010; Patel et al., 2017), sham light therapy (Rios Romenets et al., 2013), or TAU (Kraepelien et al., 2020).”
From Psychological interventions for people with Parkinson's disease in the early 2020s: Where do we stand? (2021) · cites this paper as Leroi, Baker, Kehoe, Daniel, & Byrne, 2010
Multi-component CBT-based sleep therapy produced significant improvement in sleep disorders in both intervention and psychoeducation groups, with no between-group differences on any outcome measures, and the intervention was found to be well tolerated.
“Sleep disorders in improved significantly in both intervention and psychoeducation”
From Psychological interventions for people with Parkinson's disease in the early 2020s: Where do we stand? (2021) · cites this paper as Leroi et al., 2010
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- Authors
- Leroi, I., Baker, P., Kehoe, P., Daniel, E., & Byrne, E. J.
- Affiliations
- North Manchester General Hospital (GB)
- University of Manchester (GB)
- Tameside and Glossop Integrated Care NHS Foundation Trust (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Corresponding author
- Leroi, Iracema
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2010-02-15
- Volume
- 25
- Issue
- 10
- Pages
- 1073-1079
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W2153580971
- Cited by
- 36
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- Parkinson's disease, sleep disorders, sleep therapy, sleep hygiene education, caregivers, non-pharmacological treatment, psychiatric functioning, feasibility and tolerability
- MeSH terms
- Aged, Aged, 80 and over, Feasibility Studies, Female, Humans, Life Style, Male, Parkinson Disease, Pilot Projects, Sleep, Sleep Wake Disorders, Time Factors, Caregivers, Patient Satisfaction
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