Circadian disruption and sleep disorders in neurodegeneration

Shen, Yun; Lv, Qian-kun; Xie, Wei-ye; Gong, Si-yi; Zhuang, Sheng; Liu, Jun-yi; Mao, Cheng-jie; Liu, Chun-feng

doi:10.1186/s40035-023-00340-6

Cited by 171Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and related disorders

Circadian disruption and sleep disorders in neurodegeneration

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Shen, Yun, Lv, Qian-kun, Xie, Wei-ye, Gong, Si-yi, Zhuang, Sheng, Liu, Jun-yi, Mao, Cheng-jie, Liu, Chun-feng·2023·Translational Neurodegeneration

DOI 10.1186/s40035-023-00340-6PMC PMC9926748

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Abstract

Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of circadian rhythms and sleep cycles and neurodegenerative diseases. Circadian disruption and sleep disorders aggravate neurodegeneration and neurodegenerative diseases can in turn disrupt circadian rhythms and sleep. Importantly, circadian disruption and various sleep disorders can increase the risk of neurodegenerative diseases. Thus, harnessing the circadian biology findings from preclinical and translational research in neurodegenerative diseases is of importance for reducing risk of neurodegeneration and improving symptoms and quality of life of individuals with neurodegenerative disorders via approaches that normalize circadian in the context of precision medicine. In this review, we discuss the implications of circadian disruption and sleep disorders in neurodegenerative diseases by summarizing evidence from both human and animal studies, focusing on the bidirectional links of sleep and circadian rhythms with prevalent forms of neurodegeneration. These findings provide valuable insights into the pathogenesis of neurodegenerative diseases and suggest a promising role of circadian-based interventions.

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For Alzheimer's disease and Alzheimer-related dementias, chronodisruption is labelled as both a causative factor and physiological consequence of this neurodegenerative, neuroinflammatory disease.
“This is similarly observed for Alzheimer’s disease and Alzheimer‐related dementias, where chronodisruption is labelled as both a causative factor and physiological consequence of this neurodegenerative, neuroinflammatory disease [40].”
From Ocular light exposure interventions for sleep, circadian rhythms, rest-activity cycles, mood, and cognitive function in older adults: An Overview of Cochrane and non-Cochrane Systematic Reviews (2025) · cites this paper as [40]
In “Progression of neurodegenerative disease promotes circadian disruption and sleep disorders” (page unavailable), the review says AD pathology can alter circadian rhythms. Its sections on circadian disruption and AD describe a bidirectional relationship and evidence that disruption can worsen neurodegeneration, but characterize its role in the occurrence of AD as potential rather than establishing it as a causative factor. (LLM, conf=0.84)
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Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma
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Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic
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Wearables in Chronomedicine and Interpretation of Circadian Health
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Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery
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Natural Compounds for Preventing Age-Related Diseases and Cancers
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Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum
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Fighting Against the Clock: Circadian Disruption and Parkinson’s Disease
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Circadian regulation in aging: Implications for spaceflight and life on earth
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The future of healthy ageing: Wearables in public health, disease prevention and healthcare
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Butyrate improves abnormal sleep architecture in a Parkinson’s disease mouse model via BDNF/TrkB signaling
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The Bidirectional Relationship between Sleep and Neurodegeneration: Actionability to Improve Brain Health
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Understanding Sleep Regulation in Normal and Pathological Conditions, and Why It Matters
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The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective
Huang, W., Zong, J., Zhang, Y. L., Zhou, Y., Zhang, L., Wang, Y., Shan, Z., Xie, Q., Li, M., Pan, S., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0921 · Cited by 16 · see citing works
A global transcriptional atlas of the effect of acute sleep deprivation in the mouse frontal cortex
Ford, K., Zuin, E., Righelli, D., Medina, E., Schoch, H., Singletary, K. G., Muheim, C., Frank, M. G., Hicks, S. C., Risso, D., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110752 · Cited by 15 · see citing works
Circadian control of polycyclic aromatic hydrocarbon-induced dysregulation of endothelial tight junctions and mitochondrial bioenergetics
Téglás, T., Marcos, A. C., Torices, S., & Toborek, M. J. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.175886 · Cited by 15 · see citing works
Circadian system and aging: where both times interact
Cobarro, C., Soares, L. I., Kutsenko, Y., & Tomás‐Loba, A. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1646794 · Cited by 15 · see citing works
Melatonin as a Chronobiotic/Cytoprotective Agent in REM Sleep Behavior Disorder
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Noradrenergic dysregulation in the locus coeruleus: Implications for neuropsychiatric disease pathophysiology- A systematic review
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Oral quercetin nanoparticles in hydrogel microspheres alleviate high-altitude sleep disturbance based on the gut-brain axis
Wu, Y., Tang, Z., Du, S., Dai, J., Shen, J., Niu, H., Song, X., Huang, G., Du, L., & Jin, Y. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124225 · Cited by 13 · see citing works
Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration
Ling, Z., Zhou, S., Zhou, Y., Zhong, W., Su, Z., & Qin, Z. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109834 · Cited by 14 · see citing works
Sleep timing, sleep timing regularity, and cognitive performance in women entering late adulthood: the Study of Women’s Health Across the Nation (SWAN)
Swanson, L. M., Hood, M. M., Thurston, R. C., Butters, M. A., Kline, C. E., Kravitz, H. M., Avis, N. E., Neal-Perry, G. S., Joffe, H., Harlow, S. D., et al. (2025) · SLEEP · doi:10.1093/sleep/zsaf041 · Cited by 10 · see citing works
Smart Sleep Monitoring: IoMT and GRU for Effective Sleep Disorders Management
Jenefa, A., Rithick, S., Vishal, A., Jesman, T., Robert, R. C., & Kuriakose, B. M. (2023) · International Conference on Electronics, Communication and Aerospace Technology (ICECA) · doi:10.1109/iceca58529.2023.10394887 · Cited by 10 · see citing works
Assessment of sleep patterns in dementia and general population cohorts using passive in-home monitoring technologies
Rigny, L., Fletcher‐Lloyd, N., Capstick, A., Nilforooshan, R., & Barnaghi, P. M. (2024) · Communications Medicine · doi:10.1038/s43856-024-00646-0 · Cited by 12 · see citing works
Bimetallic Fe/Cu-doped carbon-based nanozymes with peroxidase-like properties for multimodal determination of neurodegenerative related substance acetylcholinesterase
Han, Z., Wang, N., Lv, Y., Liu, P., & Su, X. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.137955 · Cited by 10 · see citing works
Puerarin alleviates sleep disorders in aged mice related to repairing intestinal mucosal barrier
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Authors: Shen, Y., Lv, Q.-K., Xie, W.-Y., Gong, S.-Y., Zhuang, S., Liu, J.-Y., Mao, C.-J., & Liu, C.-F.
Affiliations: Second Affiliated Hospital of Soochow University (CN)
Soochow University (CN)
Corresponding author: Liu, Chun-feng
ORCID: Zhuang, Sheng
Liu, Chun-feng
Venue: Translational Neurodegeneration
Publisher: Springer Science and Business Media LLC
Published: 2023-02-13
Volume: 12
Issue: 1
Pages: 8-8
ISSN: 2047-9158 (ISSN-L)
DOI: 10.1186/s40035-023-00340-6
PMC: PMC9926748
OpenAlex: W4320483859
Cited by: 171
References: 308
Citations by year: 2026: 50 · 2025: 71 · 2024: 35 · 2023: 15
FWCI: 6.46
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Translational Neurodegeneration (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (82071420)
Discipline Construction Program of the Second Affiliated Hospital of Soochow University (XKTJ-XK202001)
Suzhou Medical and Health Technology Innovation Project (SKJY2021090)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: circadian rhythm disruption, circadian rhythm, sleep disorders, neurodegenerative diseases, precision medicine, neurodegeneration pathogenesis
MeSH terms: Animals, Circadian Rhythm, Humans, Quality of Life, Sleep, Sleep Wake Disorders, Neurodegenerative Diseases

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