Association of the cumulative burden of late‐life anxiety and depressive symptoms with functional impairment
Open accessAbstract
Objectives: This study investigates the association of the cumulative burden of anxiety‐only, depression‐only, and comorbid anxiety and depression symptoms with (a) incident self‐care or household activities impairment among those with no baseline self‐care or household activities impairment, respectively, or (b) change in status of self‐care or household activities impairment among those with baseline impairment. Methods: This study consists of participants (N = 4619) from the National Health and Aging Trends Study, a longitudinal study that examines a nationally representative sample of US adults aged 65 years and older. Outcomes included incident or change in self‐care or household activity impairment. Primary independent variables were yearly counts of screening positive for clinically significant symptoms for anxiety‐only, depression‐only, or co‐occurring anxiety and depression. Multivariable logistic regression models examined incident impairment and change in impairment status. Results: Yearly counts of anxiety‐only symptoms were associated with incident impairment in self‐care and household activities and less improvement in self‐care functioning. Yearly counts of depression‐only symptoms were associated with incident impairment in self‐care and household activities. Yearly counts of co‐occurring symptoms of anxiety and depression were associated with incident impairment in self‐care and household activities, less improvement in self‐care activities, and worsening impairment in household activities. Conclusions: This study finds that the cumulative burden of co‐occurring anxiety and depression symptoms is associated with incident impairment in functioning, persistent self‐care impairment, and deterioration in household activity impairment. These findings emphasize the importance of managing late‐life anxiety and depressive symptoms, which are treatable, frequently co‐occur, and contribute to disability.
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Cites
The Patient Health Questionnaire-2: Validity of a Two-Item Depression Screener
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2003) · Medical Care · doi:10.1097/01.mlr.0000093487.78664.3c · Cited by 6,359 · see citing works
Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection
Kroenke, K., Spitzer, R. L., Williams, J. B. W., Monahan, P. O., & Löwe, B. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-5-200703060-00004 · Cited by 4,741 · see citing works
Lenze, E. J., Rogers, J. C., Martire, L. M., Mulsant, B. H., Rollman, B. L., Dew, M. A., Schulz, R., & Reynolds, C. F. (2001) · The American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200105000-00004 · Cited by 593 · see citing works
Penninx, B. W., Leveille, S., Ferrucci, L., van Eijk, J. T., & Guralnik, J. M. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.9.1346 · Cited by 570 · see citing works
Cognitive Impairment, Depressive Symptoms, and Functional Decline in Older People
Mehta, K. M., Yaffe, K. S., & Covinsky, K. E. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50259.x · Cited by 263 · see citing works
Home-based care program reduces disability and promotes aging in place
Szanton, S. L., Leff, B., Wolff, J. L., Roberts, L., & Gitlin, L. N. (2016) · Health Affairs · doi:10.1377/hlthaff.2016.0140 · Cited by 222 · see citing works
Lenze, E. J., Schulz, R., Martire, L. M., Zdaniuk, B., Glass, T. A., Kop, W. J., Jackson, S., & Reynolds, C. F. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53202.x · Cited by 204 · see citing works
Physical Limitations and Depressive Symptoms: Exploring the Nature of the Association
Gayman, M. D., Turner, R. J., & Cui, M. (2008) · The Journals of Gerontology Series B · doi:10.1093/geronb/63.4.s219 · Cited by 190 · see citing works
Increased mortality among people with anxiety disorders: total population study.
Meier, S. M., Mattheisen, M., Mors, O., Mortensen, P. B., Laursen, T. M., & Penninx, B. W. (2016) · British Journal of Psychiatry · doi:10.1192/bjp.bp.115.171975 · Cited by 181 · see citing works
The Influence of Anxiety on the Progression of Disability
Brenes, G. A., Guralnik, J. M., Williamson, J. D., Fried, L. P., Simpson, C. F., Simonsick, E. M., & Penninx, B. W. J. H. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53007.x · Cited by 177 · see citing works
Cronin‐Stubbs, D., de Leon, C. F. M., Beckett, L. A., Field, T. S., Glynn, R. J., & Evans, D. A. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.20.3074 · Cited by 175 · see citing works
Relationship between Physical Disability and Depression by Gender: A Panel Regression Model
Noh, J., Kwon, Y. D., Park, J., Oh, I., & Kim, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166238 · Cited by 166 · see citing works
Stineman, M. G., Xie, D., Pan, Q., Kurichi, J. E., Zhang, Z. M., Saliba, D., Henry‐Sánchez, J. T., & Streim, J. E. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03867.x · Cited by 155 · see citing works
Braam, A. W., Copeland, J. R. M., Delespaul, P., Beekman, A. T. F., Çomo, A., Dewey, M. E., Fichter, M. M., Holwerda, T. J., LAWLOR, B. A., Lobo, A., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.11.011 · Cited by 146 · see citing works
Onset of disability in depressed and non-depressed primary care patients
Ormel, J., VonKorff, M., Oldehinkel, A. J., SIMON, G., Tiemens, B. G., & Üstün, T. B. (1999) · Psychological Medicine · doi:10.1017/s0033291799008600 · Cited by 141 · see citing works
Anxiety, depression and disability across the lifespan
Brenes, G. A., Penninx, B. W. J. H., Judd, P. H., Rockwell, E., Sewell, D. D., & Wetherell, J. L. (2008) · Aging & Mental Health · doi:10.1080/13607860601124115 · Cited by 125 · see citing works
Cairney, J., Corna, L., Veldhuizen, S., Herrmann, N., & Streiner, D. L. (2008) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000300627.93523.c8 · Cited by 120 · see citing works
Longitudinal Association Between Depressive Symptoms and Disability Burden Among Older Persons
Barry, L. C., Allore, H. G., BRUCE, M. L., & Gill, T. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp135 · Cited by 113 · see citing works
Geerlings, S. W., Beekman, A. T. F., Deeg, D. J. H., Twisk, J. W. R., & van Tilburg, W. (2001) · Psychological Medicine · doi:10.1017/s0033291701004639 · Cited by 106 · see citing works
Armenian, H. K., Pratt, L. A., Gallo, J. J., & Eaton, W. W. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009635 · Cited by 105 · see citing works
Depressive Disorder as a Predictor of Physical Disability in Old Age
Kivelä, S., & Pahkala, K. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.4930290.x · Cited by 103 · see citing works
Kang, H., Bae, K., Kim, S., Shin, H., Shin, I., Yoon, J., & Kim, J. (2017) · Psychiatry Investigation · doi:10.4306/pi.2017.14.3.240 · Cited by 95 · see citing works
Hennessy, S., Kurichi, J. E., Pan, Q., Streim, J. E., Bogner, H. R., Xie, D., & Stineman, M. G. (2015) · PM&R · doi:10.1016/j.pmrj.2015.05.014 · Cited by 92 · see citing works
Hajek, A., & König, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146967 · Cited by 89 · see citing works
Covinsky, K. E., Yaffe, K. S., Lindquist, K. J., Cherkasova, E., Yelin, E. H., & Blazer, D. G. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02723.x · Cited by 87 · see citing works
Murphy, R. A., Hagaman, A. K., Reinders, I., Steeves, J. A., Newman, A. B., Rubin, S. M., Satterfield, S., Kritchevsky, S. B., Yaffe, K. S., Ayonayon, H. N., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv139 · Cited by 82 · see citing works
Li, L., & Conwell, Y. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln023 · Cited by 73 · see citing works
Association Between Indicators of Disability Burden and Subsequent Depression Among Older Persons
Barry, L. C., Soulos, P. R., Murphy, T. E., Kasl, S. V., & Gill, T. M. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls179 · Cited by 59 · see citing works
Depressive Symptoms and Functional Transitions Over Time in Older Persons
Barry, L. C., Murphy, T. E., & Gill, T. M. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181ff6669 · Cited by 58 · see citing works
Predictors of New Onset Depression in Medically Ill, Disabled Older Adults at 1 Year Follow-Up
Weinberger, M. I., Raue, P. J., Meyers, B. S., & BRUCE, M. L. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181b0481a · Cited by 54 · see citing works
Complex Survey Data Analysis with SAS
Lewis, T. (2016) · Chapman & Hall/CRC eBooks · doi:10.1201/9781315366906 · Cited by 54 · see citing works
Sin, N. L., Yaffe, K. S., & Whooley, M. A. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13188 · Cited by 53 · see citing works
Anxiety symptoms and disorder predict activity limitations in the elderly
Norton, J. L., Ancelin, M., Stewart, R. J., Berr, C., Ritchie, K. A., & Carrière, I. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.002 · Cited by 52 · see citing works
Environmental Press and Adaptation to Disability in Hospitalized Live-Alone Older Adults
Lichtenberg, P. A., MacNeill, S. E., & Mast, B. T. (2000) · The Gerontologist · doi:10.1093/geront/40.5.549 · Cited by 50 · see citing works
Nakamura, T. I., Michikawa, T., Imamura, H., Takebayashi, T., & Nishiwaki, Y. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15107 · Cited by 48 · see citing works
Jiang, J., Tang, Z., Futatsuka, M., & Zhang, K. (2004) · Quality of Life Research · doi:10.1023/b:qure.0000037500.26166.0c · Cited by 47 · see citing works
Late life depression and incident activity limitations: Influence of gender and symptom severity
Carrière, I., Gutierrez, L. A., Pérès, K., Berr, C., Barberger‐Gateau, P., Ritchie, K. A., & Ancelin, M. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.020 · Cited by 46 · see citing works
The Effect of Changes in Depressive Symptoms on Disability Status in Patients with Diabetes
Huang, H. Y., Russo, J. E., Korff, M. V., Ciechanowski, P. S., Lin, E. H. B., Ludman, E. J., & Katon, W. J. (2012) · Psychosomatics · doi:10.1016/j.psym.2011.07.001 · Cited by 30 · see citing works
Gitlin, L. N., Szanton, S. L., Huang, J., & Roth, D. L. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13156 · Cited by 21 · see citing works
Symptomatic and functional recovery in depression in later life
Collard, R. M., Wassink‐Vossen, S., Schene, A. H., Naarding, P., Verhaak, P. F. M., Voshaar, R. C. O., & Comijs, H. C. (2018) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-018-1540-z · Cited by 21 · see citing works
Kurichi, J. E., Bogner, H. R., Streim, J. E., et al. (2017) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2017.08.005 · Cited by 18 · see citing works
Rajan, K. B., Barnes, L. L., Wilson, R. S., et al. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt074 · Cited by 14 · see citing works
Beekman, A. T. F. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.10.004 · Cited by 11 · see citing works
Tinetti, M. E. (1995) · JAMA · doi:10.1001/jama.1995.03520410042024 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [35]Kasper JD, Freedman VA. National Health and Aging Trends Study User Guide: Rounds 1–7 Final Release. Baltimore: Johns Hopkins University School of Public Health; 2018: 1– 145.
- [45]Spillman BC, Skehan ME. SAS Programming Statements for Construction of Dementia Classification in the National Health and Aging Trends Study. Addendum to NHATS Technical Paper #5. Baltimore: Johns Hopkins University School of Public Health; 2013: 1– 5.
- [46]Kasper JD, Freedman VA, Spillman B. Classification of Persons by Dementia Status in the National Health and Aging Trends Study. Technical paper #5. Baltimore: Johns Hopkins University School of Public Health; 2013: 1– 14.
Cited by
Sorted by citations
Witlox, M., Garnefski, N., Kraaij, V., de Waal, M. W. M., Smit, F., Bohlmeijer, E., & Spinhoven, P. (2021) · Journal of Medical Internet Research · doi:10.2196/24366 · Cited by 43 · see citing works
“Both anxiety disorders and subclinical anxiety in older adults are associated with limited physical and social activities, impairments in self-care, decreased well-being, comorbid depressive symptomatology, somatic problems, and increased use of benzodiazepines [4-6].”
Witlox, M., Kraaij, V., Garnefski, N., Bohlmeijer, E., Smit, F., & Spinhoven, P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262220 · Cited by 31 · see citing works
- Authors
- Simning, A., & Seplaki, C. L.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Simning, Adam
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2019-10-28
- Volume
- 35
- Issue
- 1
- Pages
- 80-90
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- PMC
- PMC6898755
- OpenAlex
- W2982087430
- Cited by
- 26
- References
- 44
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 2
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (K23AG058757, U01AG032947)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- late-life anxiety, geriatric depression, comorbid depression and anxiety, functional disability, self-care impairment, older adults, disability, National Health and Aging Trends Study
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Anxiety, Depression, Female, Humans, Longitudinal Studies, Male, Risk Factors, Self Care, United States, Comorbidity, Logistic Models
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