Cited by 196Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesMultiple Sclerosis Research Studies

Resting state sensorimotor functional connectivity in multiple sclerosis inversely correlates with transcallosal motor pathway transverse diffusivity

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Lowe, Mark J., Beall, Erik B., Sakaie, Ken E., Koenig, Katherine A., Stone, Lael, Marrie, Ruth Ann, Phillips, Micheal D.·2008·Human Brain Mapping

Abstract

Recent studies indicate that functional connectivity using low‐frequency BOLD fluctuations (LFBFs) is reduced between the bilateral primary sensorimotor regions in multiple sclerosis. In addition, it has been shown that pathway‐dependent measures of the transverse diffusivity of water in white matter correlate with related clinical measures of functional deficit in multiple sclerosis. Taken together, these methods suggest that MRI methods can be used to probe both functional connectivity and anatomic connectivity in subjects with known white matter impairment. We report the results of a study comparing anatomic connectivity of the transcallosal motor pathway, as measured with diffusion tensor imaging (DTI) and functional connectivity of the bilateral primary sensorimotor cortices (SMC), as measured with LFBFs in the resting state. High angular resolution diffusion imaging was combined with functional MRI to define the transcallosal white matter pathway connecting the bilateral primary SMC. Maps were generated from the probabilistic tracking employed and these maps were used to calculate the mean pathway diffusion measures fractional anisotropy 〈FA〉, mean diffusivity 〈MD〉, longitudinal diffusivity 〈λ 1〉, and transverse diffusivity 〈λ 2〉. These were compared with LFBF‐based functional connectivity measures (Fc) obtained at rest in a cohort of 11 multiple sclerosis patients and ∼10 age‐ and gender‐matched control subjects. The correlation between 〈FA〉 and Fc for MS patients was r = −0.63, P < 0.04. The correlation between all subjects 〈λ 2〉 and Fc was r = 0.42, P < 0.05. The correlation between all subjects 〈λ 2〉 and Fc was r = −0.50, P < 0.02. None of the control subject correlations were significant, nor were 〈FA〉, 〈λ 1〉, or 〈MD〉 significantly correlated with Fc for MS patients. This constitutes the first in vivo observation of a correlation between measures of anatomic connectivity and functional connectivity using spontaneous LFBFs. Hum Brain Mapp, 2008. © 2008 Wiley‐Liss, Inc.

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  1. Adams RD, Victor M, Ropper AH (1997): In: Adams RD, Victor M, Ropper AH, editors: Principles Of Neurology, 6th ed. New York: McGraw-Hill: pp 903-921.

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Authors
Lowe, M. J., Beall, E. B., Sakaie, K. E., Koenig, K. A., Stone, L., Marrie, R. A., & Phillips, M. D.
Affiliations
  • Cleveland Clinic (US)
  • University of Manitoba (CA)
Venue
Human Brain Mapping
Publisher
Wiley
Published
2008-04-25
Volume
29
Issue
7
Pages
818-827
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
OpenAlex
W2022349962
Cited by
196
References
69
Citations by year
2026: 2 · 2025: 5 · 2024: 12 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 13 · 2013: 21 · 2012: 18
FWCI
15.15
Type
journal article
Language
en
Open access
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords
multiple sclerosis, resting-state functional connectivity, sensorimotor cortex, fractional anisotropy, mean diffusivity, white matter connectivity, probabilistic tractography, high angular resolution diffusion imaging
MeSH terms
Brain Mapping, Corpus Callosum, Efferent Pathways, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex, Multiple Sclerosis

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