Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 353

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Tumor infiltrating lymphocytes and survival in patients with head and neck squamous cell carcinoma

Open access
Nguyen, Nghia, Bellile, Emily, Thomas, Daffyd, McHugh, Jonathan, Rozek, Laura, Virani, Shama, Peterson, Lisa, Carey, Thomas E., Walline, Heather, Moyer, Jeffery, Spector, Matthew, Perim, Daniel, Prince, Mark, McLean, Scott, Bradford, Carol R., Taylor, Jeremy M. G., Wolf, Gregory T., Head and Neck SPORE Program Investigators·2016·Head & Neck
DOI 10.1002/hed.24406
Open this paper in CoChat — free account

Abstract

BACKGROUND: Because immune responses within the tumor microenvironment are important predictors of tumor biology, correlations of types of tumor infiltrating lymphocytes (TILs) with clinical outcomes were determined in 278 patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Infiltrating levels of CD4 (helper T cells), CD8 (cytotoxic/suppressor T cells), FoxP3 (regulatory T cells), CD68 (myeloid-derived suppressor cells,) and CD1a (Langerhans) cells were measured in tissue microarrays (TMAs). Cox models tested associations with patient outcomes after adjusting for all known prognostic factors. Median follow-up was 36.6 months. RESULTS: Higher CD4 and CD8 TIL levels were associated with improved overall survival (OS; hazard ratio [HR] = 0.77; 95% confidence interval [CI] = 0.65-0.93; p = .005 and HR = 0.77; 95% CI = 0.64-0.94; p = .008, respectively), and relapse-free survival (RFS; p = .03 and .05, respectively). After controlling for prognostic factors, higher CD4 levels predicted improved OS and disease-specific survival (DSS; p = .003 and p = .004, respectively). CONCLUSION: The findings suggest that TILs are a significant independent prognostic factor for HNSCC that differ by treatment. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1074-1084, 2016.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/hed.24406

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 44 references

Cited by

See all 353

Metadata

Authors
Nguyen, N., Bellile, E., Thomas, D., McHugh, J., Rozek, L., Virani, S., Peterson, L., Carey, T. E., Walline, H., Moyer, J., Spector, M., Perim, D., Prince, M., McLean, S., Bradford, C. R., Taylor, J. M. G., Wolf, G. T., & Head and Neck SPORE Program Investigators
Venue
Head & Neck
Publisher
Wiley
Published
2016-02-16
Volume
38
Issue
7
Pages
1074-1084
ISSN
1043-3074 (ISSN-L)
DOI
10.1002/hed.24406
OpenAlex
W2282664279
Cited by
353
References
44
FWCI
33.27
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Tumor infiltrating lymphocytes and survival in patients with head and neck squamous cell carcinoma. https://app.cochat.ai/papers/10.1002/hed.24406
The paper
Nguyen, N., Bellile, E., Thomas, D., McHugh, J., Rozek, L., Virani, S., Peterson, L., Carey, T. E., Walline, H., Moyer, J., Spector, M., Perim, D., Prince, M., McLean, S., Bradford, C. R., Taylor, J. M. G., Wolf, G. T., & Head and Neck SPORE Program Investigators. (2016). Tumor infiltrating lymphocytes and survival in patients with head and neck squamous cell carcinoma. Head & Neck. https://doi.org/10.1002/hed.24406

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.