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Cited by 469

The DOI matches its Crossref record; 375 of the 375 references it cites were found in a registry or an index.

Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

Open access
Peltanova, Barbora, Raudenska, Martina, Masarik, Michal·2019·Molecular Cancer

Abstract

The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell carcinoma, focusing on oral squamous cell carcinoma, since it is becoming clear that an investigation of differences in stromal composition of the head and neck squamous cell carcinoma microenvironment and their impact on cancer development and progression may help better understand the mechanisms behind different responses to therapy and help define possible targets for clinical intervention.

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Crossref · 10.1186/s12943-019-0983-5

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Metadata

Authors
Peltanova, B., Raudenska, M., & Masarik, M.
Venue
Molecular Cancer
Published
2019-03-30
Volume
18
Issue
1
Pages
63-63
ISSN
1476-4598 (ISSN-L)
OpenAlex
W2947437175
Cited by
469
References
375
FWCI
13.14
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review. https://app.cochat.ai/papers/10.1186/s12943-019-0983-5
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Peltanova, B., Raudenska, M., & Masarik, M. (2019). Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review. Molecular Cancer. https://doi.org/10.1186/s12943-019-0983-5

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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