The DOI matches its Crossref record; 43 of the 48 references it cites were found in a registry or an index.
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury†
Open accessAbstract
Rats with chimeric livers were generated by using the protocol of injecting hepatocytes from dipeptidyl peptidase IV (DPPIV)-positive donors into retrorsine-treated DPPIV-negative recipients subjected to partial hepatectomy. Rats with established chimeric livers were subjected to bile duct ligation, with or without pretreatment with the biliary toxin methylene diamiline (DAPM). Ductules bearing the donor hepatocyte marker DPPIV were seen at 30 days after bile duct ligation. The frequency of the ductules derived from the donor hepatocytes was dramatically enhanced (36-fold) by the pretreatment with DAPM. In conclusion, our results show that hepatocytes can function as facultative stem cells and rescue the biliary epithelium during repair from injury when its proliferative capacity is being compromised.
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“Hepatocytes display remarkable plasticity and under some conditions can transdifferentiate into BECs, epithelial cells of the bile ducts with completely different morphology, gene expression and function59,[97], [98], [99]”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [97]
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“Lineage-tracing studies in animal models have confirmed that hepatocytes contribute to bile duct remodeling following cholangiocyte injury10,43–48”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [47]
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“The transdifferentiation of hepatocytes into biliary ductules is damage dependent and negligible unless significant injury is induced26.”
From Hepatic progenitor cells of biliary origin with liver repopulation capacity (2015) · cites this paper as [26]
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Citations
Cites
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The canals of hering and hepatic stem cells in humans
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Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 234
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Gong, X., Bao, L., Chen, Y., Qu, K. L., Zhou, S. F., Chen, X., & Pang, Q. (2023) · Research Square · doi:10.21203/rs.3.rs-3063827/v1
Fukasawa, H., Hashimoto, R., Hagihara, K., Takahashi, I., Sugiyama, M., & Yoshioka, K. (2024) · Research in Veterinary Science · doi:10.1016/j.rvsc.2024.105343
Anatomy and Physiology of the Biliary Epithelium
Hall, C., Glaser, S. S., & Alpini, G. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.01004-4
A new role for tissue-type plasminogen activator in liver injury
Kang, L. (2013) · D-Scholarship@Pitt (University of Pittsburgh)
Differentiation of pancreatic and hepatic cell types
Myatt, E. (2013) · The University of Bath Online Publications Store (The University of Bath)
Lan, T., Tai, Y., Zhao, C., Xiao, Y., Yang, Z., Zhang, L., Gan, C., Dai, W., Tong, H., Tang, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23689710
Lan, T., Tai, Y., Zhao, C., Xiao, Y., Yang, Z., Zhang, L., Gan, C., Dai, W., Tong, H., Tang, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23689713
Feeley, N. A., Williams, K., Field, D. T., McCaffrey, C., Davies, K., Warden, H., Boulter, L., Thorn, S., Wigmore, S. J., Harrison, E. M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.09.704844
NRF2 co-opts the SWI/SNF complex to drive liver cell plasticityPreprint
Ong, A. J. S., Wong, C. C., Karamalakis, A. P., Evason, K. J., Brown, K., & Cox, A. G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.09.704724
Schofield, A., Kamath, B., MacParland, S. A., Trauner, M., Trivedi, P., & Mann, J. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101778 · Cited by 1
Bousaleh, M. (2019) · theses.fr (ABES) · doi:10.70675/d39b3d1bzaa47z40c1zbde5z90e63b846fc9
Mechanisms of Cell Plasticity during Injury-Induced Epithelial Reprogramming
Mazzarelli, E., & Lovisa, S. (2026) · Cells Tissues Organs · doi:10.1159/000552260
Seaman, S., Ruiz, P., Nirello, V. D., Martin-Castilla, L., Elizalde-Garcia, P., Vega-Zuza, A., Vegas-Petrina, L., Lumbreras-Perales, C., Philo, M., Moreno‐Gonzalez, M., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101813
Feeley, N. A., Williams, K., McCaffrey, C., Field, D. T., Davies, K., Warden, H., Boulter, L., Thorn, S., Man, T. Y., Lu, W., et al. (2026) · The Journal of Pathology · doi:10.1002/path.70113
Metadata
- Authors
- Michalopoulos, G. K., Barua, L., & Bowen, W. C.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Michalopoulos, George K.
- Venue
- Hepatology
- Published
- 2005-03
- Volume
- 41
- Issue
- 3
- Pages
- 535-544
- ISSN
- 0270-9139 (ISSN-L)
- PMC
- PMC1821079
- OpenAlex
- W2092743512
- Cited by
- 319
- References
- 48
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 12 · 2023: 16 · 2022: 12 · 2021: 22 · 2020: 24 · 2019: 18 · 2018: 20 · 2017: 16 · 2016: 17 · 2015: 21 · 2014: 23 · 2013: 19 · 2012: 18
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ca103958-06a1)
- National Cancer Institute (CA 35373, R01CA035373, R01-CA103958, CA103958)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- hepatocyte transdifferentiation, bile duct ligation, biliary injury, dipeptidyl peptidase IV, partial hepatectomy
- MeSH terms
- Aniline Compounds, Animals, Benzhydryl Compounds, Bile Ducts, Biliary Tract, Cell Differentiation, Epithelial Cells, Ligation, Liver Regeneration, Male, Rats, Inbred F344, Dipeptidyl Peptidase 4, Hepatocytes, Cell Proliferation, Rats
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