The DOI matches its Crossref record; 43 of the 48 references it cites were found in a registry or an index.
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury†
Open accessAbstract
Rats with chimeric livers were generated by using the protocol of injecting hepatocytes from dipeptidyl peptidase IV (DPPIV)-positive donors into retrorsine-treated DPPIV-negative recipients subjected to partial hepatectomy. Rats with established chimeric livers were subjected to bile duct ligation, with or without pretreatment with the biliary toxin methylene diamiline (DAPM). Ductules bearing the donor hepatocyte marker DPPIV were seen at 30 days after bile duct ligation. The frequency of the ductules derived from the donor hepatocytes was dramatically enhanced (36-fold) by the pretreatment with DAPM. In conclusion, our results show that hepatocytes can function as facultative stem cells and rescue the biliary epithelium during repair from injury when its proliferative capacity is being compromised.
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“Hepatocytes display remarkable plasticity and under some conditions can transdifferentiate into BECs, epithelial cells of the bile ducts with completely different morphology, gene expression and function59,[97], [98], [99]”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [97]
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“Lineage-tracing studies in animal models have confirmed that hepatocytes contribute to bile duct remodeling following cholangiocyte injury10,43–48”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [47]
In the citing paper
“The transdifferentiation of hepatocytes into biliary ductules is damage dependent and negligible unless significant injury is induced26.”
From Hepatic progenitor cells of biliary origin with liver repopulation capacity (2015) · cites this paper as [26]
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Citations
Cites
Experimental pathology of the liver
Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 4,057
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828
Self-citationHiggins, G. (1931) · Cited by 2,444
The canals of hering and hepatic stem cells in humans
Theise, N. D., Saxena, R., Portmann, B. C., Thung, S. N., Yee, H. T., Chiriboga, L. A., Kumar, A., & Crawford, J. M. (1999) · Hepatology · doi:10.1002/hep.510300614 · Cited by 700
A precursor—product relationship exists between oval cells and hepatocytes in rat liver
Evarts, R. P., Nagy, P., Marsden, E. R., & Thorgeirsson, S. S. (1987) · Carcinogenesis · doi:10.1093/carcin/8.11.1737 · Cited by 447
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In vivo differentiation of rat liver oval cells into hepatocytes.
Evarts, R. P., Nagy, P., Nakatsukasa, H., Marsden, E. R., & Thorgeirsson, S. S. (1989) · PubMed · Cited by 321
Origin and Structural Evolution of the Early Proliferating Oval Cells in Rat Liver
Paku, S., Schnur, J., Nagy, P., & Thorgeirsson, S. S. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64082-5 · Cited by 291
Roskams, T., Vos, R. D., Eyken, P. V., Myazaki, H., Damme, B. V., & Desmet, V. J. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80065-2 · Cited by 287
Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 234
Cited by
Sorted by citations
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384
Self-citationA human liver cell atlas reveals heterogeneity and epithelial progenitors
Aizarani, N., Saviano, A., Sagar, Mailly, L., Durand, S., Herman, J. S., Pessaux, P., Baumert, T. F., & Grün, D. (2019) · Nature · doi:10.1038/s41586-019-1373-2 · Cited by 1,147
Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998
Self-citationNotch Signaling in Development, Tissue Homeostasis, and Disease
Siebel, C., & Lendahl, U. (2017) · Physiological Reviews · doi:10.1152/physrev.00005.2017 · Cited by 1,001
Hippo Pathway Activity Influences Liver Cell Fate
Yimlamai, D., Christodoulou, C., Galli, G. G., Yanger, K., Pepe-Mooney, B., Gurung, B., Shrestha, K., Cahan, P., Stanger, B. Z., & Camargo, F. D. (2014) · Cell · doi:10.1016/j.cell.2014.03.060 · Cited by 857
Metadata
- Authors
- Michalopoulos, G. K., Barua, L., & Bowen, W. C.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Michalopoulos, George K.
- Venue
- Hepatology
- Published
- 2005-03
- Volume
- 41
- Issue
- 3
- Pages
- 535-544
- ISSN
- 0270-9139 (ISSN-L)
- PMC
- PMC1821079
- OpenAlex
- W2092743512
- Cited by
- 319
- References
- 48
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 12 · 2023: 16 · 2022: 12 · 2021: 22 · 2020: 24 · 2019: 18 · 2018: 20 · 2017: 16 · 2016: 17 · 2015: 21 · 2014: 23 · 2013: 19 · 2012: 18
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ca103958-06a1)
- National Cancer Institute (CA 35373, R01CA035373, R01-CA103958, CA103958)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- hepatocyte transdifferentiation, bile duct ligation, biliary injury, dipeptidyl peptidase IV, partial hepatectomy
- MeSH terms
- Aniline Compounds, Animals, Benzhydryl Compounds, Bile Ducts, Biliary Tract, Cell Differentiation, Epithelial Cells, Ligation, Liver Regeneration, Male, Rats, Inbred F344, Dipeptidyl Peptidase 4, Hepatocytes, Cell Proliferation, Rats
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