Cited by 319Liver physiology and pathologyDrug-Induced Hepatotoxicity and ProtectionOrgan Transplantation Techniques and Outcomes

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Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury†

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Michalopoulos, George K., Barua, Lindsay, Bowen, William C.·2005·Hepatology

DOI 10.1002/hep.20600PMC PMC1821079

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Abstract

Rats with chimeric livers were generated by using the protocol of injecting hepatocytes from dipeptidyl peptidase IV (DPPIV)-positive donors into retrorsine-treated DPPIV-negative recipients subjected to partial hepatectomy. Rats with established chimeric livers were subjected to bile duct ligation, with or without pretreatment with the biliary toxin methylene diamiline (DAPM). Ductules bearing the donor hepatocyte marker DPPIV were seen at 30 days after bile duct ligation. The frequency of the ductules derived from the donor hepatocytes was dramatically enhanced (36-fold) by the pretreatment with DAPM. In conclusion, our results show that hepatocytes can function as facultative stem cells and rescue the biliary epithelium during repair from injury when its proliferative capacity is being compromised.

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Authors: Michalopoulos, G. K., Barua, L., & Bowen, W. C.
Affiliations: University of Pittsburgh (US)
Corresponding author: Michalopoulos, George K.
ORCID: Michalopoulos, George K.
Venue: Hepatology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-03
Volume: 41
Issue: 3
Pages: 535-544
ISSN: 0270-9139 (ISSN-L)
DOI: 10.1002/hep.20600
PMC: PMC1821079
OpenAlex: W2092743512
Cited by: 319
References: 48
Citations by year: 2026: 8 · 2025: 7 · 2024: 12 · 2023: 16 · 2022: 12 · 2021: 22 · 2020: 24 · 2019: 18 · 2018: 20 · 2017: 16 · 2016: 17 · 2015: 21 · 2014: 23 · 2013: 19 · 2012: 18
FWCI: 8.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3836 d)
Locations: Hepatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (2r01ca103958-06a1)
National Cancer Institute (CA 35373, R01CA035373, R01-CA103958, CA103958)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords: hepatocyte transdifferentiation, bile duct ligation, biliary injury, dipeptidyl peptidase IV, partial hepatectomy
MeSH terms: Aniline Compounds, Animals, Benzhydryl Compounds, Bile Ducts, Biliary Tract, Cell Differentiation, Epithelial Cells, Ligation, Liver Regeneration, Male, Rats, Inbred F344, Dipeptidyl Peptidase 4, Hepatocytes, Cell Proliferation, Rats

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Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury†

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