The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Acute liver failure: Summary of a workshop†
Open accessAbstract
Acute liver failure (ALF) is a rare but challenging clinical syndrome with multiple causes; a specific etiology cannot be identified in 15% of adult and 50% of pediatric cases. The course of ALF is variable and the mortality rate is high. Liver transplantation is the only therapy of proven benefit, but the rapidity of progression and the variable course of ALF limit its use. Currently in the United States, spontaneous survival occurs in approximately 45%, liver transplantation in 25%, and death without transplantation in 30% of adults with ALF. Higher rates of spontaneous recovery (56%) and transplantation (31%) with lower rates of death (13%) occur in children. The outcome of ALF varies by etiology, favorable prognoses being found with acetaminophen overdose, hepatitis A, and ischemia (approximately 60% spontaneous survival), and poor prognoses with drug-induced ALF, hepatitis B, and indeterminate cases (approximately 25% spontaneous survival). Excellent intensive care is critical in management of patients with ALF. Nonspecific therapies are of unproven benefit. Future possible therapeutic approaches include N-acetylcysteine, hypothermia, liver assist devices, and hepatocyte transplantation. Advances in stem cell research may allow provision of cells for bioartificial liver support. ALF presents many challenging opportunities in both clinical and basic research.
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Cites
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EASL Clinical Practice Guidelines: Liver transplantation
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.006 · Cited by 1,082
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Self-citationOutcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study
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Self-citationCell and tissue engineering for liver disease
Bhatia, S. N., Underhill, G. H., Zaret, K. S., & Fox, I. J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3005975 · Cited by 309
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The Natural History of Severe Acute Liver Injury
Koch, D. G., Speiser, J. L., Durkalski, V, Fontana, R. J., Davern, T., McGuire, B., Stravitz, R. T., Larson, A. M., Liou, I., Fix, O., et al. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2017.98 · Cited by 143
Self-citationAgarwal, R., MacMillan-Crow, L. A., Rafferty, T. M., Saba, H., Roberts, D. W., Fifer, E. K., James, L. P., & Hinson, J. A. (2011) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.176321 · Cited by 116
Saberi, B., Ybanez, M. D., Johnson, H. S., Gaarde, W. A., Han, D., & Kaplowitz, N. (2014) · Hepatology · doi:10.1002/hep.26625 · Cited by 88
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Self-citationEnhancement of hepatic autophagy increases ureagenesis and protects against hyperammonemia
Soria, L. R., Allegri, G., Melck, D., Pastore, N., Annunziata, P., Paris, D., Polishchuk, E., Nusco, E., Thöny, B., Motta, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714670115 · Cited by 61
Postponing the hypoglycemic response to partial hepatectomy delays mouse liver regeneration
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Systematic review on Chinese herbal medicine induced liver injury
Zhang, P., Ye, Y., Yang, X., & Jiao, Y. (2016) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2016/3560812 · Cited by 39
Drug-Induced Liver Injury in Children: Clinical Observations, Animal Models, and Regulatory Status
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Metadata
- Authors
- Lee, W. M., Squires, R. H., Nyberg, S. L., Doo, E., & Hoofnagle, J. H.
- Venue
- Hepatology
- Published
- 2008-04
- Volume
- 47
- Issue
- 4
- Pages
- 1401-1415
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2065261900
- Cited by
- 757
- References
- 6
- FWCI
- 31.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
