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Systematic Review on Chinese Herbal Medicine Induced Liver Injury

Zhang, Peng, Ye, Yongan, Yang, Xianzhao, Jiao, Yuntao·2016·Evidence-Based Complementary and Alternative Medicine
DOI 10.1155/2016/3560812PMC PMC5019919
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Abstract

Background. In recent years, with the popularity of CHM, its hepatotoxicity has also been increasingly noticed. However, there are still veils on causative herbs and clinical characteristics. Aim. To systematically review data on CHM induced liver injury with particular focus on causative herbs and clinical characteristics. Methods. Using terms related to CHM and liver injury, PubMed and three Chinese electronic databases were searched, which was limited to the past 5 years. Publications meeting our eligibility criteria were included and further analyzed. Results. In total, 4 single herbs, 21 patent drugs, and 4 decoctions were reported to be of hepatotoxicity, with He‐Shou‐Wu being the most common one (65/114). Dang‐Gui and other 5 herbs were the most common ingredients of patent drugs and decoctions. All patients were assessed using the RUCAM scale, with 26 being highly probable and 28 being probable. For these 54 cases, the latent period was 30 (47) days, and 81.48% were labeled as hepatocellular injuries. Most patients (96.3%) recovered, apart from the fact that one died and one is receiving liver transplantation. Conclusions. CHM should be used carefully for hepatotoxicity. Liver injury from CHM is similar to that from conventional medicines in clinical characteristics. Details about causative herbs should be illustrated, and more RUCAM should be used in future.

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Metadata

Authors
Zhang, P., Ye, Y., Yang, X., & Jiao, Y.
ORCID
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Wiley
Published
2016-01
Volume
2016
Issue
1
ISSN
  • 1741-427X
  • 1741-4288
DOI
10.1155/2016/3560812
PMC
PMC5019919
Cited by
39
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor, 241 d)
Funders
National Science and Technology Major Project of the 11th Five-Year Plan in China (2008ZX10005-006)

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