Cell and tissue engineering for liver disease
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Advances in cell and tissue engineering are moving cell-based therapies for treating liver disease and liver failure closer to the clinic.
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iPSC-derived hepatocyte-like cells are still in nascent stages of development and show characteristics similar to fetal hepatocytes.
“These iPSC-derived hepatocyte-like cells are still in nascent stages of development and show characteristics similar to fetal hepatocytes [76].”
From A liver-on-a-chip platform with bioprinted hepatic spheroids (2016) · cites this paper as [76]
For decades, expandable HHs have been a bottleneck for their applications for research purposes and clinical therapies.
“For decades, expandable HHs have been a bottleneck for their applications for research purposes and clinical therapies (Bhatia et al., 2014; Michalopoulos, 2014; Mitaka, 1998; Runge et al., 2000”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Bhatia et al., 2014
The use of hepatocyte transplantation is hampered by the limited availability of donor hepatocytes and the inability to expand primary HHs in vitro.
“However, the actual use of hepatocyte transplantation has been hampered by the limited availability of donor hepatocytes and the inability to expand primary HHs (PHHs) in vitro.”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Bhatia et al., 2014
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- Authors
- Bhatia, S. N., Underhill, G. H., Zaret, K. S., & Fox, I. J.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Illinois Urbana-Champaign (US)
- University of Pennsylvania (US)
- University of Pittsburgh (US)
- Corresponding author
- Bhatia, Sangeeta N.
- Venue
- Science Translational Medicine
- Published
- 2014-07-16
- Volume
- 6
- Issue
- 245
- Pages
- 245sr2-245sr2
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4374645
- OpenAlex
- W2109789900
- Cited by
- 309
- References
- 315
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 20 · 2023: 15 · 2022: 24 · 2021: 41 · 2020: 40 · 2019: 32 · 2018: 26 · 2017: 31 · 2016: 34 · 2015: 15 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R01GM036477, R37GM36477, R37GM036477)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099320, P01DK096990, R01DK48794, R01DK085713, R01DK85713, R01DK048794)
- National Institute of Biomedical Imaging and Bioengineering (R01EB008396, UH2EB017103, UH3EB017103)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- liver disease, liver failure, cell therapy, tissue engineering, stem cells, cellular reprogramming, clinical translation, liver regeneration
- MeSH terms
- Animals, Disease Models, Animal, Humans, Liver, Liver Diseases, Tissue Engineering, Translational Research, Biomedical, Cell Engineering
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