Drug-induced liver injury: a clinical update
Open accessAbstract
PURPOSE OF REVIEW: To gather new and important data published on idiosyncratic drug-induced liver injury (DILI) over the past 2 years in the peer-reviewed literature. Clinical studies focusing on mechanisms of injury, clinical evaluation and prognosis will be reviewed. RECENT FINDINGS: The most common drugs leading to DILI in the United States are antibiotics, central nervous system agents, herbal/dietary supplements and immunomodulatory agents. Hepatocellular type of DILI is more common in younger patients, whereas cholestatic pattern increases with older age. Certain human leukocyte antigen genotype increases the likelihood of flucloxacillin-induced liver injury. Idiosyncratic DILI was shown to have an important dose-dependency and drugs with extensive hepatic metabolism are associated with higher frequency of DILI. Chronic DILI may occur, but development of clinically important liver injury after severe DILI is rare. N-acetylcysteine seems to be beneficial for patients with acute liver failure caused by medications or herbal agents.
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Risk factors and pathogenesis of DILI are poorly understood.
“Risk factors and pathogenesis of DILI are poorly understood.”
From Albendazole-induced granulomatous hepatitis: a case report (2013) · cites this paper as [3]
The Introduction says that the risk factors and pathogenesis of *idiosyncratic* DILI are poorly understood. The claim omits that qualifier and extends the statement to DILI generally; the Epidemiology section describes acetaminophen-related DILI as well known to be dose-related. (LLM, conf=0.88)
Experimental — accuracy not yet measuredDrug-related hepatotoxicity is a cause of acute liver failure and is responsible for the elimination of new pharmacological agents during efficacy and safety studies.
“Drug-related hepatotoxicity is a common medical problem, with implications for health systems, and is also a cause of acute liver failure and, in many cases, responsible for the elimination of new pharmacological agents during efficacy and safety studies.”
From Albendazole-induced granulomatous hepatitis: a case report (2013) · cites this paper as [3]
The diagnosis of DILI is one of exclusion, because it is not easy to define a toxic etiology as the cause of liver disease due to the heterogeneity of the clinical presentation and evolution.
“The diagnosis of DILI is one of exclusion, because it is not easy to define a toxic etiology as the cause of liver disease due to the heterogeneity of the clinical presentation and evolution.”
From Albendazole-induced granulomatous hepatitis: a case report (2013) · cites this paper as [3]
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Cites
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- Authors
- Ghabril, M., Chalasani, N., & Björnsson, E.
- Affiliations
- Indiana University Indianapolis (US)
- Venue
- Current Opinion in Gastroenterology
- Published
- 2010-05
- Volume
- 26
- Issue
- 3
- Pages
- 222-226
- ISSN
- 0267-1379 (ISSN-L)
- PMC
- PMC3156474
- OpenAlex
- W2087256708
- Cited by
- 123
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 12 · 2018: 8 · 2017: 16 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 11
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (acceptedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK069290)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- drug-induced liver injury, idiosyncratic drug-induced liver injury, hepatotoxicity mechanisms, antibiotics, central nervous system agents, herbal and dietary supplements, immunomodulators, flucloxacillin, HLA typing, dose-dependent liver injury, N-acetylcysteine, acute liver failure, cholestatic liver injury, prognosis
- MeSH terms
- Humans, Chemical and Drug Induced Liver Injury
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