Telomerase gene mutations are associated with cirrhosis formation
Open accessAbstract
Telomere shortening impairs liver regeneration in mice and is associated with cirrhosis formation in humans with chronic liver disease. In humans, telomerase mutations have been associated with familial diseases leading to bone marrow failure or lung fibrosis. It is currently unknown whether telomerase mutations associate with cirrhosis induced by chronic liver disease. The telomerase RNA component (TERC) and the telomerase reverse transcriptase (TERT) were sequenced in 1,121 individuals (521 patients with cirrhosis induced by chronic liver disease and 600 noncirrhosis controls). Telomere length was analyzed in patients carrying telomerase gene mutations. Functional defects of telomerase gene mutations were investigated in primary human fibroblasts and patient-derived lymphocytes. An increased incidence of telomerase mutations was detected in cirrhosis patients (allele frequency 0.017) compared to noncirrhosis controls (0.003, P value 0.0007; relative risk [RR] 1.859; 95% confidence interval [CI] 1.552–2.227). Cirrhosis patients with TERT mutations showed shortened telomeres in white blood cells compared to control patients. Cirrhosis-associated telomerase mutations led to reduced telomerase activity and defects in maintaining telomere length and the replicative potential of primary cells in culture. Conclusion: This study provides the first experimental evidence that telomerase gene mutations are present in patients developing cirrhosis as a consequence of chronic liver disease. These data support the concept that telomere shortening can represent a causal factor impairing liver regeneration and accelerating cirrhosis formation in response to chronic liver disease. (Hepatology 2011;)
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Patients with cirrhosis have a higher incidence of telomerase mutations and bear shorter telomeres than unaffected individuals.
“Patients with cirrhosis have a higher incidence of telomerase mutations and bear shorter telomeres than unaffected individuals96.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [96]
The Abstract reports a higher frequency of telomerase mutations in 521 patients with cirrhosis than in 600 noncirrhosis controls. The Functional Analysis section reports shorter telomeres only in cirrhosis patients carrying telomerase mutations compared with controls without those mutations; it does not establish the telomere comparison for cirrhosis patients generally. Page numbers were not provided in our copy. (LLM, conf=0.86)
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Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1× · see citing works
“However, telomeres shorten as a consequence of cell division due to the ‘‘end replication problem’’ of DNA polymerase, processing of telomeres during S-phase of cell cycle, and the absence of telomerase expression in most somatic tissues.(9) Telomere shortening limits the proliferative life span of human cells to 50-7…”
BackgroundHepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
El‐Serag, H. B., & Rudolph, K. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.061 · Cited by 5,401 · see citing works
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,640 · see citing works
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066157 · Cited by 1,357 · see citing works
A telomerase component is defective in the human disease dyskeratosis congenita
Mitchell, J. R., Wood, E., & Collins, K. (1999) · Nature · doi:10.1038/990141 · Cited by 1,168 · see citing works
Inhibition of telomerase limits the growth of human cancer cells
Hahn, W. C., Stewart, S. A., Brooks, M. W., York, S. G., Eaton, E. N., Kurachi, A. L., Beijersbergen, R. L., Knoll, J. H. M., Meyerson, M. M., & Weinberg, R. A. (1999) · Nature Medicine · doi:10.1038/13495 · Cited by 1,032 · see citing works
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., & Dokal, I. (2001) · Nature · doi:10.1038/35096585 · Cited by 960 · see citing works
Adult-onset pulmonary fibrosis caused by mutations in telomerase
Tsakiri, K. D., Cronkhite, J. T., Kuan, P. J., Xing, C., Raghu, G., Weissler, J. C., Rosenblatt, R. L., Shay, J. W., & Garcia, C. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701009104 · Cited by 894 · see citing works
Short telomeres are a risk factor for idiopathic pulmonary fibrosis
Alder, J. K., Chen, J. J.-L., Lancaster, L., Danoff, S., Su, S.-C., Cogan, J. D., Vulto, I., Xie, M., Qi, X., Tuder, R. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804280105 · Cited by 805 · see citing works
Brown, J. P., Wei, W., & Sedivy, J. M. (1997) · Science · doi:10.1126/science.277.5327.831 · Cited by 804 · see citing works
Mutations in <i>TERT,</i> the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia
Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042980 · Cited by 723 · see citing works
Telomerase modulates Wnt signalling by association with target gene chromatin
Park, J.-I., Venteicher, A. S., Hong, J. Y., Choi, J., Jun, S., Shkreli, M., Chang, W., Meng, Z., Cheung, P., Ji, H., et al. (2009) · Nature · doi:10.1038/nature08137 · Cited by 707 · cited 1× · see citing works
“Recent studies have revealed telomere length-independent effects of TERT in regulating the transcriptional function of the Wnt-signaling pathway and stem cell activity in mice.(32) It remains to be seen whether cirrhosis-associated TERT mutations show defects in these noncanonical TERT-pathways and whether TERT mutati…”
BackgroundCellular and Molecular Mechanisms of Liver Injury
Malhi, H., & Gores, G. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.002 · Cited by 559 · see citing works
Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo
Allsopp, R. C., Chang, E., Kashefi-Aazam, M., Rogaev, E. I., Piatyszek, M. A., Shay, J. W., & Harley, C. B. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1306 · Cited by 533 · see citing works
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
WIEMANN, S. U., SATYANARAYANA, A., TSAHURIDU, M., TILLMANN, H. L., ZENDER, L., KLEMPNAUER, J., FLEMMING, P., FRANCO, S., BLASCO, M. A., MANNS, M. P., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0977com · Cited by 527 · see citing works
Self-citationA Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E. (2009) · Science · doi:10.1126/science.1165357 · Cited by 522 · see citing works
Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery
Rudolph, K. L., Chang, S., Millard, M., Schreiber-Agus, N., & DePinho, R. A. (2000) · Science · doi:10.1126/science.287.5456.1253 · Cited by 424 · see citing works
Assessment of Prognosis of Cirrhosis
Durand, F., & Valla, D. (2008) · Seminars in liver disease (Print) · doi:10.1055/s-2008-1040325 · Cited by 328 · see citing works
Walne, A. J., Vulliamy, T., Beswick, R., Kirwan, M., & Dokal, I. (2008) · Blood · doi:10.1182/blood-2008-05-153445 · Cited by 317 · see citing works
Association between aplastic anaemia and mutations in telomerase RNA
Vulliamy, T., Marrone, A., Dokal, I. S., & Mason, P. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09087-6 · Cited by 276 · see citing works
A Spectrum of Severe Familial Liver Disorders Associate with Telomerase Mutations
Calado, R. T., Regal, J. A., Kleiner, D. E., Schrump, D. S., Peterson, N. R., Pons, V., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007926 · Cited by 252 · see citing works
Podlevsky, J. D., Bley, C. J., Omana, R. V., Qi, X., & Chen, J. J. ‐. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm700 · Cited by 235 · see citing works
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia
Calado, R. T., Regal, J. A., Hills, M., Yewdell, W. T., Dalmazzo, L. F., Zago, M. A., Lansdorp, P. M., Hogge, D., Chanock, S. J., Estey, E. H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807057106 · Cited by 184 · see citing works
N-Terminal Domains of the Human Telomerase Catalytic Subunit Required for Enzyme Activity in Vivo
Armbruster, B. N., Banik, S. S. R., Guo, C., Smith, A. C., & Counter, C. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.22.7775-7786.2001 · Cited by 183 · see citing works
Keratin 8 Mutations in Patients with Cryptogenic Liver Disease
Ku, N., Gish, R. G., Wright, T. L., & Omary, M. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105243442103 · Cited by 170 · see citing works
Telomerase activity and telomere length in hepatocellular carcinoma and chronic liver disease
Kojima, H., Yokosuka, O., Imazeki, F., Saisho, H., & Omata, M. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9024303 · Cited by 162 · see citing works
Satyanarayana, A., Wiemann, S. U., Buer, J., Lauber, J., Dittmar, K. E. J., Wüstefeld, T., Blasco, M. A., Manns, M. P., & Rudolph, K. L. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg367 · Cited by 158 · see citing works
Self-citationDyskeratosis Congenita - A Disease of Dysfunctional Telomere Maintenance
Mason, P., Wilson, D., & Bessler, M. (2005) · Current Molecular Medicine · doi:10.2174/1566524053586581 · Cited by 129 · see citing works
Dyskeratosis congenita: The diverse clinical presentation of mutations in the telomerase complex
Vulliamy, T., & Dokal, I. S. (2007) · Biochimie · doi:10.1016/j.biochi.2007.07.017 · Cited by 126 · see citing works
Delhaye, M., Louis, H., Degraef, C., Moine, O. L., Deviere, J. M. E., Gulbis, B., Jacobovitz, D., Adler, M., & Galand, P. (1996) · Hepatology · doi:10.1002/hep.510230510 · Cited by 91 · see citing works
Delhaye, M. (1996) · Hepatology · doi:10.1053/jhep.1996.v23.pm0008621125 · Cited by 75 · see citing works
Keratin variants associate with progression of fibrosis during chronic hepatitis C infection†
Strnad, P., Lienau, T. C., Tao, G., Lazzeroni, L. C., Stickel, F., Schuppan, D., & Omary, M. B. (2006) · Hepatology · doi:10.1002/hep.21211 · Cited by 65 · see citing works
Self-citationIn Vitro Expansion of Human Hepatocytes is Restricted by Telomere-Dependent Replicative Aging
Wege, H., Chui, M. S., Le, H. T., Strom, S. C., & Zern, M. Α. (2003) · Cell Transplantation · doi:10.3727/000000003771000138 · Cited by 59 · see citing works
Lechel, A., Manns, M. P., & Rudolph, K. L. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.06.010 · Cited by 44 · see citing works
Self-citationAn efficient method for routine epstein-barr virus immortalization of human B lymphocytes
Wall, F. E., Henkel, R. D., D, M. P. S. M., Jenson, H. B., & Moyer, M. P. (1995) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02633976 · Cited by 37 · see citing works
Williams, E. J., & Iredale, J. P. (1998) · Postgraduate Medical Journal · doi:10.1136/pgmj.74.870.193 · Cited by 37 · see citing works
Takeuchi, J. S., Ly, H., Yamaguchi, H., Carroll, K. A., Kosaka, F., Sawaguchi, K., Mitamura, Y., Watanabe, A., Gomi, S., Inokuchi, K., et al. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.08.002 · Cited by 26 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Rudolph KL, DePinho RA. Telomeres and telomerase in experimental liver cirrhosis. In: Chisari FV, Fausto N, Schachter D, Shafritz DA, Arias IM, Boyer JL, eds. The Liver: Biology and Pathobiology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2001:1001-1010.
- Brown JP, Wei W, Sedivy JM. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 1997;277:831-834.
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Llovet, J. M., Zucman-Rossi, J., Pikarsky, E., Sangro, B., Schwartz, M., Sherman, M., & Gores, G. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.18 · Cited by 2,531 · see citing works
Genetic landscape and biomarkers of hepatocellular carcinoma
Zucman-Rossi, J., Villanueva, A., Nault, J.-C., & Llovet, J. M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.061 · Cited by 1,325 · see citing works
Genetics and epigenetics of NAFLD and NASH: Clinical impact
Eslam, M., Valenti, L., & Romeo, S. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.09.003 · Cited by 971 · see citing works
Telomere dysfunction in ageing and age-related diseases
Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754 · see citing works
Nault, J., Mallet, M., Pilati, C., Caldéraro, J., Bioulac‐Sage, P., Laurent, C., Laurent, A., Cherqui, D., Balabaud, C. P., & Zucman‐Rossi, J. (2013) · Nature Communications · doi:10.1038/ncomms3218 · Cited by 691 · see citing works
NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications
Farrell, G. C., Rooyen, D. M. V., Gan, L. T., & Chitturi, S. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.2.149 · Cited by 396 · see citing works
Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population
Rattan, P., Penrice, D. D., Ahn, J. C., Ferrer, A., Patnaik, M. M., Shah, V. H., Kamath, P. S., Mangaonkar, A. A., & Simonetto, D. A. (2021) · Hepatology Communications · doi:10.1002/hep4.1803 · Cited by 364 · see citing works
Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury
Lin, S., Nascimento, E. M., Gajera, C. R., Chen, L., Neuhöfer, P., Garbuzov, A., Wang, S., & Artandi, S. E. (2018) · Nature · doi:10.1038/s41586-018-0004-7 · Cited by 241 · see citing works
The role of telomeres and telomerase in cirrhosis and liver cancer
Nault, J., Ningarhari, M., Rebouissou, S., & Zucman‐Rossi, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0165-3 · Cited by 241 · see citing works
Ramakrishna, G., Rastogi, A., Trehanpati, N., Sen, B., Khosla, R., & Sarin, S. K. (2013) · Liver Cancer · doi:10.1159/000343852 · Cited by 237 · see citing works
Genetics of human telomere biology disorders
Revy, P., Kannengiesser, C., & Bertuch, A. A. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00527-z · Cited by 243 · see citing works
Dongiovanni, P., Anstee, Q. M., & Valenti, L. V. C. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990381 · Cited by 231 · see citing works
Telomere Dynamics in Mice and Humans
Calado, R. T., & Dumitriu, B. (2013) · Seminars in Hematology · doi:10.1053/j.seminhematol.2013.03.030 · Cited by 214 · see citing works
Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances
Dhanasekaran, R., Bandoh, S., & Roberts, L. (2016) · F1000Research · doi:10.12688/f1000research.6946.1 · Cited by 199 · see citing works
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Dhanasekaran, R., Nault, J., Roberts, L. R., & Zucman‐Rossi, J. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.11.001 · Cited by 205 · see citing works
Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease
Amano, H., Chaudhury, A., Rodriguez-Aguayo, C., Lu, L., Akhanov, V., Catic, A., Popov, Y. V., Verdin, E., Johnson, H., Stossi, F., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.001 · Cited by 182 · see citing works
Senescence in chronic liver disease: Is the future in aging?
Aravinthan, A. D., & Alexander, G. J. M. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.030 · Cited by 174 · see citing works
Borie, R., Kannengiesser, C., Hirschi, S., Pavec, J. L., Mal, H., Bergot, E., Jouneau, S., Naccache, J., Revy, P., Boutboul, D., et al. (2014) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2014.11.010 · Cited by 144 · see citing works
Telomeres and human reproduction
Kalmbach, K., Antunes, D. M. F., Dracxler, R. C., Knier, T. W., Seth-Smith, M. L., Wang, F., Liu, L., & Keefe, D. L. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.11.039 · Cited by 137 · see citing works
Genetics of nonalcoholic fatty liver disease
Dongiovanni, P., & Valenti, L. V. C. (2015) · Metabolism · doi:10.1016/j.metabol.2015.08.018 · Cited by 115 · see citing works
Clinical outcomes of lung transplant recipients with telomerase mutations
Tokman, S., Singer, J. P., Devine, M., Westall, G. P., Aubert, J., Tamm, M., Snell, G. I., Lee, J. S., Goldberg, H. J., Kukreja, J., et al. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.05.002 · Cited by 107 · see citing works
Chen, R., Zhang, K., Chen, H., Zhao, X., Wang, J., Li, L., Cong, Y., Ju, Z., Xu, D., Williams, B. R. G., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.681619 · Cited by 89 · see citing works
Self-citationTelomeres and immune competency
Weng, N.-P. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.05.001 · Cited by 87 · see citing works
Management of suspected monogenic lung fibrosis in a specialised centre
Borie, R., Kannengiesser, C., de Fontbrune, F. S., Gouya, L., Nathan, N., & Crestani, B. (2017) · European Respiratory Review · doi:10.1183/16000617.0122-2016 · Cited by 81 · see citing works
Zocchi, L., Lontano, A., Merli, M., Dika, E., Nagore, E., Quaglino, P., Puig, S., & Ribero, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163760 · Cited by 77 · see citing works
Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs
Winkler, T., Hong, S. G., Decker, J. E., Morgan, M. J., Wu, C., Hughes, W. M., Yang, Y., Wangsa, D., Padilla‐Nash, H. M., Ried, T., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67146 · Cited by 72 · see citing works
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Donati, B., & Valenti, L. V. C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030383 · Cited by 68 · see citing works
Jiao, J., Watt, G. P., Stevenson, H. L., Calderone, T. L., Fisher‐Hoch, S. P., Ye, Y., Wu, X., Vierling, J. M., & Beretta, L. (2018) · Hepatology Communications · doi:10.1002/hep4.1187 · Cited by 69 · see citing works
Kozlitina, J., & Garcia, C. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051046 · Cited by 68 · see citing works
Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of TelomeresPreprint
Roake, C. M., & Artandi, S. E. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026088 · Cited by 67 · see citing works
Yıldız, G., Arslan-Ergül, A., Baǧışlar, S., Konu, Ö., Yuzugullu, H., Gürsoy-Yüzügüllü, Ö., Öztürk, N., Özen, Ç., Özdağ, H., Erdal, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064016 · Cited by 60 · see citing works
Telomeres and Telomerase in the Development of Liver Cancer
der Stroth, L. I., Tharehalli, U., Güneş, Ç., & Lechel, A. (2020) · Cancers · doi:10.3390/cancers12082048 · Cited by 63 · see citing works
Self-citationCellular Senescence in Liver Disease and Regeneration
Ferreira-González, S., Rodrigo‐Torres, D., Gadd, V. L., & Forbes, S. J. (2021) · Seminars in Liver Disease · doi:10.1055/s-0040-1722262 · Cited by 58 · see citing works
Telomere and telomerase in chronic liver disease and hepatocarcinoma
Carulli, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i20.6287 · Cited by 54 · see citing works
Fu, X., Wan, S., Hann, H., Myers, R. E., Hann, R. S., Au, J. S., Chen, B., Xing, J., & Yang, H. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.02.066 · Cited by 55 · see citing works
Tümpel, S., & Rudolph, K. L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06547.x · Cited by 54 · see citing works
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Czaja, A. J. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2525-5 · Cited by 54 · see citing works
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Devine, M., & Garcia, C. K. (2011) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2011.11.001 · Cited by 53 · see citing works
Donati, B., Pietrelli, A., Pingitore, P., Dongiovanni, P., Caddeo, A. M., Walker, L., Baselli, G., Pelusi, S., Rosso, C., Vanni, E., et al. (2017) · Cancer Medicine · doi:10.1002/cam4.1078 · Cited by 52 · see citing works
Feurstein, S. K., Adegunsoye, A., Mojsilovic, D., Vij, R., DePersia, A., Rajagopal, P. S., Osman, A. E. G., Collins, R. H., Kim, R. H., Gore, S. D., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001721 · Cited by 52 · see citing works
Borie, R., Kannengiesser, C., Nathan, N., Tabèze, L., Pradère, P., & Crestani, B. (2014) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2014.07.017 · Cited by 52 · see citing works
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Kalmbach, K., Robinson, L. G., Wang, F., Liu, L., & Keefe, D. L. (2014) · BioMed Research International · doi:10.1155/2014/925121 · Cited by 49 · see citing works
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Gao, L., Thakur, A., Liang, Y., Zhang, S., Wang, T., Chen, T., Meng, J., Wang, L., Wu, F., Jin, T., et al. (2014) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000086 · Cited by 48 · see citing works
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Meena, J. K., Rudolph, K. L., & Güneş, Ç. (2015) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-20291-4_3 · Cited by 47 · see citing works
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Aalbers, A. M., Calado, R. T., Young, N. S., Zwaan, C. M., Wu, C. O., Kajigaya, S., Coenen, E. A., Baruchel, A., Geleijns, K. P. W., de Haas, V., et al. (2013) · Leukemia · doi:10.1038/leu.2013.57 · Cited by 44 · see citing works
The relationship between telomere length and aging-related diseases
Huang, X., Huang, L., Lu, J., Cheng, L., Wu, D. A., Li, L., Zhang, S., Lai, X., & Xu, L. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01608-z · Cited by 52 · see citing works
Mast cells and the liver aging process
Grizzi, F., Caro, G. D., Laghi, L., Hermonat, P. L., Mazzola, P., Nguyen, D. D. T., Radhi, S., Figueroa, J. A., Cobos, E., Annoni, G., et al. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-9 · Cited by 41 · see citing works
Molecular Targets in Hepatocarcinogenesis and Implications for Therapy
Wu, M., Yiang, G.-T., Cheng, P., Chu, P., & Li, C. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7080213 · Cited by 41 · see citing works
Telomere-Regulating Genes and the Telomere Interactome in Familial Cancers
Robles‐Espinoza, C. D., Velasco‐Herrera, M. D. C., Hayward, N. K., & Adams, D. J. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0305 · Cited by 40 · see citing works
Trust Your Gut: The Association of Gut Microbiota and Liver Disease
Manzoor, R., Ahmed, W., Afify, N., Memon, M., Yasin, M., Memon, H., Rustom, M., Akeel, M. A., & Alhajri, N. (2022) · Microorganisms · doi:10.3390/microorganisms10051045 · Cited by 40 · see citing works
Telomeres as hotspots for innate immunity and inflammation
Nassour, J., Przetocka, S., & Karlseder, J. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103591 · Cited by 40 · see citing works
Insights from human genetic studies of lung and organ fibrosis
Garcia, C. K. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93556 · Cited by 37 · see citing works
Sphingolipids at the Crossroads of NAFLD and Senescence
Nikolova‐Karakashian, M. (2018) · Advances in cancer research · doi:10.1016/bs.acr.2018.05.002 · Cited by 35 · see citing works
Lara‐Astiaso, D., Izarra, A., Estrada, J. C., Albo, C., Moscoso, I., Samper, E., Moncayo, J., Solano, A., Bernad, A., & Díez‐Juan, A. (2012) · SpringerPlus · doi:10.1186/2193-1801-1-63 · Cited by 33 · see citing works
Understanding telomere diseases through analysis of patient-derived iPS cells
Batista, L. F. Z., & Artandi, S. E. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.07.006 · Cited by 33 · see citing works
van Steenbeek, F. G., den Bossche, L. V., Leegwater, P. A. J., & Rothuizen, J. J. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9364-0 · Cited by 32 · see citing works
Bone marrow failure and the new telomere diseases: practice and research
Young, N. S. (2012) · Hematology · doi:10.1179/102453312x13336169155132 · Cited by 30 · see citing works
Multiple genetic pathways regulate replicative senescence in telomerase‐deficient yeast
Ballew, B. J., & Lundblad, V. (2013) · Aging Cell · doi:10.1111/acel.12099 · Cited by 28 · see citing works
Alves‐Paiva, R. M., Kajigaya, S., Feng, X., Chen, J., Desierto, M. J., Wong, S. C., Townsley, D. M., Donaires, F. S., Bertola, A., Gao, B., et al. (2017) · Liver International · doi:10.1111/liv.13529 · Cited by 30 · see citing works
Güneş, Ç., Avila, A. I., & Rudolph, K. L. (2017) · Differentiation · doi:10.1016/j.diff.2017.12.004 · Cited by 26 · see citing works
Novel variants in Nordic patients referred for genetic testing of telomere-related disorders
Norberg, A., Rosén, A., Raaschou‐Jensen, K., Kjeldsen, L., Moilanen, J. S., Paulsson-Karlsson, Y., Baliakas, P., Lohi, O., Ahmed, A. B., Kittang, A. O., et al. (2018) · European Journal of Human Genetics · doi:10.1038/s41431-018-0112-8 · Cited by 26 · see citing works
Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma
Donaires, F. S., Scatena, N. F., Alves‐Paiva, R. M., Podlevsky, J. D., Logeswaran, D., Santana, B. A., Teixeira, A. C., Chen, J. J. ‐., Calado, R. T., & Martinelli, A. D. L. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183287 · Cited by 25 · see citing works
Sidali, S., Borie, R., de Fontbrune, F. S., Husseini, K. E., Rautou, P., Lainey, É., Goria, O., Crestani, B., Cadranel, J. L., Cottin, V., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000667 · Cited by 24 · see citing works
Role of cellular senescence in hepatic wound healing and carcinogenesis
Ramakrishna, G., Anwar, T., Angara, R. K., Chatterjee, N., Kiran, S., & Singh, S. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.08.002 · Cited by 24 · see citing works
Carulli, L., Dei, A., & Nascimbeni, F. (2012) · Hepatology · doi:10.1002/hep.26089 · Cited by 24 · see citing works
Telomeres: Dysfunction, Maintenance, Aging and Cancer
Liao, P., Yan, B., Wang, C., & Lei, P. (2023) · Aging and Disease · doi:10.14336/ad.2023.1128 · Cited by 22 · see citing works
Telomerase mutation: A genetic risk factor for cirrhosis
Chaiteerakij, R., & Roberts, L. R. (2011) · Hepatology · doi:10.1002/hep.24304 · Cited by 22 · see citing works
Telomere shortening as genetic risk factor of liver cirrhosis
Carulli, L. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i2.379 · Cited by 21 · see citing works
Familial forms of nonspecific interstitial pneumonia/idiopathic pulmonary fibrosis
Borie, R., Kannengiesser, C., & Crestani, B. (2012) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328356b15c · Cited by 20 · see citing works
Wan, S., HANN, H.-W. L., Myers, R. E., Fu, X., Hann, R. S., Kim, S. H., Tang, H. Y., Xing, J., & Yang, H. (2012) · Liver International · doi:10.1111/j.1478-3231.2012.02801.x · Cited by 20 · see citing works
Vittal, A., Niewisch, M. R., Bhala, S., Kudaravalli, P., Rahman, F., Hercun, J., Kleiner, D. E., Savage, S. A., Koh, C., Heller, T., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000461 · Cited by 19 · see citing works
Munroe, M., Niero, E. L. D. O., Fok, W. C., Vessoni, A. T., Jeong, H., Brenner, K. A., & Batista, L. F. Z. (2020) · Hepatology · doi:10.1002/hep.31414 · Cited by 19 · see citing works
Valenti, L. V. C., Dongiovanni, P., Maggioni, M., Motta, B. M., Rametta, R., Milano, M., Fargion, S. R., Reggiani, P., & Fracanzani, A. L. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.09.011 · Cited by 19 · see citing works
Rolles, B., Tometten, M., Meyer, R., Kirschner, M., Beier, F., & Brümmendorf, T. H. (2024) · Transfusion Medicine and Hemotherapy · doi:10.1159/000540109 · Cited by 18 · see citing works
Telomere Dysfunction and Hematologic Disorders
Paiva, R. M. A., & Calado, R. T. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397898-1.00006-2 · Cited by 18 · see citing works
Arnold, F., Mahaddalkar, P. U., Kraus, J. M., Zhong, X., Bergmann, W., Srinivasan, D., Gout, J., Roger, E., Beutel, A. K., Zizer, E., et al. (2021) · Advanced Science · doi:10.1002/advs.202100626 · Cited by 18 · see citing works
Self-citationNatural regression of fibrosis in chronic hepatitis B
Ohkoshi, S., Hirono, H., Watanabe, K., Hasegawa, K., Kamimura, K., & Yano, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i24.5459 · Cited by 18 · see citing works
Recent advances in understanding telomere diseases
Carvalho, V. S., Gomes, W. R., & Calado, R. T. (2022) · Faculty Reviews · doi:10.12703/r/11-31 · Cited by 17 · see citing works
Relationships Between Regeneration, Wound Healing, and Cancer
Maggiore, G., & Zhu, H. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-062822-123558 · Cited by 17 · see citing works
Genomic risk of hepatitis C-related hepatocellular carcinoma
Hoshida, Y., Fuchs, B. C., & Tanabe, K. K. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.08.015 · Cited by 16 · see citing works
Ferrara-Romeo, I., Martínez, P., & Blasco, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204909 · Cited by 15 · see citing works
Zheng, X., Wezel, F., Azoitei, A., Meessen, S., Wang, W., Najjar, G., Wang, X., Kraus, J. M., Kestler, H. A., John, A., et al. (2021) · Cancers · doi:10.3390/cancers13153774 · Cited by 14 · see citing works
Telomerase Variants in Patients with Cirrhosis Awaiting Liver Transplantation
Chiu, V. Y., Hogen, R., Sher, L. S., Wadé, N. B., Conti, D. V., Martynova, A., Li, H., Liang, G., & O'Connell, C. L. (2019) · Hepatology · doi:10.1002/hep.30557 · Cited by 15 · see citing works
Role of genetic testing in hepatic, pancreatic, and biliary cancers
Hewitt, D. B., Aziz, H., Brown, Z. J., & Pawlik, T. M. (2022) · Surgical Oncology · doi:10.1016/j.suronc.2022.101844 · Cited by 14 · see citing works
Telomere dysfunction in chronic liver disease: The link from aging
Penrice, D. D., Jalan‐Sakrikar, N., Jurk, D., Passos, J. F., & Simonetto, D. A. (2023) · Hepatology · doi:10.1097/hep.0000000000000426 · Cited by 14 · see citing works
Castillo, R. D. B., Bleesing, J., McCormick, T., Squires, J. E., Mazariegos, G. V., Squires, J. H., & McKiernan, P. J. (2020) · Pediatric Transplantation · doi:10.1111/petr.13695 · Cited by 14 · see citing works
Babushok, D. V., Grignon, A., Li, Y., Atienza, J., Xie, H. M., Lam, H., Hartung, H. D., Bessler, M., & Olson, T. S. (2015) · American Journal of Hematology · doi:10.1002/ajh.24256 · Cited by 14 · see citing works
Jalan‐Sakrikar, N., Anwar, A. A., Yaqoob, U., Gan, C., Lagnado, A. B., Wixom, A. Q., Jurk, D., & Huebert, R. C. (2023) · JCI Insight · doi:10.1172/jci.insight.170320 · Cited by 13 · see citing works
Non-Alcoholic Steatohepatitis, Liver Cirrhosis and Hepatocellular Carcinoma: The Molecular Pathways
Mezale, D., Štrumfa, I., Vanags, A., Mežals, M., Fridrihsone, I., Štrumfs, B., & Balodis, D. (2017) · InTech eBooks · doi:10.5772/intechopen.68771 · Cited by 13 · see citing works
Can telomere shortening be the main indicator of non-viable fetus elimination?
Huleyuk, N. L., Tkach, I. R., Zastavna, D. V., & Tyrka, M. (2018) · Molecular Cytogenetics · doi:10.1186/s13039-018-0361-9 · Cited by 13 · see citing works
The Genomic Landscape and Its Clinical Implications in Hepatocellular Carcinoma
Sun, Y.-Y., & Lee, J.-S. (2019) · Journal of Liver Cancer · doi:10.17998/jlc.19.2.97 · Cited by 9 · see citing works
Borie, R., Kannengiesser, C., Dupin, C., Debray, M., Cazes, A., & Crestani, B. (2020) · La Presse Médicale · doi:10.1016/j.lpm.2020.104024 · Cited by 12 · see citing works
Short Telomeres: Cause and Consequence in Liver Disease
Penrice, D. D., & Simonetto, D. A. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1713007 · Cited by 11 · see citing works
Choi, Y., Kim, M. S., Rhoades, J. H., Johnson, N. M., Berry, C. T., Root, S., Chen, Q., Tian, Y., Fernandez, R. J., Cramer, Z., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.06.003 · Cited by 11 · see citing works
Cheng, G., Yuan, X., Wang, F., Sun, Q., Xin, Q., Li, K., Sun, C., Lin, Z., Luan, Y., Xu, Y., et al. (2017) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2017.9 · Cited by 10 · see citing works
Liver Transplant for Management of Hepatic Complications of Dyskeratosis Congenita: A Case Report
Alebrahim, M., Akateh, C., Arnold, C. A., Benissan‐Messan, D., Chavez, J. A., Singh, N., Al-Adwan, Y., El‐Hinnawi, A., Michaels, A. J., & Black, S. M. (2020) · Experimental and Clinical Transplantation · doi:10.6002/ect.2020.0073 · Cited by 10 · see citing works
Tometten, M., Kirschner, M., Isfort, S., Berres, M., Brümmendorf, T. H., & Beier, F. (2021) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-021-02024-8 · Cited by 11 · see citing works
Nelson, N. E., Feurstein, S. K., Niaz, A., Truong, J. Q., Holien, J. K., Lucas, S. E. M., Fairfax, K. A., Dickinson, J. L., & Bryan, T. M. (2022) · Genetics in Medicine · doi:10.1016/j.gim.2022.11.021 · Cited by 8 · see citing works
- Authors
- Hartmann, D., Srivastava, U., Thaler, M., Kleinhans, K. N., N'Kontchou, G., Scheffold, A., Bauer, K., Kratzer, R. F., Kloos, N., Katz, S.-F., Song, Z., Begus-Nahrmann, Y., Kleger, A., von Figura, G., Strnad, P., Lechel, A., Günes, C., Potthoff, A., Deterding, K., Wedemeyer, H., Ju, Z., Song, G., Xiao, F., Gillen, S., Schrezenmeier, H., Mertens, T., Ziol, M., Friess, H., Jarek, M., Manns, M. P., Beaugrand, M., & Rudolph, L. K.
- Affiliations
- Universität Ulm (DE)
- Medizinische Hochschule Hannover (DE)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Technical University of Munich (DE)
- University Hospital Ulm (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Helmholtz Centre for Infection Research (DE)
- ORCID
- Venue
- Hepatology
- Published
- 2011-05
- Volume
- 53
- Issue
- 5
- Pages
- 1608-1617
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1995293424
- Cited by
- 173
- References
- 36
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 13 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 10 · 2018: 14 · 2017: 13 · 2016: 11 · 2015: 10 · 2014: 15 · 2013: 13 · 2012: 14
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- European Commission (202230)
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- telomerase mutations, liver cirrhosis, chronic liver disease, telomere shortening, telomerase reverse transcriptase (TERT), telomere length, liver regeneration, replicative potential, genetic susceptibility
- MeSH terms
- Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Humans, Liver Cirrhosis, Liver Diseases, Male, Middle Aged, Mutation, Telomerase
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