The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Serum Ferritin Is An Independent Predictor of Histologic Severity and Advanced Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
Open accessAbstract
Serum ferritin (SF) levels are commonly elevated in patients with nonalcoholic fatty liver disease (NAFLD) because of systemic inflammation, increased iron stores, or both. The aim of this study was to examine the relationship between elevated SF and NAFLD severity. Demographic, clinical, histologic, laboratory, and anthropometric data were analyzed in 628 adult patients with NAFLD (age, ≥18 years) with biopsy–proven NAFLD and an SF measurement within 6 months of their liver biopsy. A threshold SF >1.5 × upper limit of normal (ULN) (i.e., >300 ng/mL in women and >450 ng/mL in men) was significantly associated with male sex, elevated serum alanine aminotransferase, aspartate aminotransferase, iron, transferrin–iron saturation, iron stain grade, and decreased platelets ( P < 0.01). Histologic features of NAFLD were more severe among patients with SF >1.5 × ULN, including steatosis, fibrosis, hepatocellular ballooning, and diagnosis of NASH ( P < 0.026). On multiple regression analysis, SF >1.5 × ULN was independently associated with advanced hepatic fibrosis (odds ratio [OR], 1.66; 95% confidence interval [CI], 1.05–2.62; P = 0.028) and increased NAFLD Activity Score (NAS) (OR, 1.99; 95% CI, 1.06–3.75; P = 0.033). Conclusions: A SF >1.5 × ULN is associated with hepatic iron deposition, a diagnosis of NASH, and worsened histologic activity and is an independent predictor of advanced hepatic fibrosis among patients with NAFLD. Furthermore, elevated SF is independently associated with higher NAS, even among patients without hepatic iron deposition. We conclude that SF is useful to identify NAFLD patients at risk for NASH and advanced fibrosis. (Hepatology 2012)
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
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Self-citationHepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
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Regulation of ferritin genes and protein
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Hemochromatosis and Iron-Overload Screening in a Racially Diverse Population
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Cited by
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239
Self-citationNew trends on obesity and NAFLD in Asia
Fan, J.-G., Kim, S.-U., & Wong, V. W.-S. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.06.003 · Cited by 1,083
Kell, D. B., & Pretorius, E. (2014) · Metallomics · doi:10.1039/c3mt00347g · Cited by 667
Recent insights into the pathogenesis of nonalcoholic fatty liver disease
Arab, J. P., Arrese, M., & Trauner, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043617 · Cited by 573
Xu, X., Poulsen, K. L., Wu, L., Liu, S., Miyata, T., Song, Q., Wei, Q., Zhao, C., Lin, C., & Yang, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01119-3 · Cited by 359
Metadata
- Authors
- Kowdley, K. V., Belt, P., Wilson, L. A., Yeh, M. M., Neuschwander–Tetri, B. A., Chalasani, N., Sanyal, A. J., & Nelson, J. E.
- Venue
- Hepatology
- Published
- 2012-01
- Volume
- 55
- Issue
- 1
- Pages
- 77-85
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2095075233
- Cited by
- 543
- References
- 64
- FWCI
- 22.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Kowdley, K. V., Belt, P., Wilson, L. A., Yeh, M. M., Neuschwander–Tetri, B. A., Chalasani, N., Sanyal, A. J., & Nelson, J. E. (2012). Serum Ferritin Is An Independent Predictor of Histologic Severity and Advanced Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Hepatology. https://doi.org/10.1002/hep.24706
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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