Recent insights into the pathogenesis of nonalcoholic fatty liver disease

An obesity-associated gut microbiome with increased capacity for energy harvest

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Pathogen Recognition and Innate Immunity

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Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

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Pattern Recognition Receptors and Inflammation

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

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EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Autophagy regulates lipid metabolism

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The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

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Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

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Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

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Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

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The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

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Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides

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Sterile inflammation: sensing and reacting to damage

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Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

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Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

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Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

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Pathogen Recognition by the Innate Immune System

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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial

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Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

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Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

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Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

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Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities

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TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

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Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

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Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

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The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis

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Hepatic stellate cells as key target in liver fibrosis

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The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

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Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

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The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

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The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

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Liver inflammation and fibrosis

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Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

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Endoplasmic reticulum stress in liver disease

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NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

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Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States

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Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

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Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites†

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Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease

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Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management

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Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

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Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

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Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis

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Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus: A Randomized Trial

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The role of the gut microbiota in NAFLD

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Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis

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The Liver as a Lymphoid Organ

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Liver lipid metabolism

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Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

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NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

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Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

Sookoian, S. C., & Pirola, C. J. (2011) · Hepatology · doi:10.1002/hep.24283 · Cited by 917 · see citing works

Pathobiology of liver fibrosis: a translational success story

Lee, Y. A., Wallace, M. C., & Friedman, S. L. (2015) · Gut · doi:10.1136/gutjnl-2014-306842 · Cited by 894 · see citing works

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

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Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis

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Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

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Hepatic Stellate Cells and Liver Fibrosis

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Toll‐like receptors and adaptor molecules in liver disease: Update†

Seki, E., & Brenner, D. A. (2008) · Hepatology · doi:10.1002/hep.22306 · Cited by 722 · see citing works

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

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Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients

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Hepatic fibrosis: concept to treatment

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In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease

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Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

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Hepatocellular carcinoma in the absence of cirrhosis in United States Veterans is associated with nonalcoholic fatty liver disease

Mittal, S., El-Serag, H. B., Sada, Y. H., Kanwal, F., Duan, Z., Temple, S., May, S. B., Kramer, J. R., Richardson, P. A., & Davila, J. A. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.07.019 · Cited by 648 · see citing works

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

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TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

Liu, Y.-L., Reeves, H. L., Burt, A. D., Tiniakos, D., McPherson, S., Leathart, J. B. S., Allison, M. E. D., Alexander, G. J., Piguet, A.-C., Anty, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5309 · Cited by 623 · see citing works

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

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Pharmacological Inhibition of the Chemokine CCL2 (MCP-1) Diminishes Liver Macrophage Infiltration and Steatohepatitis in Chronic Hepatic Injury

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Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2

Haukeland, J. W., Damås, J. K., Konopski, Z., Løberg, E. M., Haaland, T., Goverud, I. L., Torjesen, P. A., Birkeland, K. I., Bjøro, K., & Aukrust, P. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.02.011 · Cited by 605 · see citing works

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

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Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study

Piscaglia, F., Svegliati‐Baroni, G., Barchetti, A., Pecorelli, A., Marinelli, S., Tiribelli, C., Bellentani, S., & on behalf of the HCC‐NAFLD Italian Study Group (2016) · Hepatology · doi:10.1002/hep.28368 · Cited by 604 · see citing works

Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team

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Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

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Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency

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Nonalcoholic fatty liver disease

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