Cytokine‐Producing B Cells Promote Immune‐Mediated Bile Duct Injury in Murine Biliary Atresia
Open accessAbstract
Biliary atresia (BA) is a neonatal T cell–mediated, inflammatory, sclerosing cholangiopathy. In the rhesus rotavirus (RRV)–induced neonatal mouse model of BA (murine BA), mice lacking B cells do not develop BA, and the lack of B cells is associated with loss of T‐cell and macrophage activation. The aim of this study was to determine the mechanism of B cell–mediated immune activation (antigen presentation versus cytokine production) in murine BA. Normal neonatal B cells in the liver are predominantly at pro‐B and pre‐B cellular development. However, BA mice exhibit a significant increase in the number and activation status of mature liver B cells. Adoptively transferred B cells into RRV‐infected, B cell–deficient mice were able to reinstate T‐cell and macrophage infiltration and biliary injury. Nonetheless, neonatal liver B cells were incompetent at antigen presentation to T cells. Moreover, 3‐83 immunoglobulin transgenic mice, in which B cells only present an irrelevant antigen, developed BA, indicating a B‐cell antigen–independent mechanism. B cells from BA mice produced a variety of innate and adaptive immune cytokines associated with immune activation. In vitro trans‐well studies revealed that BA B cells secreted cytokines that activated T cells based on increased expression of T‐cell activation marker cluster of differentiation 69. Conclusion : Neonatal liver B cells are highly activated in murine BA and contribute to immune activation through production of numerous cytokines involved in innate and adaptive immunity; this work provides increased knowledge on the capacity of neonatal B cells to contribute to an inflammatory disease through cytokine‐mediated mechanisms, and future studies should focus on targeting B cells as a therapeutic intervention in human BA.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a rhesus rotavirus (RRV)-induced neonatal mouse model of biliary atresia, liver infiltration by B cells occurs, and B-cell deficient mice are resistant to bile duct injury.
“In addition, a rhesus rotavirus (RRV)-induced neonatal mouse model of biliary atresia leads to liver infiltration by B cells, and B-cell deficient mice are resistant to bile duct injury [186].”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [186]
B-cell-mediated bile duct injury, as well as macrophage and T-cell activation, are independent of the antigen presented by B cells in the RRV model.
“Interestingly, the authors demonstrated that B-cell-mediated bile duct injury, as well as macrophage and T-cell activation, are independent of the antigen presented by B cells in this model.”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [186]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Wen, J., Zhou, Y., Wang, J., Chen, J., Yan, W., Wu, J. S., Yan, J., Zhou, K., Xiao, Y., Wang, Y., et al. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.31 · Cited by 31 · see citing works
RetractedHardy, R. R., & Hayakawa, K. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.595 · Cited by 1,236 · see citing works
Bonilla, F. A., & Oettgen, H. C. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.017 · Cited by 872 · see citing works
SERREZE, D. V., Chapman, H. D., Varnum, D. S., Hanson, M. S., Reifsnyder, P. C., Richard, S. D., Fleming, S. A., Leiter, E. H., & Shultz, L. D. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.2049 · Cited by 584 · see citing works
Cytokine-producing B lymphocytes-key regulators of immunity
Lund, F. E. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.003 · Cited by 556 · see citing works
B cells responses and cytokine production are regulated by their immune microenvironment
Vazquez, M. I., Catalan-Dibene, J., & Zlotnik, A. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.007 · Cited by 421 · see citing works
Chan, O. T. M., & Shlomchik, M. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.51 · Cited by 306 · see citing works
Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ
Gong, S., & Nussenzweig, M. C. (1996) · Science · doi:10.1126/science.272.5260.411 · Cited by 300 · see citing works
Receptor editing is the main mechanism of B cell tolerance toward membrane antigens
Halverson, R., Torres, R. M., & Pelanda, R. (2004) · Nature Immunology · doi:10.1038/ni1076 · Cited by 284 · see citing works
Self-citationPathogenesis of biliary atresia: defining biology to understand clinical phenotypes
Asai, A., Miethke, A. G., & Bezerra, J. A. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.74 · Cited by 279 · see citing works
Sundaram, S. S., Mack, C. L., Feldman, A. G., & Sokol, R. J. (2016) · Liver Transplantation · doi:10.1002/lt.24640 · Cited by 266 · see citing works
Self-citationFalcone, M., Lee, J., Patstone, G., Yeung, B., & Sarvetnick, N. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.3.1163 · Cited by 254 · see citing works
Noorchashm, H., Lieu, Y. K., Noorchashm, N., Rostami, S. Y., Greeley, S. A. W., Schlachterman, A., Song, H. K., Noto, L. E., Jevnikar, A. M., Barker, C. F., et al. (1999) · PubMed · Cited by 229 · see citing works
Mutations in Igα (CD79a) result in a complete block in B-cell development
Minegishi, Y., Coustan‐Smith, E., Rapalus, L., Ersoy, F., Campana, D., & Conley, M. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7696 · Cited by 220 · see citing works
Noorchashm, H., Lieu, Y. K., Noorchashm, N., Rostami, S. Y., Greeley, S. A. W., Schlachterman, A., Song, H. K., Noto, L. E., Jevnikar, A. M., Barker, C. F., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.743 · Cited by 211 · see citing works
Shivakumar, P., Campbell, K. M., Sabla, G. E., Miethke, A. G., Tiao, G. M., McNeal, M., Ward, R. L., & Bezerra, J. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21153 · Cited by 208 · see citing works
Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD Mouse
Wong, F. S., Li, W., Tang, M., Ramanathan, M., Visintin, I., Daugherty, J., Hannum, L. G., Janeway, C. A., & Shlomchik, M. J. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2581 · Cited by 205 · see citing works
Tumanov, A. V., Kuprash, D. V., Lagarkova, M. A., Grivennikov, S. I., Abe, K., Shakhov, A. N., Drutskaya, L. N., Stewart, C. L., Chervonsky, A. V., & Nedospasov, S. A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00397-7 · Cited by 202 · see citing works
Vasanwala, F. H., Kusam, S., Toney, L. M., & Dent, A. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1922 · Cited by 199 · see citing works
O’Neill, S. K., Shlomchik, M. J., Glant, T. T., Cao, Y., Doodes, P. D., & Finnegan, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3781 · Cited by 186 · see citing works
Biliary atresia and other cholestatic childhood diseases: Advances and future challenges
Verkade, H. J., Bezerra, J. A., Davenport, M., Schreiber, R. A., Mieli‐Vergani, G., Hulscher, J. B. F., Sokol, R. J., Kelly, D. A., Ure, B. M., Whitington, P. F., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.04.032 · Cited by 179 · see citing works
Bao, Y., & Cao, X.-T. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.04.001 · Cited by 161 · see citing works
Cooper, N., & Arnold, D. M. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08076.x · Cited by 157 · see citing works
Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia
Mack, C. L., Tucker, R. M., Lu, B., Sokol, R. J., Fontenot, A. P., Ueno, Y., & Gill, R. G. (2006) · Hepatology · doi:10.1002/hep.21366 · Cited by 128 · see citing works
Self-citationPelanda, R., Braun, U., Hobeika, E., Nussenzweig, M. C., & Reth, M. G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.865 · Cited by 120 · see citing works
Self-citationOligoclonal Expansions of CD4+ and CD8+ T-Cells in the Target Organ of Patients With Biliary Atresia
Mack, C. L., Falta, M. T., Sullivan, A. K., Karrer, F. M., Sokol, R. J., Freed, B. M., & Fontenot, A. P. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.032 · Cited by 119 · see citing works
Self-citationShivakumar, P., Sabla, G. E., Mohanty, S., McNeal, M., Ward, R. L., Stringer, K. F., Caldwell, C. C., Chougnet, C. A., & Bezerra, J. A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.031 · Cited by 112 · see citing works
TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells
Suthers, A. N., & Sarantopoulos, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00775 · Cited by 112 · see citing works
Agenès, F., & Freitas, A. A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.319 · Cited by 102 · see citing works
Mack, C. L., Tucker, R. M., Sokol, R. J., & Kotzin, B. L. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.01.012 · Cited by 102 · see citing works
Self-citationAnolik, J., Looney, R. J., Lund, F., Randall, T., & Sanz, I. (2009) · Immunologic research · doi:10.1007/s12026-009-8096-7 · Cited by 92 · see citing works
Miyazaki, Y., Li, R., Rezk, A., Misirliyan, H., Moore, C. S., Farooqi, N., Solis, M., Galleguillos, L., de Faria, O., Dang, V. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105421 · Cited by 89 · see citing works
α-Enolase Autoantibodies Cross-Reactive to Viral Proteins in a Mouse Model of Biliary Atresia
Lu, B., Brindley, S. M., Tucker, R. M., Lambert, C. L., & Mack, C. L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.042 · Cited by 83 · see citing works
Self-citationUpadhyay, G., Yin, Y., Yuan, H., Li, X., Derynck, R., & Glazer, R. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103441108 · Cited by 75 · see citing works
Microenvironmental studies of pre-B and B cell development in human and mouse fetuses.
Kamps, W. A., & Cooper, M. D. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.2.526 · Cited by 74 · see citing works
Lages, C. S., Simmons, J. R., Maddox, A., Jones, K. R., Karns, R. A., Sheridan, R. M., Shanmukhappa, S. K., Mohanty, S., Kofron, M. J., Russo, P., et al. (2016) · Hepatology · doi:10.1002/hep.28851 · Cited by 63 · see citing works
B cells participate in tolerance and autoimmunity through cytokine production
Luu, V. P., Vazquez, M. I., & Zlotnik, A. (2013) · Autoimmunity · doi:10.3109/08916934.2013.856006 · Cited by 60 · see citing works
Braun, U., Rajewsky, K., & Pelanda, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050578497 · Cited by 55 · see citing works
Self-citationPredictors of cost of liver transplantation in children: A single center study
Bucuvalas, J. C., Ryckman, F. C., Atherton, H. D., Alonso, M. P., Balistreri, W. F., & Kotagal, U. R. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.115068 · Cited by 48 · see citing works
Lownik, J. C., Luker, A. J., Damle, S., Cooley, L. F., Sayed, R. E., Hutloff, A., Pitzalis, C., Martin, R., Shikh, M. E. E., & Conrad, D. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700833 · Cited by 43 · see citing works
Feldman, A. G., Tucker, R. M., Fenner, E. K., Pelanda, R., & Mack, C. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073644 · Cited by 42 · see citing works
Self-citationHadchouel, M., Hugon, R., & Odièvre, M. (1981) · Histopathology · doi:10.1111/j.1365-2559.1981.tb01779.x · Cited by 42 · see citing works
Peripheral B-cell activation and exhaustion markers in patients with ankylosing spondylitis
Niu, X.-Y., Zhang, H.-Y., Liu, Y., Zhao, D., Shan, Y., & Jiang, Y. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.09.003 · Cited by 36 · see citing works
Cheng, S., Wang, H., & Zhou, H. (2016) · Journal of Immunology Research · doi:10.1155/2016/1719720 · Cited by 27 · see citing works
Calvert, J. E., Kim, M. F., Gathings, W. E., & Cooper, M. D. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.4.1693 · Cited by 22 · see citing works
Selective Accumulation of Th2-skewing Immature Erythroid Cells in Developing Neonatal Mouse Spleen
Rincón, M., Oppenheimer, K. H., & Bonney, E. A. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.3764 · Cited by 20 · see citing works
Bove, K., Sheridan, R. M., Fei, L., Anders, R. A., Chung, C., Cummings, O. W., Finegold, M. J., Finn, L. S., Ranganathan, S., Kim, G., et al. (2017) · Pediatric and Developmental Pathology · doi:10.1177/1093526617707851 · Cited by 16 · see citing works
Jones, M. A., DeWolf, S., Vacharathit, V., Yim, M., Spencer, S. R., & Bamezai, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157271 · Cited by 6 · see citing works
Reprint of: Environments of B cell development
Tsuneto, M., Kajikhina, E., Seiler, K., Reimer, A. S., Tornack, J., Bouquet, C., Simmons, S., Knoll, M., Wolf, I., Tokoyoda, K., et al. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.05.005 · Cited by 4 · see citing works
Regulation and Maintenance of an Adoptive T-Cell Dependent Memory B Cell Pool
Anson, M., Amado, I. F., Mailhé, M.-P., Donnadieu, E., Garcia, S., Huetz, F., & Freitas, A. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167003 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Tam, P. K. H., Wells, R. G., Tang, C. S.-M., Lui, V. C. H., Hukkinen, M., Luque, C. D., Coppi, P. D., Mack, C. L., Pakarinen, M. P., & Davenport, M. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00533-x · Cited by 163 · see citing works
Self-citationAntala, S., & Taylor, S. A. (2022) · Clinics in Liver Disease · doi:10.1016/j.cld.2022.03.001 · Cited by 93 · see citing works
Rotavirus-related systemic diseases: clinical manifestation, evidence and pathogenesis
Dian, Z., Sun, Y., Zhang, G., Xu, Y. J., Fan, X., Yang, X., Pan, Q., Peppelenbosch, M. P., & Miao, Z. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1907738 · Cited by 69 · see citing works
Ye, C., Zhu, J., Wang, J., Chen, D., Meng, L., Zhan, Y., Yang, R., He, S., Li, Z., Dai, S., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1070 · Cited by 68 · see citing works
B lymphocytes ameliorate Alzheimer’s disease-like neuropathology via interleukin-35
Feng, W., Zhang, Y., Ding, S., Chen, S., Wang, T., Wang, Z., Zou, Y., Sheng, C., Chen, Y., Pang, Y., et al. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.11.012 · Cited by 62 · see citing works
The Contribution of B Cells in Autoimmune Liver Diseases
Taylor, S. A., Assis, D. N., & Mack, C. L. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1688751 · Cited by 60 · see citing works
Self-citationThe Role of Inflammation in Cholestatic Liver Injury
Chen, J., & Zhang, S. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s430730 · Cited by 58 · see citing works
Recent advances in understanding biliary atresia
Wehrman, A., Waisbourd‐Zinman, O., & Wells, R. G. (2019) · F1000Research · doi:10.12688/f1000research.16732.1 · Cited by 36 · see citing works
Zhang, Y., Zhang, Y., Gao, W., Zhou, R., Liu, F., & Ng, T. B. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.187 · Cited by 27 · see citing works
Immunobiology of the biliary tract system
Björkström, N. K. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.08.018 · Cited by 24 · see citing works
Unique Cholangiocyte‐Targeted IgM Autoantibodies Correlate With Poor Outcome in Biliary Atresia
Luo, Y., Brigham, D., Bednarek, J. M., Torres, R., Wang, D., Ahmad, S., & Mack, C. L. (2020) · Hepatology · doi:10.1002/hep.31504 · Cited by 19 · see citing works
Self-citationSystemic cytokine profiles in biliary atresia
Udomsinprasert, W., Ungsudechachai, T., Vejchapipat, P., Poovorawan, Y., & Honsawek, S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267363 · Cited by 18 · see citing works
Update on Etiology and Pathogenesis of Biliary Atresia
dos Santos, J. L., Quelhas, P., & Cerski, C. T. S. (2022) · Current Pediatric Reviews · doi:10.2174/1573396318666220510130259 · Cited by 18 · see citing works
Luo, Y., Fraser, L. M., Jezykowski, J., Gupta, N. A., Miethke, A. G., Taylor, S. A., Alonso, E. M., Horslen, S. P., Kohli, R., Molleston, J. P., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000001195 · Cited by 17 · see citing works
Self-citationRussi, A. E., Shivakumar, P., Luo, Z., & Bezerra, J. A. (2023) · Hepatology · doi:10.1097/hep.0000000000000418 · Cited by 16 · see citing works
Pang, X., Cao, J., Chen, S., Gao, Z., Liu, G., Chong, Y., Chen, Z., Gong, J., & Li, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720841 · Cited by 13 · see citing works
Chio, C.-C., Chien, J.-C., Chan, H.-W., & Huang, H. (2024) · Biomedicines · doi:10.3390/biomedicines12122773 · Cited by 12 · see citing works
Inflammation Drives MicroRNAs to Limit Hepatocyte Bile Acid Transport in Murine Biliary Atresia
Azeltine, M., Chavez, E. J., Nemec, K. M., Bednarek, J. M., Asokan, R., Balasubramaniyan, N., Zgheib, C., Mack, C. L., & Roach, J. P. (2020) · Journal of Surgical Research · doi:10.1016/j.jss.2020.07.003 · Cited by 12 · see citing works
Self-citationZhang, Y., Zhou, L., Gu, G., Feng, M., Ding, X., Xia, Q., & Lu, L. (2020) · Immunology & Cell Biology · doi:10.1111/imcb.12366 · Cited by 9 · see citing works
Maternal Prenatal Infections and Biliary Atresia in Offspring
Wang, W.-H., Chiu, F.-Y., Kuo, T., & Shao, Y. J. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.50044 · Cited by 9 · see citing works
Oligoclonal immunoglobulin repertoire in biliary remnants of biliary atresia
Taylor, S. A., Malladi, P., Pan, X., Wechsler, J. B., Hulse, K. E., Perlman, H., & Whitington, P. F. (2019) · Scientific Reports · doi:10.1038/s41598-019-41148-7 · Cited by 8 · see citing works
A single-cell view of biliary atresia
Russi, A. E., & Bezerra, J. A. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00417-5 · Cited by 6 · see citing works
Li, Y., Ye, H., & Ding, Y.-X. (2022) · Children · doi:10.3390/children9050697 · Cited by 5 · see citing works
Galectin‐3 in biliary atresia and other pediatric cholestatic liver diseases
Yoeli, D., Mack, C. L., Luo, Y., Chaidez, A., la Rosa, N. L., Wang, Z., Cervantes‐Alvarez, E., Huang, C. A., & Navarro–Álvarez, N. (2023) · Hepatology Research · doi:10.1111/hepr.13987 · Cited by 5 · see citing works
Self-citationSi, X., Chen, J., & Huang, L. (2021) · Genes & Genomics · doi:10.1007/s13258-021-01153-5 · Cited by 5 · see citing works
Luo, Y., Bednarek, J. M., Chaidez, A., Atif, S. M., Wang, D., & Mack, C. L. (2022) · Gastro Hep Advances · doi:10.1016/j.gastha.2021.12.012 · Cited by 5 · see citing works
Self-citationA retrospective study of the ideal operation time for preterm biliary atresia patients
Jiao, C., Yu, K., Li, D., Fu, K., Wang, P., He, Y., & Feng, J. (2019) · Pediatric Surgery International · doi:10.1007/s00383-019-04464-7 · Cited by 5 · see citing works
Gupta, K., Xu, J. P., Diamond, T., de Jong, I. E. M., Glass, A., Llewellyn, J., Theise, N. D., Winkler, J. D., Behrens, E. M., Mesaros, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.02.530913 · Cited by 5 · see citing works
Gupta, K., Xu, J. P., Diamond, T., de Jong, I. E. M., Glass, A., Llewellyn, J., Theise, N. D., Waisbourd‐Zinman, O., Winkler, J. D., Behrens, E. M., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301824 · Cited by 4 · see citing works
The systemic immune-inflammation index at kasai portoenterostomy: related to clinical outcomes
Xin, L., Tenfei, L., Shaowen, L., Zhijie, L., Jianghua, Z., & Abudureyimu, A. (2024) · Pediatric Surgery International · doi:10.1007/s00383-024-05735-8 · Cited by 2 · see citing works
Chen, F., Tan, K., Lv, Z., Chen, F., Xu, W., Gong, X., Lu, L., Sun, H., Fu, Q., & Zhuang, W. (2024) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-024-05637-7 · Cited by 1 · see citing works
Helmin–Basa, A., Kubiszewska, I., Trojanek, J., Wiese‐Szadkowska, M., Janowska, M., Kułaga, Z., Pawłowska, J., & Michałkiewicz, J. (2025) · Mediators of Inflammation · doi:10.1155/mi/9889239 · Cited by 1 · see citing works
Congenital biliary atresia caused by GPC1 gene mutation in Chinese siblings: A case report
Kong, Y., Yuan, K., & Wang, C. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i3.629 · Cited by 1 · see citing works
Huang, Z., Ling, W. W., Lyu, G., Xu, S., Ye, F., Fang, Y., Weng, Z., & Wu, Q. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03972-2
Taurocholic acid induces intrahepatic cholangiocyte cell proliferation via activating NRAS and YAP1
Fube, L., Thason, A., Taliaferro, E., Heckman, C. A., & Amarachintha, S. P. (2026) · PLoS ONE · doi:10.1371/journal.pone.0339210
Diagnostic associations of hypergammaglobulinaemia in a paediatric hospital: a retrospective study
O'Gorman, T., Ford, T. J., & McLean‐Tooke, A. P. (2026) · Pathology · doi:10.1016/j.pathol.2026.05.008
Liu, M., Meng, W., Chen, Y., Wu, S., Qian, M., Chen, D., Zhang, J., Dong, J., Yifan, Y., Jiang, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.08.736942
- Authors
- Bednarek, J., Traxinger, B., Brigham, D., Roach, J., Orlicky, D., Wang, D., Pelanda, R., & Mack, C. L.
- Affiliations
- Department of Pediatrics,Section of Gastroenterology, Hepatology and Nutrition,Aurora,CO
- University of Colorado Anschutz (US)
- Corresponding author
- Mack, Cara L.
- ORCID
- Venue
- Hepatology
- Published
- 2018-07-10
- Volume
- 68
- Issue
- 5
- Pages
- 1890-1904
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- PMC
- PMC6195851
- OpenAlex
- W2801009360
- Cited by
- 38
- References
- 50
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 4 · 2020: 4 · 2019: 4
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI052310)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK094937, T32DK067009)
- Topics
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- biliary atresia, B cells, cytokine production, rhesus rotavirus, neonatal liver, antigen presentation, T cell activation, macrophage activation, CD69, B cell-deficient mice, cholangiopathy
- MeSH terms
- Adolescent, Animals, Animals, Newborn, B-Lymphocytes, Bile Ducts, Biliary Atresia, Child, Child, Preschool, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunohistochemistry, Liver, Mice, Inbred BALB C, Spleen, Cytokines, Sequence Analysis, RNA, Cell Culture Techniques, Mice, Adaptive Immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
