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HLA‐B*35:01 Allele Is a Potential Biomarker for Predicting Polygonum multiflorum–Induced Liver Injury in Humans

Li, Chaopeng, Rao, Tai, Chen, Xiaoping, Zou, Zhengsheng, Wei, Aiwu, Tang, Jinfa, Xiong, Peng, Li, Pengyan, Jing, Jing, He, Tingting, Bai, Zhaofang, Yin, Jiye, Tan, Zhirong, Yu, Peng, Zhou, Honghao, Wang, Jiabo, Xiao, Xiaohe, Ouyang, Dongsheng·2019·Hepatology
DOI 10.1002/hep.30660
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Abstract

Polygonum multiflorum (PM) is a well‐known Chinese herbal medicine that has been reported to induce inflammation‐associated idiosyncratic liver injury. This study aimed to identify the genetic basis of susceptibility to PM‐drug‐induced liver injury (PM‐DILI) and to develop biological markers for predicting the risk of PM‐DILI in humans. The major histocompatibility complex (MHC) regions of 11 patients with PM‐DILI were sequenced, and all human leukocyte antigen (HLA)–type frequencies were compared to the Han‐MHC database. An independent replication study that included 15 patients with PM‐DILI, 33 patients with other DILI, and 99 population controls was performed to validate the candidate allele by HLA‐B PCR sequence‐based typing. A prospective cohort study that included 72 outpatients receiving PM for 4 weeks was designed to determine the influence of the risk allele on PM‐DILI. In the pilot study, the frequency of HLA‐B*35:01 was 45.4% in PM‐DILI patients compared with 2.7% in the Han Chinese population (odds ratio [OR], 30.4; 95% confidence interval [CI], 11.7‐77.8; P = 1.9 × 10 −10 ). In the independent replication study and combined analyses, a logistic regression model confirmed that HLA‐B*35:01 is a high‐risk allele of PM‐DILI (PM‐DILI versus other DILI, OR, 86.5; 95% CI, 14.2‐527.8, P = 1.0 × 10 −6 ; and PM‐DILI versus population controls, OR, 143.9; 95% CI, 30.1‐687.5, P = 4.8 × 10 −10 ). In the prospective cohort study, an asymptomatic increase in transaminase levels was diagnosed in 6 patients, representing a significantly higher incidence (relative risk, 8.0; 95% CI, 1.9‐33.2; P < 0.02) in the HLA‐B*35:01 carriers (37.5%) than in the noncarriers (4.7%). Conclusion : The HLA‐B*35:01 allele is a genetic risk factor for PM‐DILI and a potential biomarker for predicting PM‐DILI in humans.

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  • Several potential biomarkers associated with the risk of liver injury caused by specific drugs or herbal medicines have been reported, such as HLA-B*35:01, immune factors, and metabolic markers that may be associated with the risk of Polygonum multiflorum-induced liver injury.

    “several potential biomarkers associated with the risk of liver injury caused by specific drugs or HMs have been reported, such as HLA-B*35:01, immune factors, and metabolic markers that may be associated with the risk of Polygonum multiflorum-induced liver injury [178][179][180].”

    From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [178]

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Research works printed but not linked: 50

  1. 2004, New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum, Ann Intern Med, 140, W30, 10.7326/0003-4819-140-7-200404060-00042-w3 · DOI
  2. 2015, Liver damage associated with Polygonum multiflorum Thunb.: a systematic review of case reports and case series, Evid Based Complement Alternat Med, 2015, 459749
  3. 2018, Clinical characteristics and outcomes of traditional Chinese medicine‐induced liver injury: a systematic review, Expert Rev Gastroenterol Hepatol, 12, 425, 10.1080/17474124.2018.1427581 · DOI · Paper page
  4. 2016, Integrated evidence chain–based identification of Chinese herbal medicine–induced hepatotoxicity and rational usage: exemplification by Polygonum Multiflorum (He shou wu), Chinese Sci Bull, 61, 971, 10.1360/N972015-01289 · DOI
  5. 2006, Acute hepatitis due to Shen‐Min: a herbal product derived from Polygonum multiflorum, J Clin Gastroenterol, 40, 629, 10.1097/00004836-200608000-00014 · DOI
  6. 2017, Idiosyncratic drug‐induced liver injury linked to Polygonum multiflorum: a case study by pharmacognosy, Chin J Integr Med, 23, 625, 10.1007/s11655-017-2543-9 · DOI
  7. 2016, Metabolomic study on idiosyncratic liver injury induced by different extracts of Polygonum multiflorum in rats integrated with pattern recognition and enriched pathways analysis, Front Pharmacol, 7, 483
  8. 2011, Drug‐induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum Thunb, Gut Liver, 5, 493, 10.5009/gnl.2011.5.4.493 · DOI · Paper page
  9. 2015, Clinical analysis of drug‐induced liver injury caused by Polygonum multiflorum and its preparations, Chin J Integr Trad West Med, 35, 1442
  10. 2015, Evidence chain–based causality identification in herb‐induced liver injury: exemplification of a well‐known liver‐restorative herb Polygonum multiflorum, Front Med, 9, 457, 10.1007/s11684-015-0417-8 · DOI
  11. 2017, Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum. Front Med, 11, 253
  12. 2018, Pharmacogenomics of drug‐induced liver injury (DILI): molecular biology to clinical applications, J Hepatol, 69, 948, 10.1016/j.jhep.2018.05.013 · DOI
  13. 2009, HLA‐B*5701 genotype is a major determinant of drug‐induced liver injury due to flucloxacillin, Nat Genet, 41, 816, 10.1038/ng.379 · DOI
  14. 2017, Minocycline hepatotoxicity: clinical characterization and identification of HLA‐B*35:02 as a risk factor, J Hepatol, 67, 137, 10.1016/j.jhep.2017.03.010 · DOI · Paper page
  15. 2016, HLA‐DRB1*16:01‐DQB1*05:02 is a novel genetic risk factor for flupirtine‐induced liver injury, Pharmacogenet Genomics, 26, 218, 10.1097/FPC.0000000000000209 · DOI
  16. 2014, Practice Parameters Committee of the American College of Gastroenterology. ACG clinical guideline: the diagnosis and management of idiosyncratic drug‐induced liver injury, Am J Gastroenterol, 109, 950, 10.1038/ajg.2014.131 · DOI · Paper page
  17. 2018, Guidelines for the diagnosis and management of herb‐induced liver injury, Chin J Integr Med, 24, 696, 10.1007/s11655-018-3000-8 · DOI · Paper page
  18. 2016, Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease, Nat Genet, 48, 740, 10.1038/ng.3576 · DOI
  19. 1988, Power calculations for matched case‐control studies, Biometrics, 44, 1157, 10.2307/2531743 · DOI
  20. 2010, Causality assessment in drug‐induced liver injury using a structured expert opinion process: comparison to the Roussel‐Uclaf Causality Assessment Method, Hepatology, 51, 2117, 10.1002/hep.23577 · DOI · Paper page
  21. 2006, HLA‐A, ‐B, and‐DRB1 polymorphism defined by sequence‐based typing of the Han population in northern China, Tissue Antigens, 67, 146, 10.1111/j.1399-0039.2006.00529.x · DOI
  22. 2010, Comprehensive, serologically equivalent DNA typing for HLA‐B by PCR using sequence‐specific primers (PCR‐SSP), Tissue Antigens, 45, 81
  23. 2015, High‐resolution analyses of human leukocyte antigens allele and haplotype frequencies based on 169,995 volunteers from the China Bone Marrow Donor Registry Program, PLoS One, 10, e0139485, 10.1371/journal.pone.0139485 · DOI
  24. 2011, Susceptibility to amoxicillin‐clavulanate‐induced liver injury is influenced by multiple HLA class I and II alleles, Gastroenterology, 141, 338, 10.1053/j.gastro.2011.04.001 · DOI
  25. 1996, Hepatitis related to the Chinese medicine Shou‐wu‐pian manufactured from Polygonum multiflorum, Vet Hum Toxicol, 38, 280
  26. 2014, CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum, Genet Mol Res, 13, 5637, 10.4238/2014.July.25.19 · DOI
  27. 2016, Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis, J Ethnopharmacol, 194, 299, 10.1016/j.jep.2016.09.011 · DOI
  28. 2012, Toxicity of raw and processed roots of Polygonum multiflorum, Fitoterapia, 83, 469, 10.1016/j.fitote.2011.12.012 · DOI · Paper page
  29. 2017, Investigation of liver injury of Polygonum multiflorum Thunb. in rats by metabolomics and traditional approaches, Front Pharmacol, 8, 791, 10.3389/fphar.2017.00791 · DOI
  30. 2017, Hepatotoxicity in rats induced by aqueous extract of Polygoni Multiflori Radix, root of Polygonum multiflorum related to the activity inhibition of CYP1A2 or CYP2E1, Evid Based Complement Alternat Med, 2017, 9456785, 10.1155/2017/9456785 · DOI
  31. 2015, Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats, J Ethnopharmacol, 162, 61, 10.1016/j.jep.2014.12.045 · DOI
  32. 2015, A new animal model for Polygonum multiflorum Thunb–induced liver injury in rats and its potential mechanisms, Toxicol Res, 4, 1085, 10.1039/C5TX00054H · DOI
  33. 2016, HLA and delayed drug‐induced hypersensitivity, Int Arch Allergy Immunol, 170, 163, 10.1159/000448217 · DOI
  34. 2016, Classification of drug hypersensitivity into allergic, p‐i, and pseudo‐allergic forms, Int Arch Allergy Immunol, 171, 166, 10.1159/000453265 · DOI
  35. 2017, Pharmacogenomics of off‐target adverse drug reactions, Br J Clin Pharmacol, 83, 1896, 10.1111/bcp.13294 · DOI
  36. 2010, HLA‐B*5701 testing to predict abacavir hypersensitivity, PLoS Curr, 2, RRN1203
  37. 2009, HLA‐B*5701 genotype is a major determinant of drug‐induced liver injury due to flucloxacillin, Nat Genet, 41, 816, 10.1038/ng.379 · DOI
  38. 2008, HLA‐B*5701 screening for hypersensitivity to abacavir, N Engl J Med, 358, 568, 10.1056/NEJMoa0706135 · DOI
  39. 2008, High sensitivity of human leukocyte antigen‐B*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients, Clin Infect Dis, 46, 1111, 10.1086/529382 · DOI
  40. 2010, A genome‐wide study identifies HLA alleles associated with lumiracoxib‐related liver injury, Nat Genet, 42, 711, 10.1038/ng.632 · DOI
  41. 2004, HLA class II genotype influences the type of liver injury in drug‐induced idiosyncratic liver disease, Hepatology, 39, 1603, 10.1002/hep.20215 · DOI
  42. 2011, HLA‐A*3101 and carbamazepine‐induced hypersensitivity reactions in Europeans, N Engl J Med, 364, 1134, 10.1056/NEJMoa1013297 · DOI
  43. 2014, Genotype–phenotype association between HLA and carbamazepine‐induced hypersensitivity reactions: strength and clinical correlations, J Dermatol Sci, 73, 101, 10.1016/j.jdermsci.2013.10.003 · DOI
  44. 2014, Genetic basis of drug‐induced liver injury: present and future, Semin Liver Dis, 34, 123, 10.1055/s-0034-1375954 · DOI
  45. 2015, Human leukocyte antigen genetic risk factors of drug‐induced liver toxicology, Expert Opin Drug Metab Toxicol, 11, 395, 10.1517/17425255.2015.992414 · DOI
  46. 2016, Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis, J Ethnopharmacol, 194, 299, 10.1016/j.jep.2016.09.011 · DOI
  47. 2017, Metabolomic study on immunological stress‐mediated the hepatotoxicity of Polygonum multiflorum and its processed products of nine times steaming and nine times sunning, Acta Pharm Sin, 57
  48. 2008, Human leukocyte antigen class I–restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity, Immunity, 28, 822, 10.1016/j.immuni.2008.04.020 · DOI
  49. 2015, HLA‐allelotype associations with nevirapine‐induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta‐analysis, Pharmacogenet Genomics, 25, 186, 10.1097/FPC.0000000000000124 · DOI
  50. 2014, HLA class I restricted CD8+ and class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity, AIDS, 28, 1891, 10.1097/QAD.0000000000000345 · DOI

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Metadata

Authors
Li, C., Rao, T., Chen, X., Zou, Z., Wei, A., Tang, J., Xiong, P., Li, P., Jing, J., He, T., Bai, Z., Yin, J., Tan, Z., Yu, P., Zhou, H., Wang, J., Xiao, X., & Ouyang, D.
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-05-21
Volume
70
Issue
1
Pages
346-357
ISSN
  • 0270-9139
  • 1527-3350
DOI
10.1002/hep.30660
Cited by
138
References
0
Language
en
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)

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