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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Clinical characteristics and outcomes of traditional Chinese medicine-induced liver injury: a systematic review

Wang, Ran, Qi, Xingshun, Yoshida, Eric M., Méndez-Sánchez, Nahum, Teschke, Rolf, Sun, Mingyu, Liu, Xu, Su, Chunping, Deng, Jiao, Deng, Han, Hou, Feifei, Guo, Xiaozhong·2018·Expert Review of Gastroenterology & Hepatology
DOI 10.1080/17474124.2018.1427581
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Abstract

Backgrounds Traditional Chinese medicine (TCM) is becoming increasingly popular and related adverse events are often ignored or underestimated. Aims This systematic review aimed to evaluate the clinical characteristics and outcomes of TCM-induced liver injury (TCM-ILI) and to estimate the proportion of TCM-ILI in all drug-induced liver injuries (DILI). Methods China National Knowledge Infrastructure, Wanfang, VIP, PubMed, and Embase databases were searched. Demographic, clinical, and survival data were extracted and pooled. Factors associated with worse outcomes were calculated. For the proportion meta-analyses, the data were pooled by using a random-effects model. Results Overall, 21,027 articles were retrieved, of which 625 were finally included. There was a predominance of female and older patients. The proportion of liver transplantation was 2.18% (7/321). The mortality was 4.67% (15/321). Male, higher aspartate aminotransferase and direct bilirubin, and lower albumin were significantly associated with an increased risk of death/liver transplantation in TCM-ILI patients. The proportion of TCM-ILI in all DILI was 25.71%. The proportion was gradually increased with year. Conclusions Our work summarises current knowledge regarding clinical presentation, disease course, and prognosis of TCM-ILI. TCM can result in hepatotoxicity, even death or necessitate life-saving liver transplantation. Governmental regulation of TCM products should be strictly established.

Overview

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Crossref · 10.1080/17474124.2018.1427581

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Research works printed but not linked: 30

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Metadata

Authors
Wang, R., Qi, X., Yoshida, E. M., Méndez-Sánchez, N., Teschke, R., Sun, M., Liu, X., Su, C., Deng, J., Deng, H., Hou, F., & Guo, X.
Affiliations
  • Department of Gastroenterology, General Hospital of Shenyang Military Area , Shenyang, China
  • Division of Gastroenterology, Vancouver General Hospital , Vancouver, Canada
  • Liver Research Unit Medica Sur Clinic & Foundation Mexico City , Mexico City, Mexico
  • Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/Main , Hanau, Germany
  • Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine , Shanghai, China
  • Library of Fourth Military Medical University , Xi’an, China
  • Department of Pharmacy, General Hospital of Shenyang Military Area , Shenyang, China
ORCID
Qi, Xingshun
Venue
Expert Review of Gastroenterology & Hepatology
Publisher
Informa UK Limited
Published
2018-01-18
Volume
12
Issue
4
Pages
425-434
ISSN
  • 1747-4124
  • 1747-4132
DOI
10.1080/17474124.2018.1427581
Cited by
50
References
3
Language
en

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