Diabetes medications and risk of HCC
Open accessAbstract
Type 2 diabetes mellitus is a recognized risk factor for HCC in patients with liver disease, independent from the etiology of their liver disease. Hence, prevention and treatment of type 2 diabetes mellitus and its underlying cause, insulin resistance, should be considered a treatment target for patients with liver disease. The drug armamentarium for diabetes is wide and consists of agents with insulin‐sensitizing activity, agents that stimulate insulin secretion, insulin itself, and agents that reduce gastrointestinal and urinary glucose absorption. From an endocrinology perspective, the main goal of treatment is the achievement of euglycemia; however, in patients at risk of, or with known underlying liver disease, the choice of diabetic medication as it relates to potential hepatic carcinogenesis remains complex and should be carefully considered. In the last decade, increasing evidence has suggested that metformin may reduce the risk of HCC, whereas evidence for other classes of diabetic medications, particularly some of the newer agents including the sodium glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists, is fewer and often inconsistent. In this review, we aim to summarize the current evidence on the potential effects of the most widely used diabetic agents on liver cancer tumorigenesis.
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Antihyperglycemic medications such as metformin, SGLT2I and GLP1RA may have additional HCC protective actions.
“Further, antihyperglycemic medications such as metformin, SGLT2I and GLP1RA may have additional HCC protective actions [100].”
From Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease? (2024) · cites this paper as [100]
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- Authors
- Plaz Torres, M. C., Jaffe, A., Perry, R., Marabotto, E., Strazzabosco, M., & Giannini, E. G.
- Affiliations
- Gastroenterology Unit, Department of Internal Medicine,IRCCS—Ospedale Policlinico San Martino, University of Genoa,Genoa,Italy
- Yale University (US)
- Ospedale Policlinico San Martino (IT)
- Corresponding author
- Strazzabosco, Mario
- Giannini, Edoardo G.
- Venue
- Hepatology
- Published
- 2022-03-22
- Volume
- 76
- Issue
- 6
- Pages
- 1880-1897
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- PMC
- PMC9790535
- OpenAlex
- W4214908687
- Cited by
- 86
- References
- 135
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 21 · 2023: 25 · 2022: 8
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (DK034989, UL1TR001863)
- National Cancer Institute (R37CA258261)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034989)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, hepatocellular carcinoma, antidiabetic drugs, metformin, SGLT2 inhibitors, GLP-1 receptor agonists, insulin sensitizers, insulin secretagogues, hepatocarcinogenesis, liver disease, insulin resistance, drug safety in liver disease
- MeSH terms
- Diabetes Mellitus, Type 2, Carcinoma, Hepatocellular, Humans, Hypoglycemic Agents, Insulin, Liver Neoplasms
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