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Excess Weight Risk Factor for Alcoholic Liver Disease
Abstract
Though the hepatotoxicity of ethanol has been established, only 8% to 20% of chronic alcoholics develop cirrhosis. The aim of this study was to assess whether being overweight is a risk factor for alcoholic liver disease. One thousand six hundred four alcoholic patients were studied. According to the liver biopsies, 194 patients had a normal liver; 402 had steatosis without fibrosis; 281 presented with fibrosis, with or without steatosis; 119 presented with acute alcoholic hepatitis (AAH) without cirrhosis; 232 indicated cirrhosis without AAH; and 179 presented with cirrhosis with AAH. One hundred ninety-seven patients had clinically obvious cirrhosis. In the study, five variables were studied as risk factors: age, sex, daily consumption of alcohol during the previous 5 years, the total duration of alcohol abuse, and tendency to be overweight (body mass index [BMI] > or = 25 in women and > or = 27 in men). The BMI was calculated according to the minimum weight over the 10 previous years. In the first stepwise logistic regression analysis, age, being overweight for at least 10 years, being of the female sex, and the total duration of alcohol abuse were independently correlated with the presence of cirrhosis. In the second analysis, female sex being overweight were the two independent risk factors of AAH. In the third analysis, being overweight for at least 10 years was the only independent risk factor of steatosis. These results show that the presence of excess weight for at least 10 years is a risk factor for cirrhosis, AAH, and steatosis. Our results suggest that there is a possible potential for the metabolic effects of ethanol ingestion caused by excess weight in patients with alcoholic liver disease.
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“This corroborates older fi ndings of BMI as an independent risk factor for fi brosis in individuals with ALD.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [85]
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Pathophysiological Similarities and Synergisms in Alcoholic and Non-Alcoholic Steatohepatitis
Hellerbrand, C. (2010) · Digestive Diseases · doi:10.1159/000324286 · Cited by 14
“A combined effect on the progression and development of liver injury seems even more reasonable in case of alcohol and the metabolic syndrome since ALD and NAFLD reveal astonishing (histo)pathological similarities. Excessive and chronic intake of either calories or alcohol leads to hepatic steatosis. Both ALD and NAFL…”
BackgroundLee, J. Y., Cho, Y., Hong, M. H., Kim, J., Lee, D. H., Jung, Y. J., Kim, B. G., Lee, K. L., & Kim, W. K. (2018) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14513 · Cited by 14
Current Management and Future Treatment of Alcoholic Hepatitis.
Mitchell, M. C., Kerr, T. A., & Herlong, H. F. (2020) · PubMed Central · Cited by 14
The wide spectrum of steatohepatitis
Lonardo, A., Bagni, A., Tarugi, P., & Loria, P. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200410000-00015 · Cited by 13
Practical Approach to the Diagnosis and Management of People With Fatty Liver Diseases
George, J., & Farrell, G. C. (2004) · doi:10.1002/9780470987438.ch15 · Cited by 14
Flavonoids-based nanomedicines for the treatment of liver fibrosis: A recent progress
Harini, K. S., & Ezhilarasan, D. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105467 · Cited by 14
Focus on alcoholic liver disease: From nosography to treatment
Streba, L. A. M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i25.8040 · Cited by 14
Khoudari, G., Singh, A., Noureddin, M., Fritze, D. M., López, R., Asaad, I., Lawitz, E., Poordad, F. F., Kowdley, K. V., & Alkhouri, N. (2019) · World Journal of Hepatology · doi:10.4254/wjh.v11.i10.710 · Cited by 13
New Approaches for Studying Alcoholic Liver Disease
Xu, J., Liu, X., Gao, B., Karin, M., Tsukamoto, H., Brenner, D. A., & Kisseleva, T. (2014) · Current Pathobiology Reports · doi:10.1007/s40139-014-0053-z · Cited by 13
The use of beebread-honey mixture in the treatment of liver diseases in alcohol-dependent patients
Čeksterytė, V., Balžekas, J., Baltuškevičius, A., et al. (2012) · Chemical Technology · doi:10.5755/j01.ct.60.2.1930 · Cited by 13
“Therefore, it is important that people with alcoholic liver disease (ALD) maintain normal weight levels [5].”
BackgroundPrognosis and treatment of patients with acute alcoholic hepatitis
Papastergiou, V., Burroughs, A. K., & Tsochatzis, E. A. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.903800 · Cited by 13
“In a retrospective analysis of 110 patients transplanted for ALD, the outcome was similar regardless of the presence of histological features of AH (n = 8) in the explant [116].”
BackgroundInfluentialAlcohol‐Associated Liver Disease: East Versus West
Charatcharoenwitthaya, P., Liangpunsakul, S., & Piratvisuth, T. (2020) · Clinical Liver Disease · doi:10.1002/cld.920 · Cited by 13
The role of osteopontin in d-galactosamine-induced liver injury in genetically obese mice
Kwon, H., Won, Y.-S., Yoon, W.-K., Nam, K., Kim, D.-Y., & Kim, H.-C. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.11.006 · Cited by 13
Metadata
- Authors
- Naveau, S., Giraud, V., Borotto, E., Aubert, A., Capron, F., & Chaput, J.
- Affiliations
- Hôpital Antoine-Béclère (FR)
- Venue
- Hepatology
- Published
- 1997-01
- Volume
- 25
- Issue
- 1
- Pages
- 108-111
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1987296974
- Cited by
- 666
- References
- 0
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 27 · 2023: 40 · 2022: 19 · 2021: 21 · 2020: 27 · 2019: 22 · 2018: 41 · 2017: 29 · 2016: 36 · 2015: 45 · 2014: 37 · 2013: 21 · 2012: 27
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- alcoholic liver disease, overweight, body mass index, alcoholic cirrhosis, alcoholic hepatitis, steatosis, risk factors, sex differences, ethanol-induced hepatotoxicity
- MeSH terms
- Adult, Aged, Female, Humans, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Obesity, Risk Factors, Multivariate Analysis
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