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Excess Weight Risk Factor for Alcoholic Liver Disease
Abstract
Though the hepatotoxicity of ethanol has been established, only 8% to 20% of chronic alcoholics develop cirrhosis. The aim of this study was to assess whether being overweight is a risk factor for alcoholic liver disease. One thousand six hundred four alcoholic patients were studied. According to the liver biopsies, 194 patients had a normal liver; 402 had steatosis without fibrosis; 281 presented with fibrosis, with or without steatosis; 119 presented with acute alcoholic hepatitis (AAH) without cirrhosis; 232 indicated cirrhosis without AAH; and 179 presented with cirrhosis with AAH. One hundred ninety-seven patients had clinically obvious cirrhosis. In the study, five variables were studied as risk factors: age, sex, daily consumption of alcohol during the previous 5 years, the total duration of alcohol abuse, and tendency to be overweight (body mass index [BMI] > or = 25 in women and > or = 27 in men). The BMI was calculated according to the minimum weight over the 10 previous years. In the first stepwise logistic regression analysis, age, being overweight for at least 10 years, being of the female sex, and the total duration of alcohol abuse were independently correlated with the presence of cirrhosis. In the second analysis, female sex being overweight were the two independent risk factors of AAH. In the third analysis, being overweight for at least 10 years was the only independent risk factor of steatosis. These results show that the presence of excess weight for at least 10 years is a risk factor for cirrhosis, AAH, and steatosis. Our results suggest that there is a possible potential for the metabolic effects of ethanol ingestion caused by excess weight in patients with alcoholic liver disease.
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“This corroborates older fi ndings of BMI as an independent risk factor for fi brosis in individuals with ALD.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [85]
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A cohort study of the effect of alcohol consumption and obesity on serum liver enzyme levels
Shen, Z., Li, Y., Yu, C., Shen, Y. L., Xu, L., Xu, C., & Xu, G.-Y. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283328b86 · Cited by 35
Lang, T., Ikejima, K., Yoshikawa, M., Enomoto, N., Iijima, K., Kitamura, T., Takei, Y., & Sato, N. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.192 · Cited by 35
The Impact of Obesity and Metabolic Syndrome on Chronic Hepatitis B and Drug-Induced Liver Disease
Pais, R., Rusu, E. E., & Ratziu, V. (2013) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.09.015 · Cited by 36
Pais, R., Lebray, P., Rousseau, G., Charlotte, F., Esselma, G., Savier, É., Thabut, D., Rudler, M., Eyraud, D., Vézinet, C., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.10.011 · Cited by 34
“For instance, excessive drinkers who are obese have cirrhosis and alcoholic hepatitis more often than nonobese drinkers.(2) Central obesity and high serum”
BackgroundDecreased Macrophage Autophagy Promotes Liver Injury and Inflammation from Alcohol
Ilyas, G., Cingolani, F., Zhao, E., Tanaka, K. E., & Czaja, M. J. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14041 · Cited by 34
“Interestingly, aging (Raynard et al., 2002; Wang et al., 2014) and obesity (Naveau et al., 1997; Ruhl and Everhart, 2005; Hart et al., 2010) are recognized cofactors that promote the development of alcoholic liver disease.”
BackgroundSerum Leptin in Patients with Alcoholic Liver Disease
Naveau, S., Perlemuter, G., Chaillet, M., Raynard, B., Balian, A., Beuzen, F., Portier, A., Galanaud, P., Émilie, D., & Chaput, J. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00170.x · Cited by 34
Self-citationPathogenesis and pathways: nonalcoholic fatty liver disease & alcoholic liver disease
Robinson, K. E., & Shah, V. H. (2020) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2019.12.05 · Cited by 33
“The combination of obesity and smoking is a greater risk factor for the progression of alcoholic steatosis to alcoholic cirrhosis than any allele thus far studied (58-60).”
BackgroundHlaing, N. K. T., Mitrani, R., Aung, S. T., Phyo, W. W., Serper, M., Kyaw, A. M. M., Bwa, A. H., Win, K. M., & Reddy, K. R. (2017) · Journal of Viral Hepatitis · doi:10.1111/jvh.12721 · Cited by 33
Mahli, A., Thasler, W. E., Patsenker, E., Müller, S., Stickel, F., Müller, M., Seitz, H. K., Cederbaum, A. I., & Hellerbrand, C. (2015) · Oncotarget · doi:10.18632/oncotarget.6203 · Cited by 32
“Furthermore, in subjects with heavy alcohol consumption, obesity is an independent risk factor for the development of both acute alcohol-induced hepatitis and cirrhosis [12, 13].”
BackgroundDoes hepatitis C virus cause severe liver disease only in people who drink alcohol?
Vento, S., & Cainelli, F. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00271-2 · Cited by 32
Changes in Microsomal Activity in Alcoholism and Obesity
de la Maza, M. P., Hirsch, S., Petermann, M., et al. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02031.x · Cited by 31
Non‐Alcoholic Fatty Liver and Non‐Alcoholic Steatohepatitis
Farrell, G. C. (2007) · doi:10.1002/9780470691861.ch13 · Cited by 31
Metadata
- Authors
- Naveau, S., Giraud, V., Borotto, E., Aubert, A., Capron, F., & Chaput, J.
- Affiliations
- Hôpital Antoine-Béclère (FR)
- Venue
- Hepatology
- Published
- 1997-01
- Volume
- 25
- Issue
- 1
- Pages
- 108-111
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1987296974
- Cited by
- 666
- References
- 0
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 27 · 2023: 40 · 2022: 19 · 2021: 21 · 2020: 27 · 2019: 22 · 2018: 41 · 2017: 29 · 2016: 36 · 2015: 45 · 2014: 37 · 2013: 21 · 2012: 27
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- alcoholic liver disease, overweight, body mass index, alcoholic cirrhosis, alcoholic hepatitis, steatosis, risk factors, sex differences, ethanol-induced hepatotoxicity
- MeSH terms
- Adult, Aged, Female, Humans, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Obesity, Risk Factors, Multivariate Analysis
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