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Excess Weight Risk Factor for Alcoholic Liver Disease
Abstract
Though the hepatotoxicity of ethanol has been established, only 8% to 20% of chronic alcoholics develop cirrhosis. The aim of this study was to assess whether being overweight is a risk factor for alcoholic liver disease. One thousand six hundred four alcoholic patients were studied. According to the liver biopsies, 194 patients had a normal liver; 402 had steatosis without fibrosis; 281 presented with fibrosis, with or without steatosis; 119 presented with acute alcoholic hepatitis (AAH) without cirrhosis; 232 indicated cirrhosis without AAH; and 179 presented with cirrhosis with AAH. One hundred ninety-seven patients had clinically obvious cirrhosis. In the study, five variables were studied as risk factors: age, sex, daily consumption of alcohol during the previous 5 years, the total duration of alcohol abuse, and tendency to be overweight (body mass index [BMI] > or = 25 in women and > or = 27 in men). The BMI was calculated according to the minimum weight over the 10 previous years. In the first stepwise logistic regression analysis, age, being overweight for at least 10 years, being of the female sex, and the total duration of alcohol abuse were independently correlated with the presence of cirrhosis. In the second analysis, female sex being overweight were the two independent risk factors of AAH. In the third analysis, being overweight for at least 10 years was the only independent risk factor of steatosis. These results show that the presence of excess weight for at least 10 years is a risk factor for cirrhosis, AAH, and steatosis. Our results suggest that there is a possible potential for the metabolic effects of ethanol ingestion caused by excess weight in patients with alcoholic liver disease.
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“This corroborates older fi ndings of BMI as an independent risk factor for fi brosis in individuals with ALD.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [85]
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Parker, R. (2018) · Liver Research · doi:10.1016/j.livres.2018.02.002 · Cited by 75
Trends in hepatocellular carcinoma due to non-alcoholic fatty liver disease
Bertot, L. C., & Adams, L. A. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1549989 · Cited by 68
“Among patients with ALD-related cirrhosis awaiting liver transplantation (LT), a history of diabetes or being overweight is associated with a higher risk of HCC, whereas obesity has been associated with HCC found on explant livers among ALD patients undergoing LT [84].”
BackgroundInfluentialAlcoholic hepatitis 2010: A clinician’s guide to diagnosis and therapy
Amini, M. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i39.4905 · Cited by 70
Inflammation is independent of steatosis in a murine model of steatohepatitis
Wang, W., Xu, M., Cai, Y., Zhou, Z., Cao, H., Mukhopadhyay, P., Pacher, P., Zheng, S., Gonzalez, F. J., & Gao, B. (2017) · Hepatology · doi:10.1002/hep.29129 · Cited by 70
“Excess alcohol consumption and obesity renders increased risk for the development of steatohepatitis, cirrhosis, and hepatocellular carcinoma.((1-4)) The collaborative relationship between obesity and alcohol on steatohepatitis has been observed and documented in clinical studies((5-7)) and in several animal models.”
Body Composition and Hepatic Steatosis As Precursors for Fibrotic Liver Disease
McCullough, A. J., & Falck-Ytter, Y. T. (1999) · Hepatology · doi:10.1002/hep.510290451 · Cited by 69
Nonalcoholic Fatty Liver Disease
Paredes, A. H., Torres, D. M., & Harrison, S. A. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.03.005 · Cited by 72
The rs738409 (I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis
Shen, J., Li, Y., Li, D., Wang, N., Jing, L., & Huang, Y. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m048777 · Cited by 68
Combined alcoholic and non-alcoholic steatohepatitis
Wandji, L. C. N., Gnemmi, V., Mathurin, P., & Louvet, A. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100101 · Cited by 70
Adiponectin: A multitasking player in the field of liver diseases
Silva, T. E., Colombo, G., & Schiavon, L. D. L. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.11.004 · Cited by 68
Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease
Naveau, S., Cassard, A., Njiké‐Nakseu, M., Bouchet‐Delbos, L., Barri‐Ova, N., Boujedidi, H., Dauvois, B., Balian, A., Maître, S., Prevot, S., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.01.029 · Cited by 66
“We have already demonstrated that excess weight is an independent risk factor for AAH and cirrhosis in alcoholic patients [1] and that BMI is an independent risk factor for fibrosis in nonobese alcoholic patients [2].”
BackgroundSelf-citationA Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease
Williams, J. A. R., & Ding, W. (2015) · Biomolecules · doi:10.3390/biom5042619 · Cited by 68
“Comorbidity with obesity [60–63] or Hepatitis C Virus [64–66] also increases ALD severity and promotes disease progression.”
BackgroundSexual Dimorphism in Alcohol Induced Adipose Inflammation Relates to Liver Injury
Fulham, M. A., & Mandrekar, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164225 · Cited by 66
Metadata
- Authors
- Naveau, S., Giraud, V., Borotto, E., Aubert, A., Capron, F., & Chaput, J.
- Affiliations
- Hôpital Antoine-Béclère (FR)
- Venue
- Hepatology
- Published
- 1997-01
- Volume
- 25
- Issue
- 1
- Pages
- 108-111
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1987296974
- Cited by
- 666
- References
- 0
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 27 · 2023: 40 · 2022: 19 · 2021: 21 · 2020: 27 · 2019: 22 · 2018: 41 · 2017: 29 · 2016: 36 · 2015: 45 · 2014: 37 · 2013: 21 · 2012: 27
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- alcoholic liver disease, overweight, body mass index, alcoholic cirrhosis, alcoholic hepatitis, steatosis, risk factors, sex differences, ethanol-induced hepatotoxicity
- MeSH terms
- Adult, Aged, Female, Humans, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Obesity, Risk Factors, Multivariate Analysis
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