The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Antibiotic Prophylaxis for the Prevention of Bacterial Infections in Cirrhotic Patients With Gastrointestinal Bleeding: A Meta–Analysis
Open accessAbstract
In cirrhotic patients with gastrointestinal bleeding, antibiotic prophylaxis decreases the incidence of infections but most randomized trials have not shown an increase in survival. The aim of this meta–analysis was to assess the efficacy of antibiotic prophylaxis in the prevention of infections and its effect on survival rate in cirrhotic patients with gastrointestinal bleeding. Four end points were assessed: infection, bacteremia and/or spontaneous bacterial peritonitis (SBP), incidence of SBP, and death. For each end point, heterogeneity and treatment efficacy were assessed by Der Simonian and Peto methods. Five trials including 534 patients, 264 treated with antibiotic prophylaxis for 4 to 10 days and 270 without, were identified. Mean follow–up was 12 days. Antibiotic prophylaxis significantly increased the mean percentage of patients free of infection (32% mean improvement rate, 95% confidence interval [CI]: 22–42, P< .001), bacteremia and/or SBP (19% mean improvement rate, 95% CI: 11–26, P< .001), and SBP (7% mean improvement rate, 95% CI: 2.1–12.6, P = .006). Antibiotic prophylaxis also significantly increased the mean survival rate (9.1% mean improvement rate, 95 % CI: 2.9–15.3, P = .004), without significant heterogeneity. In cirrhotic patients with gastrointestinal bleeding, short–term antibiotic prophylaxis significantly increases the mean percentage of patients free of infection and significantly increases short–term survival rate
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Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Transection of the oesophagus for bleeding oesophageal varices
Pugh, R. N. H., Murray-Lyon, I. M., Dawson, J. L., Pietroni, M. C., & Williams, R. (1973) · Journal of British Surgery · doi:10.1002/bjs.1800600817 · Cited by 7,941
Beta blockade during and after myocardial infarction: An overview of the randomized trials
Yusuf, S., Peto, R., Lewis, J., Collins, R., & Sleight, P. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(85)80003-7 · Cited by 3,205
Cited by
Garcia‐Tsao, G., Abraldes, J. G., Berzigotti, A., & Bosch, J. (2017) · Hepatology · doi:10.1002/hep.28906 · Cited by 2,154
Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013
Jalan, R., Fernandez, J., Wiest, R., Schnabl, B., Moreau, R., Angeli, P., Stadlbauer, V., Gustot, T., Bernardi, M., Canton, R., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.01.024 · Cited by 906
The gut–liver axis and gut microbiota in health and liver disease
Hsu, C. L., & Schnabl, B. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00904-3 · Cited by 737
Fernández, J., Acevedo, J., Castro, M., Garcia, O., de Lope, C. R., Roca, D., Pavesi, M., Sola, E., Moreira, L., Silva, A., et al. (2012) · Hepatology · doi:10.1002/hep.25532 · Cited by 620
Beyond scoring: a modern interpretation of disease progression in chronic liver disease
Rosselli, M., MacNaughtan, J., Jalan, R., & Pinzani, M. (2013) · Gut · doi:10.1136/gutjnl-2012-302826 · Cited by 96
Metadata
- Authors
- Bernard, B., Grangé, J.-D., Khac, E. N., Amiot, X., Opolon, P., & Poynard, T.
- Venue
- Hepatology
- Published
- 1999-06
- Volume
- 29
- Issue
- 6
- Pages
- 1655-1661
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1977626961
- Cited by
- 836
- References
- 3
- FWCI
- 16.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bernard, B., Grangé, J.-D., Khac, E. N., Amiot, X., Opolon, P., & Poynard, T. (1999). Antibiotic Prophylaxis for the Prevention of Bacterial Infections in Cirrhotic Patients With Gastrointestinal Bleeding: A Meta–Analysis. Hepatology. https://doi.org/10.1002/hep.510290608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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