Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

Magiorakos, A.-P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., Harbarth, S., Hindler, J. F., Kahlmeter, G., Olsson-Liljequist, B., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03570.x · Cited by 14,449 · see citing works

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,192 · see citing works

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock

Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694 · see citing works

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2769-8 · Cited by 7,282 · see citing works

Acute-Phase Proteins and Other Systemic Responses to Inflammation

Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734 · see citing works

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works

Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis

Moreau, R., Jalan, R., Ginès, P., Pavesi, M., Angeli, P., Córdoba, J., Durand, F., Gustot, T., Saliba, F., Domenicali, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.042 · Cited by 3,041 · see citing works

Revising consensus in portal hypertension: Report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension

de Franchis, R. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.06.004 · Cited by 2,291 · see citing works

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219 · see citing works

TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942 · see citing works

EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis

(2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.004 · Cited by 1,726 · see citing works

Disease Tolerance as a Defense Strategy

Medzhitov, R., Schneider, D. S., & Soares, M. P. (2012) · Science · doi:10.1126/science.1214935 · Cited by 1,718 · see citing works

Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis

Sort, P., Navasa, M., Arroyo, V., Aldeguer, X., Planas, R., Ruíz-del-Árbol, L., Castells, L., Vargas, V., Soriano, G., Guevara, M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908053410603 · Cited by 1,636 · see citing works

The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412 · see citing works

Rifaximin Treatment in Hepatic Encephalopathy

Bass, N. M., Mullen, K. D., Sanyal, A., Poordad, F., Neff, G., Leevy, C. B., Sigal, S., Sheikh, M. Y., Beavers, K., Frederick, T., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907893 · Cited by 1,300 · see citing works

Procalcitonin as a diagnostic marker for sepsis: A systematic review and meta-analysis.

Wacker, C., Prkno, A., Brunkhorst, F. M., & Schlattmann, P. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70323-7 · Cited by 1,198 · see citing works

Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining Prognosis

Arvaniti, V., D’Amico, G., Fede, G., Manousou, P., Tsochatzis, E. A., Pleguezuelo, M., & Burroughs, A. K. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.019 · Cited by 1,172 · see citing works

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., Yu, R. T., Shelton, J. M., Richardson, J. A., Repa, J. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509592103 · Cited by 1,164 · see citing works

Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document

Rimola, A., García–Tsao, G., Navasa, M., Piddock, L. J. V., Planas, R., Bernard‐Chabert, B., & Inadomi, J. M. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80201-9 · Cited by 1,058 · see citing works

Characterization of fecal microbial communities in patients with liver cirrhosis

Chen, Y., Yang, F., Lu, H., Wang, B., Chen, Y., Lei, D., Wang, Y., Zhu, B., & Li, L. (2011) · Hepatology · doi:10.1002/hep.24423 · Cited by 1,038 · see citing works

Bacterial infections in cirrhosis: Epidemiological changes with invasive procedures and norfloxacin prophylaxis

Fernández, J., Navasa, M., Gómez, J., Colmenero, J., Vila, J., Arroyo, V., & Rodés, J. (2002) · Hepatology · doi:10.1053/jhep.2002.30082 · Cited by 954 · see citing works

Liver: An organ with predominant innate immunity

Gao, B., Jeong, W.-I., & Tian, Z. (2008) · Hepatology · doi:10.1002/hep.22034 · Cited by 952 · see citing works

Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine

Marik, P. E., Pastores, S. M., Annane, D., Meduri, G. U., Sprung, C. L., Arlt, W., Keh, D., Briegel, J., Beishuizen, A., Dimopoulou, I., et al. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31817603ba · Cited by 912 · see citing works

Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance

Woodford, N., Turton, J. F., & Livermore, D. M. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00268.x · Cited by 881 · see citing works

Translocation of Certain Indigenous Bacteria from the Gastrointestinal Tract to the Mesenteric Lymph Nodes and Other Organs in a Gnotobiotic Mouse Model

Berg, R. D., & Garlington, A. W. (1979) · Infection and Immunity · doi:10.1128/iai.23.2.403-411.1979 · Cited by 845 · see citing works

Antibiotic Prophylaxis for the Prevention of Bacterial Infections in Cirrhotic Patients With Gastrointestinal Bleeding: A Meta–Analysis

Bernard‐Chabert, B., Grangé, J., Khac, E. N., Amiot, X., Opolon, P., & Poynard, T. (1999) · Hepatology · doi:10.1002/hep.510290608 · Cited by 821 · see citing works

Enteric dysbiosis associated with a mouse model of alcoholic liver disease

Yan, A. W., Fouts, D. E., Brandl, J., Stärkel, P., Torralba, M., Schott, E., Tsukamoto, H., Nelson, K. E., Brenner, D. A., & Schnabl, B. (2011) · Hepatology · doi:10.1002/hep.24018 · Cited by 791 · see citing works

Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012

Runyon, B. A. (2013) · Hepatology · doi:10.1002/hep.26359 · Cited by 776 · see citing works

Colonic microbiome is altered in alcoholism

Mutlu, E. A., Gillevet, P. M., Rangwala, H., Sikaroodi, M., Naqvi, A., Engen, P. A., Kwasny, M., Lau, C. K., & Keshavarzian, A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00380.2011 · Cited by 775 · see citing works

Primary Prophylaxis of Spontaneous Bacterial Peritonitis Delays Hepatorenal Syndrome and Improves Survival in Cirrhosis

Fernández, J., Navasa, M., Planas, R., Montoliu, S., Monfort, D., Soriano, G., Vila, C., Pardo, A., Quintero, E., Vargas, V., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.065 · Cited by 709 · see citing works

Acute-on chronic liver failure

Jalan, R., Ginès, P., Olson, J. C., Mookerjee, R. P., Moreau, R., García–Tsao, G., Arroyo, V., & Kamath, P. S. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.026 · Cited by 672 · see citing works

Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: Results of a double-blind, placebo-controlled trial

Ginés, P., Rimola, A., Planas, R., Vargas, V., Marco, F., Almela, M., Forne, M., Miranda, M. L., Llach, J., Salmerón, J. M., et al. (1990) · Hepatology · doi:10.1002/hep.1840120416 · Cited by 627 · see citing works

Prevalence and risk factors of infections by multiresistant bacteria in cirrhosis: A prospective study

Fernández, J., Acevedo, J., Castro, M., Garcia, O., de Lope, C. R., Roca, D., Pavesi, M., Sola, E., Moreira, L., Silva, A., et al. (2012) · Hepatology · doi:10.1002/hep.25532 · Cited by 620 · see citing works

Inactivation of Kupffer cells prevents early alcohol-induced liver injury

Adachi, Y., Bradford, B. U., Gao, W., Bojes, H. K., & Thurman, R. G. (1994) · Hepatology · doi:10.1002/hep.1840200227 · Cited by 555 · see citing works

Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses

Littman, D. R., & Pamer, E. G. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.004 · Cited by 548 · see citing works

Patients with acute on chronic liver failure display ‘sepsis-like’ immune paralysis

Wasmuth, H. E., Kunz, D., Yagmur, E., Timmer-Stranghöner, A., Vidacek, D., Siewert, E., Bach, J., Geier, A., Purucker, E. A., Gressner, A. M., et al. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.10.019 · Cited by 541 · see citing works

Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future

Schüetz, P., Albrich, W. C., & Müeller, B. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-107 · Cited by 529 · see citing works

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

Bajaj, J. S., Hylemon, P. B., Ridlon, J. M., Heuman, D. M., Daita, K., White, M. B., Monteith, P., Noble, N. A., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00152.2012 · Cited by 525 · see citing works

Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications

García‐Martínez, R., Caraceni, P., Bernardi, M., Ginès, P., Arroyo, V., & Jalan, R. (2013) · Hepatology · doi:10.1002/hep.26338 · Cited by 471 · see citing works

Norfloxacin vs Ceftriaxone in the Prophylaxis of Infections in Patients With Advanced Cirrhosis and Hemorrhage

Fernández, J., Arbol, L. R. D., Gómez, C., Durández, R., Serradilla, R., Guarner, C., Planas, R., Arroyo, V., & Navasa, M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.010 · Cited by 456 · see citing works

Severe sepsis in cirrhosis†

Gustot, T., Durand, F., Lebrec, D., Vincent, J., & Moreau, R. (2009) · Hepatology · doi:10.1002/hep.23264 · Cited by 439 · see citing works

Tumor necrosis factor and interleukin-6 in spontaneous bacterial peritonitis in cirrhosis: Relationship with the development of renal impairment and mortality

Navasa, M., Follo, A., Filella, X., Jiménez, W., Francitorra, A., Planas, R., Rimola, A., Arroyo, V., & Rodés, J. (1998) · Hepatology · doi:10.1002/hep.510270507 · Cited by 429 · see citing works

Management of bacterial infections in cirrhosis

Fernández, J., & Gustot, T. (2012) · Journal of Hepatology · doi:10.1016/s0168-8278(12)60002-6 · Cited by 373 · see citing works

Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome

Mookerjee, R. P., Stadlbauer, V., Lidder, S., Wright, G. A. K., Hodges, S. J., Davies, N. A., & Jalan, R. (2007) · Hepatology · doi:10.1002/hep.21737 · Cited by 332 · see citing works

Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis

Reiberger, T., Ferlitsch, A., Payer, B. A., Mandorfer, M., Heinisch, B. B., Hayden, H., Lammert, F., Trauner, M. A., Peck‐Radosavljevic, M., & Vogelsang, H. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.12.011 · Cited by 328 · see citing works

Cirrhotic Patients Are at Risk for Health Care–Associated Bacterial Infections

Merli, M., Lucidi, C., Giannelli, V., Giusto, M., Riggio, O., Falcone, M., Ridola, L., Attili, A. F., & Venditti, M. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.06.024 · Cited by 323 · see citing works

Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats

Lorenzo-Zúñiga, V., Bartolí, R., Planas, R., Hofmann, A. F., Viñado, B., Hagey, L. R., Hernández, J. M., Mañé, J., Alvarez, M. A., Ausina, V., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50116 · Cited by 321 · see citing works

Norfloxacin prevents bacterial infection in cirrhotics with gastrointestinal hemorrhage

Soriano, G., Guarner, C., Tomás, A., Villanueva, C., Torras, X., González, D., Sáinz, S., Anguera, A., Cussó, X., Balanzó, J., et al. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91514-5 · Cited by 314 · see citing works

Short-course versus long-course antibiotic treatment of spontaneous bacterial peritonitis

Runyon, B. A., McHutchison, J. G., Antillon, M. R., Akriviadis, E. A., & Montano, A. A. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90677-d · Cited by 309 · see citing works

Antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding

Chávez-Tapia, N. C., Barrientos‐Gutiérrez, T., Téllez-Ávila, F. I., Soares‐Weiser, K., & Uribe, M. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002907.pub2 · Cited by 304 · see citing works

Cirrhosis as a Risk Factor for Sepsis and Death

Foreman, M. G., Mannino, D. M., & Moss, M. (2003) · CHEST Journal · doi:10.1378/chest.124.3.1016 · Cited by 301 · see citing works

Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survival

Fernández, J., Escorsell, À., Zabalza, M., Felipe, V., Navasa, M., Mas, A., Lacy, A. M., Ginès, P., & Arroyo, V. (2006) · Hepatology · doi:10.1002/hep.21352 · Cited by 292 · see citing works

Natural killer cells in liver disease

Tian, Z., Chen, Y., & Gao, B. (2012) · Hepatology · doi:10.1002/hep.26115 · Cited by 290 · see citing works

Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock†

Tsai, M., Peng, Y., Chen, Y., Liu, N.-J., Ho, Y., Fang, J., Lien, J., Yang, C., Chen, P., & Wu, C. (2006) · Hepatology · doi:10.1002/hep.21101 · Cited by 288 · see citing works

Bacterial infection in the pathogenesis of variceal bleeding

Goulis, J., Patch, D., & Burroughs, A. K. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06020-6 · Cited by 286 · see citing works

Model for end-stage liver disease score and systemic inflammatory response are major prognostic factors in patients with cirrhosis and acute functional renal failure

Thabut, D., Massard, J., Gangloff, A., Carbonell, N., Francoz, C., Nguyen-Khac, É., Duhamel, C., Lebrec, D., Poynard, T., & Moreau, R. (2007) · Hepatology · doi:10.1002/hep.21920 · Cited by 278 · see citing works

Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation

Holler, E., Rogler, G., Herfarth, H. H., Brenmoehl, J., Wild, P. J., Hahn, J. R., Eißner, G., Schölmerich, J., & Andreesen, R. (2004) · Blood · doi:10.1182/blood-2003-10-3543 · Cited by 272 · see citing works

Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites

Pérez-Paramo, M., Muñoz, J., Albillos, A., Freile, I., Portero, F., Santos, M., & Ortiz-Berrocal, J. (2000) · Hepatology · doi:10.1002/hep.510310109 · Cited by 271 · see citing works

Small intestinal bacterial overgrowth in patients with cirrhosis: prevalence and relation with spontaneous bacterial peritonitis

Bauer, T., Steinbrückner, B., Brinkmann, F., Ditzen, A. K., Schwacha, H., Aponte, J. J., Pelz, K., Kist, M., & Blum, H. E. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04668.x · Cited by 266 · see citing works

Small Intestine Dysmotility and Bacterial Overgrowth in Cirrhotic Patients With Spontaneous Bacterial Peritonitis

Chang, C., Chen, G., Lien, H., & Yeh, H. (1998) · Hepatology · doi:10.1002/hep.510280504 · Cited by 261 · see citing works

Renal Failure in Patients With Cirrhosis and Sepsis Unrelated to Spontaneous Bacterial Peritonitis: Value of MELD Score

Terra, C., Guevara, M., Torre, A., Gilabert, R., Fernández, J., Martín–Llahí, M., Baccaro, M. E., Navasa, M., Bru, C., Arroyo, V., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.09.024 · Cited by 254 · see citing works

A Randomized Unblinded Pilot Study Comparing Albumin Versus Hydroxyethyl Starch in Spontaneous Bacterial Peritonitis * #

Fernández, J., Monteagudo, J., Bargalló, X., Jiménez, W., Bosch, J., Arroyo, V., & Navasa, M. (2005) · Hepatology · doi:10.1002/hep.20829 · Cited by 246 · see citing works

Small bowel bacterial overgrowth in patients with alcoholic cirrhosis

Morencos, F. C., Castano, G. D. L. H., Ramos, L. M., Arias, M. J. L., Ledesma, F., & Romero, F. P. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02282340 · Cited by 246 · see citing works

The systemic inflammatory response syndrome in cirrhotic patients: Relationship with their in-hospital outcome

Cazzaniga, M., Dionigi, E., Gobbo, G. F. D., Fioretti, A., Monti, V., & Salerno, F. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.04.017 · Cited by 234 · see citing works

Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth

Lichtman, S. N., Sartor, R. B., Keku, J., & Schwab, J. H. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90833-m · Cited by 209 · see citing works

Broad-Range 16S rRNA Gene Polymerase Chain Reaction for Diagnosis of Culture-Negative Bacterial Infections

Rampini, S. K., Bloemberg, G. V., Keller, P. M., Büchler, A., Dollenmaier, G., Speck, R. F., & Böttger, E. C. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir692 · Cited by 209 · see citing works

Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study

Guevara, M., Terra, C., Nazar, A., Solà, E., Fernández, J., Pavesi, M., Arroyo, V., & Ginès, P. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.013 · Cited by 207 · see citing works

Low-dose hydrocortisone in patients with cirrhosis and septic shock: a randomized controlled trial

Arabi, Y. M., Aljumah, A. A., Dabbagh, O. C., Tamim, H., Rishu, A. H., Al‐Abdulkareem, A., Knawy, B. A., Hajeer, A. H., Tamimi, W., & Cherfan, A. J. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.090707 · Cited by 204 · see citing works

Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense

Teltschik, Z., Wiest, R., Beisner, J., Nuding, S., Hofmann, C., Schöelmerich, J., Bevins, C. L., Stange, E. F., & Wehkamp, J. (2011) · Hepatology · doi:10.1002/hep.24789 · Cited by 196 · see citing works

C-Reactive protein predicts short-term mortality in patients with cirrhosis

Cervoni, J., Thévenot, T., Weil, D., Muel, E., Barbot, O., Sheppard, F., Monnet, É., & Martino, V. D. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.030 · Cited by 193 · see citing works

Evidence of neutrophil functional defect despite inflammation in stable cirrhosis

Tritto, G., Bechlis, Z., Stadlbauer, V., Davies, N. A., Francés, R., Shah, N. K., Mookerjee, R. P., Such, J. M., & Jalan, R. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.11.034 · Cited by 191 · see citing works

Systemic Antibiotic Therapy Prevents Bacterial Infection in Cirrhotic Patients With Gastrointestinal Hemorrhage

Blaise, M., Pateron, D., Trinchet, J., Levacher, S., Beaugrand, M., & Pourriat, J.-L. (1994) · Hepatology · doi:10.1002/hep.1840200107 · Cited by 189 · see citing works

Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases

Koo, H. L., & DuPont, H. L. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328333dc8d · Cited by 189 · cited 1× · see citing works

Tumor necrosis factor α and interleukin 6 plasma levels in infected cirrhotic patients

Byl, B., Roucloux, I., Crusiaux, A., Dupont, É., & Devière, J. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90361-f · Cited by 187 · see citing works

Excessive In Vitro Bacterial Lipopolysaccharide–Induced Production of Monokines in Cirrhosis

Deviere, J. M. E., Content, J., Denys, C. H., Vandenbussche, P., Schandené, L., Wybran, J., & Dupont, É. (1990) · Hepatology · doi:10.1002/hep.1840110416 · Cited by 183 · see citing works

The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study

Trawale, J., Paradis, V., Rautou, P., Francoz, C., Escolano, S., Sallée, M., Durand, F., Valla, D. C., Lebrec, D., & Moreau, R. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02182.x · Cited by 183 · see citing works

Clinical Significance and Outcome of Nosocomial Acquisition of Spontaneous Bacterial Peritonitis in Patients with Liver Cirrhosis

Cheong, H. S., Kang, C., Lee, J. A., Moon, S. Y., Joung, M. K., Chung, D. R., Koh, K. C., Lee, N. Y., Song, J., & Peck, K. R. (2009) · Clinical Infectious Diseases · doi:10.1086/597585 · Cited by 178 · see citing works

Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function

du Plessis, J., Vanheel, H., Janssen, C., Roos, L., Slavík, T., Stivaktas, P. I., Nieuwoudt, M., van Wyk, S. G., Vieira, W. A., Pretorius, E., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.01.038 · Cited by 178 · see citing works

Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis

Pardo, A., Bartolí, R., Lorenzo-Zúñiga, V., Planas, R., Viñado, B., Riba, J., Cabré, E., Santos, J., Luque, T., Ausina, V., et al. (2000) · Hepatology · doi:10.1053/he.2000.5746 · Cited by 177 · see citing works

Nosocomial Spontaneous Bacterial Peritonitis and Bacteremia in Cirrhotic Patients: Impact of Isolate Type on Prognosis and Characteristics of Infection

Campillo, B., Richardet, J. P., Kheo, T., & Dupeyron, C. (2002) · Clinical Infectious Diseases · doi:10.1086/340617 · Cited by 177 · see citing works

Risk of a first community-acquired spontaneous bacterial peritonitis in cirrhotics with low ascitic fluid protein levels

Guarner, C., Sola, R. L., Soriano, G., Andreu, M. G., Novella, M. T., Vila, M. C., Sàbat, M., Coll, S., Ortiz, J., Gómez, C., et al. (1999) · Gastroenterology · doi:10.1053/gast.1999.0029900414 · Cited by 172 · see citing works

Altered intestinal tight junctions’ expression in patients with liver cirrhosis: a pathogenetic mechanism of intestinal hyperpermeability

Assimakopoulos, S. F., Tsamandas, A. C., Tsiaoussis, G. I., Karatza, E., Triantos, C. K., Vagianos, C., Spiliopoulou, I. T., Kaltezioti, V., CHARONIS, A. S., Nikolopoulou, V. N., et al. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02609.x · Cited by 166 · see citing works

Impaired Function of Macrophage Fcγ Receptors and Bacterial Infection in Alcoholic Cirrhosis

Gomez, F., Ruiz, P., & Schreiber, A. D. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410273311704 · Cited by 165 · see citing works

The role of bacteria and pattern-recognition receptors in Crohn's disease

Man, S. M., Kaakoush, N. O., & Mitchell, H. M. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.3 · Cited by 162 · see citing works

Long-Term Treatment With Cisapride and Antibiotics in Liver Cirrhosis: Effect on Small Intestinal Motility, Bacterial Overgrowth, and Liver Function

Madrid, A. M., Hurtado, C., Venegas, M., Cumsille, F., & Defilippi, C. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03636.x · Cited by 158 · see citing works

High Prevalence of Antibiotic-Resistant Bacterial Infections Among Patients With Cirrhosis at a US Liver Center

Tandon, P., DeLisle, A., Topal, J. E., & Garcia–Tsao, G. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.08.017 · Cited by 158 · see citing works

Antimicrobial therapeutic determinants of outcomes from septic shock among patients with cirrhosis

Arabi, Y. M., Dara, S. I., Memish, Z. A., Abdulkareem, A., Tamim, H., Shirawi, N., Parrillo, J. E., Dodek, P., Lapinsky, S. E., Feinstein, D., et al. (2012) · Hepatology · doi:10.1002/hep.25931 · Cited by 157 · see citing works

Use of broad range16S rDNA PCR in clinical microbiology

Sontakke, S., Cadenas, M. B., Maggi, R. G., Diniz, P. P. V. D. P., & Breitschwerdt, E. B. (2008) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2008.11.002 · Cited by 156 · see citing works

Risk factors for resistance to ceftriaxone and its impact on mortality in community, healthcare and nosocomial spontaneous bacterial peritonitis

Ariza, X., Castellote, J., Lora-Tamayo, J., Girbau, A., Salord, S., Rota, R., Ariza, J., & Xiol, X. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.11.010 · Cited by 154 · see citing works

Small‐intestinal bacterial overgrowth in cirrhosis is related to the severity of liver disease

PANDE, C., KUMAR, A., & SARIN, S. K. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.03994.x · Cited by 152 · see citing works

Endotoxemia contributes to the immune paralysis in patients with cirrhosis

Lin, C.-Y., Tsai, I.-F., Ho, Y.-P., Huang, C.-T., Lin, Y.-C., Lin, C.-J., Tseng, S.-C., Lin, W.-P., Chen, W.-T., & Sheen, I.-S. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2006.12.018 · Cited by 145 · see citing works

Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short-term risk of severe sepsis, hepatorenal syndrome, and death

Acevedo, J., Fernández, J., Prado, V., Silva, A., Castro, M., Pavesi, M., Roca, D., Jiménez, W., Ginès, P., & Arroyo, V. (2013) · Hepatology · doi:10.1002/hep.26535 · Cited by 140 · see citing works

Tumour necrosis factor-alpha expression by activated monocytes and altered T-cell homeostasis in ascitic alcoholic cirrhosis: amelioration with norfloxacin

Albillos, A., de la Hera, A., Reyes, E., Monserrat, J., Muñoz, L., Nieto, M., I, A. P., Sanz, E., & Álvarez‐Mon, M. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2003.12.010 · Cited by 140 · see citing works

Effect of Lactobacillus johnsonii La1 and antioxidants on intestinal flora and bacterial translocation in rats with experimental cirrhosis

Chiva, M., Soriano, G., Rochat, I., Peralta, C., Rochat, F., Llovet, T., Mirelis, B., Schiffrin, E. J., Guarner, C., & Balanzó, J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00142-3 · Cited by 139 · see citing works

Adrenocortical dysfunction in liver disease: A systematic review

Fede, G., Spadaro, L., Tomaselli, T., Privitera, G., Germani, G., Tsochatzis, E. A., Thomas, M., Bouloux, P.-M. G., Burroughs, A. K., & Purrello, F. (2012) · Hepatology · doi:10.1002/hep.25573 · Cited by 134 · see citing works

Nucleotide‐binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis†

Appenrodt, B., Grünhage, F., Gentemann, M., Thyssen, L., Sauerbruch, T., & Lammert, F. (2009) · Hepatology · doi:10.1002/hep.23440 · Cited by 133 · see citing works

Small bowel bacterial overgrowth in patients with alcoholic cirrhosis

Morencos, F. C., Castano, G. D. L. H., Ramos, L. M., Arias, M. J. L., Ledesma, F., & Romero, F. P. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02065533 · Cited by 132 · see citing works

Coagulation disorders in patients with cirrhosis and severe sepsis

Plessier, A., Denninger, M., Consigny, Y., Pessione, F., Francoz, C., Durand, F., Francque, S., Bezeaud, A., Chauvelot‐Moachon, L., Lebrec, D., et al. (2003) · Liver International · doi:10.1111/j.1478-3231.2003.00870.x · Cited by 125 · see citing works

Serum levels of C-reactive protein and procalcitonin in critically ill patients with cirrhosis of the liver

Bota, D. P., Nuffelen, M. V., Zakariah, A. N., & Vincent, J. (2005) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2005.08.005 · Cited by 123 · see citing works

Failure of Current Antibiotic First-Line Regimens and Mortality in Hospitalized Patients with Spontaneous Bacterial Peritonitis

Umgelter, A., Reindl, W., Miedaner, M., Schmid, R. M., & Huber, W. (2009) · Infection · doi:10.1007/s15010-008-8060-9 · Cited by 121 · see citing works

Rapid and accurate identification of genomic species from the Acinetobacter baumannii (Ab) group by MALDI-TOF MS

Espinal, P., Seifert, H., Dijkshoorn, L., Vilà, J., & Roca, I. (2011) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03696.x · Cited by 116 · see citing works

Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholic cirrhosis

Moine, O. L., Marchant, A., Groote, D. D., Azar, C., Goldman, M., & Deviere, J. M. E. (1995) · Hepatology · doi:10.1002/hep.1840220516 · Cited by 113 · see citing works

Failure of Lactobacillus spp. to prevent bacterial translocation in a rat model of experimental cirrhosis

Bauer, T., Fernández, J., Navasa, M., Vilà, J., & Rodés, J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00003-x · Cited by 110 · see citing works

Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver disease but not active ethanol consumption

Laso, F. J., Madruga, J., Giron, J. A., Lopez, A., Ciudad, J., Miguel, J. F. S., Álvarez‐Mon, M., & Orfao, A. (1997) · Hepatology · doi:10.1002/hep.510250508 · Cited by 108 · see citing works

Acute phase proteins in the diagnosis and prediction of cirrhosis associated bacterial infections

Papp, M., Vitális, Z., Altorjay, I., Tornai, I., Udvardy, M., Hársfalvi, J., Vida, A., Kappelmayer, J., Lakatos, P. L., & Antal‐Szalmás, P. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02689.x · Cited by 105 · see citing works

Efficacy of current guidelines for the treatment of spontaneous bacterial peritonitis in the clinical practice

Angeloni, S., Leboffe, C., Parente, A., Venditti, M., Giordano, A., Merli, M., & Riggio, O. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2757 · Cited by 104 · see citing works

Infectious Complications of Acute and Chronic Liver Disease

Leber, B., Spindelboeck, W., & Stadlbauer, V. (2012) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0032-1301737 · Cited by 103 · see citing works

Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-Positive B-cell population

Doi, H., Iyer, T. K., Carpenter, E. L., Li, H., Chang, K., Vonderheide, R. H., & Kaplan, D. E. (2011) · Hepatology · doi:10.1002/hep.24689 · Cited by 101 · see citing works

Toll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosis

Nischalke, H. D., Berger, C., Aldenhoff, K., Thyssen, L., Gentemann, M., Grünhage, F., Lammert, F., Nattermann, J., Sauerbruch, T., Spengler, U., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.022 · Cited by 100 · see citing works

Upregulation of TNF-alpha production signaling pathways in monocytes from patients with advanced cirrhosis: Possible role of Akt and IRAK-M

Tazi, K. A., Quioc, J., Saada, V., Bezeaud, A., Lebrec, D., & Moreau, R. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.02.013 · Cited by 99 · see citing works

Serum lipopolysaccharide-binding protein prediction of severe bacterial infection in cirrhotic patients with ascites

Albillos, A., de-la-Hera, A., & Álvarez‐Mon, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16206-5 · Cited by 98 · see citing works

The Role of Rifaximin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis

Hanouneh, M. A., Hanouneh, I. A., Hashash, J. G., Law, R. J., Esfeh, J. M., López, R., Hazratjee, N., Smith, T. H., & Zein, N. N. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182506dbb · Cited by 93 · see citing works

Increased risk of cognitive impairment in cirrhotic patients with bacterial infections

Merli, M., Lucidi, C., Pentassuglio, I., Giannelli, V., Giusto, M., Gregorio, V. D., Pasquale, C., Nardelli, S., Lattanzi, B., Venditti, M., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.012 · Cited by 92 · see citing works

Clinical outcomes of spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiellaspecies: A retrospective matched case-control study

Song, K., Jeon, J. H., Park, W. B., Park, S., Kim, H. B., Oh, M., Lee, H.-S., Kim, N. J., & Choe, K. W. (2009) · BMC Infectious Diseases · doi:10.1186/1471-2334-9-41 · Cited by 87 · see citing works

Reduced Hepatic Injury in Toll-Like Receptor 4–Deficient Mice Following D-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure

Ben‐Ari, Z., Avlas, O., Pappo, O., Zilbermints, V., Cheporko, Y., Bachmetov, L., Zemel, R. R., Shainberg, A., Sharon, E., Grief, F., et al. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000337585 · Cited by 86 · see citing works

Infection and inflammation in liver failure: Two sides of the same coin

Malik, R., Mookerjee, R. P., & Jalan, R. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.06.013 · Cited by 83 · see citing works

Management of Adult Patients with Ascites Due to Cirrhosis

Runyon, B. A. (2009) · Hepatology · doi:10.1002/hep.23261 · Cited by 81 · see citing works

Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary cirrhosis

Moreau, R., Barrière, É., Tazi, K. A., Lardeux, B. R., Dargère, D., Urbanowicz, W., Poirel, O., Chauvelot‐Moachon, L., Guimont, M.-C., Bernuau, D., et al. (2002) · Hepatology · doi:10.1053/jhep.2002.36501 · Cited by 77 · see citing works

Diagnostic Performance of a Multiple Real-Time PCR Assay in Patients with Suspected Sepsis Hospitalized in an Internal Medicine Ward

Pasqualini, L., Mencacci, A., Leli, C., Montagna, P., Cardaccia, A., Cenci, E., Montecarlo, I., Pirro, M., di Filippo, F., Cistaro, E., et al. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.06793-11 · Cited by 76 · see citing works

Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis

Gandoura, S., Weiss, E., Rautou, P., Fasseu, M., Gustot, T., Lemoine, F., Hurtado-Nédelec, M., Hego, C., Vadrot, N., Elkrief, L., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2012.12.025 · Cited by 76 · see citing works

Production of C-reactive protein in Escherichia coli-infected patients with liver dysfunction due to liver cirrhosis

Park, W. B., Lee, K.-D., Lee, C. S., Jang, H., Kim, H. B., Lee, H., Oh, M., & Choe, K. W. (2005) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2004.11.014 · Cited by 74 · see citing works

Longitudinal monocyte Human leukocyte antigen‐DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis

Berres, M., Schnyder, B., Yagmur, E., Inglis, B., Stanzel, S. F., Tischendorf, J. J. W., Koch, A. H., Winograd, R., Trautwein, C., & Wasmuth, H. E. (2009) · Liver International · doi:10.1111/j.1478-3231.2008.01870.x · Cited by 73 · see citing works

Ex vivo effects of high‐density lipoprotein exposure on the lipopolysaccharide‐induced inflammatory response in patients with severe cirrhosis†

Galbois, A., Thabut, D., Tazi, K. A., Rudler, M., Mohammadi, M. S., Bonnefont‐Rousselot, D., Bennani, H., Bezeaud, A., Tellier, Z., Guichard, C., et al. (2008) · Hepatology · doi:10.1002/hep.22582 · Cited by 72 · see citing works

Mesenteric Th1 polarization and monocyte TNF‐α production: First steps to systemic inflammation in rats with cirrhosis†

Muñoz, L., Albillos, A., Nieto, M., Reyes, E., Lledó, L., Monserrat, J., Sanz, E., de la Hera, A., & Alvarez‐Mon, M. (2005) · Hepatology · doi:10.1002/hep.20799 · Cited by 70 · see citing works

Increased tumour necrosis factor   production in mesenteric lymph nodes of cirrhotic patients with ascites

Genesca, J. (2003) · Gut · doi:10.1136/gut.52.7.1054 · Cited by 70 · see citing works

High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats

Thabut, D., Tazi, K. A., Bonnefont‐Rousselot, D., Aller, M., Farges, O., Guimont, M.-C., Tellier, Z., Guichard, C., Ogier‐Denis, É., Poynard, T., et al. (2007) · Hepatology · doi:10.1002/hep.21875 · Cited by 69 · see citing works

NOD2 gene variants are a risk factor for culture‐positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis

Bruns, T., Peter, J., Reuken, P. A., Grabe, D. H., Schuldes, S., Brenmoehl, J., Schölmerich, J., Wiest, R., & Stallmach, A. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02561.x · Cited by 69 · see citing works

Assessment of adrenal function in cirrhotic patients using concentration of serum-free and salivary cortisol

Thévenot, T., Borot, S., Rémy-Martin, A., Sapin, R., Cervoni, J., Richou, C., Vanlemmens, C., Cléau, D., Muel, E., Minello, A., et al. (2011) · Liver International · doi:10.1111/j.1478-3231.2010.02431.x · Cited by 68 · see citing works

Role of Toll-Like Receptor 4 in Mediating Multiorgan Dysfunction in Mice With Acetaminophen Induced Acute Liver Failure

Shah, N. K., de Oca, M. M., Jover‐Cobos, M., Tanamoto, K., Muroi, M., Sugiyama, K., Davies, N. A., Mookerjee, R. P., Dhar, D. K., & Jalan, R. (2013) · Liver Transplantation · doi:10.1002/lt.23655 · Cited by 67 · see citing works

Defective thymopoiesis and poor peripheral homeostatic replenishment of T-helper cells cause T-cell lymphopenia in cirrhosis

Lario, M., Muñoz, L., Cantera, M., Borrero, M.-J., Martínez, J., Monserrat, J., Díaz, D., Álvarez‐Mon, M., & Albillos, A. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.05.042 · Cited by 67 · see citing works

Interaction between intestinal dendritic cells and bacteria translocated from the gut in rats with cirrhosis

Muñoz, L., Borrero, M. J., Cantera, M., Lario, M., Díaz, D., Francés, R., Monserrat, J., Pastor, Ó., Aguado-Fraile, E., Such, J. M., et al. (2012) · Hepatology · doi:10.1002/hep.25854 · Cited by 64 · see citing works

Nosocomial and Community-Acquired Spontaneous Bacterial Peritonitis: Comparative Microbiology and Therapeutic Implications

Bert, F., Andreu, M., Durand, F., Degos, F., Galdbart, J., Moreau, R., Branger, C., Lambert-zechovsky, N., & Valla, D. C. (2003) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-002-0840-z · Cited by 62 · see citing works

Fecal calprotectin is a useful screening parameter for hepatic encephalopathy and spontaneous bacterial peritonitis in cirrhosis

Gundling, F., Schmidtler, F., Hapfelmeier, A., Schulte, B., Schmidt, T., Pehl, C., Schepp, W., & Seidl, H. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02577.x · Cited by 61 · see citing works

Rifaximin Reduces Endotoxemia and Improves Liver Function and Disease Severity in Patients With Decompensated Cirrhosis

Kalambokis, G. N., & Tsianos, E. V. (2011) · Hepatology · doi:10.1002/hep.24751 · Cited by 61 · see citing works

In vivo altered unfolded protein response and apoptosis in livers from lipopolysaccharide-challenged cirrhotic rats

Tazi, K. A., Bièche, I., Paradis, V., Guichard, C., Laurendeau, I., Dargère, D., Legrand, A., Fay, M., Pédruzzi, E., Robin, M., et al. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.01.034 · Cited by 60 · see citing works

Clinical Features and Prognosis of Spontaneous Bacterial Peritonitis in Korean Patients with Liver Cirrhosis: A Multicenter Retrospective Study

Heo, J., Seo, Y. S., Yim, H. J., Hahn, T., Park, S. H., Ahn, S. H., Park, J. Y., Park, J. Y., Kim, M. Y., Park, S. K., et al. (2009) · Gut and Liver · doi:10.5009/gnl.2009.3.3.197 · Cited by 59 · see citing works

Acute‐phase proteins as indicators of bacterial infection in patients with cirrhosis

Tsiakalos, A., Karatzaferis, A., Ziakas, P. D., & Hatzis, G. S. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02088.x · Cited by 59 · see citing works

Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells

Lin, H.-L., Liu, T., Lui, W., & Chi, C. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990501)85:9 · Cited by 57 · see citing works

Early diagnosis of resistant pathogens

Bhattacharya, S. (2013) · Virulence · doi:10.4161/viru.23326 · Cited by 57 · see citing works

Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients

Brenmoehl, J., Herfarth, H. H., Glück, T., Audebert, F., Barlage, S., Schmitz, G., Froehlich, D., Schreiber, S., Hampe, J., Schölmerich, J., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0722-z · Cited by 56 · see citing works

Glycogen synthase kinase 3 involvement in the excessive proinflammatory response to LPS in patients with decompensated cirrhosis

Coant, N., Rudler, M., Gustot, T., Fasseu, M., Gandoura, S., Ragot, K., Abdel‐Razek, W., Thabut, D., Lettéron, P., Ogier‐Denis, É., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.12.039 · Cited by 56 · see citing works

Prognostic Significance of Infection Acquisition Sites in Spontaneous Bacterial Peritonitis: Nosocomial versus Community Acquired

Song, J. Y., Jung, S. J., Park, C. W., Sohn, J. W., Kim, W. J., Kim, M. J., & Cheong, H. J. (2006) · Journal of Korean Medical Science · doi:10.3346/jkms.2006.21.4.666 · Cited by 55 · see citing works

Identification of Bacterial Pathogens in Ascitic Fluids from Patients with Suspected Spontaneous Bacterial Peritonitis by Use of Broad-Range PCR (16S PCR) Coupled with High-Resolution Melt Analysis

Hardick, J. P., Won, H. H., Jeng, K., Hsieh, Y., Gaydos, C. A., Rothman, R. E., & Yang, S. S. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.00345-12 · Cited by 50 · see citing works

Increased prevalence of intestinal inflammation in patients with liver cirrhosis

Saitoh, O. (1999) · World Journal of Gastroenterology · doi:10.3748/wjg.v5.i5.391 · Cited by 46 · see citing works

Procalcitonin as a Biomarker for Bacterial Infections in Patients With Liver Cirrhosis in the Emergency Department

Li, C.-H., Yang, R., Pang, J. S., Chang, S.-S., Lin, C., Chen, C.-H., Chen, H., & Chiu, T. (2011) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2010.00991.x · Cited by 45 · see citing works

Bacterial epidemiology and antimicrobial resistance in ascitic fluid: A 2-year retrospective study

Piroth, L., Péchinot, A., Minello, A., Jaulhac, B., Patry, I., Hadou, T., Hansmann, Y., Rabaud, C., Chavanet, P., & Neuwirth, C. (2009) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365540903244535 · Cited by 45 · see citing works

Role of host and bacterial virulence factors in Escherichia coli spontaneous bacterial peritonitis

Cereto, F., Herranz, X., Moreno, E., Andreu, A., Vergara, M., Fontanals, D., Roget, M., Simó, M., González, A., Prats, G., et al. (2008) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3282fc7390 · Cited by 44 · see citing works

Bacterial infections in cirrhosis: A growing problem with significant implications

Fernández, J., & Arroyo, V. (2013) · Clinical Liver Disease · doi:10.1002/cld.169 · Cited by 41 · see citing works

High serum levels of free cortisol indicate severity of cirrhosis in hemodynamically stable patients

Thévenot, T., Dorin, R. I., Monnet, É., Qualls, C., Sapin, R., Grandclément, É., Borot, S., Sheppard, F., Weil, D., Degand, T., et al. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2012.07188.x · Cited by 38 · see citing works

Increased intestinal permeability as a predictor of bacterial infections in patients with decompensated liver cirrhosis and hemorrhage

Kim, B. I., Kim, H. J., Park, J. H., Park, D. I., Cho, Y. K., Sohn, C. I., Jeon, W. K., Kim, H. S., & Kim, D. J. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06490.x · Cited by 37 · see citing works

Monocyte function in cirrhosis.

Holdstock, G., Leslie, B., Hill, S., Tanner, A. R., & Wright, R. (1982) · Journal of Clinical Pathology · doi:10.1136/jcp.35.9.972 · Cited by 37 · see citing works

A Recent Evaluation of Empirical Cephalosporin Treatment and Antibiotic Resistance of Changing Bacterial Profiles in Spontaneous Bacterial Peritonitis

Yakar, T., Güçlü, M., Serin, E., & Alışkan, H. E. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0825-1 · Cited by 36 · see citing works

Is detection of bacterial DNA in ascitic fluid of clinical relevance?

Appenrodt, B., Lehmann, L. E., Thyssen, L., Gentemann, M., Rabe, C., Molitor, E., Trebicka, J., Stuber, F. E., & Sauerbruch, T. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e328340c43a · Cited by 34 · see citing works

Serum lactate level predict mortality in elderly patients with cirrhosis

Taş, A., Akbal, E., Beyazıt, Y., & Koçak, E. (2012) · Wiener klinische Wochenschrift · doi:10.1007/s00508-012-0208-z · Cited by 32 · see citing works

High-density lipoproteins reduce the effect of endotoxin on cytokine production and systemic hemodynamics in cirrhotic rats with ascites

Ramírez‐Lázaro, M. J., Ibáñez, Á., Navasa, M., Casals, E., Morales‐Ruiz, M., Jiménez, W., Arroyo, V., & Rodés, J. (2003) · Journal of Hepatology · doi:10.1016/j.jhep.2003.11.017 · Cited by 30 · see citing works

Spontaneous bacterial peritonitis due to carbapenemase-producing Klebsiella pneumoniae

Piano, S. S., Romano, A., Rosi, S., Gatta, A., & Angeli, P. (2012) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e328355d8a2 · Cited by 26 · see citing works

Brain magnetic resonance in experimental acute‐on‐chronic liver failure

Chavarria, L., Oria, M., Romero‐Giménez, J., Alonso, J., Lope‐Piedrafita, S., & Córdoba, J. (2012) · Liver International · doi:10.1111/liv.12032 · Cited by 22 · see citing works

Uncovering the molecular events associated with increased intestinal permeability in liver cirrhosis: The pivotal role of enterocyte tight junctions and future perspectives

Assimakopoulos, S. F., & CHARONIS, A. S. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.06.031 · Cited by 19 · see citing works

The new epidemiology of nosocomial bacterial infections in cirrhosis: therapeutical implications

Acevedo, J., Silva, A., Prado, V., & Fernández, J. (2012) · Hepatology International · doi:10.1007/s12072-012-9396-x · Cited by 17 · see citing works

Protein array technology to investigate cytokine production by monocytes from patients with advanced alcoholic cirrhosis: An ex vivo pilot study

Tazi, K. A., Quioc, J., Abdel‐Razek, W., Tellier, Z., Guichard, C., Ogier‐Denis, É., Lebrec, D., & Moreau, R. (2009) · Hepatology Research · doi:10.1111/j.1872-034x.2009.00498.x · Cited by 15 · see citing works

[220] INTRAVENOUS ALBUMIN IS NOT NECESSARY IN CIRRHOTIC PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS AND LOW-RISK OF MORTALITY

Casas, M., Soriano, G., Ayala, E., Guarner, C., Ordás, Í., Mercé, J., Balanzó, J., & Guarner, C. (2007) · Journal of Hepatology · doi:10.1016/s0168-8278(07)61818-2 · Cited by 13 · see citing works

Mid-regional pro-adrenomedullin (MR-proADM): An even better prognostic biomarker than C-reactive protein to predict short-term survival in patients with decompensated cirrhosis at risk of infection?

Reuken, P. A., Kiehntopf, M., Stallmach, A., & Bruns, T. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.036 · Cited by 11 · see citing works

606 CYTOKINE PRODUCTION IN PATIENTS WITH CIRRHOSIS AND D299G AND/OR T399I TOLL-LIKE RECEPTOR 4 POLYMORPHISMS

Soriano, G., Sánchez, E., Nieto, J. C., Román, E. M., Vidal, S., Oliva, L., Guarner, C., Poca, M., Torras, X., Juárez, C., et al. (2013) · Journal of Hepatology · doi:10.1016/s0168-8278(13)60608-x · Cited by 2 · see citing works

[Is D-lactate assay useful for the diagnosis of ascitic infection in patients with liver cirrhosis?].

Pelletier, G., Brivet, M., Ducreux, M. P., Briantais, M. J., Lemonnier, A., & Etienne, J. P. (1993) · PubMed · Cited by 2 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works

EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

Angeli, P., Bernardi, M., Villanueva, C., Francoz, C., Mookerjee, R. P., Trebicka, J., Krag, A. A., Laleman, W., & Ginès, P. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.024 · Cited by 2,949 · see citing works

Liver cirrhosis

Ginès, P., Krag, A., Abraldes, J. G., Solà, E., Fabrellas, N., & Kamath, P. S. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01374-x · Cited by 1,663 · see citing works

Liver Macrophages in Tissue Homeostasis and Disease

Krenkel, O., & Tacke, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.11 · Cited by 1,424 · see citing works

Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance

Albillos, A., Lario, M., & Álvarez-Mon, M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.010 · Cited by 1,242 · see citing works

Targeting hepatic macrophages to treat liver diseases

Tacke, F. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.02.026 · Cited by 1,003 · see citing works

EASL Clinical Practice Guidelines: Management of alcohol-related liver disease

Thursz, M. R., Gual, A., Lackner, C., Mathurin, P., Moreno, C., Spahr, L., Sterneck, M. R., & Cortez‐Pinto, H. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.018 · Cited by 953 · see citing works

Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure

Clària, J., Stauber, R. E., Coenraad, M. J., Moreau, R., Jalan, R., Pavesi, M., Amorós, À., Titos, E., Alcaraz‐Quiles, J., Oettl, K., et al. (2016) · Hepatology · doi:10.1002/hep.28740 · Cited by 774 · see citing works

Liver — guardian, modifier and target of sepsis

Strnad, P., Tacke, F., Koch, A., & Trautwein, C. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.168 · Cited by 692 · see citing works

The gut microbiome and liver cancer: mechanisms and clinical translation

Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634 · see citing works

Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications

Nahon, P., Bourcier, V., Layese, R., Audureau, É., Cagnot, C., Marcellin, P., Guyader, D., Fontaine, H., Larrey, D. G., Lédinghen, V. D., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.009 · Cited by 532 · see citing works

Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide

Piano, S. S., Singh, V., Caraceni, P., Maiwall, R., Alessandria, C., Fernández, J., Soares, E. C., Kim, D. J., Kim, S. E., Marino, M., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.12.005 · Cited by 528 · see citing works

Clinical states of cirrhosis and competing risks

D'Amico, G., Morabito, A., D'Amico, M., Pasta, L., Malizia, G., Rebora, P., & Valsecchi, M. G. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.10.020 · Cited by 536 · see citing works

Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy

Rose, C. F., Amodio, P., Bajaj, J. S., Dhiman, R. K., Montagnese, S., Taylor-Robinson, S. D., Vilstrup, H., & Jalan, R. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.07.013 · Cited by 473 · see citing works

Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis

Arroyo, V., Moreau, R., Jalan, R., & Ginès, P. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.11.045 · Cited by 459 · see citing works

Acute-on-chronic liver failure in cirrhosis

Arroyo, V., Moreau, R., Kamath, P. S., Jalan, R., Ginès, P., Nevens, F., Fernández, J., To, U. K., García–Tsao, G., & Schnabl, B. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.41 · Cited by 442 · see citing works

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

Heymann, F., Peusquens, J., Ludwig‐Portugall, I., Kohlhepp, M. S., Ergen, C., Niemietz, P. M., Martin, C., van Rooijen, N., Ochando, J., Randolph, G. J., et al. (2015) · Hepatology · doi:10.1002/hep.27793 · Cited by 396 · see citing works

Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with acute-on-chronic liver failure in Europe

Fernández, J., Prado, V., Trebicka, J., Amorós, À., Gustot, T., Wiest, R., Deulofeu, C., García, E., Acevedo, J., Fuhrmann, V., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.027 · Cited by 376 · see citing works

Acute-on-chronic liver failure

Bernal, W. E., Jalan, R., Quaglia, A., Simpson, K. J., Wendon, J. A., & Burroughs, A. K. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00309-8 · Cited by 336 · see citing works

Management of the critically ill patient with cirrhosis: A multidisciplinary perspective

Nadim, M. K., Durand, F., Kellum, J. A., Levitsky, J., O’Leary, J. G., Karvellas, C. J., Bajaj, J. S., Davenport, A., Jalan, R., Angeli, P., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.019 · Cited by 297 · see citing works

NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis

O’Leary, J. G., Reddy, K. R., García–Tsao, G., Biggins, S. W., Wong, F. S.-H., Fallon, M. B., Subramanian, R., Kamath, P. S., Thuluvath, P. J., Vargas, H. E., et al. (2018) · Hepatology · doi:10.1002/hep.29773 · Cited by 271 · see citing works

FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis

Sorribas, M., Jakob, M. O., Yılmaz, B., Li, H., Stutz, D., Noser, Y., Gottardi, A. D., Moghadamrad, S., Hassan, M., Albillos, A., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.06.017 · Cited by 256 · see citing works

Albumin in chronic liver disease: structure, functions and therapeutic implications

Spinella, R., Sawhney, R., & Jalan, R. (2015) · Hepatology International · doi:10.1007/s12072-015-9665-6 · Cited by 242 · see citing works

The empirical antibiotic treatment of nosocomial spontaneous bacterial peritonitis: Results of a randomized, controlled clinical trial

Piano, S. S., Fasolato, S., Salinas, F., Romano, A., Tonon, M., Morando, F., Cavallin, M., Gola, E., Sticca, A., Loregian, A., et al. (2015) · Hepatology · doi:10.1002/hep.27941 · Cited by 244 · see citing works

Towards a new definition of decompensated cirrhosis

D’Amico, G., Bernardi, M., & Angeli, P. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.06.018 · Cited by 236 · see citing works

Gut–liver axis, cirrhosis and portal hypertension: the chicken and the egg

Arab, J. P., Martín‐Mateos, R., & Shah, V. H. (2017) · Hepatology International · doi:10.1007/s12072-017-9798-x · Cited by 229 · see citing works

The Evolving Challenge of Infections in Cirrhosis

Bajaj, J. S., Kamath, P. S., & Reddy, K. R. (2021) · New England Journal of Medicine · doi:10.1056/nejmra2021808 · Cited by 225 · see citing works

EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients

Cornberg, M., Buti, M., Eberhardt, C. S., Grossi, P., & Shouval, D. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.01.032 · Cited by 206 · see citing works

Antibiotic prophylaxis in cirrhosis: Good and bad

Fernández, J., Tandon, P., Mensa, J., & García–Tsao, G. (2015) · Hepatology · doi:10.1002/hep.28330 · Cited by 205 · see citing works

The challenges of multi-drug-resistance in hepatology

Fernández, J., Bert, F., & Nicolas-Chanoine, M.-H. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.08.006 · Cited by 187 · see citing works

Acute liver failure

Maiwall, R., Kulkarni, A. V., Arab, J. P., & Piano, S. S. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00693-7 · Cited by 195 · see citing works

Malnutrition in Patients with Liver Cirrhosis

Traub, J., Reiss, L., Aliwa, B. O., & Stadlbauer, V. (2021) · Nutrients · doi:10.3390/nu13020540 · Cited by 179 · see citing works

The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction

Schwabl, P., Hambruch, E., Seeland, B. A., Hayden, H., Wagner, M., Garnys, L., Strobel, B., Schubert, T.-L., Riedl, F., Mitteregger, D., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.12.005 · Cited by 178 · see citing works

Immune Dysfunction in Cirrhosis

Noor, M. T., & Manoria, P. (2017) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2016.00056 · Cited by 174 · see citing works

Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis

Solé, C., Guilly, S., Silva, K. D., Llopis, M., Chatelier, E. L., Huelin, P., Carol, M., Moreira, R., Fabrellas, N., de Prada, G., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.08.054 · Cited by 179 · see citing works

Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure

Engelmann, C., Sheikh, M., Sharma, S., Kondo, T., Loeffler-Wirth, H., Zheng, Y. B., Novelli, S., Hall, A., Kerbert, A. J. C., Macnaughtan, J., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.01.011 · Cited by 174 · see citing works

Causes and Consequences of Innate Immune Dysfunction in Cirrhosis

Irvine, K. M., Ratnasekera, I. U., Powell, E. E., & Hume, D. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00293 · Cited by 173 · see citing works

Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure

Wong, F. S.-H., Piano, S. S., Singh, V., Bartoletti, M., Maiwall, R., Alessandria, C., Fernández, J., Soares, E. C., Kim, D. J., Kim, S. E., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.07.046 · Cited by 173 · see citing works

Infections complicating cirrhosis

Piano, S. S., Brocca, A., Mareso, S., & Angeli, P. (2018) · Liver International · doi:10.1111/liv.13645 · Cited by 169 · see citing works

Management of bacterial and fungal infections in cirrhosis: The MDRO challenge

Fernández, J., Piano, S. S., Bartoletti, M., & Wey, E. Q. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.11.010 · Cited by 170 · see citing works

Characteristics, Diagnosis and Prognosis of Acute-on-Chronic Liver Failure in Cirrhosis Associated to Hepatitis B.

Li, H., Chen, L., Zhang, N., Li, S., Zeng, B., Pavesi, M., Amorós, À., Mookerjee, R. P., Xia, Q., Xue, F., et al. (2016) · Scientific Reports · doi:10.1038/srep25487 · Cited by 161 · see citing works

Cell therapy for advanced liver diseases: repair or rebuild

Dwyer, B. J., Macmillan, M. T., Brennan, P. N., & Forbes, S. J. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.09.014 · Cited by 141 · see citing works

Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections

Piano, S. S., Bartoletti, M., Tonon, M., Baldassarre, M., Chies, G., Romano, A., Viale, P., Vettore, E., Domenicali, M., Stanco, M., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-314324 · Cited by 145 · see citing works

Spontaneous bacterial peritonitis in patients with cirrhosis: incidence, outcomes, and treatment strategies

Marciano, S., Díaz, J. M., Dirchwolf, M., & Gadano, A. C. (2019) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s164250 · Cited by 149 · see citing works

Complications and competing risks of death in compensated viral cirrhosis (ANRS CO12 CirVir prospective cohort)

Trinchet, J., Bourcier, V., Chaffaut, C., Ait‐Ahmed, M., Allam, S., Marcellin, P., Guyader, D., Pol, S., Larrey, D. G., de Lédinghen, V., et al. (2015) · Hepatology · doi:10.1002/hep.27743 · Cited by 138 · see citing works

Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis

Ariza, X., Graupera, I., Coll, M., Solà, E., Barreto, R., García, E., Moreira, R., Elia, C., Morales‐Ruiz, M., Llopis, M., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.03.002 · Cited by 137 · see citing works

Characterization of Inflammatory Response in Acute-on-Chronic Liver Failure and Relationship with Prognosis

Solé, C., Solà, E., Morales‐Ruiz, M., Fernández, G., Huelin, P., Graupera, I., Moreira, R., de Prada, G., Ariza, X., Pose, E., et al. (2016) · Scientific Reports · doi:10.1038/srep32341 · Cited by 137 · see citing works

Liver resection for cancer: New developments in prediction, prevention and management of postresectional liver failure

van Mierlo, K. M. C., Schaap, F. G., Dejong, C. H. C., & Damink, S. W. M. O. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.06.006 · Cited by 130 · see citing works

Analysis of a Urinary Biomarker Panel for Clinical Outcomes Assessment in Cirrhosis

Ariza, X., Solà, E., Elia, C., Barreto, R., Moreira, R., Morales‐Ruiz, M., Graupera, I., Rodríguez, E., Huelin, P., Solé, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128145 · Cited by 129 · see citing works

Role of systemic inflammation in cirrhosis: From pathogenesis to prognosis

Dirchwolf, M. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i16.1974 · Cited by 120 · see citing works

Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH)

Arab, J. P., Roblero, J. P., Altamirano, J., Bessone, F., Araújo, R. C., la Tijera, F. H., Restrepo, J. C., Torre, A., Urzua, A. M., Simonetto, D. A., et al. (2019) · Annals of Hepatology · doi:10.1016/j.aohep.2019.04.005 · Cited by 122 · see citing works

Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis

Horvath, A., Leber, B., Schmerboeck, B., Tawdrous, M., Zettel, G., Hartl, A., Madl, T., Stryeck, S., Fuchs, D., Lemesch, S., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13788 · Cited by 118 · see citing works

Immune dysfunction in cirrhosis: Distinct cytokines phenotypes according to cirrhosis severity

Dirchwolf, M., Podhorzer, A., Marino, M., Shulman, C., Cartier, M., Zunino, M., Paz, S., Muñoz, A., Bocassi, A., Gimenez, J., et al. (2015) · Cytokine · doi:10.1016/j.cyto.2015.10.006 · Cited by 116 · see citing works

Bacterial Infections Change Natural History of Cirrhosis Irrespective of Liver Disease Severity

Dionigi, E., Garcovich, M., Borzio, M., Leandro, G., Majumdar, A., Aikaterini, T., Arvaniti, V., Roccarina, D., Pinzani, M., Burroughs, A. K., et al. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.19 · Cited by 116 · see citing works

Acute kidney injury in acute-on-chronic liver failure: where does hepatorenal syndrome fit?

Davenport, A., Sheikh, M., Lamb, E. J., Agarwal, B., & Jalan, R. (2017) · Kidney International · doi:10.1016/j.kint.2017.04.048 · Cited by 115 · see citing works

Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation

Bolte, F. J., Bolte, A. C., Webb, L. M., Serti, E., Rivera, E., Liang, T. J., Ghany, M. G., & Rehermann, B. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.043 · Cited by 116 · see citing works

Von Willebrand factor indicates bacterial translocation, inflammation, and procoagulant imbalance and predicts complications independently of portal hypertension severity

Mandorfer, M., Schwabl, P., Paternostro, R., Pomej, K., Bauer, D. J. M., Thaler, J., Ay, C., Quehenberger, P., Fritzer‐Szekeres, M., Peck‐Radosavljevic, M., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14522 · Cited by 112 · see citing works

Sepsis in alcohol-related liver disease

Gustot, T., Fernández, J., Szabó, G., Albillos, A., Louvet, A., Jalan, R., Moreau, R., & Moreno, C. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.06.013 · Cited by 108 · see citing works

Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome

Bucsics, T., & Krones, E. (2017) · Gastroenterology report · doi:10.1093/gastro/gox009 · Cited by 108 · see citing works

Review article: therapeutic aspects of bile acid signalling in the gut‐liver axis

Simbrunner, B., Trauner, M. A., & Reiberger, T. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16602 · Cited by 107 · see citing works

Sex-hormone-driven innate antibodies protect females and infants against EPEC infection

Zeng, Z., Surewaard, B. G. J., Wong, C. H. Y., Guettler, C., Petri, B., Burkhard, R., Wyss, M., Le Moual, H., Devinney, R., Thompson, G. C., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0211-2 · Cited by 96 · see citing works

Heterogeneity and Function of Kupffer Cells in Liver Injury

Li, W., Chang, N., & Li, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940867 · Cited by 102 · see citing works

Aktualisierte S2k-Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) „Komplikationen der Leberzirrhose“

Gerbes, A. L., Labenz, J., Appenrodt, B., Dollinger, M. M., Gundling, F., Gülberg, V., Holstege, A., Lynen-Jansen, P., Steib, C. J., Trebicka, J., et al. (2019) · Zeitschrift für Gastroenterologie · doi:10.1055/a-0873-4658 · Cited by 102 · see citing works

The multifactorial mechanisms of bacterial infection in decompensated cirrhosis

der Merwe, V., Chokshi, S., Bernsmeier, C., & Albillos, A. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.11.029 · Cited by 102 · see citing works

Advances and challenges in cirrhosis and portal hypertension

Berzigotti, A. (2017) · BMC Medicine · doi:10.1186/s12916-017-0966-6 · Cited by 99 · see citing works

A prospective multicentre study of the epidemiology and outcomes of bloodstream infection in cirrhotic patients

Bartoletti, M., Giannella, M., Lewis, R. E., Caraceni, P., Tedeschi, S., Paul, M., Schramm, C., Bruns, T., Merli, M., Cobos-Trigueros, N., et al. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.08.001 · Cited by 97 · see citing works

Bloodstream infections in patients with liver cirrhosis

Bartoletti, M., Giannella, M., Lewis, R. E., & Viale, P. (2016) · Virulence · doi:10.1080/21505594.2016.1141162 · Cited by 96 · see citing works

Limitations of current techniques in clinical antimicrobial resistance diagnosis: examples and future prospects

Hassall, J., Coxon, C. H., Patel, V., Goldenberg, S. D., & Sergaki, C. (2024) · npj Antimicrobials and Resistance · doi:10.1038/s44259-024-00033-8 · Cited by 101 · see citing works

Infections in cirrhosis

Piano, S. S., Bunchorntavakul, C., Marciano, S., & Reddy, K. R. (2024) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(24)00078-5 · Cited by 95 · see citing works

Management of ascites and hepatorenal syndrome

Piano, S. S., Tonon, M., & Angeli, P. (2017) · Hepatology International · doi:10.1007/s12072-017-9815-0 · Cited by 90 · see citing works

Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver

Lopetuso, L. R., Mocci, G., Marzo, M., D’Aversa, F., Rapaccini, G. L., Guidi, L., Armuzzi, A., Gasbarrini, A., & Papa, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082199 · Cited by 88 · see citing works

Overview of Complications in Cirrhosis

Premkumar, M., & Anand, A. C. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.04.021 · Cited by 88 · see citing works

Insufficient Protein Intake Is Associated With Increased Mortality in 630 Patients With Cirrhosis Awaiting Liver Transplantation.

Ney, M., Abraldes, J., Ma, M., Belland, D., Harvey, A., Robbins, S., Heyer, V. D., & Tandon, P. (2015) · Nutrition in clinical practice · doi:10.1177/0884533614567716 · Cited by 85 · see citing works

Bacterial translocation markers in liver cirrhosis

Alexopoulou, A. A. (2017) · Annals of Gastroenterology · doi:10.20524/aog.2017.0178 · Cited by 87 · see citing works

Acute-on-chronic liver failure (ACLF): the ‘Kyoto Consensus’—steps from Asia

Choudhury, A. K., Kulkarni, A. V., Arora, V., Soin, A. S., Dökmeci, A. K., Chowdhury, A., Koshy, A., Duseja, A. K., Kumar, A., Mishra, A. K., et al. (2025) · Hepatology International · doi:10.1007/s12072-024-10773-4 · Cited by 93 · see citing works

Spontaneous bacterial and fungal peritonitis in patients with liver cirrhosis: A literature review

Shizuma, T. (2018) · World Journal of Hepatology · doi:10.4254/wjh.v10.i2.254 · Cited by 86 · see citing works

Rectal colonization by resistant bacteria increases the risk of infection by the colonizing strain in critically ill patients with cirrhosis

Prado, V., Hernández‐Tejero, M., Mücke, M. M., Marco, F., Gu, W., Amorós, À., Toapanta, D., Reverter, E., de la Peña-Ramirez, C., Altenpeter, L., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.12.042 · Cited by 87 · see citing works

Low skeletal muscle mass is associated with increased hospital costs in patients with cirrhosis listed for liver transplantation-a retrospective study

van Vugt, J. L. A., Buettner, S., Alferink, L. J. M., Bossche, N., de Bruin, R. W. F., Murad, S. D., Polak, W. G., Metselaar, H. J., & IJzermans, J. N. M. (2017) · Transplant International · doi:10.1111/tri.13048 · Cited by 83 · see citing works

Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications

Tsiaoussis, G. I. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i17.2058 · Cited by 82 · see citing works

Perioperative Care of Patients With Liver Cirrhosis: A Review

Abbas, N., Makker, J. S., Abbas, H., & Balar, B. (2017) · Health Services Insights · doi:10.1177/1178632917691270 · Cited by 82 · see citing works

Bacterial infection in compensated viral cirrhosis impairs 5-year survival (ANRS CO12 CirVir prospective cohort)

Nahon, P., Lescat, M., Layese, R., Bourcier, V., Talmat, N., Allam, S., Marcellin, P., Guyader, D., Pol, S., Larrey, D. G., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-310275 · Cited by 79 · see citing works

High risk of delisting or death in liver transplant candidates following infections: Results from the North American consortium for the study of end‐stage liver disease

Reddy, K. R., O’Leary, J. G., Kamath, P. S., Fallon, M. B., Biggins, S. W., Wong, F. S.-H., Patton, H. M., García–Tsao, G., Subramanian, R., Thacker, L. R., et al. (2015) · Liver Transplantation · doi:10.1002/lt.24139 · Cited by 80 · see citing works

An empirical broad spectrum antibiotic therapy in health‐care–associated infections improves survival in patients with cirrhosis: A randomized trial

Merli, M., Lucidi, C., Gregorio, V. D., Lattanzi, B., Giannelli, V., Giusto, M., Farcomeni, A., Ceccarelli, G., Falcone, M., Riggio, O., et al. (2015) · Hepatology · doi:10.1002/hep.28332 · Cited by 80 · see citing works

Novel perspectives in the management of decompensated cirrhosis

Bernardi, M., & Caraceni, P. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0045-2 · Cited by 79 · see citing works

Multidrug-Resistant Bacterial Infections in Solid Organ Transplant Candidates and Recipients

Bartoletti, M., Giannella, M., Tedeschi, S., & Viale, P. (2018) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2018.04.004 · Cited by 83 · see citing works

Proposal for shorter antibiotic therapies

Wintenberger, C., Guery, B. P., Bonnet, É., Castan, B., Cohen, R., Diamantis, S., Lesprit, P., Maulin, L., Pean, Y., Péju, E., et al. (2017) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2017.01.007 · Cited by 79 · see citing works

Acute kidney injury and hepatorenal syndrome in cirrhosis

Gupta, K., Bhurwal, A., Law, C., Ventre, S., Minacapelli, C. D., Kabaria, S., Li, Y., Tait, C., Catalano, C., & Rustgi, V. K. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i26.3984 · Cited by 82 · see citing works

Sepsis and Risk of Cancer Among Elderly Adults in the United States

Liu, Z., Mahale, P. S., & Engels, E. A. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy530 · Cited by 76 · see citing works

Invasive fungal infections amongst patients with acute‐on‐chronic liver failure at high risk for fungal infections

Verma, N., Singh, S., Taneja, S., Duseja, A. K., Singh, V., Dhiman, R. K., Chakrabarti, A., & Chawla, Y. K. (2018) · Liver International · doi:10.1111/liv.13981 · Cited by 76 · see citing works

The impact of infection by multidrug‐resistant agents in patients with cirrhosis. A multicenter prospective study

Salerno, F., Borzio, M., Pedicino, C., Simonetti, R. G., Rossini, A., Boccia, S., Cacciola, I., Burroughs, A. K., Manini, M. A., Mura, V. L., et al. (2016) · Liver International · doi:10.1111/liv.13195 · Cited by 74 · see citing works

Determinants of mortality in patients with cirrhosis and uncontrolled variceal bleeding

Kumar, R., Kerbert, A. J. C., Sheikh, M., Roth, N. P. G., Calvão, J., Mesquita, M., Barreira, A. I., Gurm, H. S., Ramsahye, K., Mookerjee, R. P., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.06.010 · Cited by 74 · see citing works

Gut microbiota in non‐alcoholic fatty liver disease and alcohol‐related liver disease: Current concepts and perspectives

Arab, J. P., Arrese, M. A., & Shah, V. H. (2019) · Hepatology Research · doi:10.1111/hepr.13473 · Cited by 72 · see citing works

Changes in the epidemiology and management of bacterial infections in cirrhosis

Piano, S. S., Tonon, M., & Angeli, P. (2021) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0329 · Cited by 69 · see citing works

Immune checkpoint receptors: homeostatic regulators of immunity

Riva, A., & Chokshi, S. (2018) · Hepatology International · doi:10.1007/s12072-018-9867-9 · Cited by 70 · see citing works

Bacterial infections adversely influence the risk of decompensation and survival in compensated cirrhosis

Villanueva, C., Albillos, A., Genescà, J., García‐Pagán, J. C., Brujats, A., Calleja, J. L., Aracil, C., Bañares, R., Morillas, R. M., Poca, M., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.04.022 · Cited by 69 · see citing works

Hepatorenal Syndrome in Cirrhosis

Pose, E., Piano, S. S., Juanola, A., & Ginès, P. (2024) · Gastroenterology · doi:10.1053/j.gastro.2023.11.306 · Cited by 69 · see citing works

Low 25-Hydroxyvitamin D Levels Are Associated with Infections and Mortality in Patients with Cirrhosis

Finkelmeier, F., Kronenberger, B., Zeuzem, S., Piiper, A., & Waidmann, O. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132119 · Cited by 69 · see citing works

Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver

Lutz, P. L. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i3.304 · Cited by 65 · see citing works

Antibiotic resistance in healthcare‐related and nosocomial spontaneous bacterial peritonitis

Lutz, P. L., Nischalke, H. D., Krämer, B., Goeser, F., Kaczmarek, D. J., Schlabe, S., Parčina, M., Nattermann, J., Hoerauf, A. M., Strassburg, C. P., et al. (2016) · European Journal of Clinical Investigation · doi:10.1111/eci.12701 · Cited by 66 · see citing works

Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease

Tan-Garcia, A., Wai, L.-E., Zheng, D., Ceccarello, E., Jo, J., Banu, N., Khakpoor, A., Chia, A., Tham, C. Y. L., Tan, A. T., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.04.023 · Cited by 68 · see citing works

Bacterial Infection in Patients with Cirrhosis: Don’t Get Bugged to Death

Cannon, M. D., Martin, P. B., & Carrion, A. F. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05943-6 · Cited by 21 · see citing works

Bacterial infections in cirrhosis: A critical review and practical guidance

Bunchorntavakul, C., Chamroonkul, N., & Chavalitdhamrong, D. (2016) · World Journal of Hepatology · doi:10.4254/wjh.v8.i6.307 · Cited by 227 · see citing works

Infections related morbidity and mortality in the cirrhosis of the liver

Krasniqi, A. (2020)

Acute-on-chronic liver failure due to bacterial infection in liver cirrhosis: causes and management

Han, T. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.3969/j.issn.1001-5256.2015.09.012

Infections in cirrhosis

Piano, S. S., Bunchorntavakul, C., Marciano, S., & Reddy, K. R. (2024) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(24)00078-5 · Cited by 95 · see citing works