The gut–liver axis and gut microbiota in health and liver disease

An obesity-associated gut microbiome with increased capacity for energy harvest

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A human gut microbial gene catalogue established by metagenomic sequencing

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Diversity of the Human Intestinal Microbial Flora

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Enterotypes of the human gut microbiome

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The gut microbiota as an environmental factor that regulates fat storage

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Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

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Revised Estimates for the Number of Human and Bacteria Cells in the Body

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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

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Gut microbiota in human metabolic health and disease

Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724 · see citing works

Intestinal mucosal barrier function in health and disease

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Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781 · see citing works

Non-alcoholic fatty liver disease

Powell, E. E., Wong, V. W.-S., & Rinella, M. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32511-3 · Cited by 2,789 · see citing works

The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530 · see citing works

The International Scientific Association of Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Postbiotics

Salminen, S., Collado, M. C., Endo, A., Hill, C., Lebeer, S., Quigley, E. M. M., Sanders, M. E., Shamir, R., Swann, J. R., Szajewska, H., et al. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00440-6 · Cited by 2,488 · see citing works

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study

Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357 · see citing works

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

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The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Swanson, K. S., Gibson, G. R., Hutkins, R., Reimer, R. A., Reid, G., Verbeke, K., Scott, K. P., Holscher, H. D., Azad, M. B., Delzenne, N. M., et al. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0344-2 · Cited by 2,196 · see citing works

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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Epidemiology and Management of Hepatocellular Carcinoma

Kulik, L., & El‐Serag, H. B. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.08.065 · Cited by 1,738 · see citing works

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

Zhu, L., Baker, S. S., Gill, C., Liu, W., Alkhouri, R., Baker, R. D., & Gill, S. R. (2013) · Hepatology · doi:10.1002/hep.26093 · Cited by 1,708 · see citing works

H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE

Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623 · see citing works

Neurotransmitter modulation by the gut microbiota

Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527 · see citing works

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

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Bile acid metabolites control TH17 and Treg cell differentiation

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The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412 · see citing works

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346 · see citing works

Drug-Resistant <i>E. coli</i> Bacteremia Transmitted by Fecal Microbiota Transplant

DeFilipp, Z., Bloom, P. P., Torres Soto, M., Mansour, M. K., Sater, M. R. A., Huntley, M. H., Turbett, S., Chung, R. T., Chen, Y.-B., & Hohmann, E. L. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1910437 · Cited by 1,281 · see citing works

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., Yu, R. T., Shelton, J. M., Richardson, J. A., Repa, J. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509592103 · Cited by 1,164 · see citing works

Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease

Loomba, R., Seguritan, V., Li, W., Long, T., Klitgord, N., Bhatt, A., Dulai, P. S., Caussy, C., Bettencourt, R., Highlander, S. K., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.001 · Cited by 1,123 · see citing works

Gut microbiota and cardiovascular disease.

Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051 · see citing works

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

Schulthess, J., Pandey, S., Capitani, M., Rue-Albrecht, K. C., Arnold, I., Franchini, F., Chomka, A., Ilott, N. E., Johnston, D. G. W., Pires, E., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.018 · Cited by 1,037 · see citing works

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

Song, X., Sun, X., Oh, S. F., Wu, M., Zhang, Y., Zheng, W., Geva-Zatorsky, N., Jupp, R., Mathis, D., Benoist, C., et al. (2020) · Nature · doi:10.1038/s41586-019-1865-0 · Cited by 1,024 · see citing works

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

Leclercq, S., Matamoros, S., Cani, P. D., Neyrinck, A. M., Jamar, F., Stärkel, P., Windey, K., Tremaroli, V., Bäckhed, F., Verbeke, K., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415174111 · Cited by 972 · see citing works

The human gut virome: inter-individual variation and dynamic response to diet

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Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

Campbell, C., McKenney, P. T., Konstantinovsky, D., Isaeva, O. I., Schizas, M., Verter, J., Mai, C., Jin, W.-B., Guo, C.-J., Violante, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2193-0 · Cited by 901 · see citing works

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

Duan, Y., Llorente, C., Lang, S., Brandl, K., Chu, H., Jiang, L., White, R. C., Clarke, T. H., Nguyen, K., Torralba, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1742-x · Cited by 851 · see citing works

Antibiotic Prophylaxis for the Prevention of Bacterial Infections in Cirrhotic Patients With Gastrointestinal Bleeding: A Meta–Analysis

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Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

Kakiyama, G., Pandak, W. M., Gillevet, P. M., Hylemon, P. B., Heuman, D. M., Daita, K., Takei, H., Muto, A., Nittono, H., Ridlon, J. M., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.01.003 · Cited by 782 · see citing works

Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers

Schmidt, T. M., Baxter, N. T., Waldron, C., Alexander, S. W., Venkataraman, A., & Kim, K. (2019) · mBio · doi:10.1128/mbio.02566-18 · Cited by 773 · see citing works

Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma

Ren, Z., Li, A., Jiang, J., Zhou, L., Yu, Z., Lu, H., Xie, H., Chen, X., Shao, L., Zhang, R., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315084 · Cited by 772 · see citing works

Colonocyte metabolism shapes the gut microbiota

Litvak, Y., Byndloss, M. X., & Bäumler, A. J. (2018) · Science · doi:10.1126/science.aat9076 · Cited by 765 · see citing works

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Fang, S., Suh, J. M., Reilly, S. M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3760 · Cited by 738 · see citing works

Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

Jiao, N., Baker, S. S., Chapa-Rodriguez, A., Liu, W., Nugent, C. A., Tsompana, M., Mastrandrea, L., Buck, M. J., Baker, R. D., Genco, R. J., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314307 · Cited by 737 · see citing works

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

Hoyles, L., Fernández-Real, J.-M., Federici, M., Serino, M., Abbott, J., Charpentier, J., Heymes, C., Luque, J. L., Anthony, E., Barton, R. H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0061-3 · Cited by 720 · see citing works

The composition of the gut microbiota shapes the colon mucus barrier

Jakobsson, H. E., Rodríguez‐Piñeiro, A. M., Schütte, A., Ermund, A., Boysen, P., Bemark, M., Sommer, F., Bäckhed, F., Hansson, G. C., & Johansson, M. E. (2015) · The EMBO Reports · doi:10.15252/embr.201439263 · Cited by 700 · see citing works

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z.-Z., Takahashi, S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76738 · Cited by 693 · see citing works

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

Mouries, J., Brescia, P., Silvestri, A., Spadoni, I., Sorribas, M., Wiest, R., Mileti, E., Galbiati, M., Invernizzi, P., Adorini, L., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.08.005 · Cited by 688 · see citing works

Hepatocellular Carcinoma Is Associated With Gut Microbiota Profile and Inflammation in Nonalcoholic Fatty Liver Disease

Ponziani, F. R., Bhoori, S., Castelli, C., Putignani, L., Rivoltini, L., CHIERICO, F. D., Sanguinetti, M., Morelli, D., Sterbini, F. P., Petito, V., et al. (2018) · Hepatology · doi:10.1002/hep.30036 · Cited by 670 · see citing works

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial

Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., Kheradman, R., Heuman, D. M., Wang, J., Gurry, T., et al. (2017) · Hepatology · doi:10.1002/hep.29306 · Cited by 637 · see citing works

Recovery of ethanol-induced <i>Akkermansia muciniphila</i> depletion ameliorates alcoholic liver disease

Grander, C., Adolph, T. E., Wieser, V., Lowe, P., Wrzosek, L., Gyongyosi, B., Ward, D. V., Grabherr, F., Gerner, R. R., Pfister, A., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313432 · Cited by 618 · see citing works

Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease

Llopis, M., Cassard, A., Wrzosek, L., Boschat, L., Bruneau, A., Ferrere, G., Puchois, V., Martin, J., Lepage, P., Roy, T. L., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-310585 · Cited by 562 · see citing works

SER-109, an Oral Microbiome Therapy for Recurrent <i>Clostridioides difficile</i> Infection

Feuerstadt, P., Louie, T. J., Lashner, B., Wang, E. E. L., Diao, L., Bryant, J. A., Sims, M., Kraft, C. S., Cohen, S. H., Berenson, C. S., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2106516 · Cited by 558 · see citing works

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella Pneumoniae

Yuan, J., Chen, C., Cui, J., Lu, J., Yan, C., Wei, X., Zhao, X., Li, N., Li, S., Xue, G., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.018 · Cited by 548 · see citing works

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Singh, V., Yeoh, B. S., Chassaing, B., Xiao, X., Saha, P., Aguilera Olvera, R., Lapek, J. D., Zhang, L., Wang, W.-B., Hao, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.004 · Cited by 532 · see citing works

Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology

Fuchs, C. D., & Trauner, M. (2022) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-021-00566-7 · Cited by 490 · see citing works

Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans

Bacher, P., Hohnstein, T., Beerbaum, E., Röcker, M., Blango, M. G., Kaufmann, S., Röhmel, J., Eschenhagen, P., Grehn, C., Seidel, K., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.041 · Cited by 473 · see citing works

The microbiome and gut homeostasis

Lee, J., Tsolis, R. M., & Bäumler, A. J. (2022) · Science · doi:10.1126/science.abp9960 · Cited by 430 · see citing works

NGM282 for treatment of non-alcoholic steatohepatitis: A multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Harrison, S. A., Rinella, M. E., Abdelmalek, M. F., Trotter, J. F., Paredes, A. H., Arnold, H. L., Kugelmas, M., Bashir, M. R., Jaros, M. J., Ling, L., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30474-4 · Cited by 425 · see citing works

Bile Acids as Hormones: The FXR-FGF15/19 Pathway

Kliewer, S. A., & Mangelsdorf, D. J. (2015) · Digestive Diseases · doi:10.1159/000371670 · Cited by 424 · see citing works

Exopolysaccharides of lactic acid bacteria: Structure, bioactivity and associations: A review

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An engineered <i>E. coli</i> Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Kurtz, C. B., Millet, Y. A., Puurunen, M. K., Perreault, M., Charbonneau, M. R., Isabella, V. M., Kotula, J. W., Antipov, E., Dagon, Y., Denney, W. S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau7975 · Cited by 399 · see citing works

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Lee, G., You, H. J., Bajaj, J. S., Joo, S. K., Yu, J., Park, S., Kang, H., Park, J. H., Kim, J. H., Lee, D. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18754-5 · Cited by 395 · see citing works

IgA Responses to Microbiota

Bunker, J. J., & Bendelac, A. S. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.011 · Cited by 386 · see citing works

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

Mouzaki, M., Wang, A. Y., Bandsma, R., Comelli, E. M., Arendt, B. M., Zhang, L., Fung, S., Fischer, S. E., McGilvray, I. G., & Allard, J. P. (2016) · PLOS ONE · doi:10.1371/journal.pone.0151829 · Cited by 385 · see citing works

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

Wang, L., Fouts, D. E., Stärkel, P., Hartmann, P., Chen, P., Llorente, C., DePew, J., Moncera, K. J., Ho, S. B., Brenner, D. A., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.01.003 · Cited by 384 · see citing works

Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases

Ianiro, G., Punčochář, M., Karcher, N., Porcari, S., Armanini, F., Asnicar, F., Beghini, F., Blanco-Míguez, A., Cumbo, F., Manghi, P., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01964-3 · Cited by 366 · see citing works

Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

Hendrikx, T., Duan, Y., Wang, Y., Oh, J., Alexander, L. M., Huang, W. J. M., Stärkel, P., Ho, S. B., Gao, B., Fiehn, O., et al. (2018) · Gut · doi:10.1136/gutjnl-2018-317232 · Cited by 363 · see citing works

Endotoxin Accumulation Prevents Carcinogen-Induced Apoptosis and Promotes Liver Tumorigenesis in Rodents

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Allogenic Fecal Microbiota Transplantation in Patients With Nonalcoholic Fatty Liver Disease Improves Abnormal Small Intestinal Permeability: A Randomized Control Trial

Craven, L. J., Rahman, A., Parvathy, S. N., Beaton, M. D., Silverman, J. D., Qumosani, K. M., HRAMIAK, I. M., Hegele, R., JOY, T. R., Meddings, J. B., et al. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000661 · Cited by 346 · see citing works

Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation

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Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

Ferslew, B. C., Xie, G., Johnston, C., Su, M., Stewart, P. W., Jia, W. P., Brouwer, K. L. R., & Barritt, A. S. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3776-8 · Cited by 336 · see citing works

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

Rahman, K., Desai, C., Iyer, S. S., Thorn, N. E., Kumar, P., Liu, Y., Smith, T., Neish, A. S., Li, H., Tan, S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.06.022 · Cited by 335 · see citing works

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Kasper, L., König, A., Koenig, P.-A., Gresnigt, M. S., Westman, J., Drummond, R. A., Lionakis, M. S., Groß, O., Ruland, J., Naglik, J. R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06607-1 · Cited by 297 · see citing works

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Effects of Clostridium butyricum Capsules Combined with Rosuvastatin on Intestinal Flora, Lipid Metabolism, Liver Function and Inflammation in NAFLD Patients

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Comparison of LED and LASER Colonoscopy About Linked Color Imaging and Blue Laser/Light Imaging of Colorectal Tumors in a Multinational Study

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Liver fibrosis: from basic science towards clinical progress, focusing on the central role of hepatic stellate cells

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The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review

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The Microbiome in HIV-Infected Children

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Quercetin improves gut dysbiosis in antibiotic-treated mice

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Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

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The Gut Microbiome of Children during the COVID-19 Pandemic

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