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Cited by 331

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice

Open access
Stranahan, Alexis M., Lee, Kim, Martin, Bronwen, Maudsley, Stuart, Golden, Erin, Cutler, Roy G., Mattson, Mark P.·2009·Hippocampus
DOI 10.1002/hipo.20577
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Abstract

Diabetes may adversely affect cognitive function, but the underlying mechanisms are unknown. To investigate whether manipulations that enhance neurotrophin levels will also restore neuronal structure and function in diabetes, we examined the effects of wheel running and dietary energy restriction on hippocampal neuron morphology and brain‐derived neurotrophic factor (BDNF) levels in db/db mice, a model of insulin resistant diabetes. Running wheel activity, caloric restriction, or the combination of the two treatments increased levels of BDNF in the hippocampus of db/db mice. Enhancement of hippocampal BDNF was accompanied by increases in dendritic spine density on the secondary and tertiary dendrites of dentate granule neurons. These studies suggest that diabetes exerts detrimental effects on hippocampal structure, and that this state can be attenuated by increasing energy expenditure and decreasing energy intake. Published 2009 Wiley‐Liss, Inc.

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Metadata

Authors
Stranahan, A. M., Lee, K., Martin, B., Maudsley, S., Golden, E., Cutler, R. G., & Mattson, M. P.
Venue
Hippocampus
Publisher
Wiley
Published
2009-03-11
Volume
19
Issue
10
Pages
951-961
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
DOI
10.1002/hipo.20577
OpenAlex
W2132293368
Cited by
331
References
7
FWCI
10.04
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. https://app.cochat.ai/papers/10.1002/hipo.20577
The paper
Stranahan, A. M., Lee, K., Martin, B., Maudsley, S., Golden, E., Cutler, R. G., & Mattson, M. P. (2009). Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus. https://doi.org/10.1002/hipo.20577

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.