Diabetes, a New Mutation in the Mouse
Abstract
Diabetes ( db ), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Among the most often used genetic models of MASLD are mice deficient for leptin (ob/ob) or the leptin receptor (db/db).
“Among the most often used genetic models of MASLD are mice genetically deficient for leptin (ob/ob) or the leptin receptor (db/db) (216-219).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [218]
Cites
OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
INGALLS, A. M., DICKIE, M. M., & SNELL, G. D. (1950) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a106073 · Cited by 1,090 · see citing works
Self-citationAN IMPROVED FORM OF FOLIN'S MICRO METHOD FOR BLOOD SUGAR DETERMINATIONS
Folin, O., & Malmros, H. (1929) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)70843-4 · Cited by 322 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of NAFLD development and therapeutic strategies
Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354 · see citing works
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327 · see citing works
The genetics of obesity: From discovery to biology
Loos, R. J. F., & Yeo, G. S. H. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00414-z · Cited by 1,291 · see citing works
Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
Coleman, D. L. (1978) · Diabetologia · doi:10.1007/bf00429772 · Cited by 1,307 · see citing works
Self-citationThe use of animal models in diabetes research
King, A. J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01911.x · Cited by 1,303 · see citing works
Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289 · see citing works
Mouse models in non‐alcoholic fatty liver disease and steatohepatitis research
Anstee, Q. M., & Goldin, R. D. (2006) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2006.00465.x · Cited by 714 · see citing works
Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694 · see citing works
Leptin and the endocrine control of energy balance
Friedman, J. M. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0095-y · Cited by 661 · see citing works
Leptin in Human Physiology and Pathophysiology
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works
Gao, Q., Mezei, G., Nie, Y., Rao, Y., Choi, C. S., Bechmann, I., Leranth, C., Toran-Allerand, D., Priest, C. A., Roberts, J. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1525 · Cited by 416 · see citing works
Preclinical models of non-alcoholic fatty liver disease
Santhekadur, P. K., Kumar, D. P., & Sanyal, A. J. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.10.031 · Cited by 380 · see citing works
Genetics and epigenetics of eating disorders
Bulik, C., Yilmaz, Z., & HArdaway, A. (2015) · Advances in Genomics and Genetics · doi:10.2147/agg.s55776 · Cited by 278 · see citing works
Choi, K. M., Kashyap, P. C., Dutta, N., Stoltz, G. J., Ordog, T., Shea Donohue, T., Bauer, A. J., Linden, D. R., Szurszewski, J. H., Gibbons, S. J., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.02.014 · Cited by 233 · see citing works
Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame
Ibrahim, S. H., Hirsova, P., Malhi, H., & Gores, G. J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3977-1 · Cited by 218 · see citing works
Exercise training modifies gut microbiota in normal and diabetic mice
Lambert, J. E., Myslicki, J. P., Bomhof, M. R., Belke, D. D., Shearer, J., & Reimer, R. A. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0452 · Cited by 214 · see citing works
NISHIKAWA, S., YASOSHIMA, A., DOI, K., NAKAYAMA, H., & UETSUKA, K. (2007) · Experimental Animals · doi:10.1538/expanim.56.263 · Cited by 197 · see citing works
Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*
Mounzih, K., Lu, R., & Chehab, F. F. (1997) · Endocrinology · doi:10.1210/en.138.3.1190 · Cited by 482 · see citing works
Bouret, S., Levin, B. E., & Ozanne, S. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00007.2014 · Cited by 157 · see citing works
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)
Wang, S., & Friedman, S. L. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0759 · Cited by 158 · see citing works
Endothelial nitric oxide synthase transgenic models of endothelial dysfunction
Atochin, D. N., & Huang, P. L. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0867-4 · Cited by 145 · see citing works
Laposky, A. D., Bradley, M. A., Williams, D. L., Bass, J., & Turek, F. W. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00026.2008 · Cited by 135 · see citing works
Effects of Leptin and Melanocortin Signaling Interactions on Pubertal Development and Reproduction
Israel, D. D., Sheffer-Babila, S., de Luca, C., Jo, Y.-H., Liu, S. M., Xia, Q., Spergel, D. J., Dun, S. L., Dun, N. J., & Chua, S. C. (2012) · Endocrinology · doi:10.1210/en.2011-1822 · Cited by 109 · see citing works
Kawasaki, F., Matsuda, M., Kanda, Y., Inoue, H., & Kaku, K. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00128.2004 · Cited by 99 · see citing works
Myeloid cell dysfunction and the pathogenesis of the diabetic chronic wound
Wicks, K., Torbica, T., & Mace, K. A. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.04.006 · Cited by 93 · see citing works
Advancements and challenges in generating accurate animal models of gestational diabetes mellitus
Pasek, R. C., & Gannon, M. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00425.2013 · Cited by 90 · see citing works
The influence of age and dietary conditions on diabetes in the db mouse
Wyse, B. M., & Dulin, W. E. (1970) · Diabetologia · doi:10.1007/bf01212237 · Cited by 83 · see citing works
Reperfusion injury is not affected by blockade of P-selectin in the diabetic mouse heart
Jones, S. P., Girod, W. G., Granger, D. N., Palazzo, A. J., & Lefer, D. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h763 · Cited by 80 · see citing works
INHERITED MUSCLE AND NERVE DISEASES IN MICE: A TABULATION WITH COMMENTARY *
Sidman, R. L., Cowen, J. S., & Eicher, E. M. (1979) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1979.tb56567.x · Cited by 51 · see citing works
Liu, H.-W., Chen, Y.-J., Chang, Y.-C., & Chang, S.-J. (2017) · Nutrients · doi:10.3390/nu9091040 · Cited by 47 · see citing works
Leptin, neuroinflammation and obesity
Dragano, N. R. V., Haddad-Tovolli, R., & Velloso, L. A. (2017) · Frontiers of hormone research · doi:10.1159/000452908 · Cited by 45 · see citing works
Xu, J., Zhang, J., Cai, S., Dong, J., Yang, J. Y., & Chen, Z. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2623-1 · Cited by 43 · see citing works
Oblak, A. L., Kotredes, K. P., Pandey, R. S., Reagan, A. M., Ingraham, C., Perkins, B., Lloyd, C., Baker, D., Lin, P. B., Soni, D. M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.886575 · Cited by 23 · see citing works
“Additionally, data in animals revealed that insensitivity of the leptin receptor [48] upregulated the transcriptional activity of interleukin-6 (IL-6), TNF-α, and IL-1β in the hippocampus compared to control [49].”
Background
- Authors
- Hummel, K. P., Dickie, M. M., & Coleman, D. L.
- Affiliations
- Jackson Laboratory (US)
- Venue
- Science
- Published
- 1966-09-02
- Volume
- 153
- Issue
- 3740
- Pages
- 1127-1128
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020053653
- Cited by
- 990
- References
- 2
- Citations by year
- 2026: 3 · 2025: 26 · 2024: 30 · 2023: 34 · 2022: 31 · 2021: 65 · 2020: 38 · 2019: 34 · 2018: 38 · 2017: 48 · 2016: 39 · 2015: 38 · 2014: 45 · 2013: 44 · 2012: 47
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- diabetes mellitus, inbred mouse strains, autosomal recessive inheritance, fat deposition, hyperglycemia, polyuria, glycosuria, pancreatic islets, genetic mutations
- MeSH terms
- Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Female, Male, Mutation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
