Exercise boosts hippocampal volume by preventing early age-related gray matter loss: Exercise Modulates Hippocampal Aging
Abstract
Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings in wheel running mice by longitudinal magnetic resonance imaging. Voxel-based morphometry revealed that running increases hippocampal volume by inhibiting an early age-related gray matter loss. Disruption of neurogenesis-related neuroplasticity by focalized irradiation is sufficient to block positive effects of exercise on macroscopic brain morphology.
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Some recent findings suggest that stimulating neurogenesis may be driving the macro-scale increases in hippocampal volume found in human imaging studies.
“Stimulating neurogenesis and promoting DG function is one mechanism through which AE may promote hippocampal function and some recent findings suggest this mechanisms may be driving the macro-scale increases in hippocampal volume found in human imaging studies (Erickson et al., 2011; Fuss et al., 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Fuss et al., 2014
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- Authors
- Fuss, J., Biedermann, S. V., Falfán-Melgoza, C., Auer, M. K., Zheng, L., Steinle, J., Hörner, F., Sartorius, A., Ende, G., Weber-Fahr, W., & Gass, P.
- Affiliations
- Heidelberg University (DE)
- RG Translational Imaging, Departments of Neuroimaging and Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim (ZI), Medical Faculty Mannheim; University of Heidelberg; Mannheim Germany
- Corresponding author
- Fuss, Johannes
- ORCID
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2013-11-26
- Volume
- 24
- Issue
- 2
- Pages
- 131-134
- ISSN
- 1050-9631 (ISSN-L)
- OpenAlex
- W1930154869
- Cited by
- 32
- References
- 21
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 2 · 2014: 4
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- physical activity, hippocampal volume, gray matter loss, aging, wheel running, neurogenesis, neuroplasticity, focal irradiation, brain structure, longitudinal MRI
- MeSH terms
- Aging, Animals, Hippocampus, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Physical Conditioning, Animal, Running, Cranial Irradiation, Imaging, Three-Dimensional, Mice
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