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Cited by 33Eating Disorders and BehaviorsRegulation of Appetite and ObesityHypothalamic control of reproductive hormones

Larger hippocampus size in women with anorexia nervosa who exercise excessively than healthy women.

Beadle, Janelle N., Paradiso, Sergio, Brumm, Michael, Voss, Michelle, Halmi, Katherine, McCormick, Laurie M.·2015·Psychiatry Research Neuroimaging
DOI 10.1016/j.pscychresns.2014.10.013
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Abstract

Exercise has been shown to increase hippocampal volume in healthy older adults. Observations from animal models of diabetes and hypertension suggest that the combination of exercise and caloric restriction may exert greater neuroprotection in the hippocampus than either behavior alone. Yet, in humans, the effects of exercise and caloric restriction on the hippocampus are not known. We measured the volume of the hippocampus prior to clinical treatment in women with anorexia nervosa (AN) who were restricting calories and engaging in excessive exercise, women with AN who did not exercise excessively, and healthy women who did not engage in either behavior. Women with AN were also examined longitudinally (once weight was restored and 6 months later). In the present report, we found that women with AN engaged in caloric restriction and excessive exercising prior to clinical treatment had larger hippocampal volumes than healthy comparison women. After weight restoration, women with AN who had engaged in food restriction and excessive exercise prior to treatment had hippocampal volumes similar to that of women with AN who only engaged in caloric restriction. These results advance the field by showing for the first time that hippocampal volume may be increased by exercise alone or exercise interacting with food restriction in AN.

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  • Higher levels of aerobic fitness have been correlated with larger hippocampal volumes in patients with obesity, anorexia, mild cognitive impairments, major depressive disorder, Alzheimer's disease, and multiple sclerosis.

    “Cross-sectional data has also indicated that AE may also be beneficial to non-healthy individuals as higher levels of aerobic fitness have also been correlated with larger hippocampal volumes in patients with obesity (Bugg et al., 2012), anorexia (Beadle et al., 2015), mild cognitive impairments (Gates et al., 2013; Makizako et al., 2014), MDD (Travis et al., 2015), Alzheimer’s disease (Honea et”

    From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Beadle et al., 2015

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Authors
Beadle, J. N., Paradiso, S., Brumm, M., Voss, M., Halmi, K., & McCormick, L. M.
Affiliations
  • University of Iowa Hospitals and Clinics (US)
  • Universidad Diego Portales (CL)
  • University of Iowa (US)
  • Cornell University (US)
Corresponding author
McCormick, Laurie M.
ORCID
Venue
Psychiatry Research Neuroimaging
Publisher
Elsevier BV
Published
2015-05
Volume
232
Issue
2
Pages
193-199
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2014.10.013
OpenAlex
W2015897591
Cited by
33
References
43
Citations by year
2025: 8 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 5
FWCI
2.36
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (5K23MH08387905)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
anorexia nervosa, hippocampal volume, excessive exercise, caloric restriction, dietary restriction, weight restoration, neuroprotection, women, brain structure
MeSH terms
Adult, Animals, Anorexia Nervosa, Female, Health Status, Hippocampus, Humans, Longitudinal Studies, Male, Organ Size, Exercise, Caloric Restriction, Young Adult

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