Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies
McKay, Gareth J., Patterson, Chris C., Chakravarthy, Usha, Dasari, Shilpa, Klaver, Caroline C., Vingerling, Johannes R., Ho, Lintje, de Jong, Paulus T.V.M., Fletcher, Astrid E., Young, Ian S., Seland, Johan H., Rahu, Mati, Soubrane, Gisele, Tomazzoli, Laura, Topouzis, Fotis, Vioque, Jesus, Hingorani, Aroon D., Sofat, Reecha, Dean, Michael, Sawitzke, Julie, Seddon, Johanna M., Peter, Inga, Webster, Andrew R., Moore, Anthony T., Yates, John R.W., Cipriani, Valentina, Fritsche, Lars G., Weber, Bernhard H.F., Keilhauer, Claudia N., Lotery, Andrew J., Ennis, Sarah, Klein, Michael L., Francis, Peter J., Stambolian, Dwight, Orlin, Anton, Gorin, Michael B., Weeks, Daniel E., Kuo, Chia-Ling, Swaroop, Anand, Othman, Mohammad, Kanda, Atsuhiro, Chen, Wei, Abecasis, Goncalo R., Wright, Alan F., Hayward, Caroline, Baird, Paul N., Guymer, Robyn H., Attia, John, Thakkinstian, Ammarin, Silvestri, Giuliana·2011·Human Mutation
Cited by (153)
Items 101–153 of 153
- Apolipoproteins in fish: From lipid transport to innate immunityPramod Kumar Sahoo, Amruta Mohapatra, J. K. Jena · 2017 · The Indian Journal of Animal Sciences
- APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer’s disease and related dementiaChloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A. Gagliano Taliun, Sali M.K. Farhan, Judes Poirier et al. · 2022 · PLoS Biology
- Relationship of Hearing Loss to Parkinson’s Disease, Dementia, and APOE Genotype in AdultsChih-Hung Cha, Tsu‐Kung Lin, Ching‐Nung Wu, Chao‐Hui Yang, Yi-Wen Huang, Chung‐Feng Hwang · 2024 · Medicina
- Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory AnalysisInés López‐Cuenca, Elena Salobrar‐García, Ines Gil‐Salgado, Lídia Sánchez-Puebla, Lorena Elvira‐Hurtado, José A. Fernández‐Albarral, Federico Ramírez‐Toraño, Ana Barabash, Jaisalmer de Frutos‐Lucas, Juan Jose Salazar et al. · 2022 · Journal of Personalized Medicine
- Potential gene identification and pathway crosstalk analysis of age-related macular degenerationChengda Ren, Jing Yu · 2022 · Frontiers in Genetics
- Evaluation of APOE polymorphisms and the risk for age-related macular degeneration in a Southeastern Brazilian populationMarina Gonçalves Monteiro Viturino, Jamil Miguel Neto, Flávia Fialho Bajano, Sueli Matilde da Silva Costa, Alicia Buffoni Roque, Géssica Fernandes da Silva Borges, Galina Ananina, Priscila Hae Hyun Rim, Flávio Mac Cord Medina, Fernando Ferreira Costa et al. · 2021 · Experimental Biology and Medicine
- Roles of transmembrane protein 135 in mitochondrial and peroxisomal functions - implications for age-related retinal diseaseMichael Landowski, Purnima Gogoi, Sakae Ikeda, Akihiro Ikeda · 2024 · Frontiers in Ophthalmology
- Genetic deficiency and pharmacological modulation of RORα regulate laser-induced choroidal neovascularizationChi‐Hsiu Liu, Felix Yemanyi, Kiran Bora, Neetu Singh Kushwah, Alexandra K. Blomfield, Theodore M. Kamenecka, John Paul SanGiovanni, Ye Sun, Laura A. Solt, Jing Chen · 2023 · Aging
- Classification and Clinical Features of AMDPetr Kolář · 2013 · InTech eBooks
- Systemic and Local Lipids in Nonhuman Primates With Drusen and Age-Related MaculopathiesCarol Villafuerte-Trisolini, Sophie M. Le, Tzu-Ni Sin, Leon Huynh, Megan Gong, Tony Shen, Jaewon Heo, Karolina P. Roszak, Ana Claudia Santos Raposo, James Graham et al. · 2025 · Investigative Ophthalmology & Visual Science
- The Apolipoprotein Allele and Sensorineural Hearing Loss in Older Community-Dwelling Adults in AustraliaJulia Zoe Sarant, Steven J. Bowe, Mark McEvoy, John Attia · 2019 · Ear and Hearing
- Fluorescence Lifetime Imaging Ophthalmoscopy of Mouse Models of Age-related Macular DegenerationSvenja Rebecca Sonntag, Britta Klein, Ralf Brinkmann, Salvatore Grisanti, Yoko Miura · 2024 · Translational Vision Science & Technology
- Influence of Genetic Polymorphisms on the Short-Term Response to Ranibizumab in Patients With Neovascular Age-Related Macular DegenerationLaura García‐Quintanilla, Pablo Almuiña-Varela, Olalla Maroñas, Almudena Gil-Rodríguez, María José Rodríguez‐Cid, María Gil‐Martínez, Maximino José Abraldes, Francisco Gómez-Ulla de Irazazabal, Miguel González‐Barcia, Cristina Mondelo‐García et al. · 2023 · Investigative Ophthalmology & Visual Science
- Age-related macular degeneration is associated with probable cerebral amyloid angiopathy: A case-control studyBhrugun Anisetti, Michael W. Stewart, Eric Eggenberger, Md Manjurul Islam Shourav, Hossam Youssef, Ahamed M. Elkhair, Nilüfer Ertekin‐Taner, James Frederick Meschia, Michelle Lin · 2023 · Journal of Stroke and Cerebrovascular Diseases
- TOMM40 rs2075650 polymorphism shows no association with neovascular age-related macular degeneration or polypoidal choroidal vasculopathy in a Chinese population.Jing Guo, Haiping Li, Chunfang Zhang, Yaoyao Sun, Xun Deng, Yujing Bai, Shanshan Li, Min Zhao, Heng Miao, Wenzhen Yu et al. · 2013 · Europe PMC (PubMed Central)
- Molecular and genetic landscapes of retina and brain microglia in neurodegenerative diseasesKhang Ma, Rinki Ratnapriya · 2025 · Genome Research
- Cell-specific Systemic Immune Signatures Associated with Treatment Burden in Neovascular Age-related Macular DegenerationJoseph B. Lin, Andrea C. Santeford, Darksha Usmani, Aaditya V. Shah, Philip A. Ruzycki, Rajendra S. Apte · 2023 · Ophthalmology Science
- Milk metabolites and neurodegeneration: Is there crosstalk?Keshav Thakur, Akshay Anand · 2015 · Annals of Neurosciences
- Zinc Supplementation Induced Transcriptional Changes in Primary Human Retinal Pigment Epithelium: A Single-Cell RNA Sequencing Study to Understand Age-Related Macular DegenerationEszter Emri, Oisín Cappa, Caoimhe Kelly, Elöd Körtvely, John Paul SanGiovanni, Brian S. McKay, Arthur A B Bergen, David A. C. Simpson, Imre Lengyel · 2023 · Cells
- Pleiotropy in eye disease and related traitsXiaoyi Gao · 2019 · Elsevier eBooks
- Diagnostic Markers and Molecular Dysregulation Mechanisms in the Retinal Pigmented Epithelium and Retina of Age-Related Macular DegenerationYao Li, Jing Fu, Jiawen Liu, Huayin Feng, Xueyi Chen · 2022 · Journal of Healthcare Engineering
- Genetics of Age-Related Macular DegenerationRylee A. Zavala, Patrice M. Hicks, John H. Lillvis, Charles Zhang, Michael H. Farkas, Leah A. Owen, Margaret M. DeAngelis · 2022 · Springer eBooks
- APOE ɛ2 vs APOE ɛ4 dosage shows sex-specific links to hippocampus-default network subregion co-variationChloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A. Gagliano Taliun, Sali M.K. Farhan, Judes Poirier et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular DegenerationSamaneh Farashi, Roberto Bonelli, Victoria E. Jackson, Brendan R. E. Ansell, Robyn H. Guymer, Melanie Bahlo · 2024 · Ophthalmology Science
- Paradigm of Susceptibility Genes in AMD and PCVMoeen Riaz, Paul Nigel Baird · 2017 · Essentials in ophthalmology/Essentials ophthalmology
- Genotype and PhenotypeAlan R. Templeton · 2018 · Elsevier eBooks
- Role of genetic factors in the pathogenesis of exudative age-related macular degenerationPeng Zhou, Xiaoxin Li · 2014 · Taiwan Journal of Ophthalmology
- Polygenic Liability to Alzheimer’s Disease Is Associated with a Wide Range of Chronic Diseases: A Cohort Study of 312,305 ParticipantsBang‐Sheng Wu, Ya-Ru Zhang, Yang Liu, Wei Zhang, Yue‐Ting Deng, Shi-Dong Chen, Jianfeng Feng, Wei Cheng, Jin‐Tai Yu · 2022 · Journal of Alzheimer s Disease
- Age-Related Macular Degeneration and Vision ImpairmentCharles B. Wright, Jayakrishna Ambati · 2015 · Springer eBooks
- Genetics of Age-Related Macular Degeneration in AsiaKenji Yamashiro · 2021 · Essentials in ophthalmology/Essentials ophthalmology
- Suppressing APOE4-induced mortality and cellular damage by targeting VHLWei I. Jiang, Yiming Cao, Yue Xue, Yichun Ji, Benjamin Y. Winer, Mengqi Zhang, Neel S. Singhal, Jonathan T. Pierce-Shimomura, Song Chen, K. Dengke · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Plasma Proteomic Analysis of APOE ε4 Homozygotes Identifies Preclinical Alzheimer’s Disease Alterations Potentially Modulated by SemaglutideEric B. Dammer, Shiva Afshar, Shijia Bian, Nicholas T. Seyfried, Allan I. Levey, Juan Fortea, Erik C. B. Johnson · 2026 · medRxiv
- Overview of Intersection of Genomics of Cardiometabolic Disease and Other Disease States, Such as Eye Health (Macular Degeneration)Gareth J. McKay · 2015 · Elsevier eBooks
- Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in Iranian PatientsMohammad Askari, Amin Reza Nikpoor, Hajar Aryan, Hamid Ghaedi, Javad Akhtari, Asaad Azarnejad, Kazem Mousavizadeh, Mohammad Hossein Sanati, Alireza Irani, Khalil Ghasemi Falavarjani et al. · 2015 · DOAJ (DOAJ: Directory of Open Access Journals)
- Animal Models of Age-Related Macular Degeneration: Subretinal InflammationFlorian Sennlaub · 2015 · Essentials in ophthalmology/Essentials ophthalmology
- Contributions of Promoter Variants to Complex Eye DiseasesTsz Kin Ng, Chi Pui Pang · 2021 · Essentials in ophthalmology/Essentials ophthalmology
- References2021 · Wiley eBooks
- Genetics of Age-Related Macular DegenerationRylee A. Zavala, Patrice M. Hicks, John H. Lillvis, Charles Zhang, Michael H. Farkas, Leah A. Owen, Margaret M. DeAngelis · 2021 · Springer eBooks
- A ten-gene retinal pigment epithelium (RPE)/choroid complex diagnosis signature for age-related macular degenerationHeyan Li, Dong Li, Wen‐Da Zhou, Haotian Wu, Yifan Li, Ruiheng Zhang, Wenbin Wei · 2022 · Research Square
- Additional file 1 of Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degenerationChristophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E. Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo‐Garcia, Patrick M. Sullivan, Emmanuel L. Gautier et al. · 2024 · Figshare
- Flipping APOE to reverse Alzheimer’s disease traitsJeff Y. L. Lam, Kai Wang, Guojun Bu · 2025 · Nature Neuroscience
- Putative Survival Advantages in Infant, Child, and Young Adult Apolipoprotein ε4 CarriersCarr J. Smith, John Wesson Ashford, Thomas A. Perfetti · 2025 · Springer eBooks
- Additional file 2 of Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degenerationChristophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E. Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo‐Garcia, Patrick M. Sullivan, Emmanuel L. Gautier et al. · 2024 · Figshare
- APOE Gene Editing as a Therapeutic Target Toward Precision Medicine in ADBruce Teter, Jesus J. Campagna, Patricia R. Spilman, Varghese John · 2025 · Springer eBooks
- Peptides vipérins à activité anti-intégrines : intérêt dans le traitement des pathologies ischémiques de la rétine et les DMLAFadoua Montassar · 2017 · theses.fr (ABES)
- La sérine protéase HTRA1 et l'inflammation sous-rétinienne dans le contexte de la dégénérescence maculaire liée à l'âgeFanny Béguier · 2018 · theses.fr (ABES)
- Rôle de l'interleukine - 1 bêta dans la dégénérescence des photorécepteurs associée à la dégénérescence maculaire liée à l'âgeHugo Charles‐Messance · 2018 · theses.fr (ABES)
- Maladie de Parkinson et DMLA : y a-t-il un lien ?Thibaud Mathis · 2020 · theses.fr (ABES)
- APOE Gene Editing as a Therapeutic Target Toward Precision Medicine in ADBruce Teter, Jesus J. Campagna, Patricia Spilman, Varghese John · 2026 · Springer eBooks
- Parent-of-origin effects in Alzheimer’s liability dissociate neurocognitive and cardiovascular traits in at-risk individualsChloé Savignac, Frédéric St‐Onge, Sylvia Villeneuve, AmanPreet Badhwar, Sarah A. Gagliano Taliun, Sali Farhan, Maiya Rachel Geddes, Yasser Iturria Medina, Judes Poirier, R. Nathan Spreng et al. · 2026 · Cell Reports Medicine
- Apolipoprotein E2/2 (APOE2/2) Genotype Is Associated With Reduced Choroidal ThicknessGrace A. Borchert, Lino A. F. Ferreira, Shabnam Raji, Jing Yu, Matias Segovia, Robert E. MacLaren, S. Downes, Jasmina Cehajic-Kapetanovic, Kan-Min Xue, S. D. De Silva · 2026 · Investigative Ophthalmology and Visual Science
- Should ApoE4 gene editing therapy be approached with caution when AD is accompanied by retinal neurodegenerative diseases?Yi Wenhua, Ma Wenjing, Dai Yan, Li Fei, Juan Chen, Tang Xia, Yu Guan, Li Xin, Yanlin Huang, Ya Guo et al. · 2026 · Frontiers in Neurology
- Brain Blindness Versus Eye Blindness: Genetic and Molecular Connections Between Alzheimer’s Disease and Visual ImpairmentEva Bagyinszky, Seong Soo A. An · 2026 · Current Issues in Molecular Biology