Sixteen years and counting: The current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854 · see citing works

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

Batlle, E., Sancho, E., Francı́, C., Dominguez-Sola, D., Monfar, M., Baulida, J., & de Herreros, A. G. (2000) · Nature Cell Biology · doi:10.1038/35000034 · Cited by 2,671 · see citing works

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M., & Tabin, C. J. (1996) · Science · doi:10.1126/science.273.5275.613 · Cited by 1,999 · see citing works

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

Daughaday, W. H., & Rotwein, P. S. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-1-68 · Cited by 1,718 · see citing works

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

Franke, T. F., Kaplan, D., Cantley, L., & Toker, A. (1997) · Science · doi:10.1126/science.275.5300.665 · Cited by 1,609 · see citing works

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,522 · see citing works

PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

Lanske, B., Karaplis, A. C., Lee, K., Luz, A., Vortkamp, A., Pirro, A. E., Karperien, M., Defize, L. H. K., Ho, C., Mulligan, R. C., et al. (1996) · Science · doi:10.1126/science.273.5275.663 · Cited by 1,325 · see citing works

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia.

Shiang, R., Thompson, L., Zhu, Y.-Z., Church, D., Fielder, T., Bocian, M., Winokur, S., & Wasmuth, J. (1994) · Cell · doi:10.1016/0092-8674(94)90302-6 · Cited by 1,291 · see citing works

Structural and functional diversity in the FGF receptor multigene family.

Johnson, D. E., & Williams, L. (1993) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60821-0 · Cited by 1,270 · see citing works

Ten years of protein kinase B signalling: a hard Akt to follow

Brazil, D. P., & Hemmings, B. A. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01958-2 · Cited by 1,177 · see citing works

Receptor Specificity of the Fibroblast Growth Factor Family

Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M., & Ornitz, D. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601252200 · Cited by 1,164 · see citing works

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint

Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., & Mulligan, R. C. (1994) · Genes & Development · doi:10.1101/gad.8.3.277 · Cited by 1,151 · see citing works

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

Mohammadi, M., McMahon, G., Sun, L., Tang, C., Hirth, P., Yeh, B. K., Hubbard, S. R., & Schlessinger, J. (1997) · Science · doi:10.1126/science.276.5314.955 · Cited by 1,099 · see citing works

Fibroblast growth factor receptor 3 is a negative regulator of bone growth.

Deng, C.-X., Wynshaw-Boris, A., Zhou, F., Kuo, A., & Leder, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81069-7 · Cited by 1,095 · see citing works

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

Rousseau, F., Bonaventure, J., Legeai-Mallet, L., Pelet, A., Rozet, J., Maroteaux, P., Merrer, M. L., & Munnich, A. (1994) · Nature · doi:10.1038/371252a0 · Cited by 920 · see citing works

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.

Kouhara, H., Hadari, Y., Spivak-Kroizman, T., Schilling, J., Bar-Sagi, D., Lax, I., & Schlessinger, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80252-4 · Cited by 908 · see citing works

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Mediated by STAT1

Chin, Y. E., Kitagawa, M., Su, W.-C., You, Z.-H., Iwamoto, Y., & Fu, X.-Y. (1996) · Science · doi:10.1126/science.272.5262.719 · Cited by 893 · see citing works

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

Colvin, J. S., Bohne, B. A., Harding, G. W., McEwen, D. G., & Ornitz, D. M. (1996) · Nature Genetics · doi:10.1038/ng0496-390 · Cited by 868 · see citing works

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2Preprint

Peng, X.-D., Xu, P.-Z., Chen, M.-L., Hahn-Windgassen, A., Skeen, J. E., Jacobs, J., Sundararajan, D., Chen, W. S., Crawford, S. E., Coleman, K. G., et al. (2003) · Genes & Development · doi:10.1101/gad.1089403 · Cited by 819 · see citing works

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas

Cappellen, D., de Oliveira, C. C. B., Ricol, D., de Medina, S. D., Bourdin, J., Sastre-Garau, X., Chopin, D., Thiery, J., & Radvanyi, F. (1999) · Nature Genetics · doi:10.1038/12615 · Cited by 743 · see citing works

Mechanisms underlying differential responses to FGF signaling.

Dailey, L., Ambrosetti, D., Mansukhani, A., & Basilico, C. (2005) · Cytokine & growth factor reviews · doi:10.1016/j.cytogfr.2005.01.007 · Cited by 701 · see citing works

Toward a molecular understanding of skeletal development

Erlebacher, A., Filvaroff, E. H., Gitelman, S. E., & Derynck, R. (1995) · Cell · doi:10.1016/0092-8674(95)90487-5 · Cited by 683 · see citing works

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

Long, F., Zhang, X. M., Karp, S. J., Yang, Y., & McMahon, A. P. (2001) · Development · doi:10.1242/dev.128.24.5099 · Cited by 654 · see citing works

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

Chesi, M., Nardini, E., Brents, L. A., Schröck, E., Ried, T., Kuehl, W. M., & Bergsagel, P. L. (1997) · Nature Genetics · doi:10.1038/ng0797-260 · Cited by 637 · cited 1× · see citing works

Achondroplasia

Horton, W. A., Hall, J. G., & Hecht, J. T. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61090-3 · Cited by 604 · see citing works

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3

Tavormina, P. L., Shiang, R., Thompson, L., Zhu, Y.-Z., Wilkin, D. J., Lachman, R., Wilcox, W., Rimoin, D., Cohn, D., & Wasmuth, J. (1995) · Nature Genetics · doi:10.1038/ng0395-321 · Cited by 591 · see citing works

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

Naski, M., Wang, Q., Xu, J.-S., & Ornitz, D. (1996) · Nature Genetics · doi:10.1038/ng0696-233 · Cited by 525 · see citing works

Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.Preprint

Liu, Z.-H., Xu, J.-S., Colvin, J. S., & Ornitz, D. (2002) · Genes & Development · doi:10.1101/gad.965602 · Cited by 501 · see citing works

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

Mohammadi, M., Froum, S., Hamby, J. M., Schroeder, M. C., Panek, R. L., Lu, G. H., Eliseenkova, A. V., Green, D., Schlessinger, J., & Hubbard, S. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.20.5896 · Cited by 484 · see citing works

Achondroplasia is defined by recurrent G380R mutations of FGFR3.

Bellus, G. A., Hefferon, T. W., Luna, R. I. O. D., Hecht, J. T., Horton, W. A., Machado, M. A., Kaitila, I., McIntosh, I., & Francomano, C. A. (1995) · PubMed Central · Cited by 474 · see citing works

Integrating the MAP kinase signal into the G1 phase cell cycle machinery

Roovers, K., & Assoian, R. K. (2000) · BioEssays · doi:10.1002/1521-1878(200009)22:9 · Cited by 469 · see citing works

Dwarfism and early death in mice lacking C-type natriuretic peptide

Chusho, H., Tamura, N., Ogawa, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071389098 · Cited by 468 · see citing works

Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

Peters, K. G., Ornitz, D. M., Werner, S., & Williams, L. T. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1040 · Cited by 455 · see citing works

PTHrP and Skeletal Development

Kronenberg, H. M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1346.002 · Cited by 431 · see citing works

Molecular biology and biochemistry of the natriuretic peptide system. II: Natriuretic peptide receptors

Nakao, K., Ogawa, Y., Suga, S., et al. (1992) · Journal of Hypertension · doi:10.1097/00004872-199210000-00002 · Cited by 427 · see citing works

Signal transduction by fibroblast growth factor receptors

Klint, P. (1999) · Frontiers in bioscience · doi:10.2741/klint · Cited by 422 · see citing works

Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3

Naski, M. C., Colvin, J. S., Coffin, J. D., & Ornitz, D. M. (1998) · Development · doi:10.1242/dev.125.24.4977 · Cited by 420 · see citing works

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

Pfeifer, A., Aszódi, A., Seidler, U. E., Ruth, P., Hofmann, F. B., & Fässler, R. (1996) · Science · doi:10.1126/science.274.5295.2082 · Cited by 403 · see citing works

VEGFA is necessary for chondrocyte survival during bone development

Zelzer, E., Mamluk, R., Ferrara, N., Johnson, R. S., Schipani, E., & Olsen, B. R. (2004) · Development · doi:10.1242/dev.01053 · Cited by 401 · see citing works

Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway

Yasoda, A., Komatsu, Y., Chusho, H., Miyazawa, T., Ozasa, A., Miura, M., Kurihara, T., Rogi, T., Tanaka, S., Suda, M., et al. (2004) · Nature Medicine · doi:10.1038/nm971 · Cited by 396 · see citing works

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway.Preprint

Sahni, M., Ambrosetti, D., Mansukhani, A., Gertner, R., Levy, D., & Basilico, C. (1999) · Genes & Development · doi:10.1101/gad.13.11.1361 · Cited by 391 · see citing works

Mutations in the Transmembrane Natriuretic Peptide Receptor NPR-B Impair Skeletal Growth and Cause Acromesomelic Dysplasia, Type Maroteaux

Bartels, C. F., Bükülmez, H., Padayatti, P. S., Rhee, D. K., van Ravenswaaij‐Arts, C. M. A., Pauli, R. M., Mundlos, S., Chitayat, D. A., Shih, L.-Y., Al-Gazali, L. I., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422013 · Cited by 364 · see citing works

FGF signaling in the developing endochondral skeleton

Ornitz, D. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.02.003 · Cited by 355 · see citing works

Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

Hadari, Y., Kouhara, H., Lax, I., & Schlessinger, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3966 · Cited by 333 · see citing works

Activation of Statl by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

Su, W.-C., Kitagawa, M., Xue, N., Xie, B., Garofalo, S., Cho, J., Deng, C., Horton, W., & Fu, X.-Y. (1997) · Nature · doi:10.1038/386288a0 · Cited by 316 · see citing works

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

Ong, S. H., Hadari, Y. R., Gotoh, N., Guy, G. R., Schlessinger, J., & Lax, I. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111114298 · Cited by 314 · see citing works

Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia.

Webster, M. K., & Donoghue, D. (1996) · EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00384.x · Cited by 303 · see citing works

CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.

Trudel, S., Li, Z.-H., Wei, E., Wiesmann, M., Chang, H., Chen, C., Reece, D., Heise, C., & Stewart, A. (2004) · Blood · doi:10.1182/blood-2004-10-3913 · Cited by 302 · see citing works

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

Chesi, M., Brents, L. A., Ely, S. A., Bais, C., Robbiani, D. F., Mesri, E. A., Kuehl, W. M., & Bergsagel, P. L. (2001) · Blood · doi:10.1182/blood.v97.3.729 · Cited by 289 · see citing works

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

Hart, K. C., Robertson, S. C., Kanemitsu, M. Y., Meyer, A. N., Tynan, J., & Donoghue, D. (2000) · Oncogene · doi:10.1038/sj.onc.1203650 · Cited by 287 · see citing works

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotypePreprint

Murakami, S., Balmes, G. C., McKinney, S., Zhang, Z., Givol, D., & Crombrugghe, B. D. (2004) · Genes & Development · doi:10.1101/gad.1179104 · Cited by 279 · see citing works

Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis.

Chen, L., Adar, R., Yang, X., Monsonego, E. O., Li, C.-L., Hauschka, P. V., Yayon, A., & Deng, C.-X. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6690 · Cited by 257 · see citing works

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

Qing, J., Du, X., Chen, Y., Chan, P., Li, H., Wu, P., Marsters, S. A., Stawicki, S. S., Tien, J., Tótpál, K., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38017 · Cited by 253 · see citing works

Collagen gene expression during limb cartilage differentiation.

Kosher, R. A., Kulyk, W. M., & Gay, S. W. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.4.1151 · Cited by 237 · see citing works

A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors.

Li, C.-L., Chen, L., Iwata, T., Kitagawa, M., Fu, X.-Y., & Deng, C.-X. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.1.35 · Cited by 227 · see citing works

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

L’Hôte, C., & Knowles, M. A. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.11.012 · Cited by 218 · see citing works

Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi.

Hafner, C., van Oers, J. V., Vogt, T., Landthaler, M., Stoehr, R., Blaszyk, H., Hofstaedter, F., Zwarthoff, E., & Hartmann, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28163 · Cited by 217 · see citing works

A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.

Iwata, T., Chen, L., Li, C.-L., Ovchinnikov, D., Behringer, R., Francomano, C., & Deng, C.-X. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.11.1603 · Cited by 217 · see citing works

Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

Goriely, A., Hansen, R. M. S., Taylor, I. B., Olesen, I. A., Jacobsen, G. K., McGowan, S. J., Pfeifer, S. P., McVean, G. A. T., Meyts, E. R.-D., & Wilkie, A. O. M. (2009) · Nature Genetics · doi:10.1038/ng.470 · Cited by 205 · cited 1× · see citing works

FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl

Wong, A., Lamothe, B., Lee, A., Schlessinger, J., & Lax, I. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.052138899 · Cited by 204 · see citing works

Stop codon FGFR3 mutations in thanatophoric dwarfism type 1

Rousseau, F., Saugier-Véber, P., Merrer, M. F. L., Münnich, A., Delezoide, A., MAROTEAUX, P., Bonaventure, J., Narcy, F., & Sanak, M. (1995) · Nature Genetics · doi:10.1038/ng0595-11 · Cited by 199 · see citing works

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

Sims, N. A., Jenkins, B. J., Quinn, J. M. W., Nakamura, A., Glatt, M., Gillespie, M. T., Ernst, M., & Martin, T. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19872 · Cited by 192 · see citing works

Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans.

Logié, A., Dunois‐Lardé, C., Rosty, C., Levrel, O., Blanche, M., Ribeiro, A., Gasc, J., Jorcano, J., Werner, S., Sastre-Garau, X., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi127 · Cited by 191 · see citing works

Null Leukemia Inhibitory Factor Receptor (LIFR) Mutations in Stüve-Wiedemann/Schwartz-Jampel Type 2 Syndrome

Dagoneau, N., Scheffer, D. I., Huber, C., Al-Gazali, L. I., Rocco, M. D., Godard, A., Martinovic, J., Raas‐Rothschild, A., Sigaudy, S., Unger, S., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/381715 · Cited by 189 · see citing works

The population‐based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US

Waller, D. K., Correa, A., Tuan, V. M., Wang, Y., Hobbs, C. A., Langlois, P. H., Pearson, K., Romitti, P. A., Shaw, G. M., & Hecht, J. T. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32485 · Cited by 188 · see citing works

Achondroplasia and hypochondroplasia. Comments on frequency, mutation rate, and radiological features in skull and spine.

Oberklaid, F., Danks, D. M., Jensen, F., et al. (1979) · Journal of Medical Genetics · doi:10.1136/jmg.16.2.140 · Cited by 184 · see citing works

Shisa Promotes Head Formation through the Inhibition of Receptor Protein Maturation for the Caudalizing Factors, Wnt and FGF

Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., & Aizawa, S. (2005) · Cell · doi:10.1016/j.cell.2004.11.051 · Cited by 183 · see citing works

Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis.

Plowright, E. E., Li, Z.-H., Bergsagel, P., Chesi, M., Barber, D., Branch, D. R., Hawley, R. G., & Stewart, A. K. (2000) · Blood · doi:10.1182/blood.v95.3.992.003k29_992_998 · Cited by 177 · see citing works

Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II

Webster, M. K., d'Avis, P. Y., Robertson, S. C., & Donoghue, D. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4081 · Cited by 177 · see citing works

Distinct Missense Mutations of the FGFR3 Lys650 Codon Modulate Receptor Kinase Activation and the Severity of the Skeletal Dysplasia Phenotype

Bellus, G. A., Spector, E., Speiser, P., Weaver, C. A., Garber, A. T., Bryke, C. R., Israel, J., Rosengren, S. S., Webster, M. K., Donoghue, D. J., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/316892 · Cited by 174 · see citing works

The Docking Protein FRS2α Controls a MAP Kinase-Mediated Negative Feedback Mechanism for Signaling by FGF Receptors

Lax, I., Wong, A., Lamothe, B., Lee, A., Frost, A. S., Hawes, J. J., & Schlessinger, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00689-5 · Cited by 166 · see citing works

A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia.

Chen, L., Li, C.-L., Qiao, W., Xu, X.-L., & Deng, C.-X. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.457 · Cited by 166 · see citing works

FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway

Matsushita, T., Wilcox, W. R., Chan, Y. Y., Kawanami, A., Bükülmez, H., Balmes, G. C., Krejčı́, P., Mekikian, P. B., Otani, K., Yamaura, I., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn339 · Cited by 166 · see citing works

A Novel Skeletal Dysplasia with Developmental Delay and Acanthosis Nigricans Is Caused by a Lys650Met Mutation in the Fibroblast Growth Factor Receptor 3 Gene

Tavormina, P. L., Bellus, G. A., Webster, M. K., Bamshad, M. J., Fraley, A. E., McIntosh, I., Szabo, J., Jiang, W. G., Jabs, E. W., Wilcox, W. R., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302275 · Cited by 161 · see citing works

Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis

Krejčı́, P., Masri, B., Fontaine, V., Mekikian, P. B., Weis, M., Prats, H., & Wilcox, W. R. (2005) · Journal of Cell Science · doi:10.1242/jcs.02618 · Cited by 161 · see citing works

A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation

Dailey, L., Laplantine, E., Priore, R., & Basilico, C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302075 · Cited by 156 · see citing works

Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair

Macsai, C. E., Foster, B. K., & Xian, C. J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21342 · Cited by 152 · see citing works

A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome.

Toydemir, R., Brassington, A.-M. E., Bayrak-Toydemir, P., Krakowiak, P., Jorde, L., Whitby, F., Longo, N., Viskochil, D., Carey, J., & Bamshad, M. (2006) · American Journal of Human Genetics · doi:10.1086/508433 · Cited by 150 · see citing works

A Loss-of-Function Mutation in Natriuretic Peptide Receptor 2 (Npr2) Gene Is Responsible for Disproportionate Dwarfism in cn/cn Mouse

Tsuji, T., & Kunieda, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500024200 · Cited by 149 · see citing works

ERK Negatively Regulates the Epidermal Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase

Yu, C. F., Liu, Z., & Cantley, L. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200732200 · Cited by 149 · see citing works

The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells

Trudel, S., Stewart, A. K., Rom, E., Wei, E. N., Li, Z. H., Kotzer, S., Chumakov, I., Singer, Y., Chang, H., Liang, S., et al. (2006) · Blood · doi:10.1182/blood-2005-10-4179 · Cited by 142 · see citing works

Fibroblast Growth Factor Receptor 3 Mutations Promote Apoptosis but Do Not Alter Chondrocyte Proliferation in Thanatophoric Dysplasia

Legeai‐Mallet, L., Benoist-Lasselin, C., Delezoide, A., Münnich, A., & Bonaventure, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13007 · Cited by 141 · see citing works

Achondroplasia

Baujat, G., Legeai‐Mallet, L., Finidori, G., Cormier‐Daire, V., & Merrer, M. F. L. (2008) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2007.12.008 · Cited by 141 · see citing works

STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2

Sahni, M., Raz, R., Coffin, J. D., et al. (2001) · Development · doi:10.1242/dev.128.11.2119 · Cited by 140 · see citing works

The Transmembrane Mutation G380R in Fibroblast Growth Factor Receptor 3 Uncouples Ligand-Mediated Receptor Activation from Down-Regulation

Ornan, E. M., Adar, R., Feferman, T., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.516-522.2000 · Cited by 140 · see citing works

Clinical and genetic heterogeneity of hypochondroplasia.

Rousseau, F., Bonaventure, J., Legeai‐Mallet, L., et al. (1996) · Journal of Medical Genetics · doi:10.1136/jmg.33.9.749 · Cited by 137 · see citing works

Cbfa1 as a regulator of osteoblast differentiation and function

Karsenty, G., Ducy, P. F., Starbuck, M. W., Priemel, M., Shen, J. J., Geoffroy, V., & Amling, M. (1999) · Bone · doi:10.1016/s8756-3282(99)00111-8 · Cited by 134 · see citing works

A common FGFR3 gene mutation in hypochondroplasia

Prinos, P., Costa, T., Sommer, A., et al. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.11.2097 · Cited by 134 · see citing works

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.

Hart, K. C., Robertson, S. C., & Donoghue, D. J. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.4.931 · Cited by 131 · see citing works

The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

Scuto, A., Krejci, P., Popplewell, L., Wu, J., Wang, Y., Kujawski, M., Kowolik, C., Xin, H., Chen, L., Wang, Y., et al. (2010) · Leukemia · doi:10.1038/leu.2010.289 · Cited by 128 · see citing works

BMP Signaling in the Cartilage Growth Plate

Pogue, R. E., & Lyons, K. M. (2006) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(06)76001-x · Cited by 122 · see citing works

Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice

Iwata, T. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.12.1255 · Cited by 122 · see citing works

Activation of the ERK1/2 and p38 Mitogen-activated Protein Kinase Pathways Mediates Fibroblast Growth Factor-induced Growth Arrest of Chondrocytes

Raucci, A., Laplantine, E., Mansukhani, A., & Basilico, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310384200 · Cited by 121 · see citing works

Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations

Ronchetti, D., Greco, A., Compasso, S., Colombo, G., Dell'Era, P., Otsuki, T., Lombardi, L., & Neri, A. (2001) · Oncogene · doi:10.1038/sj.onc.1204465 · Cited by 119 · see citing works

Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone–related protein in mice

Chen, X., Macica, C. M., Nasiri, A. R., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23985 · Cited by 116 · see citing works

Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3G380R transgenic mice

Segev, O. L. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.2.249 · Cited by 113 · see citing works

Cyclic-GMP-Dependent Protein Kinase Inhibits the Ras/Mitogen-Activated Protein Kinase Pathway

Suhasini, M., Li, H., Lohmann, S. M., et al. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.6983 · Cited by 111 · see citing works

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia

Cho, J. Y., Guo, C., Torello, M., Lunstrum, G. P., Iwata, T., Deng, C., & Horton, W. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237184100 · Cited by 110 · see citing works

Hypochondroplasia: Clinical and Radiological Aspects in 39 cases

Hall, B. D., & Spranger, J. (1979) · Radiology · doi:10.1148/133.1.95 · Cited by 108 · see citing works

Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias

Legeai‐Mallet, L., Benoist-Lasselin, C., Münnich, A., & Bonaventure, J. (2003) · Bone · doi:10.1016/j.bone.2003.09.002 · Cited by 107 · see citing works

Fibroblast Growth Factor Inhibits Chondrocytic Growth through Induction of p21 and Subsequent Inactivation of Cyclin E-Cdk2

Aikawa, T., Segre, G. V., & Lee, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101859200 · Cited by 101 · see citing works

The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells.

Li, Z.-H., Zhu, Y.-X., Plowright, E. E., Bergsagel, P., Chesi, M., Patterson, B., Hawley, T., Hawley, R. G., & Stewart, A. K. (2001) · Blood · doi:10.1182/blood.v97.8.2413 · Cited by 100 · see citing works

New Molecular and Biological Mechanism of Antitumor Activities of KW-2478, a Novel Nonansamycin Heat Shock Protein 90 Inhibitor, in Multiple Myeloma Cells

Nakashima, T., Ishii, T., Tagaya, H., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3112 · Cited by 94 · see citing works

FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

Chen, J., Lee, B. H., Williams, I. R., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208989 · Cited by 91 · see citing works

Snail1 Is a Transcriptional Effector of FGFR3 Signaling during Chondrogenesis and Achondroplasias

de Frutos, C. A., Vega, S., Manzanares, M., et al. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.09.016 · Cited by 89 · see citing works

Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma

Zhu, L.-J., Somlo, G., Zhou, B.-S., Shao, J., Bedell, V., Slovak, M., Liu, X.-Y., Luo, J.-H., & Yun, Y. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0330 · Cited by 89 · see citing works

FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells

Krejčı́, P., Bryja, V., Pachernı́k, J., Hampl, A., Pogue, R. E., Mekikian, P. B., & Wilcox, W. R. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.03.011 · Cited by 81 · see citing works

The Kinase Activity of Fibroblast Growth Factor Receptor 3 with Activation Loop Mutations Affects Receptor Trafficking and Signaling

Lievens, P., Mutinelli, C., Baynes, D., & Liboi, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405247200 · Cited by 75 · see citing works

C-natriuretic peptide: An important regulator of cartilage

Pejchalova, K., Krejčı́, P., & Wilcox, W. R. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.06.014 · Cited by 75 · see citing works

A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodysplasia in sheep.

Beever, J., Smit, M., Meyers, S. N., Hadfield, T. S., Bottema, C., Albretsen, J., & Cockett, N. (2006) · Animal Genetics · doi:10.1111/j.1365-2052.2005.01398.x · Cited by 74 · see citing works

Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I.

d'AVIS, P. Y., Robertson, S., Meyer, A. L., Bardwell, W., Webster, M. K., & Donoghue, D. J. (1998) · PubMed · Cited by 74 · see citing works

Fibroblast Growth Factors 1, 2, 17, and 19 Are the Predominant FGF Ligands Expressed in Human Fetal Growth Plate Cartilage

Krejčı́, P., Krakow, D., Mekikian, P. B., & Wilcox, W. R. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e318030d157 · Cited by 70 · see citing works

Expression of FGFR3 with the G380R Achondroplasia Mutation Inhibits Proliferation and Maturation of CFK2 Chondrocytic Cells

Henderson, J. E., Naski, M. C., Aarts, M. M., et al. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.155 · Cited by 70 · see citing works

Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection

Zhang, Y., Qu, Z., Kim, S., Shi, V., Liao, B., Kraft, P., Bandaru, R., Wu, Y. S., Greenberger, L. M., & Horak, I. D. (2010) · Gene Therapy · doi:10.1038/gt.2010.133 · Cited by 68 · see citing works

The Thanatophoric Dysplasia Type II Mutation Hampers Complete Maturation of Fibroblast Growth Factor Receptor 3 (FGFR3), Which Activates Signal Transducer and Activator of Transcription 1 (STAT1) from the Endoplasmic Reticulum

Lievens, P., & Liboi, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212710200 · Cited by 67 · see citing works

The Cbl Family: Ubiquitin Ligases Regulating Signaling by Tyrosine Kinases

Sanjay, A., Horne, W. C., & Baron, R. (2001) · Science s STKE · doi:10.1126/stke.2001.110.pe40 · Cited by 66 · see citing works

CHIR-258 Is Efficacious in A Newly Developed Fibroblast Growth Factor Receptor 3–Expressing Orthotopic Multiple Myeloma Model in Mice

Xin, X., Abrams, T. J., Hollenbach, P. W., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0957 · Cited by 66 · see citing works

Analysis of Mutations in Fibroblast Growth Factor (FGF) and a Pathogenic Mutation in FGF Receptor (FGFR) Provides Direct Evidence for the Symmetric Two-End Model for FGFR Dimerization

Ibrahimi, O. A., Yeh, B. K., Eliseenkova, A. V., Zhang, F., Olsen, S. K., Igarashi, M., Aaronson, S. A., Linhardt, R. J., & Mohammadi, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.2.671-684.2005 · Cited by 66 · see citing works

rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in mice.

Davidoff, A. M., Nathwani, A. C., Spurbeck, W. W., et al. (2002) · PubMed · Cited by 62 · see citing works

Platyspondylic lethal skeletal dysplasia, San Diego type, is caused by FGFR3 mutations.

Brodie, S., Kitoh, H., Lachman, R., Nolasco, L. M., Mekikian, P., & Wilcox, W. R. (1999) · American journal of medical genetics · doi:10.1002/(sici)1096-8628(19990611)84:5 · Cited by 62 · see citing works

Fibroblast Growth Factor Receptor-3 as a Therapeutic Target for Achondroplasia - Genetic Short Limbed Dwarfism

Aviezer, D., Golembo, M., & Yayon, A. (2003) · Current Drug Targets · doi:10.2174/1389450033490993 · Cited by 62 · see citing works

FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

Krejčı́, P., Procházková, J., Smutny, J., Chlebová, K., Lin, P. W., Aklian, A., Bryja, V., Kozubı́k, A., & Wilcox, W. R. (2010) · Bone · doi:10.1016/j.bone.2010.03.021 · Cited by 61 · see citing works

FGF receptors ubiquitylation: dependence on tyrosine kinase activity and role in downregulation

Ornan, E. M., Adar, R., Rom, E., & Yayon, A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03255-6 · Cited by 61 · see citing works

Downregulation of Akt activity contributes to the growth arrest induced by FGF in chondrocytes

Priore, R., Dailey, L., & Basilico, C. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20620 · Cited by 58 · see citing works

Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling

Ben‐Zvi, T., Yayon, A., Gertler, A., & Ornan, E. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.02740 · Cited by 56 · see citing works

Description of a new mutation and characterization of FGFR1, FGFR2, and FGFR3 mutations among Brazilian patients with syndromic craniosynostoses

Passos‐Bueno, M. R., Sertie, A. L., Richieri‐Costa, A., Alonso, L. G., Zatz, M., Alonso, N., Brunoni, D., & Ribeiro, S. F. M. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980707)78:3 · Cited by 55 · see citing works

Flg-2, a new member of the family of fibroblast growth factor receptors.

Avivi, A., Zimmer, Y., Yayon, A., et al. (1991) · PubMed · Cited by 55 · see citing works

Analysis of STAT1 Activation by Six FGFR3 Mutants Associated with Skeletal Dysplasia Undermines Dominant Role of STAT1 in FGFR3 Signaling in Cartilage

Krejčı́, P., Salazar, L., Kashiwada, T. A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003961 · Cited by 50 · see citing works

[Thanatophoric dwarfism].

Maroteaux, P., Lamy, M., & Robert, J. M. (1967) · PubMed · Cited by 49 · see citing works

Effect of Transmembrane and Kinase Domain Mutations on Fibroblast Growth Factor Receptor 3 Chimera Signaling in PC12 Cells

Raffioni, S., Zhu, Y., Bradshaw, R. A., & Thompson, L. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35250 · Cited by 48 · see citing works

Organization of the Indian hedgehog – parathyroid hormone-related protein system in the postnatal growth plate

Chau, M. M., Forcinito, P., de Andrade, A. C., et al. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-10-0177 · Cited by 48 · see citing works

Fibroblast Growth Factor Receptor 3 (FGFR3) Is a Strong Heat Shock Protein 90 (Hsp90) Client

Laederich, M. B., Degnin, C., Lunstrum, G. P., Holden, P. K., & Horton, W. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.206151 · Cited by 46 · see citing works

Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal

Sebastian, A. S., Matsushita, T., Kawanami, A., et al. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21262 · Cited by 44 · see citing works

The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor

Bonaventure, J., Gibbs, L., Horne, W. C., & Baron, R. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05835.x · Cited by 42 · see citing works

Insulin-like Growth Factor-1 Rescues the Mutated FGF Receptor 3 (G380R) Expressing ATDC5 Cells From Apoptosis Through Phosphatidylinositol 3-Kinase and MAPK

Koike, M., Yamanaka, Y., Inoue, M., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.11.2043 · Cited by 42 · see citing works

Nordihydroguaiaretic Acid Inhibits an Activated FGFR3 Mutant, and Blocks Downstream Signaling in Multiple Myeloma Cells

Meyer, A. N., McAndrew, C. W., & Donoghue, D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0575 · Cited by 39 · see citing works

PP2A-Mediated Dephosphorylation of p107 Plays a Critical Role in Chondrocyte Cell Cycle Arrest by FGF

KOLUPAEVA, V. G., Laplantine, E., & Basilico, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003447 · Cited by 39 · see citing works

STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes

Krejci, P., Salazar, L., Goodridge, H., Kashiwada, T. A., Schibler, M. J., Jelínková, P., Thompson, L., & Wilcox, W. (2008) · Journal of Cell Science · doi:10.1242/jcs.017160 · Cited by 39 · see citing works

K644E/M FGFR3 Mutants Activate Erk1/2 from the Endoplasmic Reticulum through FRS2α and PLCγ-independent Pathways

Lievens, P., Roncador, A., & Liboi, E. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.01.058 · Cited by 38 · see citing works

Review of the recently defined molecular mechanisms underlying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia

Martínez‐Frías, M. L., de Frutos, C. A., Bermejo, E., ECEMC Working Group, & Nieto, M. A. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33188 · Cited by 38 · see citing works

NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells*

Krejci, P., Murakami, S., Procházková, J., Trantírek, L., Chlebová, K., Ouyang, Z.-F., Aklian, A., Smutny, J., Bryja, V., Kozubík, A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083626 · Cited by 38 · see citing works

Abnormal FGFR 3 Expression in Cartilage of Thanatophoric Dysplasia Fetuses

Delezoide, A., Benoist-Lasselin, C., Legeai‐Mallet, L., et al. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1899 · Cited by 38 · see citing works

Bisindolylmaleimide I Suppresses Fibroblast Growth Factor-mediated Activation of Erk MAP Kinase in Chondrocytes by Preventing Shp2 Association with the Frs2 and Gab1 Adaptor Proteins

Krejčı́, P., Masri, B., Salazar, L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606144200 · Cited by 35 · see citing works

Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCγ-activated STAT1

Harada, D., Yamanaka, Y., Ueda, K., et al. (2007) · Bone · doi:10.1016/j.bone.2006.11.030 · Cited by 35 · see citing works

Fibroblast growth factor inhibits interferon γ-STAT1 and interleukin 6-STAT3 signaling in chondrocytes

Krejčı́, P., Procházková, J., Bryja, V., et al. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.10.006 · Cited by 34 · see citing works

FGFR3-related dwarfism and cell signaling

Harada, D., Yamanaka, Y., Ueda, K., et al. (2008) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-008-0009-7 · Cited by 33 · see citing works

Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: A severe form of human achondroplasia

Guo, C., Degnin, C., Laederich, M. B., Lunstrum, G. P., Holden, P. K., Bihlmaier, J., Krakow, D., Cho, Y., & Horton, W. A. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.04.001 · Cited by 32 · see citing works

FGF upregulates osteopontin in epiphyseal growth plate chondrocytes: Implications for endochondral ossification

Weizmann, S., Tong, A., Reich, A., Genina, O., Yayon, A., & Ornan, E. M. (2005) · Matrix Biology · doi:10.1016/j.matbio.2005.07.003 · Cited by 31 · see citing works

Prader-Willi-like syndrome in a patient with an Xq23q25 duplication

Monaghan, K. G., Dyke, D. L. V., & Feldman, G. L. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19981116)80:3 · Cited by 29 · see citing works

Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells

Nowroozi, N., Raffioni, S., Wang, T. S., Apostol, B. L., Bradshaw, R. A., & Thompson, L. M. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi161 · Cited by 29 · see citing works

PTHrP Rescues ATDC5 Cells From Apoptosis Induced by FGF Receptor 3 Mutation

Yamanaka, Y., Tanaka, H., Koike, M., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.8.1395 · Cited by 24 · see citing works

Parathyroid Hormone Receptor Type 1/Indian Hedgehog Expression Is Preserved in the Growth Plate of Human Fetuses Affected with Fibroblast Growth Factor Receptor Type 3 Activating Mutations

Cormier, S., Delezoide, A., Benoist-Lasselin, C., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64409-4 · Cited by 21 · see citing works

PTH has the potential to rescue disturbed bone growth in achondroplasia

Ueda, K., Yamanaka, Y., Harada, D., et al. (2007) · Bone · doi:10.1016/j.bone.2007.02.028 · Cited by 19 · see citing works

Guanylate Cyclase Receptor Family

Garbers, D. L. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-571146-3.50008-0 · Cited by 16 · see citing works

Lys650Met substitution in the tyrosine kinase domain of the fibroblast growth factor receptor gene causes thanatophoric dysplasia Type I. Mutations in brief no. 199. Online.

Kitoh, H., Brodie, S. G., Kupke, K. G., et al. (1998) · PubMed · Cited by 14 · see citing works

Simple, mammalian cell-based assay for identification of inhibitors of the Erk MAP kinase pathway

Krejčı́, P., Pejchalova, K., & Wilcox, W. R. (2007) · Investigational New Drugs · doi:10.1007/s10637-007-9054-7 · Cited by 12 · see citing works

Thanatophoric dwarfism

Kozlowski, K. S., Prokop, E., & Zybaczynski, J. (1970) · British Journal of Radiology · doi:10.1259/0007-1285-43-512-565 · Cited by 11 · see citing works

Untitled work

(1999) · doi:10.1002/(sici)1098-1004(1999)14:2

The Fibroblast Growth Factor signaling pathway

Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050 · see citing works

FGF/FGFR signaling in health and disease

Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904 · see citing works

Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies

Kunova Bosakova, M., Varecha, M., Hampl, M., Duran, I., Nita, A., Buchtova, M., Dosedelova, H., Machat, R., Xie, Y., Ni, Z., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy031 · Cited by 50 · see citing works

The Hippo signal transduction network for exercise physiologists

Gabriel, B. M., Hamilton, D. L., Tremblay, A. M., & Wackerhage, H. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01076.2015 · Cited by 48 · see citing works

FDA approves Voxzogo for children, first drug to improve growth in most common form of dwarfism

(2021) · The Brown University Child & Adolescent Psychopharmacology Update · doi:10.1002/cpu.30643

[Homozygous form of achondroplasia and thanatophoric dwarfism--bone dysplasias to be diagnosed before birth].

Rogovits, N., Weissenbacher, G., & Zweymüller, E. (1972) · PubMed · Cited by 3 · see citing works

Achondroplasia and thanatophoric dwarfism: a study in cell culture.

Danes, B. S. (1974) · PubMed · Cited by 4 · see citing works

Thanatophoric Dwarfism ‐ A Delivery Dilemma

Teoh, G., Morrison, J., & Chang, A. (1977) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.1977.tb02626.x · Cited by 1 · see citing works

Typical Reason of Dwarfism: Achondroplasia

Mayer, P. (2014) · HAL (Le Centre pour la Communication Scientifique Directe)