Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin
Abstract
Human mu-opioid receptor (OPRM1) is the major site for the analgesic action of most opioid drugs such as morphine, methadone and heroin. It was previously reported that a single nucleotide polymorphism (SNP) in exon1 (c.118A-->G) of OPRM1 might modestly alter the affinity in beta-endorphin-Mu interaction. Using denaturing high performance liquid chromatography (DHPLC) the complete coding region of the OPRM1 gene was screened for SNPs in Han-Chinese heroin addicts and normal control. Three novel SNPs were detected, one in exon3, one in intron3 and one in the 3' untranslated region. The SNP c.118A-->G reportedly altered the interaction of Mu receptor with opioid had no statistically significant correlation with heroin addition in Han Chinese. However, addicted subjects with the SNP in intron2 (IVS2 +31G-->A) tended to show much higher heroin intake dosages than those without this SNP. We also observed that individuals carrying both SNP c.118A-->G and IVS2 +31G-->A consumed relatively more drugs compared to other addicts. Thus our study further highlights the importance of studing the various regions of the mu opioid receptor gene, coding as well as non-coding, for genetic markers that may be linked to, or directly contribute to opioid drug-seeking behavior.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The increase in serum prolactin caused by nicotine may be due to nicotine reducing dopamine turnover and release by occupying mu or kappa opioid receptors or cholinergic receptors on dopaminergic cells, leading to over-production of prolactin by lactotroph cells.
“This might be the ability of nicotine to reduce the turnover and release of dopamine through occupying mu or kappa receptors of endorphins or through cholinergic receptors for nicotine[1920] presented on dopaminergic cells. Local reduction of dopamine could lead to over-production of prolactin by lactotroph cells.[21]”
From Nicotine alters male reproductive hormones in male albino rats: The role of cessation (2013) · cites this paper as [21]
Other mutations in OPRM1 are associated to heroin addiction, pain perception, but also sociality traits.
“Other mutations in this gene are associated to heroin addiction178, and pain perception179, but also sociality traits180.”
From A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) · cites this paper as [178]
Cites
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687 · see citing works
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
Horikawa, Y., Oda, N., Cox, N. J., Li, X., Orho‐Melander, M., Hara, M., Hinokio, Y., Lindner, T. H., Mashima, H., Schwarz, P. E. H., et al. (2000) · Nature Genetics · doi:10.1038/79876 · Cited by 1,467 · see citing works
A potent and selective endogenous agonist for the µ-opiate receptor
Zadina, J. E., Hackler, L., Ge, L.-J., & Kastin, A. J. (1997) · Nature · doi:10.1038/386499a0 · Cited by 1,309 · see citing works
Bond, C. E., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., Gong, J., Schluger, J. H., Strong, J. A., Leal, S. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9608 · Cited by 1,072 · see citing works
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792 · see citing works
Testing for linkage disequilibrium in genotypic data using the Expectation-Maximization algorithm
Slatkin, M., & Excoffier, L. (1996) · Heredity · doi:10.1038/hdy.1996.55 · Cited by 567 · see citing works
Pharmacological Mechanisms of Opioid Analgesics
Pasternak, G. W. (1993) · Clinical Neuropharmacology · doi:10.1097/00002826-199302000-00001 · Cited by 554 · see citing works
Hoehe, M. R. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.19.2895 · Cited by 288 · see citing works
μ opioid receptor gene variants: lack of association with alcohol dependence
Bergen, A. W., Kokoszka, J., Peterson, R. J., Long, J. C., Virkkunen, M. E., Linnoila, M., & Goldman, D. A. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000331 · Cited by 271 · see citing works
Gelernter, J. E., Kranzler, H. R., & Cubells, J. F. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000556 · Cited by 241 · see citing works
Uhl, G. R., Sora, I., & Wang, Z. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7752 · Cited by 206 · see citing works
Detection of Single-Nucleotide Polymorphisms with the WAVE™ DNA Fragment Analysis System
Kuklin, A. I., MUNSON, K., Gjerde, D. T., Haefele, R., & Taylor, P. D. (1997) · Genetic Testing · doi:10.1089/gte.1997.1.201 · Cited by 151 · see citing works
Franke, P. E., Wang, T., Nöthen, M. M., Knapp, M., Neidt, H., Albrecht, S., Jahnes, E., Propping, P., & Maier, W. (2001) · PubMed · Cited by 119 · see citing works
Sirand‐Pugnet, P., Durosay, P., Brody, E. N., & Marie, J. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.17.3501 · Cited by 114 · see citing works
Kreek, M. J. (1996) · Neurochemical Research · doi:10.1007/bf02532387 · Cited by 87 · see citing works
Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse
Berrettini, W. H., Hoehe, M. R., Ferraro, T. N., DeMaria, P. A., & Gottheil, E. (1997) · Addiction Biology · doi:10.1080/13556219772598 · Cited by 77 · see citing works
Hu, Q., Kukull, W. A., Bressler, S. L., Gray, M. D., Cam, J. A., Larson, E. B., Martin, G. M., & Deeb, S. S. (1998) · Human Genetics · doi:10.1007/s004390050820 · Cited by 65 · see citing works
Selley, D. E., & Bidlack, J. M. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10364-9 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Molecular mechanisms of opioid receptor-dependent signaling and behavior
Al-Hasani, R., & Bruchas, M. R. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318238bba6 · Cited by 1,067 · see citing works
Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments
Kreek, M. J., Bart, G., Lilly, C., Laforge, K. S., & Nielsen, D. A. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.1 · Cited by 391 · see citing works
Ray, L. A., & Hutchison, K. E. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000148114.34000.b9 · Cited by 312 · see citing works
Ray, L. A., & Hutchison, K. E. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.9.1069 · Cited by 258 · see citing works
Genetic Predictors of the Clinical Response to Opioid Analgesics
L??tsch, J., Skarke, C., Liefhold, J., & Geißlinger, G. (2004) · Clinical Pharmacokinetics · doi:10.2165/00003088-200443140-00003 · Cited by 257 · see citing works
Bart, G. B., Kreek, M. J., Ott, J., LaForge, K. S., Proudnikov, D., Pollak, L., & Heilig, M. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300598 · Cited by 220 · see citing works
Arias, A. J., Feinn, R., & Kranzler, H. R. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.11.024 · Cited by 177 · see citing works
How individual sensitivity to opiates can be predicted by gene analyses
Ikeda, K., Ide, S., Han, W., Hayashida, M., Uhl, G. R., & Sora, I. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.04.001 · Cited by 161 · see citing works
Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases
Clemente, N., Raineri, D., Cappellano, G., Boggio, E., Favero, F., Soluri, M. F., Dianzani, C., Comi, C., Dianzani, U., & Chiocchetti, A. (2016) · Journal of Immunological Research · doi:10.1155/2016/7675437 · Cited by 156 · see citing works
Zhang, H., Luο, X., Kranzler, H. R., Lappalainen, J., Yang, B., Krupitsky, E. M., Zvartau, E. E., & Gelernter, J. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl024 · Cited by 153 · see citing works
Genes Associated With Addiction: Alcoholism, Opiate, and Cocaine Addiction
Kreek, M. J., Nielsen, D. A., & LaForge, K. S. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:1:085 · Cited by 146 · see citing works
Are μ-opioid receptor polymorphisms important for clinical opioid therapy?
Lötsch, J., & Geißlinger, G. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.006 · Cited by 144 · see citing works
The genetics of the opioid system and specific drug addictions
Levran, O., Yuferov, V. P., & Kreek, M. J. (2012) · Human Genetics · doi:10.1007/s00439-012-1172-4 · Cited by 143 · see citing works
Hayashida, M., Nagashima, M., Satoh, Y., Katoh, R., Tagami, M., Ide, S., Kasai, S., Nishizawa, D., Ogai, Y., Hasegawa, J., et al. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.11.1605 · Cited by 140 · see citing works
The Mu-Opioid Receptor Polymorphism A118G Predicts Cortisol Responses to Naloxone and Stress
Chong, R. Y., Oswald, L. M., Yang, X., Uhart, M., Lin, P., & Wand, G. S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300856 · Cited by 138 · see citing works
OPRM1 SNP (A118G): Involvement in disease development, treatment response, and animal models
Mague, S. D., & Blendy, J. A. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.12.016 · Cited by 136 · see citing works
Polymorphisms in the osteopontin promoter affect its transcriptional activity.
Giacopelli, F., Marciano, R., Pistorio, A., Catarsi, P., Canini, S., Karsenty, G., & Ravazzolo, R. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00138.2004 · Cited by 140 · see citing works
A review of opioid addiction genetics
Crist, R. C., Reiner, B. C., & Berrettini, W. H. (2018) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.07.014 · Cited by 131 · see citing works
Genetic–epigenetic interaction modulates µ-opioid receptor regulation
Oertel, B. G., Doehring, A., Roskam, B., Kettner, M., Hackmann, N., Ferreirós, N., Schmidt, P. H., & Lötsch, J. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds314 · Cited by 124 · see citing works
Bruehl, S. P., Apkarian, A. V., Ballantyne, J. C., Berger, A. M., Borsook, D., Chen, W., Farrar, J. T., Haythornthwaite, J. A., Horn, S. D., Iadarola, M. J., et al. (2013) · Journal of Pain · doi:10.1016/j.jpain.2012.10.016 · Cited by 114 · see citing works
Crist, R. C., & Berrettini, W. H. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.10.018 · Cited by 112 · see citing works
A catalog of single nucleotide changes distinguishing modern humans from archaic hominins
Kuhlwilm, M., & Boeckx, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-44877-x · Cited by 108 · see citing works
Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?
Mura, E., Govoni, S. M., Racchi, M., Carossa, Ranzani, G. N., Allegri, M., & van Schaik, A. (2013) · Journal of Pain Research · doi:10.2147/jpr.s42040 · Cited by 105 · see citing works
Genetic modulation of the pharmacological treatment of pain
Lötsch, J., Geißlinger, G., & Tegeder, I. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.06.010 · Cited by 104 · see citing works
Deb, I., Chakraborty, J., Gangopadhyay, P. K., Choudhury, S. R., & Das, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06472.x · Cited by 104 · see citing works
The opioid system in alcohol and drug dependence: Family‐based association study
Xuei, X., Wetherill, L. F., Bierut, L. J., Dick, D. M., Nürnberger, J. I., Foroud, T., & Edenberg, H. J. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30531 · Cited by 91 · see citing works
OPRM1 rs1799971 Polymorphism and Opioid Dependence: Evidence from a Meta-Analysis
Haerian, B. S., & Haerian, M. S. (2013) · Pharmacogenomics · doi:10.2217/pgs.13.57 · Cited by 90 · see citing works
Ray, L. A., Barr, C. S., Blendy, J. A., Oslin, D. W., Goldman, D. A., & Anton, R. F. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01633.x · Cited by 80 · see citing works
Lötsch, J., Stuck, B. A., & Hummel, T. R. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.6.1218 · Cited by 80 · see citing works
Pharmacogenetics of opioid receptors and addiction
Mayer, P. E., & Höllt, V. (2006) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000182781.87932.0d · Cited by 77 · see citing works
Association of Functional Opioid Receptor Genotypes With Alcohol Dependence in Koreans
Kim, S., Kim, C., Kang, D., Kim, Y., Byun, W., Kim, S., Park, J., Kim, M.-J., & Oslin, D. W. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000130803.62768.ab · Cited by 74 · see citing works
Burns, J. A., Kroll, D. S., Feldman, D. E., Liu, C. K., Manza, P., Wiers, C. E., Volkow, N. D., & Wang, G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00626 · Cited by 72 · see citing works
Hall, F. S., Drgonová, J., Jain, S., & Uhl, G. R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.006 · Cited by 71 · see citing works
Pharmacogenetics of Naltrexone in Asian Americans: A Randomized Placebo-Controlled Laboratory Study
Ray, L. A., Bujarski, S., Chin, P. F., & Miotto, K. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.192 · Cited by 70 · see citing works
Endogenous Opioid Receptor Genes and Alcohol Dependence Among Taiwanese Han
Loh, E. W., Fann, C. S. J., Chang, Y. T., Chang, C. J., & Cheng, A. T.-A. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000106303.41755.b8 · Cited by 67 · see citing works
Nicotine alters male reproductive hormones in male albino rats: The role of cessation
Oyeyipo, I., Raji, Y., & Bolarinwa, A. (2013) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.112380 · Cited by 67 · see citing works
Zhang, D., Shao, C., Shao, M., Yan, P., Wang, Y., Liu, Y., Liu, W., Lin, T., Xie, Y., Zhao, Y., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.012 · Cited by 63 · see citing works
Mahmoud, S., Thorsell, A., Sommer, W. H., Heilig, M. A., Holgate, J. K., Bartlett, S. E., & Ruiz-Velasco, V. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318231fc11 · Cited by 62 · see citing works
Association between human μ‐opioid receptor gene polymorphism, pain tolerance, and opioid addiction
Compton, P. A., Geschwind, D. H., & Alarcón, M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20057 · Cited by 62 · see citing works
Pharmacogenomics of the Human µ-Opioid Receptor
Kasai, S., & Ikeda, K. (2011) · Pharmacogenomics · doi:10.2217/pgs.11.68 · Cited by 61 · see citing works
Gene Polymorphisms of the Mu Opioid Receptor in Methamphetamine Abusers
Ide, S., Kobayashi, H., Tanaka, K., Ujike, H., Sekine, Y., Ozaki, N., Inada, T., Harano, M., Komiyama, T., Yamada, M., et al. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.039 · Cited by 60 · see citing works
Glatt, S. J., Bousman, C., Wang, R. S., Murthy, K. K., Rana, B. K., Lasky-Su, J. A., Zhu, S. C., Zhang, R., Li, J., Zhang, B., et al. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.02.022 · Cited by 57 · see citing works
Xu, J., Lu, Z., Xu, M., Pan, L., Deng, Y., Xie, X., Liu, H., Ding, S., Hurd, Y. L., Pasternak, G. W., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3986-13.2014 · Cited by 55 · see citing works
Huang, C., Liu, H., Su, N. ‐., Hsu, Y. ‐., Yang, C. ‐., Chen, C. ‐., & Tsai, P. (2008) · Anaesthesia · doi:10.1111/j.1365-2044.2008.05760.x · Cited by 55 · see citing works
Wang, S., Tsou, H., Chen, C., Chen, Y.-T., Ho, I.-K., Hsiao, C., Chou, S., Lin, K., Fang, K.-C., Huang, C.-L., et al. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.02.002 · Cited by 54 · see citing works
Wong, C. A., McCarthy, R. J., Blouin, J. L., & Landau, R. (2010) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2009.09.005 · Cited by 54 · see citing works
Ehlers, C. L., Lind, P. A., & Wilhelmsen, K. C. (2008) · BMC Medical Genetics · doi:10.1186/1471-2350-9-35 · Cited by 52 · see citing works
Oefner, P. J., & Huber, C. G. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00700-6 · Cited by 52 · see citing works
Margas, W., Zubkoff, I., Schuler, H. G., Janicki, P. K., & Ruiz-Velasco, V. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01007.2006 · Cited by 52 · see citing works
Taqi, M. M., Faisal, M., & Zaman, H. (2019) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s198654 · Cited by 50 · see citing works
An overview of the genetics of substance use disorders
Lachman, H. M. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0013-3 · Cited by 47 · see citing works
Rhodin, A., Grönbladh, A., Ginya, H., Nilsson, K. W., Rosenblad, A., Zhou, Q., Enlund, M., Hallberg, M., Gordh, T., & Nyberg, F. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-8 · Cited by 47 · see citing works
Daws, S. E., Whittard, J. D., Jacobs, M. M., Ren, Y., Mazloom, A. R., Caputi, F. F., Horváth, M., Keller, É., Ma’ayan, A., Pan, Y., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.012 · Cited by 43 · see citing works
Endogenous opiates and behavior: 2002
Bodnar, R. J., & Hadjimarkou, M. M. (2003) · Peptides · doi:10.1016/j.peptides.2003.08.002 · Cited by 59 · see citing works
Ide, S., Kobayashi, H., Ujike, H., Ozaki, N., Sekine, Y., Inada, T., Harano, M., Komiyama, T., Yamada, M., Iyo, M., et al. (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500355 · Cited by 43 · see citing works
The genetic predisposition to adverse outcome after trauma
Giannoudis, P. V., van Griensven, M., Tsiridis, E. E., & Pape, H. (2007) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.89b10.19022 · Cited by 36 · see citing works
Woodcock, E. A., Lundahl, L. H., Burmeister, M., & Greenwald, M. K. (2015) · American Journal on Addictions · doi:10.1111/ajad.12187 · Cited by 38 · see citing works
Genome-Wide Association of Heroin Dependence in Han Chinese
Kalsi, G., Euesden, J., Coleman, J. R. I., Ducci, F., Alıev, F., Newhouse, S., Liu, X., Ma, X., Wang, Y., Collier, D. A., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167388 · Cited by 37 · see citing works
Osteopontin Alleles Are Associated with Clinical Characteristics in Systemic Lupus Erythematosus
Trivedi, T. K., Franek, B., Green, S. L., Kariuki, S. N., Kumabe, M., Mikolaitis, R., Jolly, M., Utset, T., & Niewold, T. (2011) · Journal of Biomedicine and Biotechnology · doi:10.1155/2011/802581 · Cited by 37 · see citing works
Enhanced prolactin levels in opium smokers
Moshtaghi‐Kashanian, G., Esmaeeli, F., & Dabiri, S. (2005) · Addiction Biology · doi:10.1080/13556210500351263 · Cited by 34 · see citing works
Chen, Y.-T., Tsou, H., Kuo, H., Fang, C., Wang, S., Ho, I.-K., Chang, Y.-S., Chen, C., Hsiao, C., Wu, H.-Y., et al. (2012) · Journal of Human Genetics · doi:10.1038/jhg.2012.139 · Cited by 33 · see citing works
Abijo, T., Blum, K., & Gondré‐Lewis, M. C. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191118125702 · Cited by 33 · see citing works
Characterization of the 3′ untranslated region of the human mu-opioid receptor (MOR-1) mRNA
Ide, S., Han, W., Kasai, S., Hata, H., Sora, I., & Ikeda, K. (2005) · Gene · doi:10.1016/j.gene.2005.05.040 · Cited by 33 · see citing works
Candidate gene polymorphisms predicting individual sensitivity to opioids
Kasai, S., Hayashida, M., Sora, I., & Ikeda, K. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0205-3 · Cited by 33 · see citing works
Nikolov, M. A., Beltcheva, O., Galabova, A., Ljubenova, A., Jankova, E., Gergov, G., Russev, A. A., Lynskey, M. T., Nelson, E. C., Nesheva, E., et al. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.12.026 · Cited by 33 · see citing works
Gfi-1 takes center stage in hematopoietic stem cells
Duan, Z., & Horwitz, M. S. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.003 · Cited by 32 · see citing works
Somogyi, A. A. (2009) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s4865 · Cited by 25 · see citing works
Comprehensive Mu-Opioid-Receptor Genotyping by Pyrosequencing
Skarke, C., Kirchhof, A., Geißlinger, G., & Lötsch, J. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.027607 · Cited by 25 · see citing works
Genetic variability of pain perception and treatment—clinical pharmacological implications
Lötsch, J. (2011) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1012-9 · Cited by 24 · see citing works
Cornett, E. M., Turpin, M. A. C., Pinner, A., Thakur, P., Gnanasekaran, T. S., Siddaiah, H. B., Rivas, J. L. M., Yates, A., Huang, G. J., Senthil, A., et al. (2020) · Current Oncology Reports · doi:10.1007/s11912-020-0865-4 · Cited by 24 · see citing works
Szumlinski, K. K., Lominac, K. D., Frys, K. A., & Middaugh, L. D. (2004) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2004.00111.x · Cited by 24 · see citing works
Bruehl, S. P., Burns, J. W., Passik, S. D., Gupta, R. K., Buvanendran, A., Chont, M., Schuster, E., Orlowska, D., & France, C. R. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.04.001 · Cited by 22 · see citing works
Knapman, A., & Connor, M. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12644 · Cited by 22 · see citing works
Swingler, M., Donadoni, M., Unterwald, E. M., Maggirwar, S. B., & Sariyer, I. K. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1597922 · Cited by 21 · see citing works
Pedram, P., Zhai, G., Gulliver, W. P., Zhang, H., & Sun, G. (2017) · Appetite · doi:10.1016/j.appet.2017.01.004 · Cited by 23 · see citing works
Gondré‐Lewis, M. C., Elman, I., Alim, T. N., Chapman, E., Settles-Reaves, B., Galvao, C., Gold, M. S., Baron, D. A., Kazmi, S., Gardner, E. L., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10040870 · Cited by 21 · see citing works
Rees, C. L., White, C. M., & Ascoli, G. A. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170414163506 · Cited by 20 · see citing works
Is there genetic polymorphism evidence for individual human sensitivity to opiates?
Nagashima, M., Katoh, R., Satô, Y., Tagami, M., Kasai, S., & Ikeda, K. (2007) · Current Pain and Headache Reports · doi:10.1007/s11916-007-0008-8 · Cited by 20 · see citing works
Genetic disposition to addictive disorders — current knowledge and future perspectives
Mayer, P. E., & Höllt, V. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.08.009 · Cited by 20 · see citing works
Convergent Balancing Selection on the Mu-Opioid Receptor in Primates
Sweeney, C. G., Rando, J. M., Panas, H. N., Miller, G. M., Platt, D. M., & Vallender, E. J. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx105 · Cited by 15 · see citing works
The genetics of pain: implications for evaluation and treatment of spinal disease
Kim, D. H., & Schwartz, C. E. (2010) · The Spine Journal · doi:10.1016/j.spinee.2010.05.013 · Cited by 15 · see citing works
Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review
Kafshdooz, L., Kahroba, H., Kafshdooz, T., Sheervalilou, R., & Pourfathi, H. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1573736 · Cited by 14 · see citing works
Li, X., Liu, K., Pan, Y., Zhang, J., Lv, Q., Hua, L., Wang, Z., Li, J., & Yin, C. (2015) · BioMed Research International · doi:10.1155/2015/315043 · Cited by 13 · see citing works
Hurd, Y. L. (2006) · CNS Spectrums · doi:10.1017/s1092852900015005 · Cited by 13 · see citing works
Huang, C., Kuo, S.-C., Yeh, T., Yeh, Y., Chen, C., Liang, C., Tsou, C., Lin, C., Ho, P., & Huang, S. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.028 · Cited by 12 · see citing works
Regan, P. M., Langford, D., & Khalili, K. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25237 · Cited by 12 · see citing works
Liu, J., Hu, D., Jiang, Y., Xi, H., & Li, W. (2014) · Pharmacology · doi:10.1159/000368082 · Cited by 11 · see citing works
Collins, D., Zhang, Y., Blendy, J. A., & Kreek, M. J. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107864 · Cited by 10 · see citing works
A Complex Relationship Among the Circadian Rhythm, Reward Circuit and Substance Use Disorder (SUD)
Samanta, S., Bagchi, D., Gold, M. S., Badgaiyan, R. D., Barh, D., & Blum, K. (2024) · Psychology Research and Behavior Management · doi:10.2147/prbm.s473310 · Cited by 9 · see citing works
Wang, L., Hu, F., Li, W., Li, Q., Li, Y., Zhu, J., Wei, X., Yang, J., Guo, J., Qin, Y., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721003937 · Cited by 8 · see citing works
Collins, D., Randesi, M., da Rosa, J. C., Zhang, Y., & Kreek, M. J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4965-x · Cited by 8 · see citing works
Binge-Like Eating Is Not Influenced by the Murine Model of OPRM1 A118G Polymorphism
Sachdeo, B. L. Y., Yu, L., Giunta, G. M., & Bello, N. T. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00246 · Cited by 8 · see citing works
Hall, F. S., Chen, Y., & Resendiz-Gutierrez, F. (2020) · Brain Behavior and Evolution · doi:10.1159/000516169 · Cited by 7 · see citing works
Franke, P. E., Wendel, B., Knapp, M., Schwab, S. G., Neef, D., Maier, W., Wildenauer, D. B., & Hoehe, M. R. (2003) · European Psychiatry · doi:10.1016/s0924-9338(02)00005-6 · Cited by 6 · see citing works
Annis, A. C., Gunaseelan, V., Smith, A. V., Abecasis, G. R., Larach, D. B., Zawistowski, M., Frangakis, S. G., & Brummett, C. M. (2024) · Genetic Epidemiology · doi:10.1002/gepi.22588 · Cited by 6 · see citing works
Tolami, H. F., Sharafshah, A., Tolami, L. F., & Keshavarz, P. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01443-4 · Cited by 5 · see citing works
Endogenous Opiates, Addiction, and the Stress Response
Chong, R. Y., Uhart, M., & Wand, G. S. (2007) · Elsevier eBooks · doi:10.1016/b978-012370632-4/50007-3 · Cited by 5 · see citing works
Enfermedad renal crónica asociada a diacetilmorfina (heroína)
Arias, J. K. B. (2008) · IATREIA · doi:10.17533/udea.iatreia.4533 · Cited by 4 · see citing works
Cobos, J. P. D. L., Alcaraz, S., Siñol, N., Arranz, M. J., Trujols, J., Batlle, F., Calafell, F., Duran‐Sindreu, S., & Salazar, J. (2017) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000698 · Cited by 4 · see citing works
Blum, K., Gold, M. S., Cadet, J. L., Lewis, M., McLaughlin, T., Braverman, E. R., Elman, I., Carney, B., Cortese, R., Abijo, T., et al. (2023) · Medical Research Archives · doi:10.18103/mra.v11i8.4211 · Cited by 5 · see citing works
- Authors
- Shi, J., Hui, L., Xu, Y., Wang, F., Huang, W., & Hu, G.
- Affiliations
- Chinese Academy of Sciences (CN)
- Chinese National Human Genome Center at Shanghai (CN)
- Venue
- Human Mutation
- Publisher
- Hindawi Limited
- Published
- 2002-03-18
- Volume
- 19
- Issue
- 4
- Pages
- 459-460
- ISSN
- 1059-7794 (ISSN-L)
- 1098-1004
- OpenAlex
- W2017514322
- Cited by
- 140
- References
- 19
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 8
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Mutation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- mu-opioid receptor, OPRM1, heroin addiction, opioid use disorder, single nucleotide polymorphisms, genetic susceptibility, Han Chinese, 3' untranslated region, drug-seeking behavior
- MeSH terms
- China, Chromatography, High Pressure Liquid, Exons, Gene Frequency, Genetic Testing, Genotype, Heroin Dependence, Humans, Introns, Phenotype, Genetic Variation, Receptors, Opioid, mu, Genetic Predisposition to Disease, 3' Untranslated Regions, Asian People
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
