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Cited by 124Treatment of Major DepressionAntioxidant Activity and Oxidative StressTryptophan and brain disorders

The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.

Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients

Gałecki, Piotr, Szemraj, Janusz, Bieńkiewicz, Małgorzata, Zboralski, Krzysztof, Gałecka, Elżbieta·2009·Human Psychopharmacology: Clinical and Experimental
DOI 10.1002/hup.1014
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Abstract

Objective: There are numerous reports indicating disturbed equilibrium between oxidative processes and antioxidative defense in patients with depression. Moreover, depressive patients are characterized by the presence of elements of an inflammatory process, which is one of the sources of reactive oxygen species (ROS). In view of the above, it was decided to study both the effect of fluoxetine monotherapy and that of fluoxetine co‐administered with acetylsalicylic acid on lipid peroxidation and antioxidative defense in patients with the first depressive episode in their life. Method: Seventy seven patients with major depressive disorder (MDD), divided into two groups were included in the study. The first group, consisting of 52 patients, received fluoxetine 20 mg, and the second one, in addition to fluoxetine 20 mg, received 150 mg of acetylsalicylic acid. The activity of antioxidative enzymes, copper‐zinc superoxide dismutase (CuZnSOD, SOD1), catalase (CAT), glutathione peroxidase (GPSH‐x) and the concentration of malonyldialdehyde (MDA) was determined in erythrocytes, whereas the total antioxidant status (TAS) was determined in the plasma. All parameters were measured before and after three month therapy. Results: The obtained results indicate a significant decrease in the activity of SOD1, CAT and GSHP‐x, as well as in MDA concentration after the combined therapy. Also a significant TAS increase was observed after the combined therapy. The study demonstrated that combined therapy with fluoxetine and ASA is characterized by the same efficacy and clinical safety as fluoxetine monotherapy, resulting additionally in improvement of oxidative stress parameters in the patients treated for depression. Copyright © 2009 John Wiley & Sons, Ltd.

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Research works printed but not linked: 5

  1. American Psychiatry Association, 1994, Diagnostic and statistical Manual of Mental Disorder
  2. 10.1016/j.resp22006.09.004 · DOI
  3. Editorial, 1998, Fatty acid, cytokines, and major depression, Biol Psychiatry, 43, 313
  4. 10.1016/j.intimp2003.11.006 · DOI
  5. 10.1016/j. psychres.2006.04.013 · DOI

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Metadata

Authors
Gałecki, P., Szemraj, J., Bieńkiewicz, M., Zboralski, K., & Gałecka, E.
Affiliations
Medical University of Lodz (PL)
Corresponding author
Gałecki, Piotr
ORCID
Venue
Human Psychopharmacology: Clinical and Experimental
Publisher
Wiley
Published
2009-03-24
Volume
24
Issue
4
Pages
277-286
ISSN
  • 0885-6222 (ISSN-L)
  • 1099-1077
DOI
10.1002/hup.1014
OpenAlex
W2097745840
Cited by
124
References
116
Citations by year
2024: 5 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 6 · 2015: 16 · 2014: 7 · 2013: 8 · 2012: 16
FWCI
7.43
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Human Psychopharmacology Clinical and Experimental (publishedVersion)
  • PubMed (publishedVersion)
Funders
Uniwersytet Łódzki
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
major depressive disorder, fluoxetine, aspirin, oxidative stress, lipid peroxidation, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, total antioxidant status, combination therapy, first-episode depression, erythrocytes
MeSH terms
Adult, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Aspirin, Major Depressive Disorder, Drug Therapy, Combination, Fluoxetine, Humans, Psychiatric Status Rating Scales, Lipid Peroxidation, Oxidative Stress, Antidepressive Agents, Second-Generation

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