Acetylsalicylic acid as an augmentation agent in fluoxetine treatment resistant depressive rats
Abstract
Clinical studies have reported that adjunctive acetylsalicylic acid (aspirin) therapy is beneficial for patients with treatment resistant depression (TRD). However, there still exist negative epidemiological data on the link between aspirin and depression. Therefore, this study aimed to further investigate whether aspirin can be used as an augmentation agent in fluoxetine treatment resistant depressive rats induced by chronic unpredictable mild stress (CUMS). In this study, the effects of CUMS regimen and antidepressant treatment were assessed by behavioral testing, hippocampal expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)). 4-week fluoxetine treatment reversed the behavioral changes in approximately 70-80% depressive rats. That is, 20-30% depressive rats were resistant to fluoxetine. In the hippocampus of fluoxetine treatment resistant depressive rats, a significant upregulation of COX-2 level and PGE(2) concentration was observed. However, in these rats adjunctive aspirin treatment significantly improved the depressive behaviors and downregulated the COX-2 level and PGE(2) concentration in the hippocampus. Thus, our results suggest that aspirin can be served as an effective adjunctive agent in the treatment resistant depression mediated by inhibition of the COX-2 level and PGE(2) concentration.
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Celecoxib augmentation therapy can accelerate treatment responses in depressive episodes of patients with bipolar disorder.
“Celecoxib augmentation therapy can accelerate the treatment responses in depressive episodes of patients with bipolar disorder[66].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [66]
Cites
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007 · see citing works
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070 · see citing works
Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879 · see citing works
Behavioral despair in mice: a primary screening test for antidepressants.
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,275 · see citing works
Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention
Solomon, S. D., McMurray, J. J. V., Pfeffer, M. A., Wittes, J. T., Fowler, R. A., Finn, P. V., Anderson, W. F., Zauber, A. G., Hawk, E. T., & Bertagnolli, M. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050405 · Cited by 2,046 · see citing works
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650 · see citing works
New approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works
Assessing antidepressant activity in rodents: recent developments and future needs
Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551 · see citing works
Cytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735 · see citing works
Maes, M., Bosmans, E., De Jongh, R., Kenis, G., Vandoolaeghe, E., & Neels, H. (1997) · Cytokine · doi:10.1006/cyto.1997.0238 · Cited by 728 · see citing works
The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
Müller, N., & Schwarz, M. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002006 · Cited by 670 · see citing works
Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621 · see citing works
Prevalence of suicide ideation and suicide attempts in nine countries
Weissman, M. M., Bland, R. C., CANINO, G. J., Greenwald, S., Hwu, H., Joyce, P. R., Karam, E. G., Lee, C.-Y., Lellouch, J., Lépine, J., et al. (1999) · Psychological Medicine · doi:10.1017/s0033291798007867 · Cited by 583 · see citing works
Jiang, W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25509 · Cited by 527 · see citing works
Self-citationThe effects of chronic antidepressant treatment in an animal model of anxiety
Bodnoff, S., Suranyi-Cadotte, B., Aitken, D., Quirion, R., & Meaney, M. (1988) · Psychopharmacology · doi:10.1007/bf00181937 · Cited by 437 · see citing works
Kochanek, K. D., Murphy, S. L., Anderson, R. N., & Scott, C. (2004) · PubMed · Cited by 385 · see citing works
Suicide and Aging I: Patterns of Psychiatric Diagnosis
Conwell, Y., & Brent, D. A. (1995) · International Psychogeriatrics · doi:10.1017/s1041610295001943 · Cited by 237 · see citing works
Mendlewicz, J., Kriwin, P., Oswald, P., Souery, D., Alboni, S., & Brunello, N. (2006) · International Clinical Psychopharmacology · doi:10.1097/00004850-200607000-00005 · Cited by 229 · see citing works
Novel Drugs and Therapeutic Targets for Severe Mood Disorders
Mathew, S. J., Manji, H. K., & Charney, D. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301652 · Cited by 222 · see citing works
Depression as a major component of public health for older adults.
Chapman, D. P., & Perry, G. S. (2008) · PubMed Central · Cited by 206 · see citing works
Do Lithium and Anticonvulsants Target the Brain Arachidonic Acid Cascade in Bipolar Disorder?
Rapoport, S. I., & Bosetti, F. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.7.592 · Cited by 188 · see citing works
Bosetti, F., Rintala, J., Seemann, R., Rosenberger, T. A., Contreras, M. A., Рапопорт, С. И., & Chang, M. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001111 · Cited by 137 · see citing works
Sluzewska, A., Sobieska, M., & Rybakowski, J. K. (2008) · Neuropsychobiology · doi:10.1159/000119332 · Cited by 134 · see citing works
Bergström, A., Jayatissa, M. N., Thykjær, T., & Wiborg, O. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0065-9 · Cited by 123 · see citing works
Additive Benefits of Pravastatin and Aspirin to Decrease Risks of Cardiovascular Disease
Hennekens, C. H., Sacks, F. M., Tonkin, A. M., Jukema, J. W., Byington, R. P., Pitt, B., Berry, D. A., Berry, S. M., Ford, N. F., Walker, A. J., et al. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.1.40 · Cited by 111 · see citing works
Brunello, N., Alboni, S., Capone, G., Benatti, C., Blom, J. M. C., Tascedda, F., Kriwin, P., & Mendlewicz, J. (2006) · International Clinical Psychopharmacology · doi:10.1097/00004850-200607000-00004 · Cited by 104 · see citing works
Benedetti, F., Lucca, A., Brambilla, F., Colombo, C., & Smeraldi, E. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00255-5 · Cited by 73 · see citing works
Treatment resistant depression and Axis I co-morbidity
PETERSEN, T., Gordon, J., Kant, A. J., D, M. F. M., Rosenbaum, J. F., & Nierenberg, A. A. (2001) · Psychological Medicine · doi:10.1017/s0033291701004305 · Cited by 52 · see citing works
ASPIRIN USE, DEPRESSION, AND COGNITIVE IMPAIRMENT IN LATER LIFE: THE HEALTH IN MEN STUDY
Almeida, O. P., Alfonso, H. S., Jamrozik, K. D., Hankey, G. J., & Flicker, L. A. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02827.x · Cited by 44 · see citing works
Lieb, J. (1983) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(83)90039-5 · Cited by 40 · see citing works
Conley, R. K., & Hutson, P. H. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.02.063 · Cited by 34 · see citing works
Poul, E. L., Lima, L. V., Laporte, A., et al. (1995) · PubMed · Cited by 14 · see citing works
Romero, S. C., Rosa, K. M. D., & Linz, P. E. (2008) · Southern Medical Journal · doi:10.1097/smj.0b013e318178e58e · Cited by 13 · see citing works
Samson, R. (2005) · Perspectives in Vascular Surgery · doi:10.1177/153100350501700115 · Cited by 2 · see citing works
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Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529 · see citing works
Is depression an inflammatory disorder?
Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524 · see citing works
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325 · see citing works
Jeon, S. W., & Kim, Y. K. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i3.283 · Cited by 247 · see citing works
Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets
Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works
Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95 · see citing works
Berk, M., Woods, R. L., Nelson, M. R., Shah, R. C., Reid, C. M., Storey, E., Fitzgerald, S., Lockery, J. E., Wolfe, R., Mohebbi, M., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.1214 · Cited by 89 · see citing works
Wang, J.-M., Yang, L.-H., Zhang, Y.-Y., Niu, C.-L., Cui, Y., Feng, W.-S., & Wang, G.-F. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.08.008 · Cited by 72 · see citing works
- Authors
- Wang, Y., Yang, F., Liu, Y.-F., Gao, F., & Jiang, W.
- Affiliations
- Xijing Hospital (CN)
- Corresponding author
- Jiang, Wen
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 499
- Issue
- 2
- Pages
- 74-79
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2085868592
- Cited by
- 56
- References
- 35
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 2 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of China (30870840)
- Program for New Century Excellent Talents in University
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- aspirin, treatment-resistant depression, fluoxetine, antidepressant augmentation, chronic unpredictable mild stress, cyclooxygenase-2, prostaglandin E2, hippocampus
- MeSH terms
- Animals, Antidepressive Agents, Aspirin, Depression, Drug Therapy, Combination, Fluoxetine, Hippocampus, Male, Treatment Outcome, Rats, Sprague-Dawley, Rats
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