Cited by 56Treatment of Major DepressionTryptophan and brain disordersStress Responses and Cortisol

Acetylsalicylic acid as an augmentation agent in fluoxetine treatment resistant depressive rats

Wang, Ying, Yang, Feng, Liu, Yang-Feng, Gao, Fei, Jiang, Wen·2011·Neuroscience Letters

Abstract

Clinical studies have reported that adjunctive acetylsalicylic acid (aspirin) therapy is beneficial for patients with treatment resistant depression (TRD). However, there still exist negative epidemiological data on the link between aspirin and depression. Therefore, this study aimed to further investigate whether aspirin can be used as an augmentation agent in fluoxetine treatment resistant depressive rats induced by chronic unpredictable mild stress (CUMS). In this study, the effects of CUMS regimen and antidepressant treatment were assessed by behavioral testing, hippocampal expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)). 4-week fluoxetine treatment reversed the behavioral changes in approximately 70-80% depressive rats. That is, 20-30% depressive rats were resistant to fluoxetine. In the hippocampus of fluoxetine treatment resistant depressive rats, a significant upregulation of COX-2 level and PGE(2) concentration was observed. However, in these rats adjunctive aspirin treatment significantly improved the depressive behaviors and downregulated the COX-2 level and PGE(2) concentration in the hippocampus. Thus, our results suggest that aspirin can be served as an effective adjunctive agent in the treatment resistant depression mediated by inhibition of the COX-2 level and PGE(2) concentration.

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Crossref · 10.1016/j.neulet.2011.05.035

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Authors
Wang, Y., Yang, F., Liu, Y.-F., Gao, F., & Jiang, W.
Affiliations
Xijing Hospital (CN)
Corresponding author
Jiang, Wen
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2011-07
Volume
499
Issue
2
Pages
74-79
ISSN
0304-3940 (ISSN-L)
OpenAlex
W2085868592
Cited by
56
References
35
Citations by year
2025: 4 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 2 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 5 · 2012: 5
FWCI
4.22
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation of China (30870840)
  • Program for New Century Excellent Talents in University
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
aspirin, treatment-resistant depression, fluoxetine, antidepressant augmentation, chronic unpredictable mild stress, cyclooxygenase-2, prostaglandin E2, hippocampus
MeSH terms
Animals, Antidepressive Agents, Aspirin, Depression, Drug Therapy, Combination, Fluoxetine, Hippocampus, Male, Treatment Outcome, Rats, Sprague-Dawley, Rats

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