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Cited by 72Traffic and Road SafetySleep and Work-Related FatigueTreatment of Major Depression

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

A placebo controlled investigation into the effects of paroxetine and mirtazapine on measures related to car driving performance

Ridout, F., Meadows, R., Johnsen, S., Hindmarch, I.·2003·Human Psychopharmacology: Clinical and Experimental
DOI 10.1002/hup.494
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Abstract

Objective: To assess the effects of paroxetine and mirtazapine on psychometric performance related to car driving, including an on‐the‐road test of BRT. Method: In a 4‐way, double blind randomised crossover study, 12 healthy volunteers received paroxetine 20 mg mane, mirtazapine 15 mg/30 mg nocte (comparator), mirtazapine 15 mg mane/15 mg b.i.d.(verum) and placebo over a 5 day period with a washout period of 7 days between treatments. Psychometric assessments included ‘on‐the‐road’ BRT (BRT), CFF (CFF), CRT (CRT) and subjective measures of sedation and sleep parameters. Results: Paroxetine had no significant effect on BRT compared with placebo. Although subjective ratings of sleep quality and sedation were impaired, there were significant improvements in both CFF and the recognition reaction component of CRT with paroxetine. Mirtazapine 15 mg/30 mg nocte impaired laboratory performance and some subjective tests. Mirtazapine 15 mg mane/15 mg b.i.d. improved sleep, but significantly impaired all other measures. Conclusion: Paroxetine 20 mg/day has no psychomotor or behavioural toxicity and has no negative impact on BRT. Further research into the chronic and sub‐chronic effects of mirtazapine is needed to establish the clinical significance of these results. Copyright © 2003 John Wiley & Sons, Ltd.

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Crossref · 10.1002/hup.494

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1 of 1 references verified0 citation errors · 0 not checkable

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  • Paroxetine (20mg) was associated with longer sleep latency and poorer reports of sleep quality than mirtazapine (15-30mg).

    “(Ridout et al., 2003) demonstrated that paroxetine (20mg) was associated with longer sleep latency and poorer reports of sleep quality than mirtazapine (15-30mg).”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Ridout et al., 2003

  • Earlier analyses comparing mirtazapine to other antidepressants indicated less nocturnal disturbance and better sleep efficiency than with paroxetine.

    “Earlier analyses comparing mirtazapine to other antidepressants, indicated less nocturnal disturbance and better sleep efficiency than with fluoxetine (Winokur et al., 2003) or paroxetine (Ridout et al., 2003), and better HAMD sleep scores than with paroxetine (Schatzberg et al., 2002) or venlafaxine (Guelfi et al., 2001).”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Ridout et al., 2003

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Metadata

Authors
Ridout, F., Meadows, R., Johnsen, S., & Hindmarch, I.
Affiliations
University of Surrey (GB)
Corresponding author
Ridout, F.
ORCID
Venue
Human Psychopharmacology: Clinical and Experimental
Publisher
Wiley
Published
2003-03-27
Volume
18
Issue
4
Pages
261-269
ISSN
  • 0885-6222 (ISSN-L)
  • 1099-1077
DOI
10.1002/hup.494
OpenAlex
W2164892811
Cited by
72
References
1
Citations by year
2025: 1 · 2023: 2 · 2022: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 5 · 2012: 8
FWCI
18.34
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Human Psychopharmacology Clinical and Experimental (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Topics
  • Physical Sciences › Engineering › Safety, Risk, Reliability and Quality › Traffic and Road Safety
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
paroxetine, mirtazapine, sedation, sleep quality, antidepressant side effects
MeSH terms
Mirtazapine, Adrenergic alpha-Antagonists, Adult, Antidepressive Agents, Automobile Driving, Double-Blind Method, Female, Humans, Male, Mianserin, Surveys and Questionnaires, Reaction Time, Sleep, Sleep Stages, Selective Serotonin Reuptake Inhibitors, Paroxetine, Cross-Over Studies

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