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Cited by 176Sleep and related disordersTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Zolpidem for Persistent Insomnia in SSRI-Treated Depressed Patients

Asnis, Gregory M., Chakraburtty, Amal, DuBoff, Eugene A., Krystal, Andrew, Londborg, Peter D., Rosenberg, Russell, Roth-Schechter, Barbara, Scharf, Martin B., Walsh, James K.·1999·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.v60n1005
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Abstract

Background Depressed individuals effectively treated with selective serotonin reuptake inhibitors (SSRIs) often report persistent insomnia and require adjunctive sleep-promoting therapy. Method Men (N = 40) and women (N = 150) with a mean age of 41.6 years who had persistent insomnia in the presence of effective and stable treatment (at least 2 weeks) with fluoxetine ( or =30 minutes or a sleep time of Results Compared with placebo, zolpidem was associated with improved sleep: longer sleep times (weeks 1 through 4, p Conclusion In this defined patient population, zolpidem, 10 mg, was effectively and safely co-administered with an SSRI, resulting in improved self-rated sleep, daytime functioning, and well-being.

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  • In the single-blind placebo phase, the zolpidem group presented significant worsening of sleep.

    “In the singleblind phase of placebo, the zolpidem group presented significant worsening of sleep, but no evidence of withdrawal effects.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Asnis et al., 1999

  • Zolpidem demonstrated significant improvements in subsequent daytime perceptions.

    “Those receiving zolpidem demonstrated improved sleep (longer TST, better sleep quality, and reduced WASO) and significant improvements in subsequent daytime perceptions.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Asnis et al., 1999

  • In the single-blind placebo phase, there was no evidence of withdrawal effects in the zolpidem group.

    “In the singleblind phase of placebo, the zolpidem group presented significant worsening of sleep, but no evidence of withdrawal effects.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Asnis et al., 1999

  • In SSRI-treated depressed patients with significant insomnia, zolpidem 10 mg demonstrated improved sleep (longer TST, better sleep quality, reduced WASO).

    “Those receiving zolpidem demonstrated improved sleep (longer TST, better sleep quality, and reduced WASO) and significant improvements in subsequent daytime perceptions.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Asnis et al., 1999

Cited by

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Authors
Asnis, G. M., Chakraburtty, A., DuBoff, E. A., Krystal, A., Londborg, P. D., Rosenberg, R., Roth-Schechter, B., Scharf, M. B., & Walsh, J. K.
Affiliations
Montefiore Medical Center (US)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
1999-10-15
Volume
60
Issue
10
Pages
668-676
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.v60n1005
OpenAlex
W1970151346
Cited by
176
References
0
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 13 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 5
FWCI
2.75
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
zolpidem, chronic insomnia, major depressive disorder, dysthymia, minor depressive disorder, selective serotonin reuptake inhibitors, fluoxetine, sertraline, paroxetine, hypnotic efficacy, sleep quality, number of awakenings, sleep latency, daytime dysfunction, adverse events, treatment discontinuation
MeSH terms
Zolpidem, Adult, Depressive Disorder, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Hypnotics and Sedatives, Sleep Initiation and Maintenance Disorders, Male, Placebos, Pyridines, Sleep, Comorbidity, Single-Blind Method, Treatment Outcome, Selective Serotonin Reuptake Inhibitors

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