The neuropsychology of ecstasy (MDMA) use: a quantitative review.

Zakzanis, Konstantine K.; Campbell, Zachariah; Jovanovski, Diana

doi:10.1002/hup.873

Cited by 87Psychedelics and Drug StudiesForensic Toxicology and Drug AnalysisSubstance Abuse Treatment and Outcomes

The neuropsychology of ecstasy (MDMA) use: a quantitative review.

Zakzanis, Konstantine K., Campbell, Zachariah, Jovanovski, Diana·2007·Human Psychopharmacology: Clinical and Experimental

DOI 10.1002/hup.873

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Abstract

A growing number of empirical studies have found varying neuropsychological impairments associated with use of 3,4-methylenedioxymethamphetamine (MDMA) use. We set out to determine to what extent neuropsychological abilities are impaired in MDMA users. To do so, meta-analytical methods were used to determine the magnitude of neuropsychological impairment in MDMA users across pre-specified cognitive domains. We found that cognitive impairment secondary to recreational drug use may result in what might be described as small-to-medium effects across all cognitive domains with learning and memory being most impaired. We also found that total lifetime ingestion of MDMA appears to be negatively associated with performance on tasks ranging from attention and concentration to learning and memory. Implications and limitations of these findings are discussed.

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There is only a very small effect size for MDMA use (EF composite d = 0.25).
“only a very small effect size for MDMA use (EF composite d = 0.25, Zakzanis et al., 2007).”
From Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches (2015) · cites this paper as Zakzanis et al., 2007

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Authors: Zakzanis, K. K., Campbell, Z., & Jovanovski, D.
Affiliations: University of Toronto (CA)
Corresponding author: Zakzanis, Konstantine K.
ORCID: Zakzanis, Konstantine K.
Venue: Human Psychopharmacology: Clinical and Experimental
Publisher: Wiley
Published: 2007-09-25
Volume: 22
Issue: 7
Pages: 427-435
ISSN: 0885-6222 (ISSN-L)
1099-1077
DOI: 10.1002/hup.873
OpenAlex: W2000906264
Cited by: 87
References: 73
Citations by year: 2025: 2 · 2024: 3 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 8 · 2013: 4 · 2012: 11
FWCI: 1.76
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Human Psychopharmacology Clinical and Experimental (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: MDMA, ecstasy, neuropsychological deficits, cognitive impairment, recreational drug use, learning and memory, attention and concentration, cognitive domain
MeSH terms: Attention, Cognition Disorders, Hallucinogens, Humans, Learning, Memory, Neuropsychological Tests, Psychomotor Performance, N-Methyl-3,4-methylenedioxyamphetamine

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The neuropsychology of ecstasy (MDMA) use: a quantitative review.

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