Neuropsychological consequences of chronic opioid use: a quantitative review and meta-analysis.
Abstract
Introduction It is widely assumed within the accumulated literature that neuropsychological function is commonly impaired as a consequence of chronic opioid use. Method Quantitative and systematic review of the literature on the neuropsychology of chronic opioid use using the meta-analysis of observational studies in epidemiology (MOOSE) and the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Results This meta-analysis suggests that chronic opioid exposure is associated with deficits across a range of different neuropsychological domains. However, the only domains where meta-analysis suggests robust impairment were those of verbal working memory, cognitive impulsivity (risk taking) and cognitive flexibility (verbal fluency). The magnitude of effect across these cognitive domains was medium according to Cohen's benchmark criteria. Discussion This analysis highlighted methodological problems present in the literature used and the value of utilising meta-analytic techniques to help further elucidate the neuropsychological consequences of chronic opioid use from 'core' addiction phenotypes.
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A meta-analysis found no deficits on a composite of inhibition and shifting tasks for chronic opioid users.
“However, a meta-analysis found no deficits on a composite of inhibition and shifting tasks for chronic opioid users (Baldacchino et al., 2012)”
From Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches (2015) · cites this paper as Baldacchino et al., 2012
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Self-citation
- Authors
- Baldacchino, A., Balfour, D. J. K., Passetti, F., Humphris, G., & Matthews, K.
- Affiliations
- University of Dundee (GB)
- University of St Andrews (GB)
- Corresponding author
- Baldacchino, A.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 36
- Issue
- 9
- Pages
- 2056-2068
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2080803007
- Cited by
- 263
- References
- 94
- Citations by year
- 2026: 17 · 2025: 13 · 2024: 22 · 2023: 20 · 2022: 26 · 2021: 22 · 2020: 25 · 2019: 25 · 2018: 18 · 2017: 21 · 2016: 23 · 2015: 11 · 2014: 11 · 2013: 9
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- Funders
- NHS Fife Research and Development Department
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- chronic opioid use, opioid use disorder, neuropsychological deficits, cognitive impairment, verbal working memory, impulsivity, risk-taking, cognitive flexibility, verbal fluency
- MeSH terms
- Cognition, Humans, Impulsive Behavior, Memory, Opioid-Related Disorders, Risk-Taking
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