Characterizing the cognitive effects of cocaine: a comprehensive review.
Abstract
Understanding the cognitive sequela of repeated cocaine use is a growing area of research and is crucial to the development of cognitive models of addiction. We systematically reviewed all available placebo-controlled and case-controlled studies on the acute and long-term effects of cocaine on cognitive functioning. In order to compare the magnitude of cognitive effects across cognitive domains we conducted several meta-analyses on a subset of data from long-term effect studies. Studies on acute cocaine administration suggest enhancement of response inhibition and psychomotor speed, while all other domains appear to be unaffected or not investigated adequately. Long-term effects of cocaine show a wide array of deteriorated cognitive functions, indicating that long term cocaine use is characterized by a general cognitive impairment across functions, rather than by specific cognitive deficits. Literature on long-term cocaine effects is more substantial than literature on acute effects. This comprehensive review outlines possible dissociations and similarities of acute vs. long-term cocaine effects in the human brain. Atherosclerosis after cocaine exposure may underlie cognitive dysfunction, suggesting involvement of multiple brain areas. Acute drug studies are important to the future development of addiction models.
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Deficits in shifting and inhibition are associated with cocaine use.
“and deficits in shifting and inhibition associated with cocaine use (Spronk et al., 2013).”
From Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches (2015) · cites this paper as Spronk et al., 2013
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- Authors
- Spronk, D. B., van Wel, J. H. P., Ramaekers, J. G., & Verkes, R. J.
- Affiliations
- Radboud University Nijmegen (NL)
- Maastricht University (NL)
- Corresponding author
- Spronk, Desirée B.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 37
- Issue
- 8
- Pages
- 1838-1859
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2020765636
- Cited by
- 245
- References
- 159
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 20 · 2023: 23 · 2022: 19 · 2021: 14 · 2020: 29 · 2019: 30 · 2018: 23 · 2017: 27 · 2016: 18 · 2015: 17 · 2014: 8
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- cocaine, cognitive effects, acute cocaine administration, cognitive impairment, response inhibition, psychomotor speed, atherosclerosis
- MeSH terms
- Attention, Brain, Cocaine, Cognition, Cognition Disorders, Humans, Neuropsychological Tests, Reaction Time, Cocaine-Related Disorders
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