Objective versus subjective assessment of oral medication adherence in pediatric inflammatory bowel disease
Open accessAbstract
BACKGROUND: The objective was to examine the prevalence and frequency of oral medication nonadherence using a multimethod assessment approach consisting of objective, subjective, and biological data in adolescents with inflammatory bowel disease (IBD). METHODS: Medication adherence was assessed via pill counts, patient/parent interview, and 6-thioguanine nucleotide (6-TGN)/6-methylmercaptopurine nucleotide (6-MMPN) metabolite bioassay in 42 adolescents with IBD. Pediatric gastroenterologists provided disease severity assessments. RESULTS: The objective nonadherence prevalence was 64% for 6-MP/azathioprine (AZA) and 88% for 5-aminosalicylate (5-ASA) medications, whereas subjective nonadherence prevalence was 10% for 6-MP/AZA and 2% for 5-ASA. The objective nonadherence frequency was 38% for 6-MP/AZA and 49% for 5-ASA medications, and subjective nonadherence frequency was 6% for 6-MP/AZA and 3% for 5-ASA. The bioassay data revealed that only 14% of patients had therapeutic 6-TGN levels. CONCLUSIONS: The results indicate that objectively measured medication nonadherence prevalence is consistent with that observed in other pediatric chronic illness populations, and that objective nonadherence frequency is considerable, with 40%-50% of doses missed by patients. Subjective assessments appeared to overestimate adherence. Bioassay adherence data, while compromised by pharmacokinetic variation, might be useful as a cursory screener for nonadherence with follow-up objective assessment. Nonadherence in 1 medication might also indicate nonadherence in other medications. Clinical implications and future research directions are provided.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Medication non-adherence is a common issue for adolescents with IBD.
“Medication non-adherence is a common issue for adolescents with IBD 8, 9 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [8]
Difficulties in IBD self-management experienced by CA include treatment non-adherence.
“Difficulties in IBD self-management experienced by CA include treatment non-adherence 8, 9 and impaired psychosocial function 10, 11 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Adherence to Long-Term Therapies: Evidence for Action
Geest, S. D., & Sabate, E. J. (2003) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(03)00091-4 · Cited by 6,274 · see citing works
Adherence to Long‐Term Therapies: Evidence for Action
Burkhart, P. V., & Sabaté, E. (2003) · Journal of Nursing Scholarship · doi:10.1111/j.1547-5069.2003.tb00001.x · Cited by 2,526 · see citing works
Cyclosporine in Severe Ulcerative Colitis Refractory to Steroid Therapy
Lichtiger, S., Present, D. H., Kornbluth, A. A., Gelernt, I. M., Bauer, J. J., Galler, G. W., Michelassi, F., & Hanauer, S. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406303302601 · Cited by 1,715 · see citing works
Development and Validation of a Pediatric Crohn's Disease Activity Index
Hyams, J. S., Ferry, G. D., Mandel, F. S., Gryboski, J. D., Kibort, P. M., Kirschner, B. S., Griffiths, A. M., Katz, A. J., Grand, R. J., Boyle, J. T., et al. (1991) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.1991.tb10268.x · Cited by 1,054 · see citing works
Dubinsky, M. C., Lamothe, S., Yang, H. Y., Targan, S. R., Sinnett, D., Théorêt, Y., & Seidman, E. G. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70140-5 · Cited by 995 · see citing works
Development and Validation of a Pediatric Crohnʼs Disease Activity Index
Hyams, J. S., Ferry, G. D., Mandel, F. S., Gryboski, J. D., Kibort, P. M., Kirschner, B. S., Griffiths, A. M., Katz, A. J., Grand, R. J., Boyle, J. T., et al. (1991) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199105000-00005 · Cited by 949 · see citing works
Kappelman, M. D., Rifas‐Shiman, S. L., KLEINMAN, K. P., Ollendorf, D., Bousvaros, A., Grand, R. J., & Finkelstein, J. A. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.07.012 · Cited by 931 · see citing works
Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis
Kane, S. V., Huo, D., Aikens, J. E., & Hanauer, S. B. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01383-9 · Cited by 568 · see citing works
Adherence to Pediatric Medical Regimens
Rapoff, M. A. (1999) · Springer eBooks · doi:10.1007/b102349 · Cited by 357 · see citing works
Patient Nonadherence To Medication in Inflammatory Bowel Disease
Sewitch, M. J., Abrahamowicz, M., Barkun, A. N., Bitton, A., Wild, G., Cohen, A., & Dobkin, P. L. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07522.x · Cited by 327 · see citing works
Predictors of Medication Adherence in Inflammatory Bowel Disease
Ediger, J. P., Walker, J. R., Graff, L. A., Lix, L. M., Clara, I. P., Rawsthorne, P. E., Rogala, L., Miller, N., McPhail, C., Deering, K. L., et al. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01212.x · Cited by 276 · see citing works
Medication compliance: a healthcare problem.
Berg, J. S., Dischler, J. E., Wagner, D. J., Raia, J., & Palmer-Shevlin, N. L. (1993) · PubMed · Cited by 272 · see citing works
Buchman, A. L. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01280.x · Cited by 253 · see citing works
The Illness Management Survey: Identifying Adolescents' Perceptions of Barriers to Adherence
Logan, D. E. (2003) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsg028 · Cited by 132 · see citing works
Oral Medication Adherence in Pediatric Inflammatory Bowel Disease
Mackner, L. M., & Crandall, W. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000186409.15392.54 · Cited by 121 · see citing works
Zelikovsky, N., & Schast, A. P. (2008) · PubMed · Cited by 111 · see citing works
Medication-Taking Behavior in a Cohort of Patients with Inflammatory Bowel Disease
Bernal, I., Domènech, E., García-Planella, E., Marín, L., Mañosa, M., Navarro, M., Cabré, E., & Gassull, M. A. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9444-2 · Cited by 108 · see citing works
Therapeutic Drug Monitoring of Azathioprine and 6-Mercaptopurine Metabolites in Crohn Disease
Bélaïche, J., Desager, J. P., Horsmans, Y., & Louis, E. J. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520150218084 · Cited by 107 · see citing works
Assessing activity of pediatric Crohn's disease: Which index to use?
Otley, A. R., van der Zaag–Loonen, H. J., Parekh, N., Corey, M. L., Sherman, P. M., & Griffiths, A. M. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70173-3 · Cited by 104 · see citing works
Cuffari, C., Seidman, E. G., Latour, S., & Théorêt, Y. (1996) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y96-056 · Cited by 77 · see citing works
Adherence Issues in the Medical Management of Asthma
Lemanek, K. L. (1990) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/15.4.437 · Cited by 75 · see citing works
The Beliefs About Medication Scale: Development, Reliability, and Validity
Riekert, K. A., & Drotar, D. (2002) · Journal of Clinical Psychology in Medical Settings · doi:10.1023/a:1014900328444 · Cited by 67 · see citing works
Oliva‐Hemker, M. M., Abadom, V., Cuffari, C., & Thompson, R. E. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31802b320e · Cited by 59 · see citing works
Mortality from asthma in children 1979-1984.
Sly, R. M. (1988) · PubMed · Cited by 53 · see citing works
Treatment Regimen Adherence in Pediatric Gastroenterology
Hommel, K. A., Mackner, L. M., Denson, L. A., & Crandall, W. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318175dda1 · Cited by 48 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [20]Zelikovsky N Medical Adherence Measure Unpublished data 2007 18543839
Cited by
Sorted by citations
Medication Adherence and Health Care Utilization in Pediatric Chronic Illness: A Systematic Review
McGrady, M. E., & Hommel, K. A. (2013) · PEDIATRICS · doi:10.1542/peds.2013-1451 · Cited by 227 · see citing works
Self-citationWaaijman, R., Keukenkamp, R., de Haart, M., Polomski, W. P., Nollet, F., & Bus, S. A. (2013) · Diabetes Care · doi:10.2337/dc12-1330 · Cited by 183 · see citing works
Gray, W. N., Denson, L. A., Baldassano, R. N., & Hommel, K. A. (2012) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsr092 · Cited by 143 · see citing works
Self-citationCole, R., Ashok, D., Razack, A., Azaz, A., & Sebastian, S. (2015) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2015.04.012 · Cited by 142 · see citing works
Telehealth behavioral treatment for medication nonadherence
Hommel, K. A., Hente, E. A., Herzer, M., Ingerski, L. M., & Denson, L. A. (2013) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32835c2a1b · Cited by 134 · see citing works
Self-citationLangberg, J. M., & Becker, S. P. (2012) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-012-0117-8 · Cited by 129 · see citing works
Badawy, S. M., & Kuhns, L. M. (2016) · JMIR mhealth and uhealth · doi:10.2196/mhealth.6425 · Cited by 104 · see citing works
Inflammatory bowel disease in young people
Goodhand, J., Dawson, R., Hefferon, M., Tshuma, N., Swanson, G. R., Wahed, M., Croft, N. M., & Lindsay, J. O. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21145 · Cited by 99 · see citing works
Systematic Review of Digital Interventions for Pediatric Asthma Management
Ramsey, R. R., Plevinsky, J. M., Kollin, S. R., Gibler, R. C., Guilbert, T. W., & Hommel, K. A. (2020) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2019.12.013 · Cited by 95 · see citing works
Self-citationPractical Strategies for Enhancing Adherence to Treatment Regimen in Inflammatory Bowel Disease
Greenley, R. N., Kunz, J. H., Walter, J. G., & Hommel, K. A. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182813482 · Cited by 95 · see citing works
Self-citationTreatment Adherence in Patients With Headache: A Systematic Review
Ramsey, R. R., Ryan, J. L., Hershey, A. D., Powers, S. W., Aylward, B. S., & Hommel, K. A. (2014) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12353 · Cited by 89 · see citing works
Self-citationPrevalence, predictors, and clinical consequences of medical adherence in IBD: How to improve it?
Lakatos, P. L. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.4234 · Cited by 87 · see citing works
Hommel, K. A., Greenley, R. N., Maddux, M. H., Gray, W. N., & Mackner, L. M. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182999b21 · Cited by 85 · see citing works
“Nonadherence prevalence for 5-aminosalicylate (5-ASA) is as high as 88%, whereas 6-mercaptopurine (MP)/azathioprine (AZA) nonadherence prevalence is 64% (31).”
InfluentialSelf-citationReed, B., Lewis, J. D., & Blount, R. L. (2010) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsq076 · Cited by 85 · see citing works
Loiselle, K. A., Lee, J. L., Szulczewski, L., Drake, S., Crosby, L. E., & Pai, A. L. H. (2015) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsv084 · Cited by 83 · see citing works
Gray, W. N., Holbrook, E., Morgan, P. J., Saeed, S. A., Denson, L. A., & Hommel, K. A. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000352 · Cited by 82 · see citing works
Self-citationBrief Report: Barriers to Treatment Adherence in Pediatric Inflammatory Bowel Disease
Hommel, K. A., & Baldassano, R. N. (2009) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsp126 · Cited by 81 · see citing works
Self-citationBarriers to adherence among adolescents with inflammatory bowel disease
Greenley, R. N., Stephens, M., Doughty, A., Raboin, T., & Kugathasan, S. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20988 · Cited by 77 · see citing works
Adherence to Oral Maintenance Treatment in Adolescents with Inflammatory Bowel Disease
Spekhorst, L. M., Hummel, T. Z., Benninga, M. A., van Rheenen, P. F., & Kindermann, A. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000924 · Cited by 71 · see citing works
Schaefer, M. R., & Kavookjian, J. (2017) · Patient Education and Counseling · doi:10.1016/j.pec.2017.05.037 · Cited by 63 · see citing works
Factors associated with thiopurine non-adherence in patients with inflammatory bowel disease
Goodhand, J., Kamperidis, N., Sirwan, B., Macken, L., Tshuma, N., Koodun, Y., Chowdhury, F., Croft, N. M., Direkze, N. C., Langmead, L., et al. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12476 · Cited by 70 · see citing works
Papus, M., Dima, A. L., Viprey, M., Schott, A., Schneider, M. P., & Novais, T. (2022) · Patient Education and Counseling · doi:10.1016/j.pec.2022.06.013 · Cited by 70 · see citing works
Bus, S. A., Waaijman, R., & Nollet, F. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2012.06.019 · Cited by 65 · see citing works
Rates and Predictors of Oral Medication Adherence in Pediatric Patients with IBD
LeLeiko, N. S., Lobato, D. J., Hagin, S., McQuaid, E. L., Seifer, R., Kopel, S. J., Boergers, J., Nassau, J. H., Suorsa, K. I., Shapiro, J. M., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182802b57 · Cited by 63 · see citing works
Use of exclusive enteral nutrition in paediatric Crohn's disease in The Netherlands
de Bie, C., Kindermann, A., & Escher, J. C. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2012.07.001 · Cited by 61 · see citing works
The Impact of COVID-19 on Pediatric Adherence and Self-Management
Plevinsky, J. M., Young, M. A., Carmody, J. K., Durkin, L. K., Gamwell, K. L., Klages, K. L., Ghosh, S., & Hommel, K. A. (2020) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsaa079 · Cited by 56 · see citing works
Self-citationHommel, K. A., Hente, E. A., Odell, S., Herzer, M., Ingerski, L. M., Guilfoyle, S. M., & Denson, L. A. (2012) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32834d09f1 · Cited by 55 · see citing works
Self-citationHommel, K. A., Odell, S., Sander, E., Baldassano, R. N., & Barg, F. K. (2010) · Health & Social Care in the Community · doi:10.1111/j.1365-2524.2010.00951.x · Cited by 54 · see citing works
Self-citationLakatos, P. L., Czegledi, Z., Dávid, G., Kispál, Z., Kiss, L. S., Palatka, K., Kristóf, T., Nagy, F. T., Salamon, A., Demeter, P., et al. (2009) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.11.011 · Cited by 49 · see citing works
Landier, W., Chen, Y., Hageman, L., Kim, H., Bostrom, B., Casillas, J., Dickens, D. S., Evans, W. E., Maloney, K. W., Mascarenhas, L., et al. (2017) · Blood · doi:10.1182/blood-2016-07-726893 · Cited by 46 · see citing works
Individually tailored treatment of medication nonadherence
Hommel, K. A., Herzer, M., Ingerski, L. M., Hente, E., & Denson, L. A. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182203a91 · Cited by 45 · see citing works
Self-citationOral medication adherence and disease severity in pediatric inflammatory bowel disease
Hommel, K. A., Denson, L. A., & Baldassano, R. N. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e328344019c · Cited by 44 · see citing works
Self-citationPatient-Reported Outcomes for Pediatric Adherence and Self-Management: A Systematic Review
Plevinsky, J. M., Gutierrez‐Colina, A. M., Carmody, J. K., Hommel, K. A., Crosby, L. E., McGrady, M. E., Pai, A. L. H., Ramsey, R. R., & Modi, A. C. (2019) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsz096 · Cited by 42 · see citing works
Self-citationGreenley, R. N., Kunz, J. H., Biank, V., Martínez, A., Miranda, A., Noe, J. D., Telega, G. W., Tipnis, N. A., Werlin, S. L., & Stephens, M. C. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21859 · Cited by 41 · see citing works
Diest, A. M. K. V., Ramsey, R. R., Aylward, B. S., Kroner, J. W., Sullivan, S. M., Nause, K., Allen, J. R., Chamberlin, L. A., Slater, S. K., Hommel, K. A., et al. (2016) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12836 · Cited by 41 · see citing works
Self-citationAdherence to Medication During Transition to Adult Services
Campagna, B. R., Weatherley, K., Shemesh, E., & Annunziato, R. A. (2020) · Pediatric Drugs · doi:10.1007/s40272-020-00414-2 · Cited by 39 · see citing works
Managing inflammatory bowel disease in adolescent patients
Day, A. S., Bishop, J., & Lemberg, D. A. (2014) · Adolescent Health Medicine and Therapeutics · doi:10.2147/ahmt.s37956 · Cited by 39 · see citing works
Keerthy, D., Youk, A. O., Srinath, A. I., Malas, N., Bujoreanu, S. I., Bousvaros, A., Keljo, D. J., DeMaso, D. R., & Szigethy, E. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001207 · Cited by 36 · see citing works
Treatment Nonadherence in Inflammatory Bowel Disease
Herman, M. L., & Kane, S. V. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000581 · Cited by 35 · see citing works
Practice-Based Approach to Assessing and Treating Nonadherence in Pediatric Regimens
Duncan, C. L., Mentrikoski, J. M., Wu, Y. P., & Fredericks, E. M. (2014) · Clinical Practice in Pediatric Psychology · doi:10.1037/cpp0000066 · Cited by 34 · see citing works
Text Messaging Effect on Adherence in Children With Inflammatory Bowel Disease
Miloh, T., Shub, M. D., Montes, R. G., Ingebo, K. R., Silber, G. H., & Pasternak, B. A. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001399 · Cited by 34 · see citing works
Vitamin and Mineral Supplement Adherence in Pediatric Inflammatory Bowel Disease
Greenley, R. N., Stephens, K. A., Nguyen, E., Kunz, J. H., Janas, Ł., Goday, P. S., & Schurman, J. V. (2013) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jst037 · Cited by 33 · see citing works
Depressive Symptoms in Youth with Inflammatory Bowel Disease Compared with a Community Sample
Reed, B., Lobato, D. J., Hagin, S., McQuaid, E. L., Seifer, R., Kopel, S. J., Boergers, J., Nassau, J. H., Suorsa, K. I., Bancroft, B., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000442678.62674.b7 · Cited by 30 · see citing works
Treatment Adherence in Child and Adolescent Chronic Migraine Patients
Diest, A. M. K. V., Ramsey, R. R., Kashikar‐Zuck, S., Slater, S. K., Hommel, K. A., Kroner, J. W., LeCates, S. L., Kabbouche, M. A., O’Brien, H. L., Kacperski, J. E., et al. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000481 · Cited by 30 · see citing works
Self-citationLim, J. K., Lee, Y. J., & Park, J. H. (2020) · Journal of Korean Medical Science · doi:10.3346/jkms.2020.35.e92 · Cited by 30 · see citing works
Current Practice and Perception of Screening for Medication Adherence in Inflammatory Bowel Disease
Trindade, A. J., Morisky, D. E., Ehrlich, A. C., Tinsley, A., & Ullman, T. A. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182192207 · Cited by 30 · see citing works
Fu, N., Jacobson, K., Round, A. M., Evans, K., Qian, H., & Bressler, B. L. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i29.5405 · Cited by 28 · see citing works
Longitudinal stability of medication adherence among adolescent solid organ transplant recipients
Loiselle, K. A., Gutierrez‐Colina, A. M., Eaton, C. K., Simons, L. E., Devine, K. A., Mee, L. L., & Blount, R. L. (2015) · Pediatric Transplantation · doi:10.1111/petr.12480 · Cited by 28 · see citing works
Supported self-care for children and adolescents with chronic disease and their families
Fernandes, L. T. B., da Nóbrega, V. M., Silva, M. E. D. A., Machado, A. N., & Collet, N. (2017) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167-2016-0553 · Cited by 28 · see citing works
Behavioral functioning and treatment adherence in pediatric eosinophilic gastrointestinal disorders
Hommel, K. A., Franciosi, J. P., Gray, W. N., Hente, E. A., Ahrens, A., & Rothenberg, M. E. (2012) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2012.01297.x · Cited by 27 · see citing works
Self-citationNiechciał, E., Acerini, C. L., Chiesa, S. T., Stevens, T., Dalton, R. N., Daneman, D., Deanfield, J. E., Jones, T. W., Mahmud, F. H., Marshall, S. M., et al. (2020) · Diabetes Care · doi:10.2337/dc19-0884 · Cited by 26 · see citing works
del Hoyo, J., Millán, M., Garrido‐Marín, A., & Aguas, M. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i7.1139 · Cited by 26 · see citing works
Gray, W. N., Reed, B., Morgan, P. J., Holbrook, E., Kugathasan, S., Saeed, S. A., Denson, L. A., & Hommel, K. A. (2018) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2018.01.008 · Cited by 25 · see citing works
Self-citationSuccessful Transition from Pediatric to Adult Care in Inflammatory Bowel Disease: What is the Key?
Kim, J., & Ye, B. D. (2019) · Pediatric Gastroenterology Hepatology & Nutrition · doi:10.5223/pghn.2019.22.1.28 · Cited by 24 · see citing works
Hommel, K. A., Gray, W. N., Hente, E. A., Loreaux, K., Ittenbach, R. F., Maddux, M. H., Baldassano, R. N., Sylvester, F. A., Crandall, W., Doarn, C. R., et al. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.05.013 · Cited by 24 · see citing works
Self-citationUsefulness of the measurement of azathioprine metabolites in the assessment of non-adherence
Stocco, G., Londero, M., Campanozzi, A., Martelossi, S., Marino, S., Malusà, N., Bartoli, F., Decorti, G., & Ventura, A. (2010) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2010.04.003 · Cited by 23 · see citing works
Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders
Hommel, K. A., Franciosi, J. P., Hente, E. A., Ahrens, A., & Rothenberg, M. E. (2011) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsr090 · Cited by 23 · see citing works
Self-citationVarni, J. W., Shulman, R. J., Self, M. M., Saeed, S. A., Zacur, G. M., Patel, A., Nurko, S., Neigut, D. A., Franciosi, J. P., Saps, M., et al. (2017) · Quality of Life Research · doi:10.1007/s11136-017-1702-6 · Cited by 23 · see citing works
Hommel, K. A., Carmody, J. K., Hershey, A. D., Holbein, C. E., Kabbouche, M. A., Peugh, J., & Powers, S. W. (2020) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13805 · Cited by 23 · see citing works
Self-citationTran, L., & Mulligan, K. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy299 · Cited by 22 · see citing works
Maddux, M. H., Ricks, S., DeLurgio, S. A., & Hommel, K. A. (2017) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2017.03.006 · Cited by 22 · see citing works
Self-citationObjective Versus Self-Reported Adherence to Airway Clearance Therapy in Cystic Fibrosis
Oates, G. R., Štěpáníková, I., Rowe, S. M., Gamble, S., Gutierrez, H. H., & Harris, W. T. (2018) · Respiratory Care · doi:10.4187/respcare.06436 · Cited by 22 · see citing works
Wu, Y. P., Pai, A. L. H., Gray, W. N., Denson, L. A., & Hommel, K. A. (2013) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jst043 · Cited by 22 · see citing works
Self-citationLongitudinal non‐adherence predicts treatment escalation in paediatric ulcerative colitis
Carmody, J. K., Plevinsky, J. M., Peugh, J., Denson, L. A., Hyams, J. S., Lobato, D. J., LeLeiko, N. S., & Hommel, K. A. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15445 · Cited by 21 · see citing works
Self-citationKnowledge of disease and self‐management of adolescents with inflammatory bowel diseases
Krauthammer, A., Harel, T., Zevit, N., Shouval, D. S., Shamir, R., & Weiss, B. (2020) · Acta Paediatrica · doi:10.1111/apa.15211 · Cited by 21 · see citing works
A Systematic Review of Medication Adherence Interventions in Pediatric Sickle Cell Disease
Shih, S. W., & Cohen, L. L. (2020) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsaa031 · Cited by 20 · see citing works
Schaefer, M. R., Wagoner, S. T., Young, M. E., Rawlinson, A. R., Kavookjian, J., Shapiro, S. K., & Gray, W. N. (2018) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000602 · Cited by 19 · see citing works
Abraham, O., Alexander, D. S., Schleiden, L. J., & Carpenter, D. M. (2017) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-22.6.412 · Cited by 19 · see citing works
6-Thioguanine Levels in Pediatric IBD Patients
LeLeiko, N. S., Lobato, D. J., Hagin, S., Hayes, C. E., McQuaid, E. L., Seifer, R., Kopel, S. J., Boergers, J., Nassau, J. H., Suorsa, K. I., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000436960.00405.56 · Cited by 18 · see citing works
Messerli, M., Vriends, N., & Hersberger, K. E. (2018) · Patient Preference and Adherence · doi:10.2147/ppa.s160789 · Cited by 18 · see citing works
Evaluation of a Novel Educational Tool in Adolescents With Inflammatory Bowel Disease
Vaz, K. K. H., Carmody, J. K., Zhang, Y., Denson, L. A., & Hommel, K. A. (2019) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002431 · Cited by 18 · see citing works
Self-citationSkeens, M. A., Sezgın, E., Stevens, J. H., Landier, W., Pai, A. L. H., & Gerhardt, C. A. (2022) · JMIR Research Protocols · doi:10.2196/39098 · Cited by 17 · see citing works
Reed, B., Lewis, J. D., & Blount, R. L. (2012) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jss122 · Cited by 16 · see citing works
Samson, C. M., MAGER, D. E., Frazee, S. G., & Yu, F. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001304 · Cited by 16 · see citing works
Broekman, M. M. T. J., Coenen, M. J. H., Wanten, G. J. A., van Marrewijk, C. J., Kievit, W., Klungel, O. H., Verbeek, A. L. M., Wong, D. R., Hooymans, P. M., Guchelaar, H., et al. (2017) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001025 · Cited by 15 · see citing works
Digital Therapeutic Self‐Management Intervention in Adolescents With Inflammatory Bowel Disease
Hommel, K. A., Ramsey, R. R., Gray, W. N., & Denson, L. A. (2022) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003623 · Cited by 14 · see citing works
Self-citationSoobraty, A., Boughdady, S., & Selinger, C. P. (2017) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v8.i1.67 · Cited by 13 · see citing works
Medication Adherence Across the Life Span in Inflammatory Bowel Disease
Knowles, S. R., & Alex, G. (2020) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000467 · Cited by 13 · see citing works
Tóbi, L., Prehoda, B., Balogh, A., Nagy-Pál, P., Kovács, K., Miheller, P., Iliás, Á., Dezsőfi‐Gottl, A., & Cseh, Á. (2024) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848241252947 · Cited by 12 · see citing works
Loreaux, K., Gray, W. N., Denson, L. A., & Hommel, K. A. (2014) · Children s Health Care · doi:10.1080/02739615.2014.912943 · Cited by 11 · see citing works
Self-citationDepression Predicts Prolonged Length of Hospital Stay in Pediatric Inflammatory Bowel Disease
Patel, P. V., Pantell, M. S., Heyman, M. B., & Verstraete, S. G. (2019) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002426 · Cited by 11 · see citing works
Maddux, M. H., Gordy, A., Schurman, C., Cole, T., & Staggs, V. S. (2019) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-019-09636-0 · Cited by 10 · see citing works
Hommel, K. A., Noser, A. E., Plevinsky, J. M., Gamwell, K., & Denson, L. A. (2024) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.12229 · Cited by 10 · see citing works
Self-citationInflammatory bowel disease in adolescents: What problems does it pose?
Lu, Y. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i22.2691 · Cited by 9 · see citing works
Alsous, M. M., Hawwa, A. F., Imrie, C., Szabo, A., Alefishat, E. A., Farha, R. K. A., Rwalah, M., Horne, R., & McElnay, J. C. (2020) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2020/9562192 · Cited by 8 · see citing works
Successful transition from pediatric to adult care in inflammatory bowel disease: what is the key?
Kim, J., & Ye, B. D. (2018) · Intestinal Research · doi:10.5217/ir.2018.00128 · Cited by 8 · see citing works
Patient, Parent, and Provider Perceptions of Barriers to Pediatric Inflammatory Bowel Disease Care
Dotson, J. L., Bricker, J. B., Chisolm, D. J., & Mackner, L. M. (2023) · JPGN Reports · doi:10.1097/pg9.0000000000000386 · Cited by 7 · see citing works
Roberts, C. M., Plevinsky, J. M., Gamwell, K. L., Noser, A. E., Denson, L. A., & Hommel, K. A. (2023) · Health Care Transitions · doi:10.1016/j.hctj.2023.100031 · Cited by 6 · see citing works
Self-citationVernon‐Roberts, A., Gearry, R. B., & Day, A. S. (2021) · Gastrointestinal Disorders · doi:10.3390/gidisord3020007 · Cited by 6 · see citing works
Practice survey: adherence monitoring and intervention in pediatric gastroenterology and hepatology
Maddux, M. H., Ricks, S., Bass, J., Daniel, J. F., Carpenter, E. S., & Radford, K. (2018) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s159611 · Cited by 5 · see citing works
Bąk-Drabik, K. K., Adamczyk, P., Duda-Wrońska, J., Dąbrowska-Piechota, D., Jarzumbek, A., & Kwiecień, J. (2021) · Gastroenterology Research and Practice · doi:10.1155/2021/9970019 · Cited by 5 · see citing works
Reidy, B. L., Powers, S. W., Coffey, C. S., Chamberlin, L. A., Ecklund, D. J., Klingner, E. A., Yankey, J. W., Korbee, L. L., Porter, L. L., Peugh, J., et al. (2021) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsab123 · Cited by 5 · see citing works
Ababneh, A. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.211519 · Cited by 5 · see citing works
BIOPSYCHOSOCIAL APPROACH OF GASTROINTESTINAL DISORDERS
Pojoga, C., & Stănculete, M. F. (2014) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-289 · Cited by 4 · see citing works
Li, S., Li, P., Sun, H., Hu, W., Hu, S., Chen, Y., & Lv, M. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s330842 · Cited by 4 · see citing works
Medication adherence in youths with CKD: habits for success
Eaton, C. K., Comer, M., Pruette, C. S., & Riekert, K. A. (2023) · Pediatric Nephrology · doi:10.1007/s00467-023-05976-0 · Cited by 3 · see citing works
Lakatos, L., Czegledi, Z., Dávid, G., Kispál, Z., Kiss, L. S., Palatka, K., Kristóf, T., Molnár, T., Salamon, A., Demeter, P., et al. (2010) · Orvosi Hetilap · doi:10.1556/oh.2010.28805 · Cited by 3 · see citing works
Wagner, D. V., Stoeckel, M., Hansen, T., Muir, L. V., & Harris, M. A. (2023) · Clinical Practice in Pediatric Psychology · doi:10.1037/cpp0000481 · Cited by 3 · see citing works
Karimi, N., Lukin, A., Moore, A. R., Pipicella, J. L., Kanazaki, R., Williams, A., Ng, W., Kariyawasam, V. C., Mitrev, N., Pandya, K., et al. (2023) · International Journal of Adolescent Medicine and Health · doi:10.1515/ijamh-2023-0078 · Cited by 3 · see citing works
Castillo, G., Mack, D. R., Lalu, M. M., Singleton, R., Fergusson, D. A., Stintzi, A. P., Harrison, M. E., & Presseau, J. (2021) · Pilot and Feasibility Studies · doi:10.1186/s40814-021-00815-1 · Cited by 3 · see citing works
- Authors
- Hommel, K. A., Davis, C. M., & Baldassano, R. N.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Children's Hospital of Philadelphia (US)
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04
- Volume
- 15
- Issue
- 4
- Pages
- 589-593
- ISSN
- 1078-0998 (ISSN-L)
- PMC
- PMC2663377
- OpenAlex
- W2007722541
- Cited by
- 127
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 13 · 2020: 12 · 2019: 9 · 2018: 8 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 11 · 2012: 5
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK0789392, K23DK079037)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Keywords
- medication adherence, pediatric inflammatory bowel disease
- MeSH terms
- Assessment of Medication Adherence, Administration, Oral, Adolescent, Psychology, Adolescent, Female, Gastrointestinal Agents, Humans, Male, Severity of Illness Index, Inflammatory Bowel Diseases, Prevalence, Drug Monitoring, Medication Adherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
