Adherence to Oral Maintenance Treatment in Adolescents with Inflammatory Bowel Disease
Open accessAbstract
OBJECTIVES: The aim of this study was to systematically review the rates of nonadherence to oral maintenance treatment in adolescents with inflammatory bowel disease (IBD), and to describe perceived barriers to adherence and psychosocial factors involved. METHODS: The article considered studies published in MEDLINE, Embase, and PsycINFO up to March 2015. Studies that had collected data on adherence to thiopurines or aminosalicylates in a cohort of adolescents with IBD. Case reports and case series were excluded. RESULTS: A total of 25 studies were included. Lack of uniformity of outcome measures made pooling of data impossible. Rates of medication nonadherence ranged from 2% to 93%. The most frequently reported barriers were "just forgot," "wasn't home," and "interferes with activity." Family dysfunction, peer victimization, poor health-related quality of life, poor child-coping strategies, anxiety, and depressive symptoms were associated with medication nonadherence. CONCLUSIONS: Nonadherence to oral maintenance therapy in adolescents with IBD is a significant health care problem and can lead to unnecessary escalation in therapy. Difficulties in family and social interactions, and psychosocial dysfunction can jeopardize IBD treatment outcome and should receive attention early in the course of the disease.
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Patients with IBD and comorbid depression and/or anxiety may be less likely to adhere to medical care procedures and therapeutic schemes, resulting in unnecessary escalation in therapy and complications.
“patients with IBD and co-morbid depression and/or anxiety may be less likely to adhere to medical care procedures and therapeutic schemes, resulting in unnecessary escalation in therapy and complications [50,51,52].”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [52]
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- Authors
- Spekhorst, L. M., Hummel, T. Z., Benninga, M. A., van Rheenen, P. F., & Kindermann, A.
- Affiliations
- Medisch Spectrum Twente (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Department of Pediatric Gastroenterology University Medical Center Groningen Groningen The Netherlands
- Corresponding author
- Spekhorst, Lieke M.
- Hummel, Thalia Z.
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2016-02
- Volume
- 62
- Issue
- 2
- Pages
- 264-270
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2413873158
- Cited by
- 71
- References
- 44
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 10 · 2022: 5 · 2021: 13 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Health Professions › Speech and Hearing › Adolescent and Pediatric Healthcare
- Keywords
- medication adherence, inflammatory bowel disease, adolescents, oral maintenance therapy, thiopurines, aminosalicylates, barriers to adherence, psychosocial factors, family dysfunction, peer victimization, health-related quality of life, anxiety, depressive symptoms, coping strategies
- MeSH terms
- Adaptation, Psychological, Adolescent, Anxiety, Depression, Humans, Quality of Life, Stress, Psychological, Inflammatory Bowel Diseases, Medication Adherence
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