Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity
Open accessAbstract
DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome end, is involved in the regulation of the replicative life span by maintaining telomere length. This enzyme is activated in germ and stem cells, repressed in normal somatic cells and reactivated in a large majority of tumor cells. The promoter region of the hTERT gene, encoding for the catalytic subunit of human telomerase, has been located in a CpG island and may therefore be regulated at least in part by DNA methylation. We analyzed the methylation status of 27 CpG sites within the hTERT promoter core region by methylation‐sensitive single‐strand conformation analysis (MS‐SSCA) and direct sequencing using bisulfite‐modified DNA in 56 human tumor cell lines, as well as tumor and normal tissues from different organs. A positive correlation was observed among hypermethylation of the hTERT promoter, hTERT mRNA expression and telomerase activity (p < 0.00001). Furthermore, this correlation was confirmed in normal tissues where hypermethylation of the hTERT promoter was found exclusively in hTERT‐expressing telomerase‐positive samples and was absent in telomerase‐negative samples (p < 0.00002). Since tumor tissues contain also nonneoplastic stromal elements, we performed microdissection to allow confirmation that the hTERT promoter methylation truly occurred in tumor cells. Our results suggest that methylation may be involved in the regulation of hTERT gene expression. To our knowledge, this is the first gene in which methylation of its promoter sequence has been found to be positively correlated with gene expression. © 2002 Wiley‐Liss, Inc.
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There is a strong correlation between hTERT expression and telomerase activity, and recent studies have linked hTERT promoter hypermethylation to CRC and other cancer types.
“There is a strong correlation between hTERT expression and TA, and recent studies have linked hTERT promoter hypermethylation to CRC and other cancer types [206].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [206]
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Cites
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
Herman, J. G., Graff, J. R., Myöhänen, S., Nelkin, B. D., & Baylin, S. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9821 · Cited by 5,610 · see citing works
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,734 · see citing works
Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia
Baylln, S. B., Herman, J. G., Graff, J. R., Vertino, P. M., & Issa, J. J. (1997) · Advances in cancer research · doi:10.1016/s0065-230x(08)60702-2 · Cited by 1,913 · see citing works
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin.
Nan, X.-S., Campoy, F., & Bird, A. (1997) · Cell · doi:10.1016/s0092-8674(00)81887-5 · Cited by 1,403 · see citing works
Weinrich, S. L., Pruzan, R., Ma, L., Ouellette, M. M., Tesmer, V. M., Holt, S. E., Bodnar, A. G., Lichtsteiner, S., Kim, N. W., Trager, J. B., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-498 · Cited by 963 · see citing works
The essentials of DNA methylation
Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90526-i · Cited by 948 · see citing works
Direct activation of TERT transcription by c-MYC
Wu, K.-J., Grandori, C., Amacker, M., Simon-Vermot, N., Polack, A., Lingner, J., & Dalla-Favera, R. (1999) · Nature Genetics · doi:10.1038/6010 · Cited by 893 · see citing works
Telomere maintenance by recombination in human cells
Dunham, M. A., Neumann, A. A., Fasching, C. L., & Reddel, R. R. (2000) · Nature Genetics · doi:10.1038/82586 · Cited by 879 · see citing works
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Boyes, J., & Bird, A. P. (1991) · Cell · doi:10.1016/0092-8674(91)90267-3 · Cited by 733 · see citing works
High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines
Antequera, F., Boyes, J., & Bird, A. P. (1990) · Cell · doi:10.1016/0092-8674(90)90015-7 · Cited by 708 · see citing works
Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region
Prendergast, G. C., & Ziff, E. B. (1991) · Science · doi:10.1126/science.1987636 · Cited by 565 · see citing works
Estrogen activates telomerase.
Kyo, S., Takakura, M., Kanaya, T., Zhuo, W., FUJIMOTO, K., Nishio, Y., Orimo, A., & Inoue, M. (1999) · PubMed · Cited by 509 · see citing works
Cong, Y. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.1.137 · Cited by 485 · see citing works
高倉, 正. (2002) · Medical Entomology and Zoology · Cited by 475 · see citing works
Takakura, M., Kyo, S., Kanaya, T., Hirano, H., Takeda, J., Yutsudo, M., & Inoue, M. (1999) · PubMed · Cited by 446 · see citing works
Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.
Horikawa, I., Cable, P. L., Afshari, C. A., & Barrett, J. C. (1999) · PubMed · Cited by 395 · see citing works
Putnam, J. B., Light, R. W., Rodriguez, R. M., Ponn, R. B., Olak, J., Pollak, J. S., Lee, R. B., Payne, D. K., Graeber, G., & Kovitz, K. L. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19991115)86:10 · Cited by 385 · see citing works
Investigating stem cells in human colon by using methylation patterns
Yatabe, Y., Tavaré, S., & Shibata, D. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191225998 · Cited by 368 · see citing works
Forsyth, N. R., Wright, W. E., & Shay, J. W. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.690412.x · Cited by 345 · see citing works
Telomeres and telomerase in aging and cancer
Harley, C. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80016-6 · Cited by 325 · see citing works
Zingg, J.-M. A. (1997) · Carcinogenesis · doi:10.1093/carcin/18.5.869 · Cited by 321 · see citing works
Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)
Poole, J. C., Andrews, L. G., & Tollefsbol, T. O. (2001) · Gene · doi:10.1016/s0378-1119(01)00440-1 · Cited by 275 · see citing works
Studies of the molecular mechanisms in the regulation of telomerase activity
Liu, J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2091 · Cited by 253 · see citing works
Hypermethylation of tumor suppressor genes in cancer
Herman, J. G. (1999) · Seminars in Cancer Biology · doi:10.1006/scbi.1999.0138 · Cited by 221 · see citing works
Devereux, T. R., Horikawa, I., Anna, C. H., Annab, L. A., Afshari, C. A., & Barrett, J. C. (1999) · PubMed · Cited by 214 · see citing works
A Bisulfite Method of 5-Methylcytosine Mapping That Minimizes Template Degradation
Raizis, A. M., Schmitt, F., & Jost, J. P. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.1204 · Cited by 212 · see citing works
Methylation of the human telomerase gene CpG island.
Dessain, S. K., Yu, H., Reddel, R. R., Beijersbergen, R. L., & Weinberg, R. A. (2000) · PubMed · Cited by 185 · see citing works
Tahara, H., Yasui, W., Tahara, E., Fujimoto, J., Ito, K., Tamai, K., Nakayama, J., Ishikawa, F., Tahara, E., & Ide, T. (1999) · Oncogene · doi:10.1038/sj.onc.1202458 · Cited by 152 · see citing works
Kong, F., Jirtle, R. L., Huang, D. H., Clough, R. W., & Anscher, M. S. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19991101)86:9 · Cited by 133 · see citing works
DNA Methylation from Embryo to Adult
Razin, A., & Kafri, T. (1994) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60853-3 · Cited by 128 · see citing works
DNA methylation analysis a review of current methodologies
Oakeley, E. J. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00043-1 · Cited by 106 · see citing works
Oh, S., Song, Y., Kim, U.-J., Yim, J., & Kim, T. K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1366 · Cited by 71 · see citing works
Battistuzzi, G., D’Urso, M., Toniolo, D., Persico, G. M., & Luzzatto, L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.5.1465 · Cited by 68 · see citing works
Studies of DNA methylation in animals
Bird, A., Tate, P., Nan, X.-S., Campoy, J., Meehan, R., Cross, S., Tweedie, S., Charlton, J., & Macleod, D. (1995) · Journal of Cell Science · doi:10.1242/jcs.1995.supplement_19.5 · Cited by 63 · see citing works
Bednarik, D. P., Duckett, C. S., Kim, S. U., Perez, V. L., Griffis, K., Guenthner, P. C., & Folks, T. M. (1991) · PubMed · Cited by 62 · see citing works
The composition of CD34 subpopulations differs between bone marrow, blood and cord blood.
Fritsch, G., Stimpfl, M., Kurz, M., Printz, D., Buchinger, P., Fischmeister, G., Hoecker, P., & Gadner, H. (1996) · PubMed · Cited by 61 · see citing works
Yan, P., Coindre, J., Benhattar, J., Bosman, F. T., & Guillou, L. (1999) · PubMed · Cited by 54 · see citing works
Self-citationChaubert, P., Bautista, D., & Benhattar, J. (1993) · PubMed · Cited by 49 · see citing works
Self-citationBian, Y.-S., Yan, P., Osterheld, M. C., Fontolliet, C., & Benhattar, J. (2001) · BioTechniques · doi:10.2144/01301st02 · Cited by 46 · see citing works
Self-citationCell proliferation, carcinogenesis and diverse mechanisms of telomerase regulation
Krupp, G., Klapper, W., & Parwaresch, R. M. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000708 · Cited by 36 · see citing works
FOCAL INTRATUMORAL HETEROGENEITY FOR TELOMERASE ACTIVITY IN HUMAN PROSTATE CANCER
Wullich, B., Rohde, V., Oehlenschlager, B., Bonkhoff, H., Ketter, R., Zwergel, T., & Sattler, H.-P. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(05)68872-6 · Cited by 34 · see citing works
Baïsse, B., Bia, Y.-S., & Benhattar, J. (2000) · BioTechniques · doi:10.2144/00285bm06 · Cited by 32 · see citing works
Self-citationHermann, R., & Doerfler, W. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80391-f · Cited by 31 · see citing works
Tissue Quality is an Important Determinant of Telomerase Activity as Measured by TRAP Assay
Yan, P., Bosman, F. T., & Benhattar, J. (1998) · BioTechniques · doi:10.2144/98254dt05 · Cited by 28 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Wu A, Ichihashi M, Ueda M. Correlation of the expression of human telomerase subunits with telomerase activity in normal skin and skin tumors. Cancer 1999;86:2038 -44
- Delgado R, Rathi A, Albores-Saavedra J, Gazdar AF. Expression of the RNA component of human telomerase in adult testicular germ cell neoplasia. Cancer 1999;86:1802-11.
Cited by
Sorted by citations
Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role
Crider, K. S., Yang, T. P., Berry, R. J., & Bailey, L. B. (2012) · Advances in Nutrition · doi:10.3945/an.111.000992 · Cited by 1,022 · see citing works
The relationship between COPD and lung cancer
Durham, A. L., & Adcock, I. M. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.08.017 · Cited by 456 · see citing works
Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines
Meeran, S. M., Patel, S. N., & Tollefsbol, T. O. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011457 · Cited by 372 · see citing works
Kyo, S., Takakura, M., Fujiwara, T., & Inoue, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00878.x · Cited by 347 · see citing works
TERT—Regulation and Roles in Cancer Formation
Dratwa, M., Wysoczańska, B., Łacina, P., Kubik, T., & Bogunia‐Kubik, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.589929 · Cited by 314 · see citing works
Promoter DNA Hypermethylation and Paradoxical Gene Activation
Smith, J., Sen, S., Weeks, R. J., Eccles, M. R., & Chatterjee, A. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.02.007 · Cited by 268 · see citing works
Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
Leao, R. R. N., Apolónio, J. D., Lee, D., Figueiredo, A., Tabori, U. Y., & Castelo‐Branco, P. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0422-8 · Cited by 266 · see citing works
Impact on DNA Methylation in Cancer Prevention and Therapy by Bioactive Dietary Components
Li, Y.-C., & Tollefsbol, T. O. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791299966 · Cited by 256 · see citing works
Castelo‐Branco, P., Choufani, S., Mack, S. C., Gallagher, D., Zhang, C., Lipman, T., Zhukova, N., Walker, E. J., Martin, D. C., Merino, D. M., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70110-4 · Cited by 250 · see citing works
Telomerase regulation and stem cell behaviour
Flores, I., Benetti, R., & Blasco, M. A. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.03.003 · Cited by 232 · see citing works
Differential hypermethylation of SOCS genes in ovarian and breast carcinomas
Sutherland, K. D., Lindeman, G. J., Choong, D. Y. H., Wittlin, S., Brentzell, L., Phillips, W., Campbell, I. G., & Visvader, J. E. (2004) · Oncogene · doi:10.1038/sj.onc.1207787 · Cited by 217 · see citing works
Zinn, R. L., Pruitt, K., Eguchi, S., Baylin, S. B., & Herman, J. G. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3396 · Cited by 210 · see citing works
Kim, W., Ludlow, A. T., Min, J., Robin, J. D., Stadler, G., Mender, I., Lai, T., Zhang, N., Wright, W. E., & Shay, J. W. (2016) · PLoS Biology · doi:10.1371/journal.pbio.2000016 · Cited by 213 · see citing works
Renaud, S., Loukinov, D. I., Abdullaev, Z., Guilleret, I., Bosman, F. T., Lobanenkov, V. V., & Benhattar, J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1125 · Cited by 204 · see citing works
Self-citationGenistein depletes telomerase activity through cross‐talk between genetic and epigenetic mechanisms
Li, Y., Liu, L., Andrews, L. G., & Tollefsbol, T. O. (2009) · International Journal of Cancer · doi:10.1002/ijc.24398 · Cited by 194 · see citing works
Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis
Parris, B. A., O’Farrell, H. E., Fong, K. M., & Yang, I. A. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.10.54 · Cited by 193 · see citing works
DNA hypermethylation within TERT promoter upregulates TERT expression in cancer
Lee, D. D., Leao, R. R. N., Komosa, M., Gallo, M., Zhang, C. H., Lipman, T., Remke, M., Heidari, A., Nunes, N. M., Apolónio, J. D., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci121303 · Cited by 185 · see citing works
Aging, cancer and nutrition: the DNA methylation connection
Liu, L., Wylie, R. C., Andrews, L. G., & Tollefsbol, T. O. (2003) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.08.001 · Cited by 165 · see citing works
Epigenetic Control of Gene Expression in the Lung
Yang, I. V., & Schwartz, D. A. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1579pp · Cited by 161 · see citing works
Pathology and molecular biology of gastric cancer
Vauhkonen, M., Vauhkonen, H., & Sipponen, P. (2006) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2006.03.016 · Cited by 154 · see citing works
Long telomeres and cancer risk: the price of cellular immortality
McNally, E. J., Luncsford, P. J., & Armanios, M. Y. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120851 · Cited by 151 · see citing works
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
Ramlee, M. K., Wang, J., Toh, W. H., & Li, S. (2016) · Genes · doi:10.3390/genes7080050 · Cited by 149 · see citing works
TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma
Spiegl‐Kreinecker, S., Lötsch, D., Neumayer, K., Kastler, L., Gojo, J., Pirker, C., Pichler, J., Weis, S., Kumar, R., Webersinke, G., et al. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy104 · Cited by 146 · see citing works
Genomic footprints of activated telomere maintenance mechanisms in cancer
Sieverling, L., Hong, C., Koser, S. D., Ginsbach, P., Kleinheinz, K., Hutter, B., Braun, D. M., Cortés‐Ciriano, I., Xi, R., Kabbe, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13824-9 · Cited by 133 · see citing works
Telomere Maintenance Mechanisms in Cancer
Gaspar, T. B., Sá, A., Lopes, J. M., Sobrinho-Simões, M. A., Soares, P., & Vinagre, J. (2018) · Genes · doi:10.3390/genes9050241 · Cited by 132 · see citing works
Dioni, L., Hoxha, M., Nordio, F., Bonzini, M., Tarantini, L., Albetti, B., Savarese, A., Schwartz, J. D., Bertazzi, P. A., Apostoli, P., et al. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1002486 · Cited by 127 · see citing works
de Mendoza, A., Nguyen, T. V., Ford, E., Poppe, D., Buckberry, S., Pflueger, J., Grimmer, M., Stolzenburg, S., Bogdanović, O., Oshlack, A., et al. (2022) · Genome biology · doi:10.1186/s13059-022-02728-5 · Cited by 123 · see citing works
Genetic and epigenetic modulation of telomerase activity in development and disease
Liu, L., Lai, S. R., Andrews, L. G., & Tollefsbol, T. O. (2004) · Gene · doi:10.1016/j.gene.2004.06.011 · Cited by 121 · see citing works
Clément, G., Braunschweig, R., Pasquier, N., Bosman, F. T., & Benhattar, J. (2005) · The Journal of Pathology · doi:10.1002/path.1884 · Cited by 121 · see citing works
Self-citationKeyes, M. K., Jang, H., Mason, J. B., Liu, Z., Crott, J. W., Smith, D. E., Friso, S., & Choi, S. (2007) · Journal of Nutrition · doi:10.1093/jn/137.7.1713 · Cited by 116 · see citing works
On the road to immortality: hTERT upregulation in cancer cells
Janknecht, R. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00356-4 · Cited by 116 · see citing works
TERT promoter mutations contribute to subset prognostication of lower-grade gliomas
Chan, A. K., Yao, Y., Zhang, Z., Chung, N. Y., Liu, J. S.-M., Li, K. K., Shi, Z., Chan, D. T. M., Poon, W. S., Zhou, L., et al. (2014) · Modern Pathology · doi:10.1038/modpathol.2014.94 · Cited by 111 · see citing works
Guilleret, I., & Benhattar, J. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00281-7 · Cited by 110 · see citing works
DNA and histone methylation in gastric carcinogenesis
Calcagno, D. Q. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i8.1182 · Cited by 110 · see citing works
Regulation of Telomerase and Telomeres: Human Tumor Viruses Take Control
Bellon, M., & Nicot, C. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm269 · Cited by 103 · see citing works
Telomerase Regulation: A Role for Epigenetics
Doğan, F., & Forsyth, N. R. (2021) · Cancers · doi:10.3390/cancers13061213 · Cited by 104 · see citing works
Kang, H.-J., Cui, Y., Yin, H., Scheid, A., Hendricks, W. P. D., Schmidt, J. E., Sekulić, A., Kong, D., Trent, J. M., Gokhale, V. M., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b07598 · Cited by 100 · see citing works
Immunohistochemical localization of hTERT protein in human tissues
Seelentag, W. K. F., Stehle, J., Bosman, F. T., Yan, P., & Benhattar, J. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0645-5 · Cited by 94 · see citing works
Self-citationTelomerase in Cancer: Function, Regulation, and Clinical Translation
Robinson, N. J., & Schiemann, W. P. (2022) · Cancers · doi:10.3390/cancers14030808 · Cited by 94 · see citing works
Telomeres and telomerase as targets for anticancer drug development
Olaussen, K. A., Dubrana, K., Dômont, J., Spano, J., Sabatier, L., & Soria, J. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.08.007 · Cited by 92 · see citing works
Influence of age on wound healing and fibrosis
Kapetanaki, M. G., Mora, A. L., & Rojas, M. M. (2012) · The Journal of Pathology · doi:10.1002/path.4122 · Cited by 90 · see citing works
Unusual distribution of DNA methylation within the hTERT CpG island in tissues and cell lines
Guilleret, I., & Benhattar, J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.137 · Cited by 81 · see citing works
Self-citationChromatin and epigenetic regulation of the telomerase reverse transcriptase gene
Zhu, J., Zhao, Y., & Wang, S. (2010) · Protein & Cell · doi:10.1007/s13238-010-0014-1 · Cited by 81 · see citing works
Li, Y., & Tollefsbol, T. O. (2016) · Epigenomics · doi:10.2217/epi-2016-0078 · Cited by 75 · see citing works
Arita, H., Narita, Y., Takami, H., Fukushima, S., Matsushita, Y., Yoshida, A., Miyakita, Y., Ohno, M., Shibui, S., & Ichimura, K. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1203-9 · Cited by 74 · see citing works
Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology
Meeker, A. K. (2006) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2005.11.002 · Cited by 73 · see citing works
Widschwendter, A., Müller, H. M., Hubalek, M., Wiedemair, A., Fiegl, H., GOEBEL, G., Mueller‐Holzner, E., Marth, C., & Widschwendter, M. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.01.036 · Cited by 73 · see citing works
Keratin 23 promotes telomerase reverse transcriptase expression and human colorectal cancer growth
Zhang, N., Zhang, R., Zou, K., Yu, W., Guo, W., Gao, Y., Li, J., Li, M., Tai, Y., Huang, W., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.339 · Cited by 67 · see citing works
Gene-Specific Targeting of DNA Methylation in the Mammalian Genome
Urbano, A., Smith, J., Weeks, R. J., & Chatterjee, A. (2019) · Cancers · doi:10.3390/cancers11101515 · Cited by 64 · see citing works
MCAF1/AM Is Involved in Sp1-mediated Maintenance of Cancer-associated Telomerase Activity
Liu, L., Ishihara, K., Ichimura, T., Fujita, N., Hino, S., Tomita, S., Watanabe, S., Saitoh, N., Ito, T., & Nakao, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807098200 · Cited by 64 · see citing works
Shin, K.-H., Kang, M., Dicterow, E., & Park, N.-H. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601291 · Cited by 65 · see citing works
Liu, L., Saldanha, S. N., Pate, M. S., Andrews, L. G., & Tollefsbol, T. O. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20058 · Cited by 65 · see citing works
Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.204 · Cited by 63 · see citing works
hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis
de Wilde, J., Kooter, J. M., Overmeer, R., Claassen-Kramer, D., Meijer, C. J. L. M., Snijders, P. J. F., & Steenbergen, R. D. M. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-271 · Cited by 62 · see citing works
Renaud, S., Loukinov, D. I., Alberti, L., Vostrov, A. A., Kwon, Y., Bosman, F. T., Lobanenkov, V. V., & Benhattar, J. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq827 · Cited by 62 · see citing works
Self-citationShukla, S., Khan, S. U., Kumar, S., Sinha, S., Farhan, M., Bora, H. K., Maurya, R., & Meeran, S. M. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0286 · Cited by 62 · see citing works
Telomeres and Telomerase in the Development of Liver Cancer
der Stroth, L. I., Tharehalli, U., Güneş, Ç., & Lechel, A. (2020) · Cancers · doi:10.3390/cancers12082048 · Cited by 63 · see citing works
Hong, H. X., Zhang, Y. M., Xu, H., Su, Z., & Sun, P. (2007) · Molecules and Cells · doi:10.1016/s1016-8478(23)07351-x · Cited by 61 · see citing works
Ge, Z., Li, W., Wang, N., Liu, C., Zhu, Q., Björkholm, M., Gruber, A., & Xu, D. (2009) · The FASEB Journal · doi:10.1096/fj.09-140087 · Cited by 59 · see citing works
POT1-TPP1 telomere length regulation and disease
Aramburu, T. M., Plucinsky, S. M., & Skordalakes, E. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.06.040 · Cited by 56 · see citing works
Recent advances in telomere biology: implications for human cancer
Meeker, A. K., & De Marzo, A. M. (2004) · Current Opinion in Oncology · doi:10.1097/00001622-200401000-00007 · Cited by 56 · see citing works
Eldholm, V., Haugen, A., & Zienolddiny, S. (2013) · International Journal of Cancer · doi:10.1002/ijc.28570 · Cited by 56 · see citing works
Ohba, S., Mukherjee, J., Johannessen, T.-C. A., Mancini, A., Chow, T. T., Wood, M. D., Jones, L. E., Mazor, T., Marshall, R. E., Viswanath, P., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0696 · Cited by 55 · see citing works
TERT aberrancies: a screening tool for malignancy in follicular thyroid tumours
Paulsson, J. O., Mu, N., Shabo, I., Wang, N., Zedenius, J., Larsson, C., & Juhlin, C. C. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0050 · Cited by 57 · see citing works
BORIS: a key regulator of cancer stemness
Soltanian, S., & Dehghani, H. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0650-8 · Cited by 54 · see citing works
The Solo Play of TERT Promoter Mutations
Hafezi, F., & Perez-Bercoff, D. (2020) · Cells · doi:10.3390/cells9030749 · Cited by 53 · see citing works
Li, C.-T., Hsiao, Y., Wu, T., Lin, Y. L., Yeh, K., & Ko, J. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23229 · Cited by 53 · see citing works
Kumari, A., Srinivasan, R., Vasishta, R. K., & Wig, J. D. (2009) · Annals of Surgical Oncology · doi:10.1245/s10434-009-0333-8 · Cited by 53 · see citing works
Progress on the role of DNA methylation in aging and longevity
Xiao, F., Kong, Q., Perry, B., & He, Y. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elw009 · Cited by 51 · see citing works
Betaine supplementation attenuates atherosclerotic lesion in apolipoprotein E-deficient mice
Lv, S., Fan, R., Du, Y., Hou, M., Tang, Z., Ling, W., & Zhu, H. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0003-4 · Cited by 53 · see citing works
Farahzadi, R., Fathi, E., Mesbah‐Namin, S. A., & Zarghami, N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188052 · Cited by 52 · see citing works
RetractedOzair, A., Bhat, V., Alisch, R. S., Khosla, A. A., Kotecha, R. R., Odia, Y., McDermott, M. W., & Ahluwalia, M. S. (2023) · Cancers · doi:10.3390/cancers15041342 · Cited by 51 · see citing works
Durham, A. L., Wiegman, C., & Adcock, I. M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.03.006 · Cited by 52 · see citing works
Micronutrient status and global DNA methylation in school-age children
Perng, W., Rozek, L. S., Mora‐Plazas, M., Duchin, O., Marín, C., Forero, Y., Baylín, A., & Villamor, E. (2012) · Epigenetics · doi:10.4161/epi.21915 · Cited by 51 · see citing works
Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature
Cantarella, C. D., Ragusa, D., Giammanco, M., & Tosi, S. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0560-8 · Cited by 51 · see citing works
Wang, N., Kjellin, H., Sofiadis, A., Fotouhi, O., Juhlin, C. C., Bäckdahl, M., Zedenius, J., Xu, D., Lehtiö, J., & Larsson, C. (2016) · Oncotarget · doi:10.18632/oncotarget.7237 · Cited by 50 · see citing works
Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis
Breda, S. G. J. V., Claessen, S. M. H., Lo, K. C., van Herwijnen, M. H. M., Brauers, K. J. J., Lisanti, S., Theunissen, D. H. J., Jennen, D. G. J., Gaj, S., de Kok, T. M. C. M., et al. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1351-2 · Cited by 47 · see citing works
Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines
Abbas, A., Hall, J. A., Patterson, W. L., Ho, E., Hsu, A., Al‐Mulla, F., & Georgel, P. T. (2015) · Biochemistry and Cell Biology · doi:10.1139/bcb-2015-0038 · Cited by 46 · see citing works
Epigenetic control of telomerase and modes of telomere maintenance in aging and abnormal systems
Serene, R. L. (2005) · Frontiers in bioscience · doi:10.2741/1661 · Cited by 46 · see citing works
Ellingsen, E. B., Mangsbo, S. M., Hovig, E. J., & Gaudernack, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.682492 · Cited by 44 · see citing works
hTERTmethylation and expression in gastric cancer
Gigek, C. O., Leal, M. F., Silva, P. N., Lisboa, L. C. F., Lima, E. M., Calcagno, D. Q., de Assumpção, P. P., Burbano, R. M. R., & Smith, M. D. A. C. (2009) · Biomarkers · doi:10.3109/13547500903225912 · Cited by 43 · see citing works
A column method for determination of DNA cytosine-C5-methyltransferase activity
Kim, B., Kwon, O. S., Joo, S. A., Park, J. A., Heo, K. Y., Kim, M. S., & Ahn, J. S. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2003.11.009 · Cited by 43 · see citing works
Takasawa, K., Arai, Y., Yamazaki‐Inoue, M., Toyoda, M., Akutsu, H., Umezawa, A., & Nishino, K. (2017) · Human Cell · doi:10.1007/s13577-017-0190-x · Cited by 42 · see citing works
Lee, J. C., Solomon, D. A., & Tihan, T. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-016-2349-9 · Cited by 41 · see citing works
TERT, a promoter of CNS malignancies
Patel, B., Taiwo, R., Kim, A. H., & Dunn, G. P. (2020) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaa025 · Cited by 40 · see citing works
Bougel, S., Lhermitte, B., Gallagher, G., Flaugergues, J. C., Janzer, R. C., & Benhattar, J. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1246 · Cited by 39 · see citing works
Self-citationWilson, S. L., Liu, Y., & Robinson, W. P. (2016) · Placenta · doi:10.1016/j.placenta.2016.10.001 · Cited by 39 · see citing works
Zhang, X., Li, B., de Jonge, N., Björkholm, M., & Xu, D. (2015) · Oncotarget · doi:10.18632/oncotarget.2917 · Cited by 38 · see citing works
Santourlidis, S., Wernet, P., Ghanjati, F., Graffmann, N., Springer, J., Kriegs, C., Zhao, X., Brands, J., Araúzo-Bravo, M. J., Neves, R. P., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2010.08.003 · Cited by 38 · see citing works
He, Y., Wu, Y., He, X., Liu, F. J., He, X., & Zhang, Y. (2009) · Theriogenology · doi:10.1016/j.theriogenology.2009.01.012 · Cited by 37 · see citing works
Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works
Gojo, J., Lötsch, D., Spiegl‐Kreinecker, S., Pajtler, K. W., Neumayer, K., Korbel, P., Araki, A., Brandstetter, A., Mohr, T. T., Hovestadt, V., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox027 · Cited by 38 · see citing works
Methylation of CpG island promoters in uveal melanoma
Moulin, A., Clément, G., Bosman, F. T., Zografos, L., & Benhattar, J. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.127035 · Cited by 37 · see citing works
Self-citationTelomerase as a new target for the treatment of hormone-refractory prostate cancer
Biroccio, A., & Leonetti, C. (2004) · Endocrine Related Cancer · doi:10.1677/erc.1.00764 · Cited by 37 · see citing works
Long, W. S., Zeng, Y., Zheng, B., Li, Y., Wang, Y., Chan, K., She, M., Lu, Y., Cao, C., & Wong, W. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01255 · Cited by 37 · see citing works
Tao, S. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i19.2334 · Cited by 34 · see citing works
Wang, S., Hu, C., & Zhu, J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0840 · Cited by 34 · see citing works
Chatagnon, A., Bougel, S., Perriaud, L., Lachuer, J., Benhattar, J., & Dante, R. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn240 · Cited by 33 · see citing works
Self-citationJiang, J., Zhao, L., Zhao, C., Zhang, G., Zhao, Y., Li, J., Li, X., & Wei, L. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.11.023 · Cited by 33 · see citing works
Epigenetics in Asthma and Other Inflammatory Lung Diseases
Durham, A. L., Chou, P.-C., Kirkham, P., & Adcock, I. M. (2010) · Epigenomics · doi:10.2217/epi.10.27 · Cited by 34 · see citing works
- Authors
- Guilleret, I., Yan, P., Grange, F., Braunschweig, R., Bosman, F. T., & Benhattar, J.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Benhattar, Jean
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2002-08-29
- Volume
- 101
- Issue
- 4
- Pages
- 335-341
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2055902044
- Cited by
- 260
- References
- 44
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 10 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 18 · 2019: 13 · 2018: 12 · 2017: 12 · 2016: 19 · 2015: 18 · 2014: 5 · 2013: 12 · 2012: 8
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- hTERT, telomerase, promoter hypermethylation, DNA methylation, CpG islands, telomerase activity, gene expression regulation, tumor suppressor, gene silencing, cancer cell lines, telomere length
- MeSH terms
- DNA-Binding Proteins, Humans, Neoplasms, Promoter Regions, Genetic, RNA, Messenger, Tumor Cells, Cultured, Gene Expression Regulation, Enzymologic, Polymorphism, Single-Stranded Conformational, Telomerase, DNA Methylation
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