The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Molecular genetic evidence that endometriosis is a precursor of ovarian cancer
Abstract
Histopathology and epidemiology studies have consistently demonstrated a strong link between endometriosis and endometriosis‐associated ovarian cancers (EAOCs)—in particular, the endometrioid and clear cell subtypes. However, it is still unclear whether endometriosis is a precursor to EAOCs, or whether there is an indirect link because similar factors predispose to both diseases. In order to search for evidence of clonal progression, we analyzed 10 EAOCs (endometrioid = 4; clear cell = 6) with coexisting endometriosis for common molecular genetic alterations in both the carcinoma and corresponding endometriosis. We used 82 microsatellite markers spanning the genome to examine loss of heterozygosity (LOH) in the coexisting carcinoma and endometriosis samples. A total of 63 LOH events were detected in the carcinoma samples; twenty two of these were also detected in the corresponding endometriosis samples. In each case, the same allele was lost in the endometriosis and cancer samples. Interestingly, no marker showed LOH in the endometriosis alone. These data provide evidence that endometriosis is a precursor to EAOCs. © 2006 Wiley‐Liss, Inc.
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Berkley, K. J., Rapkin, A. J., & Papka, R. E. (2005) · Science · doi:10.1126/science.1111445 · Cited by 455
Ovarian atypical endometriosis: its close association with malignant epithelial tumours
FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., & USHIGOME, S. (1997) · Histopathology · doi:10.1046/j.1365-2559.1997.d01-592.x · Cited by 333 · cited 1×
“However, it has been reported that 5–10% of women with ovarian endometriomas have ovarian carcinomas,(6,14) with clear cell and endometrioid carcinomas by far the predominant EAOCs (40–55% clear cell, 20–40% endometrioid and <10% serous/mucinous).(5,8,13) Although many of the risk factors associated with both diseases…”
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Cited by
Yamamoto, S., Tsuda, H., Takano, M., Iwaya, K., Tamai, S., & Matsubara, O. (2011) · The Journal of Pathology · doi:10.1002/path.2940 · Cited by 152
Endometriosis-associated Malignancy
Krawczyk, N., Banys-Paluchowski, M., Schmidt, D., Ulrich, U., & Fehm, T. (2016) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0035-1558239 · Cited by 107
Dawson, A., Llauradó Fernandez, M., Anglesio, M., Yong, P. J., & Carey, M. S. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.803 · Cited by 106
Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: A meta-analysis
li, J., Liu, R., Tang, S., Feng, F., Liu, C., Wang, L., Zhao, W., Zhang, T., Yao, Y., Wang, X., et al. (2019) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-018-4968-1 · Cited by 56
Metadata
- Authors
- Prowse, A. H., Manek, S., Varma, R., Liu, J., Godwin, A. K., Maher, E. R., Tomlinson, I. P. M., & Kennedy, S. H.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2006-05-08
- Volume
- 119
- Issue
- 3
- Pages
- 556-562
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2156223374
- Cited by
- 164
- References
- 2
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Prowse, A. H., Manek, S., Varma, R., Liu, J., Godwin, A. K., Maher, E. R., Tomlinson, I. P. M., & Kennedy, S. H. (2006). Molecular genetic evidence that endometriosis is a precursor of ovarian cancer. International Journal of Cancer. https://doi.org/10.1002/ijc.21845
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