Endometriosis and endometriosis-associated cancers: new insights into the molecular mechanisms of ovarian cancer development
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Endometriosis is a fascinating disease that we strive to better understand. Molecular techniques are shedding new light on many important aspects of this disease: from pathogenesis to the recognition of distinct disease variants like deep infiltrating endometriosis. The observation that endometriosis is a cancer precursor has now been strengthened with the knowledge that mutations that are present in endometriosis-associated cancers can be found in adjacent endometriosis lesions. Recent genomic studies, placed in context, suggest that deep infiltrating endometriosis may represent a benign neoplasm that invades locally but rarely metastasises. Further research will help elucidate distinct aberrations which result in this phenotype. With respect to identifying those patients who may be at risk of developing endometriosis-associated cancers, a combination of molecular, pathological, and inheritance markers may define a high-risk group that might benefit from risk-reducing strategies.
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Endometriosis seems associated with a higher risk of cancer.
“Endometriosis seems associated with a higher risk of cancer, as recently reviewed (139, 140).”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [140]
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- Authors
- Dawson, A., Llauradó Fernandez, M., Anglesio, M., Yong, P. J., & Carey, M. S.
- Affiliations
- University of British Columbia (CA)
- BC Cancer Agency (CA)
- Corresponding author
- Carey, Mark S
- Venue
- ecancermedicalscience
- Publisher
- Ecancer Global Foundation
- Published
- 2018-01-25
- Volume
- 12
- Pages
- 803-803
- ISSN
- 1754-6605 (ISSN-L)
- PMC
- PMC5813919
- OpenAlex
- W2791748771
- Cited by
- 106
- References
- 142
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 17 · 2021: 18 · 2020: 20 · 2019: 13 · 2018: 6
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- ecancermedicalscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, endometriosis-associated cancer, ovarian cancer, deep infiltrating endometriosis, cancer precursors, molecular pathogenesis, genetic alterations, high-risk patient identification, risk mitigation strategies
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