Cited by 106Endometriosis Research and TreatmentOvarian cancer diagnosis and treatmentEndometrial and Cervical Cancer Treatments

Endometriosis and endometriosis-associated cancers: new insights into the molecular mechanisms of ovarian cancer development

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Dawson, Amy, Llauradó Fernandez, Marta, Anglesio, Michael, Yong, Paul J, Carey, Mark S·2018·ecancermedicalscience

Abstract

Endometriosis is a fascinating disease that we strive to better understand. Molecular techniques are shedding new light on many important aspects of this disease: from pathogenesis to the recognition of distinct disease variants like deep infiltrating endometriosis. The observation that endometriosis is a cancer precursor has now been strengthened with the knowledge that mutations that are present in endometriosis-associated cancers can be found in adjacent endometriosis lesions. Recent genomic studies, placed in context, suggest that deep infiltrating endometriosis may represent a benign neoplasm that invades locally but rarely metastasises. Further research will help elucidate distinct aberrations which result in this phenotype. With respect to identifying those patients who may be at risk of developing endometriosis-associated cancers, a combination of molecular, pathological, and inheritance markers may define a high-risk group that might benefit from risk-reducing strategies.

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Crossref · 10.3332/ecancer.2018.803

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  1. [34]Jansen M Wright N Advances in Experimental Medicine and Biology Series. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract 2016 908 Switzerland Springer 486

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Authors
Dawson, A., Llauradó Fernandez, M., Anglesio, M., Yong, P. J., & Carey, M. S.
Affiliations
  • University of British Columbia (CA)
  • BC Cancer Agency (CA)
Corresponding author
Carey, Mark S
Venue
ecancermedicalscience
Published
2018-01-25
Volume
12
Pages
803-803
ISSN
1754-6605 (ISSN-L)
OpenAlex
W2791748771
Cited by
106
References
142
Citations by year
2026: 3 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 17 · 2021: 18 · 2020: 20 · 2019: 13 · 2018: 6
FWCI
2.15
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • ecancermedicalscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords
endometriosis, endometriosis-associated cancer, ovarian cancer, deep infiltrating endometriosis, cancer precursors, molecular pathogenesis, genetic alterations, high-risk patient identification, risk mitigation strategies

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